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Fusion gene ID: 22108 |
FusionGeneSummary for MKNK2_MKNK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MKNK2_MKNK2 | Fusion gene ID: 22108 | Hgene | Tgene | Gene symbol | MKNK2 | MKNK2 | Gene ID | 2872 | 2872 |
| Gene name | MAP kinase interacting serine/threonine kinase 2 | MAP kinase interacting serine/threonine kinase 2 | |
| Synonyms | GPRK7|MNK2 | GPRK7|MNK2 | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase signal-integrating kinase 2MAPK signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase signal-integrating kinase 2MAPK signal-integrating kinase 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HBH9 | Q9HBH9 | |
| Ensembl transtripts involved in fusion gene | ENST00000591142, ENST00000591601, ENST00000309340, ENST00000250896, ENST00000541165, ENST00000591588, ENST00000588014, | ENST00000591142, ENST00000591601, ENST00000309340, ENST00000250896, ENST00000541165, ENST00000591588, ENST00000588014, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 4 X 4 X 2=32 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MKNK2 [Title/Abstract] AND MKNK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MKNK2 | GO:0006468 | protein phosphorylation | 11463832 |
| Hgene | MKNK2 | GO:0030097 | hemopoiesis | 21149447 |
| Hgene | MKNK2 | GO:0035556 | intracellular signal transduction | 11463832 |
| Hgene | MKNK2 | GO:0071243 | cellular response to arsenic-containing substance | 18299328 |
| Tgene | MKNK2 | GO:0006468 | protein phosphorylation | 11463832 |
| Tgene | MKNK2 | GO:0030097 | hemopoiesis | 21149447 |
| Tgene | MKNK2 | GO:0035556 | intracellular signal transduction | 11463832 |
| Tgene | MKNK2 | GO:0071243 | cellular response to arsenic-containing substance | 18299328 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU674802 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000591142 | ENST00000591142 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591142 | ENST00000591601 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591142 | ENST00000309340 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591142 | ENST00000250896 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591142 | ENST00000541165 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591142 | ENST00000591588 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591142 | ENST00000588014 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591601 | ENST00000591142 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591601 | ENST00000591601 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591601 | ENST00000309340 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591601 | ENST00000250896 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591601 | ENST00000541165 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591601 | ENST00000591588 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591601 | ENST00000588014 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000309340 | ENST00000591142 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000309340 | ENST00000591601 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000309340 | ENST00000309340 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000309340 | ENST00000250896 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000309340 | ENST00000541165 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000309340 | ENST00000591588 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000309340 | ENST00000588014 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000250896 | ENST00000591142 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000250896 | ENST00000591601 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000250896 | ENST00000309340 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000250896 | ENST00000250896 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000250896 | ENST00000541165 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000250896 | ENST00000591588 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000250896 | ENST00000588014 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000541165 | ENST00000591142 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000541165 | ENST00000591601 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000541165 | ENST00000309340 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000541165 | ENST00000250896 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000541165 | ENST00000541165 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000541165 | ENST00000591588 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000541165 | ENST00000588014 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591588 | ENST00000591142 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591588 | ENST00000591601 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591588 | ENST00000309340 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000591588 | ENST00000250896 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591588 | ENST00000541165 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591588 | ENST00000591588 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000591588 | ENST00000588014 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000588014 | ENST00000591142 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000588014 | ENST00000591601 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000588014 | ENST00000309340 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-3UTR | ENST00000588014 | ENST00000250896 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000588014 | ENST00000541165 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000588014 | ENST00000591588 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
| intron-intron | ENST00000588014 | ENST00000588014 | MKNK2 | chr19 | 2037548 | + | MKNK2 | chr19 | 2037605 | - |
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FusionProtFeatures for MKNK2_MKNK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MKNK2 | MKNK2 |
| Serine/threonine-protein kinase that phosphorylatesSFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response toenvironmental stress and cytokines. Appears to regulatetranslation by phosphorylating EIF4E, thus increasing the affinityof this protein for the 7-methylguanosine-containing mRNA cap.Required for mediating PP2A-inhibition-induced EIF4Ephosphorylation. Triggers EIF4E shuttling from cytoplasm tonucleus. Isoform 1 displays a high basal kinase activity, butisoform 2 exhibits a very low kinase activity. Acts as a mediatorof the suppressive effects of IFNgamma on hematopoiesis. Negativeregulator for signals that control generation of arsenic trioxideAs(2)O(3)-dependent apoptosis and anti-leukemic responses.Involved in anti-apoptotic signaling in response to serumwithdrawal. {ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141,ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020,ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271,ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. | Serine/threonine-protein kinase that phosphorylatesSFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response toenvironmental stress and cytokines. Appears to regulatetranslation by phosphorylating EIF4E, thus increasing the affinityof this protein for the 7-methylguanosine-containing mRNA cap.Required for mediating PP2A-inhibition-induced EIF4Ephosphorylation. Triggers EIF4E shuttling from cytoplasm tonucleus. Isoform 1 displays a high basal kinase activity, butisoform 2 exhibits a very low kinase activity. Acts as a mediatorof the suppressive effects of IFNgamma on hematopoiesis. Negativeregulator for signals that control generation of arsenic trioxideAs(2)O(3)-dependent apoptosis and anti-leukemic responses.Involved in anti-apoptotic signaling in response to serumwithdrawal. {ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141,ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020,ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271,ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MKNK2_MKNK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MKNK2_MKNK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MKNK2_MKNK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MKNK2_MKNK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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