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Fusion gene ID: 22011 |
FusionGeneSummary for MIR34A_BOLA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MIR34A_BOLA2 | Fusion gene ID: 22011 | Hgene | Tgene | Gene symbol | MIR34A | BOLA2 | Gene ID | 407040 | 654483 |
| Gene name | microRNA 34a | bolA family member 2B | |
| Synonyms | MIRN34A|miRNA34A|mir-34|mir-34a | BOLA2 | |
| Cytomap | 1p36.22|1p36.22 | 16p11.2 | |
| Type of gene | ncRNA | protein-coding | |
| Description | hsa-mir-34a | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q9H3K6 | ||
| Ensembl transtripts involved in fusion gene | ENST00000385130, | ENST00000330978, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 19 X 26 X 1=494 |
| # samples | 1 | 28 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MIR34A [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MIR34A | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 23426265 |
| Hgene | MIR34A | GO:0016525 | negative regulation of angiogenesis | 20424141|24048733 |
| Hgene | MIR34A | GO:0035195 | gene silencing by miRNA | 20424141|22651868|23426265|24792364 |
| Hgene | MIR34A | GO:0051152 | positive regulation of smooth muscle cell differentiation | 25526086 |
| Hgene | MIR34A | GO:0061044 | negative regulation of vascular wound healing | 26493107 |
| Hgene | MIR34A | GO:0071672 | negative regulation of smooth muscle cell chemotaxis | 26493107 |
| Hgene | MIR34A | GO:0110058 | positive regulation of blood vessel endothelial cell differentiation | 24792364 |
| Hgene | MIR34A | GO:1901985 | positive regulation of protein acetylation | 20424141 |
| Hgene | MIR34A | GO:1903671 | negative regulation of sprouting angiogenesis | 23426265 |
| Hgene | MIR34A | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | 24792364|26493107 |
| Hgene | MIR34A | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration | 26493107 |
| Hgene | MIR34A | GO:1905563 | negative regulation of vascular endothelial cell proliferation | 28276476 |
| Hgene | MIR34A | GO:2000774 | positive regulation of cellular senescence | 20424141 |
| Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
| Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI013096 | MIR34A | chr1 | 9227880 | - | BOLA2 | chr16 | 30005986 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000385130 | ENST00000330978 | MIR34A | chr1 | 9227880 | - | BOLA2 | chr16 | 30005986 | - |
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FusionProtFeatures for MIR34A_BOLA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MIR34A | BOLA2 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MIR34A_BOLA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MIR34A_BOLA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MIR34A_BOLA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MIR34A_BOLA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MIR34A | C0015695 | Fatty Liver | 1 | CTD_human |
| Hgene | MIR34A | C0018799 | Heart Diseases | 1 | CTD_human |
| Hgene | MIR34A | C0021368 | Inflammation | 1 | CTD_human |
| Hgene | MIR34A | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| Hgene | MIR34A | C0028754 | Obesity | 1 | CTD_human |
| Hgene | MIR34A | C0271650 | Impaired glucose tolerance | 1 | CTD_human |
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