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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22105

FusionGeneSummary for MKNK1_EFCAB14

check button Fusion gene summary
Fusion gene informationFusion gene name: MKNK1_EFCAB14
Fusion gene ID: 22105
HgeneTgene
Gene symbol

MKNK1

EFCAB14

Gene ID

8569

9813

Gene nameMAP kinase interacting serine/threonine kinase 1EF-hand calcium binding domain 14
SynonymsMNK1KIAA0494
Cytomap

1p33

1p33

Type of geneprotein-codingprotein-coding
DescriptionMAP kinase-interacting serine/threonine-protein kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1EF-hand calcium-binding domain-containing protein 14
Modification date2018052320180522
UniProtAcc

Q9BUB5

O75071

Ensembl transtripts involved in fusion geneENST00000371946, ENST00000371945, 
ENST00000341183, ENST00000428112, 
ENST00000545730, ENST00000465783, 
ENST00000525888, ENST00000371944, 
ENST00000544071, ENST00000371933, 
ENST00000484461, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 2=50
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/50*10)=0
Context

PubMed: MKNK1 [Title/Abstract] AND EFCAB14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKNK1

GO:0006468

protein phosphorylation

9155018

HgeneMKNK1

GO:0018105

peptidyl-serine phosphorylation

17130135

HgeneMKNK1

GO:0035556

intracellular signal transduction

9155018


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-KP-A3W4-01AMKNK1chr1

47082383

-EFCAB14chr1

47182115

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000371946ENST00000544071MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000371946ENST00000371933MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-intronENST00000371946ENST00000484461MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000371945ENST00000544071MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000371945ENST00000371933MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-intronENST00000371945ENST00000484461MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000341183ENST00000544071MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000341183ENST00000371933MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-intronENST00000341183ENST00000484461MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000428112ENST00000544071MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000428112ENST00000371933MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-intronENST00000428112ENST00000484461MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
5UTR-3CDSENST00000545730ENST00000544071MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
5UTR-3CDSENST00000545730ENST00000371933MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
5UTR-intronENST00000545730ENST00000484461MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000465783ENST00000544071MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000465783ENST00000371933MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-intronENST00000465783ENST00000484461MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000525888ENST00000544071MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000525888ENST00000371933MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-intronENST00000525888ENST00000484461MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000371944ENST00000544071MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-3CDSENST00000371944ENST00000371933MKNK1chr1

47082383

-EFCAB14chr1

47182115

-
intron-intronENST00000371944ENST00000484461MKNK1chr1

47082383

-EFCAB14chr1

47182115

-

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FusionProtFeatures for MKNK1_EFCAB14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MKNK1

Q9BUB5

EFCAB14

O75071

May play a role in the response to environmental stressand cytokines. Appears to regulate translation by phosphorylatingEIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832,ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018,ECO:0000269|PubMed:9878069}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MKNK1_EFCAB14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MKNK1_EFCAB14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MKNK1FANCA, MAPK1, EIF4E, EIF4G1, EIF4G2, MAPK3, MAPK14, CREBBP, HSP90AB1, PRKDC, DNAJC7, EIF4G3, DDAH2, ATXN3, UBE2D1, PHAX, SPRY2, APP, RCN3, TNIP2, HGS, HIPK2, MAPK11, MOV10, XPO1, ID1, LLGL2, PDK1, PPIA, RAB5A, MYH13, KIF1C, RNASEH2B, KIF18A, PARD6B, BOD1L1, PAK2, TRIM25EFCAB14ELAVL1, CSNK2A2, CSNK2A1, GRAMD3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MKNK1_EFCAB14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MKNK1_EFCAB14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMKNK1C0236969Substance-Related Disorders1CTD_human