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Fusion gene ID: 22105 |
FusionGeneSummary for MKNK1_EFCAB14 |
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Fusion gene information | Fusion gene name: MKNK1_EFCAB14 | Fusion gene ID: 22105 | Hgene | Tgene | Gene symbol | MKNK1 | EFCAB14 | Gene ID | 8569 | 9813 |
Gene name | MAP kinase interacting serine/threonine kinase 1 | EF-hand calcium binding domain 14 | |
Synonyms | MNK1 | KIAA0494 | |
Cytomap | 1p33 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | MAP kinase-interacting serine/threonine-protein kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1 | EF-hand calcium-binding domain-containing protein 14 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9BUB5 | O75071 | |
Ensembl transtripts involved in fusion gene | ENST00000371946, ENST00000371945, ENST00000341183, ENST00000428112, ENST00000545730, ENST00000465783, ENST00000525888, ENST00000371944, | ENST00000544071, ENST00000371933, ENST00000484461, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 2=50 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/50*10)=0 | |
Context | PubMed: MKNK1 [Title/Abstract] AND EFCAB14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MKNK1 | GO:0006468 | protein phosphorylation | 9155018 |
Hgene | MKNK1 | GO:0018105 | peptidyl-serine phosphorylation | 17130135 |
Hgene | MKNK1 | GO:0035556 | intracellular signal transduction | 9155018 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-KP-A3W4-01A | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000371946 | ENST00000544071 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000371946 | ENST00000371933 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-intron | ENST00000371946 | ENST00000484461 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000371945 | ENST00000544071 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000371945 | ENST00000371933 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-intron | ENST00000371945 | ENST00000484461 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000341183 | ENST00000544071 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000341183 | ENST00000371933 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-intron | ENST00000341183 | ENST00000484461 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000428112 | ENST00000544071 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000428112 | ENST00000371933 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-intron | ENST00000428112 | ENST00000484461 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
5UTR-3CDS | ENST00000545730 | ENST00000544071 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
5UTR-3CDS | ENST00000545730 | ENST00000371933 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
5UTR-intron | ENST00000545730 | ENST00000484461 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000465783 | ENST00000544071 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000465783 | ENST00000371933 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-intron | ENST00000465783 | ENST00000484461 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000525888 | ENST00000544071 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000525888 | ENST00000371933 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-intron | ENST00000525888 | ENST00000484461 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000371944 | ENST00000544071 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-3CDS | ENST00000371944 | ENST00000371933 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
intron-intron | ENST00000371944 | ENST00000484461 | MKNK1 | chr1 | 47082383 | - | EFCAB14 | chr1 | 47182115 | - |
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FusionProtFeatures for MKNK1_EFCAB14 |
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Hgene | Tgene |
MKNK1 | EFCAB14 |
May play a role in the response to environmental stressand cytokines. Appears to regulate translation by phosphorylatingEIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832,ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018,ECO:0000269|PubMed:9878069}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MKNK1_EFCAB14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MKNK1_EFCAB14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MKNK1 | FANCA, MAPK1, EIF4E, EIF4G1, EIF4G2, MAPK3, MAPK14, CREBBP, HSP90AB1, PRKDC, DNAJC7, EIF4G3, DDAH2, ATXN3, UBE2D1, PHAX, SPRY2, APP, RCN3, TNIP2, HGS, HIPK2, MAPK11, MOV10, XPO1, ID1, LLGL2, PDK1, PPIA, RAB5A, MYH13, KIF1C, RNASEH2B, KIF18A, PARD6B, BOD1L1, PAK2, TRIM25 | EFCAB14 | ELAVL1, CSNK2A2, CSNK2A1, GRAMD3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MKNK1_EFCAB14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MKNK1_EFCAB14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MKNK1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |