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Fusion gene ID: 22131 |
FusionGeneSummary for MLF1_RSRC1 |
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Fusion gene information | Fusion gene name: MLF1_RSRC1 | Fusion gene ID: 22131 | Hgene | Tgene | Gene symbol | MLF1 | RSRC1 | Gene ID | 4291 | 51319 |
Gene name | myeloid leukemia factor 1 | arginine and serine rich coiled-coil 1 | |
Synonyms | - | BM-011|SFRS21|SRrp53 | |
Cytomap | 3q25.32 | 3q25.32 | |
Type of gene | protein-coding | protein-coding | |
Description | myeloid leukemia factor 1myelodysplasia-myeloid leukemia factor 1testis tissue sperm-binding protein Li 49e | serine/Arginine-related protein 53arginine/serine-rich coiled-coil 1arginine/serine-rich coiled-coil protein 1splicing factor, arginine/serine-rich 21 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P58340 | Q96IZ7 | |
Ensembl transtripts involved in fusion gene | ENST00000355893, ENST00000484955, ENST00000359117, ENST00000471745, ENST00000497004, ENST00000469452, ENST00000482628, ENST00000478894, ENST00000392822, | ENST00000480820, ENST00000295930, ENST00000464171, ENST00000312179, ENST00000475278, ENST00000496268, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MLF1 [Title/Abstract] AND RSRC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MLF1 | GO:0007050 | cell cycle arrest | 15861129 |
Tgene | RSRC1 | GO:0000398 | mRNA splicing, via spliceosome | 15798186 |
Tgene | RSRC1 | GO:0008380 | RNA splicing | 15798186 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-4Z-AA7Q-01A | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000355893 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000355893 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000355893 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000355893 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000355893 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000355893 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000484955 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000484955 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000484955 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000484955 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000484955 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000484955 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000359117 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000359117 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000359117 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000359117 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000359117 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000359117 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000471745 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000471745 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000471745 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000471745 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000471745 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000471745 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
3UTR-3CDS | ENST00000497004 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
3UTR-3CDS | ENST00000497004 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
3UTR-3CDS | ENST00000497004 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
3UTR-3CDS | ENST00000497004 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
3UTR-intron | ENST00000497004 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
3UTR-intron | ENST00000497004 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000469452 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000469452 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000469452 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000469452 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000469452 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000469452 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000482628 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000482628 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000482628 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000482628 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000482628 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000482628 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000478894 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000478894 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000478894 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000478894 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000478894 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000478894 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000392822 | ENST00000480820 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000392822 | ENST00000295930 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000392822 | ENST00000464171 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
In-frame | ENST00000392822 | ENST00000312179 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000392822 | ENST00000475278 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
5CDS-intron | ENST00000392822 | ENST00000496268 | MLF1 | chr3 | 158310370 | + | RSRC1 | chr3 | 158261124 | + |
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FusionProtFeatures for MLF1_RSRC1 |
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Hgene | Tgene |
MLF1 | RSRC1 |
Involved in lineage commitment of primary hemopoieticprogenitors by restricting erythroid formation and enhancingmyeloid formation. Interferes with erythropoietin-inducederythroid terminal differentiation by preventing cells fromexiting the cell cycle through suppression of CDKN1B/p27Kip1levels. Suppresses COP1 activity via CSN3 which activates p53 andinduces cell cycle arrest. Binds DNA and affects the expression ofa number of genes so may function as a transcription factor in thenucleus. {ECO:0000269|PubMed:15861129}. | Plays a role in pre-mRNA splicing. Involved in bothconstitutive and alternative pre-mRNA splicing. May have a role inthe recognition of the 3' splice site during the second step ofsplicing. {ECO:0000269|PubMed:15798186}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | RSRC1 | chr3:158310370 | chr3:158261124 | ENST00000295930 | + | 7 | 10 | 180_236 | 253 | 335 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | RSRC1 | chr3:158310370 | chr3:158261124 | ENST00000312179 | + | 6 | 9 | 180_236 | 195 | 277 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | RSRC1 | chr3:158310370 | chr3:158261124 | ENST00000464171 | + | 6 | 9 | 180_236 | 195 | 277 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | RSRC1 | chr3:158310370 | chr3:158261124 | ENST00000480820 | + | 7 | 10 | 180_236 | 253 | 335 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | RSRC1 | chr3:158310370 | chr3:158261124 | ENST00000295930 | + | 7 | 10 | 3_147 | 253 | 335 | Compositional bias | Note=Arg/Ser-rich |
Tgene | RSRC1 | chr3:158310370 | chr3:158261124 | ENST00000312179 | + | 6 | 9 | 3_147 | 195 | 277 | Compositional bias | Note=Arg/Ser-rich |
Tgene | RSRC1 | chr3:158310370 | chr3:158261124 | ENST00000464171 | + | 6 | 9 | 3_147 | 195 | 277 | Compositional bias | Note=Arg/Ser-rich |
Tgene | RSRC1 | chr3:158310370 | chr3:158261124 | ENST00000480820 | + | 7 | 10 | 3_147 | 253 | 335 | Compositional bias | Note=Arg/Ser-rich |
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FusionGeneSequence for MLF1_RSRC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MLF1_RSRC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MLF1 | MAGEA11, GRIK5, COPS3, CENPU, DNAJB8, DNAJB6, MAP1B, ERCC6L, TRO, AKAP11, BRCA2, SYNRG, FAM83H, ZWINT, SPC24, PRKACB, FAM21A, HEATR5B, CDK5RAP2, RIPK1, KIF11, CASC5, ATG2B, HAUS6, PDE4DIP, ALMS1, RGPD5, HAUS8, HERC1, PRKAR1B, CCDC88A, APOB, TP73, CRYBG3, BUB1, DSN1, TARBP2, HYPK, DUSP16, CEP295, AARSD1, KIF20B, PROZ, NDC80, PLEC, PMF1, WNK1, THSD4, RABGAP1L, CDC16, TSHR, EPB41L2, PRKACG, TBCE, DNAJC13, EDRF1, C1orf168, IRF2BP1, NMT1 | RSRC1 | EEF1A1, GDF9, LSM2, UTP14A, JMJD6, SRPK2, SRPK1, BMI1, DDX23, TSSC4, TFIP11, C17orf85, PAXBP1, SNRNP40, CSNK2A1, CSNK2A2, NTRK1, DVL2, NCBP1, PPP3CB, DLGAP5, PAPOLA, RACGAP1, ING3, VPS18, TGS1, NELFE, HDAC11, SNRPE, CFAP20, SNRPG, SNRPF, SLIT2, EXOSC9, EXOSC2, EXOSC7, EXOSC4, LUM, LRRC47 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | MLF1 | chr3:158310370 | chr3:158261124 | ENST00000355893 | + | 2 | 7 | 50_125 | 65 | 269 | COPS3 |
Hgene | MLF1 | chr3:158310370 | chr3:158261124 | ENST00000359117 | + | 2 | 7 | 50_125 | 40 | 244 | COPS3 |
Hgene | MLF1 | chr3:158310370 | chr3:158261124 | ENST00000392822 | + | 3 | 9 | 50_125 | 81 | 300 | COPS3 |
Hgene | MLF1 | chr3:158310370 | chr3:158261124 | ENST00000469452 | + | 3 | 7 | 50_125 | 40 | 201 | COPS3 |
Hgene | MLF1 | chr3:158310370 | chr3:158261124 | ENST00000471745 | + | 3 | 9 | 50_125 | 40 | 259 | COPS3 |
Hgene | MLF1 | chr3:158310370 | chr3:158261124 | ENST00000478894 | + | 3 | 9 | 50_125 | 40 | 259 | COPS3 |
Hgene | MLF1 | chr3:158310370 | chr3:158261124 | ENST00000482628 | + | 3 | 8 | 50_125 | 40 | 244 | COPS3 |
Hgene | MLF1 | chr3:158310370 | chr3:158261124 | ENST00000484955 | + | 3 | 8 | 50_125 | 40 | 244 | COPS3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MLF1_RSRC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MLF1_RSRC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MLF1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |