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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22131

FusionGeneSummary for MLF1_RSRC1

check button Fusion gene summary
Fusion gene informationFusion gene name: MLF1_RSRC1
Fusion gene ID: 22131
HgeneTgene
Gene symbol

MLF1

RSRC1

Gene ID

4291

51319

Gene namemyeloid leukemia factor 1arginine and serine rich coiled-coil 1
Synonyms-BM-011|SFRS21|SRrp53
Cytomap

3q25.32

3q25.32

Type of geneprotein-codingprotein-coding
Descriptionmyeloid leukemia factor 1myelodysplasia-myeloid leukemia factor 1testis tissue sperm-binding protein Li 49eserine/Arginine-related protein 53arginine/serine-rich coiled-coil 1arginine/serine-rich coiled-coil protein 1splicing factor, arginine/serine-rich 21
Modification date2018052320180519
UniProtAcc

P58340

Q96IZ7

Ensembl transtripts involved in fusion geneENST00000355893, ENST00000484955, 
ENST00000359117, ENST00000471745, 
ENST00000497004, ENST00000469452, 
ENST00000482628, ENST00000478894, 
ENST00000392822, 
ENST00000480820, 
ENST00000295930, ENST00000464171, 
ENST00000312179, ENST00000475278, 
ENST00000496268, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MLF1 [Title/Abstract] AND RSRC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLF1

GO:0007050

cell cycle arrest

15861129

TgeneRSRC1

GO:0000398

mRNA splicing, via spliceosome

15798186

TgeneRSRC1

GO:0008380

RNA splicing

15798186


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-4Z-AA7Q-01AMLF1chr3

158310370

+RSRC1chr3

158261124

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355893ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000355893ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000355893ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000355893ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000355893ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000355893ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000484955ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000484955ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000484955ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000484955ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000484955ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000484955ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000359117ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000359117ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000359117ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000359117ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000359117ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000359117ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000471745ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000471745ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000471745ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000471745ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000471745ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000471745ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+
3UTR-3CDSENST00000497004ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
3UTR-3CDSENST00000497004ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
3UTR-3CDSENST00000497004ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
3UTR-3CDSENST00000497004ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
3UTR-intronENST00000497004ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
3UTR-intronENST00000497004ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000469452ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000469452ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000469452ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000469452ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000469452ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000469452ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000482628ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000482628ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000482628ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000482628ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000482628ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000482628ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000478894ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000478894ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000478894ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000478894ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000478894ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000478894ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000392822ENST00000480820MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000392822ENST00000295930MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000392822ENST00000464171MLF1chr3

158310370

+RSRC1chr3

158261124

+
In-frameENST00000392822ENST00000312179MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000392822ENST00000475278MLF1chr3

158310370

+RSRC1chr3

158261124

+
5CDS-intronENST00000392822ENST00000496268MLF1chr3

158310370

+RSRC1chr3

158261124

+

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FusionProtFeatures for MLF1_RSRC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLF1

P58340

RSRC1

Q96IZ7

Involved in lineage commitment of primary hemopoieticprogenitors by restricting erythroid formation and enhancingmyeloid formation. Interferes with erythropoietin-inducederythroid terminal differentiation by preventing cells fromexiting the cell cycle through suppression of CDKN1B/p27Kip1levels. Suppresses COP1 activity via CSN3 which activates p53 andinduces cell cycle arrest. Binds DNA and affects the expression ofa number of genes so may function as a transcription factor in thenucleus. {ECO:0000269|PubMed:15861129}. Plays a role in pre-mRNA splicing. Involved in bothconstitutive and alternative pre-mRNA splicing. May have a role inthe recognition of the 3' splice site during the second step ofsplicing. {ECO:0000269|PubMed:15798186}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRSRC1chr3:158310370chr3:158261124ENST00000295930+710180_236253335Coiled coilOntology_term=ECO:0000255
TgeneRSRC1chr3:158310370chr3:158261124ENST00000312179+69180_236195277Coiled coilOntology_term=ECO:0000255
TgeneRSRC1chr3:158310370chr3:158261124ENST00000464171+69180_236195277Coiled coilOntology_term=ECO:0000255
TgeneRSRC1chr3:158310370chr3:158261124ENST00000480820+710180_236253335Coiled coilOntology_term=ECO:0000255
TgeneRSRC1chr3:158310370chr3:158261124ENST00000295930+7103_147253335Compositional biasNote=Arg/Ser-rich
TgeneRSRC1chr3:158310370chr3:158261124ENST00000312179+693_147195277Compositional biasNote=Arg/Ser-rich
TgeneRSRC1chr3:158310370chr3:158261124ENST00000464171+693_147195277Compositional biasNote=Arg/Ser-rich
TgeneRSRC1chr3:158310370chr3:158261124ENST00000480820+7103_147253335Compositional biasNote=Arg/Ser-rich


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FusionGeneSequence for MLF1_RSRC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MLF1_RSRC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MLF1MAGEA11, GRIK5, COPS3, CENPU, DNAJB8, DNAJB6, MAP1B, ERCC6L, TRO, AKAP11, BRCA2, SYNRG, FAM83H, ZWINT, SPC24, PRKACB, FAM21A, HEATR5B, CDK5RAP2, RIPK1, KIF11, CASC5, ATG2B, HAUS6, PDE4DIP, ALMS1, RGPD5, HAUS8, HERC1, PRKAR1B, CCDC88A, APOB, TP73, CRYBG3, BUB1, DSN1, TARBP2, HYPK, DUSP16, CEP295, AARSD1, KIF20B, PROZ, NDC80, PLEC, PMF1, WNK1, THSD4, RABGAP1L, CDC16, TSHR, EPB41L2, PRKACG, TBCE, DNAJC13, EDRF1, C1orf168, IRF2BP1, NMT1RSRC1EEF1A1, GDF9, LSM2, UTP14A, JMJD6, SRPK2, SRPK1, BMI1, DDX23, TSSC4, TFIP11, C17orf85, PAXBP1, SNRNP40, CSNK2A1, CSNK2A2, NTRK1, DVL2, NCBP1, PPP3CB, DLGAP5, PAPOLA, RACGAP1, ING3, VPS18, TGS1, NELFE, HDAC11, SNRPE, CFAP20, SNRPG, SNRPF, SLIT2, EXOSC9, EXOSC2, EXOSC7, EXOSC4, LUM, LRRC47


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMLF1chr3:158310370chr3:158261124ENST00000355893+2750_12565269COPS3
HgeneMLF1chr3:158310370chr3:158261124ENST00000359117+2750_12540244COPS3
HgeneMLF1chr3:158310370chr3:158261124ENST00000392822+3950_12581300COPS3
HgeneMLF1chr3:158310370chr3:158261124ENST00000469452+3750_12540201COPS3
HgeneMLF1chr3:158310370chr3:158261124ENST00000471745+3950_12540259COPS3
HgeneMLF1chr3:158310370chr3:158261124ENST00000478894+3950_12540259COPS3
HgeneMLF1chr3:158310370chr3:158261124ENST00000482628+3850_12540244COPS3
HgeneMLF1chr3:158310370chr3:158261124ENST00000484955+3850_12540244COPS3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MLF1_RSRC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MLF1_RSRC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLF1C0038356Stomach Neoplasms1CTD_human