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Fusion gene ID: 22109 |
FusionGeneSummary for MKNK2_RNF126 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MKNK2_RNF126 | Fusion gene ID: 22109 | Hgene | Tgene | Gene symbol | MKNK2 | RNF126 | Gene ID | 2872 | 55658 |
| Gene name | MAP kinase interacting serine/threonine kinase 2 | ring finger protein 126 | |
| Synonyms | GPRK7|MNK2 | - | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase signal-integrating kinase 2MAPK signal-integrating kinase 2 | E3 ubiquitin-protein ligase RNF126 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HBH9 | Q9BV68 | |
| Ensembl transtripts involved in fusion gene | ENST00000591142, ENST00000591601, ENST00000309340, ENST00000250896, ENST00000541165, ENST00000591588, ENST00000588014, | ENST00000292363, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 4 X 2 X 4=32 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MKNK2 [Title/Abstract] AND RNF126 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MKNK2 | GO:0006468 | protein phosphorylation | 11463832 |
| Hgene | MKNK2 | GO:0030097 | hemopoiesis | 21149447 |
| Hgene | MKNK2 | GO:0035556 | intracellular signal transduction | 11463832 |
| Hgene | MKNK2 | GO:0071243 | cellular response to arsenic-containing substance | 18299328 |
| Tgene | RNF126 | GO:0006511 | ubiquitin-dependent protein catabolic process | 24981174 |
| Tgene | RNF126 | GO:0006513 | protein monoubiquitination | 23277564 |
| Tgene | RNF126 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 24981174 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LAML | TCGA-AB-2897-03A | MKNK2 | chr19 | 2041839 | - | RNF126 | chr19 | 652884 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000591142 | ENST00000292363 | MKNK2 | chr19 | 2041839 | - | RNF126 | chr19 | 652884 | - |
| In-frame | ENST00000591601 | ENST00000292363 | MKNK2 | chr19 | 2041839 | - | RNF126 | chr19 | 652884 | - |
| Frame-shift | ENST00000309340 | ENST00000292363 | MKNK2 | chr19 | 2041839 | - | RNF126 | chr19 | 652884 | - |
| Frame-shift | ENST00000250896 | ENST00000292363 | MKNK2 | chr19 | 2041839 | - | RNF126 | chr19 | 652884 | - |
| Frame-shift | ENST00000541165 | ENST00000292363 | MKNK2 | chr19 | 2041839 | - | RNF126 | chr19 | 652884 | - |
| In-frame | ENST00000591588 | ENST00000292363 | MKNK2 | chr19 | 2041839 | - | RNF126 | chr19 | 652884 | - |
| Frame-shift | ENST00000588014 | ENST00000292363 | MKNK2 | chr19 | 2041839 | - | RNF126 | chr19 | 652884 | - |
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FusionProtFeatures for MKNK2_RNF126 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MKNK2 | RNF126 |
| Serine/threonine-protein kinase that phosphorylatesSFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response toenvironmental stress and cytokines. Appears to regulatetranslation by phosphorylating EIF4E, thus increasing the affinityof this protein for the 7-methylguanosine-containing mRNA cap.Required for mediating PP2A-inhibition-induced EIF4Ephosphorylation. Triggers EIF4E shuttling from cytoplasm tonucleus. Isoform 1 displays a high basal kinase activity, butisoform 2 exhibits a very low kinase activity. Acts as a mediatorof the suppressive effects of IFNgamma on hematopoiesis. Negativeregulator for signals that control generation of arsenic trioxideAs(2)O(3)-dependent apoptosis and anti-leukemic responses.Involved in anti-apoptotic signaling in response to serumwithdrawal. {ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141,ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020,ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271,ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. | E3 ubiquitin-protein ligase that mediates ubiquitinationoF target proteins (PubMed:23277564, PubMed:24275455,PubMed:24981174). Depending on the associated E2 ligase, mediates'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (Bysimilarity). Part of a BAG6-dependent quality control processensuring that proteins of the secretory pathway that aremislocalized to the cytosol are degraded by the proteasome.Probably acts by providing the ubiquitin ligase activityassociated with the BAG6 complex and be responsible forubiquitination of the hydrophobic mislocalized proteins and theirtargeting to the proteasome (PubMed:24981174, PubMed:29042515).May also play a role in the endosomal recycling of IGF2R, thecation-independent mannose-6-phosphate receptor (PubMed:24275455).May play a role in the endosomal sorting and degradation ofseveral membrane receptors including EGFR, FLT3, MET and CXCR4, bymediating their ubiquitination (PubMed:23418353). Byubiquitinating CDKN1A/p21 and targeting it for degradation, mayalso promote cell proliferation (PubMed:23026136). Maymonoubiquitinate AICDA (PubMed:23277564).{ECO:0000250|UniProtKB:Q91YL2, ECO:0000269|PubMed:23277564,ECO:0000269|PubMed:23418353, ECO:0000269|PubMed:24275455,ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:29042515,ECO:0000305|PubMed:23026136}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000250896 | - | 11 | 14 | 60_66 | 315 | 466 | Motif | Note=Nuclear localization signal |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000309340 | - | 11 | 14 | 60_66 | 315 | 415 | Motif | Note=Nuclear localization signal |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000591601 | - | 10 | 13 | 60_66 | 315 | 466 | Motif | Note=Nuclear localization signal |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000250896 | - | 11 | 14 | 90_98 | 315 | 466 | Nucleotide binding | ATP |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000309340 | - | 11 | 14 | 90_98 | 315 | 415 | Nucleotide binding | ATP |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000591601 | - | 10 | 13 | 90_98 | 315 | 466 | Nucleotide binding | ATP |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000250896 | - | 11 | 14 | 160_162 | 315 | 466 | Region | Note=Staurosporine binding |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000309340 | - | 11 | 14 | 160_162 | 315 | 415 | Region | Note=Staurosporine binding |
| Hgene | MKNK2 | chr19:2041839 | chr19:652884 | ENST00000591601 | - | 10 | 13 | 160_162 | 315 | 466 | Region | Note=Staurosporine binding |
| Tgene | >RNF126 | chr19:2041839 | chr19:652884 | ENST00000292363 | - | 0 | 9 | 289_303 | 25 | 312 | Compositional bias | Note=Ser-rich |
| Tgene | >RNF126 | chr19:2041839 | chr19:652884 | ENST00000292363 | - | 0 | 9 | 229_270 | 25 | 312 | Zinc finger | RING-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MKNK2 | chr19:2041839 | chr19:652884 | ENST00000250896 | - | 11 | 14 | 84_388 | 315 | 466 | Domain | Protein kinase |
| Hgene | >MKNK2 | chr19:2041839 | chr19:652884 | ENST00000309340 | - | 11 | 14 | 84_388 | 315 | 415 | Domain | Protein kinase |
| Hgene | >MKNK2 | chr19:2041839 | chr19:652884 | ENST00000591601 | - | 10 | 13 | 84_388 | 315 | 466 | Domain | Protein kinase |
| Hgene | >MKNK2 | chr19:2041839 | chr19:652884 | ENST00000250896 | - | 11 | 14 | 444_448 | 315 | 466 | Motif | MAP kinase binding |
| Hgene | >MKNK2 | chr19:2041839 | chr19:652884 | ENST00000309340 | - | 11 | 14 | 444_448 | 315 | 415 | Motif | MAP kinase binding |
| Hgene | >MKNK2 | chr19:2041839 | chr19:652884 | ENST00000591601 | - | 10 | 13 | 444_448 | 315 | 466 | Motif | MAP kinase binding |
| Tgene | RNF126 | chr19:2041839 | chr19:652884 | ENST00000292363 | - | 0 | 9 | 13_32 | 25 | 312 | Zinc finger | C4-type |
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FusionGeneSequence for MKNK2_RNF126 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MKNK2_ENST00000591142_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_346aa MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQDYICPRCESGFIEELPEETRSTENGSAPSTA PTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTL EGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDY >In-frame_MKNK2_ENST00000591601_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_602aa MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVL GEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEAS IYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQ HLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITP ATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHL >In-frame_MKNK2_ENST00000591588_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_346aa MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQDYICPRCESGFIEELPEETRSTENGSAPSTA PTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTL EGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MKNK2_ENST00000591142_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_1038nt ATGGCCCCGGAGGTAGTGGAGGCCTTCAGCGAGGAGGCTAGCATCTACGACAAGCGCTGCGACCTGTGGAGCCTGGGCGTCATCTTGTAT ATCCTACTCAGCGGCTACCCGCCCTTCGTGGGCCGCTGTGGCAGCGACTGCGGCTGGGACCGCGGCGAGGCCTGCCCTGCCTGCCAGGAT TATATCTGTCCAAGATGCGAGTCTGGTTTTATCGAGGAGCTTCCGGAAGAGACCAGGAGCACAGAAAATGGTTCTGCCCCCTCCACAGCT CCCACAGACCAGAGCCGGCCACCGTTGGAGCACGTGGACCAGCACCTGTTCACGCTGCCGCAGGGCTACGGACAGTTTGCTTTCGGCATC TTCGATGACAGCTTCGAGATCCCCACGTTCCCTCCTGGGGCGCAGGCTGACGACGGCAGGGACCCTGAGAGCCGGCGGGAGAGAGACCAT CCGTCCCGGCACCGGTACGGCGCCCGACAGCCCCGCGCCCGCCTCACCACGCGGCGGGCCACCGGCCGGCACGAAGGCGTCCCCACGCTG GAAGGGATCATCCAGCAGCTCGTCAACGGCATCATCACGCCCGCCACCATCCCCAGCCTGGGCCCCTGGGGAGTCCTGCACTCAAACCCT ATGGACTACGCCTGGGGGGCCAACGGCCTGGATGCCATCATCACACAGCTCCTCAATCAGTTTGAAAACACAGGCCCCCCACCGGCAGAT AAAGAGAAAATCCAGGCCCTCCCCACCGTCCCCGTCACTGAGGAGCACGTAGGCTCCGGGCTCGAGTGCCCTGTGTGCAAGGACGACTAC GCGCTGGGTGAGCGTGTGCGGCAGCTGCCCTGCAACCACCTGTTCCACGACGGCTGCATCGTGCCCTGGCTGGAGCAGCACGACAGCTGC CCCGTCTGCCGAAAAAGCCTCACGGGACAGAACACGGCCACGAACCCCCCTGGCCTCACTGGGGTGAGCTTCTCCTCCTCGTCGTCATCG >In-frame_MKNK2_ENST00000591601_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_1806nt ATGGTGCAGAAGAAACCAGCCGAACTTCAGGGTTTCCACCGTTCGTTCAAGGGGCAGAACCCCTTCGAGCTGGCCTTCTCCCTAGACCAG CCCGACCACGGAGACTCTGACTTTGGCCTGCAGTGCTCAGCCCGCCCTGACATGCCCGCCAGCCAGCCCATTGACATCCCGGACGCCAAG AAGAGGGGCAAGAAGAAGAAGCGCGGCCGGGCCACCGACAGCTTCTCGGGCAGGTTTGAAGACGTCTACCAGCTGCAGGAAGATGTGCTG GGGGAGGGCGCTCATGCCCGAGTGCAGACCTGCATCAACCTGATCACCAGCCAGGAGTACGCCGTCAAGATCATTGAGAAGCAGCCAGGC CACATTCGGAGCAGGGTTTTCAGGGAGGTGGAGATGCTGTACCAGTGCCAGGGACACAGGAACGTCCTAGAGCTGATTGAGTTCTTCGAG GAGGAGGACCGCTTCTACCTGGTGTTTGAGAAGATGCGGGGAGGCTCCATCCTGAGCCACATCCACAAGCGCCGGCACTTCAACGAGCTG GAGGCCAGCGTGGTGGTGCAGGACGTGGCCAGCGCCTTGGACTTTCTGCATAACAAAGGCATCGCCCACAGGGACCTAAAGCCGGAAAAC ATCCTCTGTGAGCACCCCAACCAGGTCTCCCCCGTGAAGATCTGTGACTTCGACCTGGGCAGCGGCATCAAACTCAACGGGGACTGCTCC CCTATCTCCACCCCGGAGCTGCTCACTCCGTGCGGCTCGGCGGAGTACATGGCCCCGGAGGTAGTGGAGGCCTTCAGCGAGGAGGCTAGC ATCTACGACAAGCGCTGCGACCTGTGGAGCCTGGGCGTCATCTTGTATATCCTACTCAGCGGCTACCCGCCCTTCGTGGGCCGCTGTGGC AGCGACTGCGGCTGGGACCGCGGCGAGGCCTGCCCTGCCTGCCAGGATTATATCTGTCCAAGATGCGAGTCTGGTTTTATCGAGGAGCTT CCGGAAGAGACCAGGAGCACAGAAAATGGTTCTGCCCCCTCCACAGCTCCCACAGACCAGAGCCGGCCACCGTTGGAGCACGTGGACCAG CACCTGTTCACGCTGCCGCAGGGCTACGGACAGTTTGCTTTCGGCATCTTCGATGACAGCTTCGAGATCCCCACGTTCCCTCCTGGGGCG CAGGCTGACGACGGCAGGGACCCTGAGAGCCGGCGGGAGAGAGACCATCCGTCCCGGCACCGGTACGGCGCCCGACAGCCCCGCGCCCGC CTCACCACGCGGCGGGCCACCGGCCGGCACGAAGGCGTCCCCACGCTGGAAGGGATCATCCAGCAGCTCGTCAACGGCATCATCACGCCC GCCACCATCCCCAGCCTGGGCCCCTGGGGAGTCCTGCACTCAAACCCTATGGACTACGCCTGGGGGGCCAACGGCCTGGATGCCATCATC ACACAGCTCCTCAATCAGTTTGAAAACACAGGCCCCCCACCGGCAGATAAAGAGAAAATCCAGGCCCTCCCCACCGTCCCCGTCACTGAG GAGCACGTAGGCTCCGGGCTCGAGTGCCCTGTGTGCAAGGACGACTACGCGCTGGGTGAGCGTGTGCGGCAGCTGCCCTGCAACCACCTG TTCCACGACGGCTGCATCGTGCCCTGGCTGGAGCAGCACGACAGCTGCCCCGTCTGCCGAAAAAGCCTCACGGGACAGAACACGGCCACG AACCCCCCTGGCCTCACTGGGGTGAGCTTCTCCTCCTCGTCGTCATCGTCCTCCTCCAGCTCGCCCAGCAACGAGAACGCCACAAGCAAC >In-frame_MKNK2_ENST00000591588_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_1038nt ATGGCCCCGGAGGTAGTGGAGGCCTTCAGCGAGGAGGCTAGCATCTACGACAAGCGCTGCGACCTGTGGAGCCTGGGCGTCATCTTGTAT ATCCTACTCAGCGGCTACCCGCCCTTCGTGGGCCGCTGTGGCAGCGACTGCGGCTGGGACCGCGGCGAGGCCTGCCCTGCCTGCCAGGAT TATATCTGTCCAAGATGCGAGTCTGGTTTTATCGAGGAGCTTCCGGAAGAGACCAGGAGCACAGAAAATGGTTCTGCCCCCTCCACAGCT CCCACAGACCAGAGCCGGCCACCGTTGGAGCACGTGGACCAGCACCTGTTCACGCTGCCGCAGGGCTACGGACAGTTTGCTTTCGGCATC TTCGATGACAGCTTCGAGATCCCCACGTTCCCTCCTGGGGCGCAGGCTGACGACGGCAGGGACCCTGAGAGCCGGCGGGAGAGAGACCAT CCGTCCCGGCACCGGTACGGCGCCCGACAGCCCCGCGCCCGCCTCACCACGCGGCGGGCCACCGGCCGGCACGAAGGCGTCCCCACGCTG GAAGGGATCATCCAGCAGCTCGTCAACGGCATCATCACGCCCGCCACCATCCCCAGCCTGGGCCCCTGGGGAGTCCTGCACTCAAACCCT ATGGACTACGCCTGGGGGGCCAACGGCCTGGATGCCATCATCACACAGCTCCTCAATCAGTTTGAAAACACAGGCCCCCCACCGGCAGAT AAAGAGAAAATCCAGGCCCTCCCCACCGTCCCCGTCACTGAGGAGCACGTAGGCTCCGGGCTCGAGTGCCCTGTGTGCAAGGACGACTAC GCGCTGGGTGAGCGTGTGCGGCAGCTGCCCTGCAACCACCTGTTCCACGACGGCTGCATCGTGCCCTGGCTGGAGCAGCACGACAGCTGC CCCGTCTGCCGAAAAAGCCTCACGGGACAGAACACGGCCACGAACCCCCCTGGCCTCACTGGGGTGAGCTTCTCCTCCTCGTCGTCATCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MKNK2_ENST00000591142_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_1764nt GGGGCGGGGTCCGAGCCGGCTGGCGCAGGTGACCCGCAGTTACCCGGGCTCGGTTCCCACGTAATGCTGGGAAACCCCGGCTGACGCGCC CCTCCCCCGCCCGCAGTGCGGCTCGGCGGAGTACATGGCCCCGGAGGTAGTGGAGGCCTTCAGCGAGGAGGCTAGCATCTACGACAAGCG CTGCGACCTGTGGAGCCTGGGCGTCATCTTGTATATCCTACTCAGCGGCTACCCGCCCTTCGTGGGCCGCTGTGGCAGCGACTGCGGCTG GGACCGCGGCGAGGCCTGCCCTGCCTGCCAGGATTATATCTGTCCAAGATGCGAGTCTGGTTTTATCGAGGAGCTTCCGGAAGAGACCAG GAGCACAGAAAATGGTTCTGCCCCCTCCACAGCTCCCACAGACCAGAGCCGGCCACCGTTGGAGCACGTGGACCAGCACCTGTTCACGCT GCCGCAGGGCTACGGACAGTTTGCTTTCGGCATCTTCGATGACAGCTTCGAGATCCCCACGTTCCCTCCTGGGGCGCAGGCTGACGACGG CAGGGACCCTGAGAGCCGGCGGGAGAGAGACCATCCGTCCCGGCACCGGTACGGCGCCCGACAGCCCCGCGCCCGCCTCACCACGCGGCG GGCCACCGGCCGGCACGAAGGCGTCCCCACGCTGGAAGGGATCATCCAGCAGCTCGTCAACGGCATCATCACGCCCGCCACCATCCCCAG CCTGGGCCCCTGGGGAGTCCTGCACTCAAACCCTATGGACTACGCCTGGGGGGCCAACGGCCTGGATGCCATCATCACACAGCTCCTCAA TCAGTTTGAAAACACAGGCCCCCCACCGGCAGATAAAGAGAAAATCCAGGCCCTCCCCACCGTCCCCGTCACTGAGGAGCACGTAGGCTC CGGGCTCGAGTGCCCTGTGTGCAAGGACGACTACGCGCTGGGTGAGCGTGTGCGGCAGCTGCCCTGCAACCACCTGTTCCACGACGGCTG CATCGTGCCCTGGCTGGAGCAGCACGACAGCTGCCCCGTCTGCCGAAAAAGCCTCACGGGACAGAACACGGCCACGAACCCCCCTGGCCT CACTGGGGTGAGCTTCTCCTCCTCGTCGTCATCGTCCTCCTCCAGCTCGCCCAGCAACGAGAACGCCACAAGCAACTCGTGAGCCCACGT CGGCCGTCGGGAAAGCACGGGGCCTTTCCCACCCACCCTCAGCCAGCGCCACACGGCACCCACAGACTGGGTGCCCCGGCGGCGCCACGC TTGGCTGGTCAGCGCTGCAGGTCCCGCCTGTTCCAGGGCAGGACCCGGGCCCGGCCCACCGGCCCCCTGGCTTGGGAAGGCGTGGGCCAC ATGGTCCCCTCTGGGGCGTCCCCAGCCTCCCCGTCCTCTGTCTAACCTCACCCTCTAAACGTTCAGCGGTGGAAAGATTTTTATAATTTT AAATTATTACTGCTTTGAAATAAACGGACGTTTGAGCTCACGTGGCGGCCATGCATGGTTTGTGGCGGAAGACGGGGCCCAGCGGCTCCC CCAGCGCTGAAGCACGGGGTTCAGCGGCTCCCCCAGTGCTGCAGGTGCCGCCAGGACGGGCCACGTGGGCCCCCAGCCTCCCCCTCGGCC GCCTCCACGACCCGGAGTAGGGGGGCTCGGGACCATGAGGATGACCAGCAAAATTCAAGAACAAAACTGCTCCAACAGACTTTTTTAAAG >In-frame_MKNK2_ENST00000591601_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_2444nt CGGTCCCCTCCCCCGCTGGCGGGGCCCGGACAGAAGATGGTGCAGAAGAAACCAGCCGAACTTCAGGGTTTCCACCGTTCGTTCAAGGGG CAGAACCCCTTCGAGCTGGCCTTCTCCCTAGACCAGCCCGACCACGGAGACTCTGACTTTGGCCTGCAGTGCTCAGCCCGCCCTGACATG CCCGCCAGCCAGCCCATTGACATCCCGGACGCCAAGAAGAGGGGCAAGAAGAAGAAGCGCGGCCGGGCCACCGACAGCTTCTCGGGCAGG TTTGAAGACGTCTACCAGCTGCAGGAAGATGTGCTGGGGGAGGGCGCTCATGCCCGAGTGCAGACCTGCATCAACCTGATCACCAGCCAG GAGTACGCCGTCAAGATCATTGAGAAGCAGCCAGGCCACATTCGGAGCAGGGTTTTCAGGGAGGTGGAGATGCTGTACCAGTGCCAGGGA CACAGGAACGTCCTAGAGCTGATTGAGTTCTTCGAGGAGGAGGACCGCTTCTACCTGGTGTTTGAGAAGATGCGGGGAGGCTCCATCCTG AGCCACATCCACAAGCGCCGGCACTTCAACGAGCTGGAGGCCAGCGTGGTGGTGCAGGACGTGGCCAGCGCCTTGGACTTTCTGCATAAC AAAGGCATCGCCCACAGGGACCTAAAGCCGGAAAACATCCTCTGTGAGCACCCCAACCAGGTCTCCCCCGTGAAGATCTGTGACTTCGAC CTGGGCAGCGGCATCAAACTCAACGGGGACTGCTCCCCTATCTCCACCCCGGAGCTGCTCACTCCGTGCGGCTCGGCGGAGTACATGGCC CCGGAGGTAGTGGAGGCCTTCAGCGAGGAGGCTAGCATCTACGACAAGCGCTGCGACCTGTGGAGCCTGGGCGTCATCTTGTATATCCTA CTCAGCGGCTACCCGCCCTTCGTGGGCCGCTGTGGCAGCGACTGCGGCTGGGACCGCGGCGAGGCCTGCCCTGCCTGCCAGGATTATATC TGTCCAAGATGCGAGTCTGGTTTTATCGAGGAGCTTCCGGAAGAGACCAGGAGCACAGAAAATGGTTCTGCCCCCTCCACAGCTCCCACA GACCAGAGCCGGCCACCGTTGGAGCACGTGGACCAGCACCTGTTCACGCTGCCGCAGGGCTACGGACAGTTTGCTTTCGGCATCTTCGAT GACAGCTTCGAGATCCCCACGTTCCCTCCTGGGGCGCAGGCTGACGACGGCAGGGACCCTGAGAGCCGGCGGGAGAGAGACCATCCGTCC CGGCACCGGTACGGCGCCCGACAGCCCCGCGCCCGCCTCACCACGCGGCGGGCCACCGGCCGGCACGAAGGCGTCCCCACGCTGGAAGGG ATCATCCAGCAGCTCGTCAACGGCATCATCACGCCCGCCACCATCCCCAGCCTGGGCCCCTGGGGAGTCCTGCACTCAAACCCTATGGAC TACGCCTGGGGGGCCAACGGCCTGGATGCCATCATCACACAGCTCCTCAATCAGTTTGAAAACACAGGCCCCCCACCGGCAGATAAAGAG AAAATCCAGGCCCTCCCCACCGTCCCCGTCACTGAGGAGCACGTAGGCTCCGGGCTCGAGTGCCCTGTGTGCAAGGACGACTACGCGCTG GGTGAGCGTGTGCGGCAGCTGCCCTGCAACCACCTGTTCCACGACGGCTGCATCGTGCCCTGGCTGGAGCAGCACGACAGCTGCCCCGTC TGCCGAAAAAGCCTCACGGGACAGAACACGGCCACGAACCCCCCTGGCCTCACTGGGGTGAGCTTCTCCTCCTCGTCGTCATCGTCCTCC TCCAGCTCGCCCAGCAACGAGAACGCCACAAGCAACTCGTGAGCCCACGTCGGCCGTCGGGAAAGCACGGGGCCTTTCCCACCCACCCTC AGCCAGCGCCACACGGCACCCACAGACTGGGTGCCCCGGCGGCGCCACGCTTGGCTGGTCAGCGCTGCAGGTCCCGCCTGTTCCAGGGCA GGACCCGGGCCCGGCCCACCGGCCCCCTGGCTTGGGAAGGCGTGGGCCACATGGTCCCCTCTGGGGCGTCCCCAGCCTCCCCGTCCTCTG TCTAACCTCACCCTCTAAACGTTCAGCGGTGGAAAGATTTTTATAATTTTAAATTATTACTGCTTTGAAATAAACGGACGTTTGAGCTCA CGTGGCGGCCATGCATGGTTTGTGGCGGAAGACGGGGCCCAGCGGCTCCCCCAGCGCTGAAGCACGGGGTTCAGCGGCTCCCCCAGTGCT GCAGGTGCCGCCAGGACGGGCCACGTGGGCCCCCAGCCTCCCCCTCGGCCGCCTCCACGACCCGGAGTAGGGGGGCTCGGGACCATGAGG ATGACCAGCAAAATTCAAGAACAAAACTGCTCCAACAGACTTTTTTAAAGGAAAAAATATGTGTATCTTGAAAGCTATTTAAAATACACT >In-frame_MKNK2_ENST00000591588_chr19_2041839_-_RNF126_ENST00000292363_chr19_652884_-_1706nt ACGTAATGCTGGGAAACCCCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCGGCTCGGCGGAGTACATGGCCCCGGAGGTAGTGGAGGCC TTCAGCGAGGAGGCTAGCATCTACGACAAGCGCTGCGACCTGTGGAGCCTGGGCGTCATCTTGTATATCCTACTCAGCGGCTACCCGCCC TTCGTGGGCCGCTGTGGCAGCGACTGCGGCTGGGACCGCGGCGAGGCCTGCCCTGCCTGCCAGGATTATATCTGTCCAAGATGCGAGTCT GGTTTTATCGAGGAGCTTCCGGAAGAGACCAGGAGCACAGAAAATGGTTCTGCCCCCTCCACAGCTCCCACAGACCAGAGCCGGCCACCG TTGGAGCACGTGGACCAGCACCTGTTCACGCTGCCGCAGGGCTACGGACAGTTTGCTTTCGGCATCTTCGATGACAGCTTCGAGATCCCC ACGTTCCCTCCTGGGGCGCAGGCTGACGACGGCAGGGACCCTGAGAGCCGGCGGGAGAGAGACCATCCGTCCCGGCACCGGTACGGCGCC CGACAGCCCCGCGCCCGCCTCACCACGCGGCGGGCCACCGGCCGGCACGAAGGCGTCCCCACGCTGGAAGGGATCATCCAGCAGCTCGTC AACGGCATCATCACGCCCGCCACCATCCCCAGCCTGGGCCCCTGGGGAGTCCTGCACTCAAACCCTATGGACTACGCCTGGGGGGCCAAC GGCCTGGATGCCATCATCACACAGCTCCTCAATCAGTTTGAAAACACAGGCCCCCCACCGGCAGATAAAGAGAAAATCCAGGCCCTCCCC ACCGTCCCCGTCACTGAGGAGCACGTAGGCTCCGGGCTCGAGTGCCCTGTGTGCAAGGACGACTACGCGCTGGGTGAGCGTGTGCGGCAG CTGCCCTGCAACCACCTGTTCCACGACGGCTGCATCGTGCCCTGGCTGGAGCAGCACGACAGCTGCCCCGTCTGCCGAAAAAGCCTCACG GGACAGAACACGGCCACGAACCCCCCTGGCCTCACTGGGGTGAGCTTCTCCTCCTCGTCGTCATCGTCCTCCTCCAGCTCGCCCAGCAAC GAGAACGCCACAAGCAACTCGTGAGCCCACGTCGGCCGTCGGGAAAGCACGGGGCCTTTCCCACCCACCCTCAGCCAGCGCCACACGGCA CCCACAGACTGGGTGCCCCGGCGGCGCCACGCTTGGCTGGTCAGCGCTGCAGGTCCCGCCTGTTCCAGGGCAGGACCCGGGCCCGGCCCA CCGGCCCCCTGGCTTGGGAAGGCGTGGGCCACATGGTCCCCTCTGGGGCGTCCCCAGCCTCCCCGTCCTCTGTCTAACCTCACCCTCTAA ACGTTCAGCGGTGGAAAGATTTTTATAATTTTAAATTATTACTGCTTTGAAATAAACGGACGTTTGAGCTCACGTGGCGGCCATGCATGG TTTGTGGCGGAAGACGGGGCCCAGCGGCTCCCCCAGCGCTGAAGCACGGGGTTCAGCGGCTCCCCCAGTGCTGCAGGTGCCGCCAGGACG GGCCACGTGGGCCCCCAGCCTCCCCCTCGGCCGCCTCCACGACCCGGAGTAGGGGGGCTCGGGACCATGAGGATGACCAGCAAAATTCAA |
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FusionGenePPI for MKNK2_RNF126 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MKNK2 | EIF4G1, MAPK1, ESR2, MAPK14, RPL7A, ELAVL1, RBX1, VHL, CUL2, VBP1, MAPK8, CSTF2, MIF, RBM4, VCL, BAG6, SYMPK, KHSRP, NOLC1, WDR46, USP15, TRAP1, CELF1, NUDT21, WWP2, EXOC3, RAB11FIP2, PLXNA3, HAUS7, ADCK1, RBM26, BHLHE41, ZCCHC6, ZMYM1, CD99L2, MRRF, TICAM1, RICTOR, TRIM25 | RNF126 | UBE2D1, UBE2D4, PSMF1, UBE2D3, UBE2D2, TSG101, UBC, FAF2, SNUPN, NUDT3, CSNK2B, PLK1, HMGCL, CDKN1A, RNF126, USP2, USP15, OTUB1, OTUB2, VCP, UBE2N, EGFR, SCAMP3, METTL21B, UBL4A, AICDA, TRIM11, TRIM52, RBX1, TRIM26, TRIM23, MDM2, SHFM1, BAG6, MAP3K1, UBB, GET4, FAM63A, TAX1BP1, LRWD1, ABCB6, CRYM, ASNA1, SKP2, SLC25A16, PJA1, WRAP73, APOD, KIAA0100, KLHL42, CAPN15, E2F1, SMC3, RAD50, RNF20, SMC1A, PFKP, SKIV2L2, POLD1, RRM1, SLC25A5, XPOT, USP7, SART3, QARS, AGL, AP2A2, ATP2A2, COPA, COPB1, COPB2, COPG1, DIS3, EIF3A, EIF4G2, EPRS, GFPT1, IARS2, IMMT, IRS4, LARP4, MCM2, MYO6, NAA15, NUP93, MSH6, MSH2, MCM4, XRCC5, XRCC6, FXN, TSPYL6, BBS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MKNK2_RNF126 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MKNK2_RNF126 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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