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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22130

FusionGeneSummary for MLF1_CIZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: MLF1_CIZ1
Fusion gene ID: 22130
HgeneTgene
Gene symbol

MLF1

CIZ1

Gene ID

4291

25792

Gene namemyeloid leukemia factor 1CDKN1A interacting zinc finger protein 1
Synonyms-LSFR1|NP94|ZNF356
Cytomap

3q25.32

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionmyeloid leukemia factor 1myelodysplasia-myeloid leukemia factor 1testis tissue sperm-binding protein Li 49ecip1-interacting zinc finger proteinnuclear protein NP94zinc finger protein 356
Modification date2018052320180519
UniProtAcc

P58340

Q9ULV3

Ensembl transtripts involved in fusion geneENST00000355893, ENST00000484955, 
ENST00000359117, ENST00000471745, 
ENST00000497004, ENST00000469452, 
ENST00000482628, ENST00000478894, 
ENST00000392822, 		ENST00000372954, 
ENST00000393608, ENST00000541172, 
ENST00000357558, ENST00000325721, 
ENST00000538431, ENST00000277465, 
ENST00000372948, ENST00000372938, 
ENST00000476727, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLF1 [Title/Abstract] AND CIZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLF1

GO:0007050

cell cycle arrest

15861129


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA423309MLF1chr3

158323076

-CIZ1chr9

130942714

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000355893ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000355893ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000355893ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000355893ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000355893ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000355893ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000355893ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000355893ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000355893ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-5UTRENST00000355893ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000484955ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-5UTRENST00000484955ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000359117ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-5UTRENST00000359117ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000471745ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-5UTRENST00000471745ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000497004ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-5UTRENST00000497004ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000469452ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-5UTRENST00000469452ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-3CDSENST00000482628ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
intron-5UTRENST00000482628ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000478894ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-5UTRENST00000478894ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000372954MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000393608MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000541172MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000357558MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000325721MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000538431MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000277465MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000372948MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-3CDSENST00000392822ENST00000372938MLF1chr3

158323076

-CIZ1chr9

130942714

+
3UTR-5UTRENST00000392822ENST00000476727MLF1chr3

158323076

-CIZ1chr9

130942714

+

Top

FusionProtFeatures for MLF1_CIZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLF1

P58340

CIZ1

Q9ULV3

Involved in lineage commitment of primary hemopoieticprogenitors by restricting erythroid formation and enhancingmyeloid formation. Interferes with erythropoietin-inducederythroid terminal differentiation by preventing cells fromexiting the cell cycle through suppression of CDKN1B/p27Kip1levels. Suppresses COP1 activity via CSN3 which activates p53 andinduces cell cycle arrest. Binds DNA and affects the expression ofa number of genes so may function as a transcription factor in thenucleus. {ECO:0000269|PubMed:15861129}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MLF1_CIZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MLF1_CIZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MLF1_CIZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MLF1_CIZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLF1C0038356Stomach Neoplasms1CTD_human
TgeneCIZ1C0013421Dystonia1CTD_human
TgeneCIZ1C0033578Prostatic Neoplasms1CTD_human
TgeneCIZ1C0553580Ewings sarcoma1CTD_human
TgeneCIZ1C1865819CERVICAL DYSTONIA, PRIMARY1CTD_human