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Fusion gene ID: 22031 |
FusionGeneSummary for MIR548H3_NUP93 |
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Fusion gene information | Fusion gene name: MIR548H3_NUP93 | Fusion gene ID: 22031 | Hgene | Tgene | Gene symbol | MIR548H3 | NUP93 | Gene ID | 100302287 | 9688 |
Gene name | microRNA 548h-3 | nucleoporin 93 | |
Synonyms | MIR548H-3|MIRN548H3|hsa-mir-548h-3 | NIC96 | |
Cytomap | 17p12 | 16q13 | |
Type of gene | ncRNA | protein-coding | |
Description | - | nuclear pore complex protein Nup9393 kDa nucleoporinnucleoporin 93kDanucleoporin Nup93 | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | Q8N1F7 | ||
Ensembl transtripts involved in fusion gene | ENST00000408771, | ENST00000308159, ENST00000569842, ENST00000564887, ENST00000569595, ENST00000542526, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 8 X 8 X 5=320 |
# samples | 3 | 7 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/320*10)=-2.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MIR548H3 [Title/Abstract] AND NUP93 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NUP93 | GO:0006998 | nuclear envelope organization | 26878725 |
Tgene | NUP93 | GO:0051292 | nuclear pore complex assembly | 26878725 |
Tgene | NUP93 | GO:0060391 | positive regulation of SMAD protein signal transduction | 26878725 |
Tgene | NUP93 | GO:0060395 | SMAD protein signal transduction | 26878725 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AU124982 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000408771 | ENST00000308159 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
intron-3CDS | ENST00000408771 | ENST00000569842 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
intron-3CDS | ENST00000408771 | ENST00000564887 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
intron-3UTR | ENST00000408771 | ENST00000569595 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
intron-3UTR | ENST00000408771 | ENST00000542526 | MIR548H3 | chr6 | 97708182 | - | NUP93 | chr16 | 56839451 | + |
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FusionProtFeatures for MIR548H3_NUP93 |
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Hgene | Tgene |
MIR548H3 | NUP93 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Plays a role in the nuclear pore complex (NPC) assemblyand/or maintenance (PubMed:9348540). May anchor nucleoporins, butnot NUP153 and TPR, to the NPC. During renal development,regulates podocyte migration and proliferation through SMAD4signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283,ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725,ECO:0000269|PubMed:9348540}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MIR548H3_NUP93 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MIR548H3_NUP93 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MIR548H3_NUP93 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MIR548H3_NUP93 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NUP93 | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | CTD_human |
Tgene | NUP93 | C4225166 | NEPHROTIC SYNDROME, TYPE 12 | 1 | UNIPROT |