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Fusion gene ID: 22145 |
FusionGeneSummary for MLLT10_CYTH1 |
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Fusion gene information | Fusion gene name: MLLT10_CYTH1 | Fusion gene ID: 22145 | Hgene | Tgene | Gene symbol | MLLT10 | CYTH1 | Gene ID | 8028 | 9267 |
Gene name | MLLT10, histone lysine methyltransferase DOT1L cofactor | cytohesin 1 | |
Synonyms | AF10 | B2-1|CYTOHESIN-1|D17S811E|PSCD1|SEC7 | |
Cytomap | 10p12.31 | 17q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot | cytohesin-1PH, SEC7 and coiled-coil domain-containing protein 1SEC7 homolog B2-1cytoadhesin 1homolog of secretory protein SEC7pleckstrin homology, Sec7 and coiled-coil domains 1 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P55197 | Q15438 | |
Ensembl transtripts involved in fusion gene | ENST00000446906, ENST00000377072, ENST00000307729, ENST00000377059, ENST00000495130, ENST00000377100, ENST00000377091, | ENST00000585509, ENST00000589297, ENST00000591455, ENST00000446868, ENST00000361101, ENST00000589296, ENST00000586175, | |
Fusion gene scores | * DoF score | 13 X 10 X 8=1040 | 5 X 5 X 2=50 |
# samples | 20 | 7 | |
** MAII score | log2(20/1040*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/50*10)=0.485426827170242 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MLLT10 [Title/Abstract] AND CYTH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MLLT10 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17868029 |
Tgene | CYTH1 | GO:0030155 | regulation of cell adhesion | 12606567 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW381251 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000446906 | ENST00000585509 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000446906 | ENST00000589297 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000446906 | ENST00000591455 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000446906 | ENST00000446868 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000446906 | ENST00000361101 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000446906 | ENST00000589296 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000446906 | ENST00000586175 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377072 | ENST00000585509 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377072 | ENST00000589297 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377072 | ENST00000591455 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377072 | ENST00000446868 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377072 | ENST00000361101 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377072 | ENST00000589296 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377072 | ENST00000586175 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000307729 | ENST00000585509 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000307729 | ENST00000589297 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000307729 | ENST00000591455 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000307729 | ENST00000446868 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000307729 | ENST00000361101 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000307729 | ENST00000589296 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000307729 | ENST00000586175 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377059 | ENST00000585509 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377059 | ENST00000589297 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377059 | ENST00000591455 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377059 | ENST00000446868 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377059 | ENST00000361101 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377059 | ENST00000589296 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377059 | ENST00000586175 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000495130 | ENST00000585509 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000495130 | ENST00000589297 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000495130 | ENST00000591455 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000495130 | ENST00000446868 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000495130 | ENST00000361101 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000495130 | ENST00000589296 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000495130 | ENST00000586175 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377100 | ENST00000585509 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377100 | ENST00000589297 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377100 | ENST00000591455 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377100 | ENST00000446868 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377100 | ENST00000361101 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377100 | ENST00000589296 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377100 | ENST00000586175 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377091 | ENST00000585509 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377091 | ENST00000589297 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377091 | ENST00000591455 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377091 | ENST00000446868 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377091 | ENST00000361101 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377091 | ENST00000589296 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
intron-intron | ENST00000377091 | ENST00000586175 | MLLT10 | chr10 | 21983195 | - | CYTH1 | chr17 | 76705733 | + |
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FusionProtFeatures for MLLT10_CYTH1 |
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Hgene | Tgene |
MLLT10 | CYTH1 |
Probably involved in transcriptional regulation. Invitro or as fusion protein with KMT2A/MLL1 has transactivationactivity. Binds to cruciform DNA. In cells, binding to unmodifiedhistone H3 regulates DOT1L functions including histone H3 'Lys-79'dimethylation (H3K79me2) and gene activation (PubMed:26439302).{ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. | Promotes guanine-nucleotide exchange on ARF1, ARF5 andARF6. Promotes the activation of ARF factors through replacementof GDP with GTP. Plays an important role in membrane trafficking,during junctional remodeling and epithelial polarization, throughregulation of ARF6 activity. {ECO:0000250|UniProtKB:Q9QX11,ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:29420262,ECO:0000269|PubMed:9653114}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MLLT10_CYTH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MLLT10_CYTH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MLLT10_CYTH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MLLT10_CYTH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MLLT10 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | MLLT10 | C0025202 | melanoma | 1 | CTD_human |
Hgene | MLLT10 | C0025286 | Meningioma | 1 | CTD_human |