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Fusion gene ID: 22011 |
FusionGeneSummary for MIR34A_BOLA2 |
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Fusion gene information | Fusion gene name: MIR34A_BOLA2 | Fusion gene ID: 22011 | Hgene | Tgene | Gene symbol | MIR34A | BOLA2 | Gene ID | 407040 | 654483 |
Gene name | microRNA 34a | bolA family member 2B | |
Synonyms | MIRN34A|miRNA34A|mir-34|mir-34a | BOLA2 | |
Cytomap | 1p36.22|1p36.22 | 16p11.2 | |
Type of gene | ncRNA | protein-coding | |
Description | hsa-mir-34a | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | Q9H3K6 | ||
Ensembl transtripts involved in fusion gene | ENST00000385130, | ENST00000330978, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 19 X 26 X 1=494 |
# samples | 1 | 28 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MIR34A [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MIR34A | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 23426265 |
Hgene | MIR34A | GO:0016525 | negative regulation of angiogenesis | 20424141|24048733 |
Hgene | MIR34A | GO:0035195 | gene silencing by miRNA | 20424141|22651868|23426265|24792364 |
Hgene | MIR34A | GO:0051152 | positive regulation of smooth muscle cell differentiation | 25526086 |
Hgene | MIR34A | GO:0061044 | negative regulation of vascular wound healing | 26493107 |
Hgene | MIR34A | GO:0071672 | negative regulation of smooth muscle cell chemotaxis | 26493107 |
Hgene | MIR34A | GO:0110058 | positive regulation of blood vessel endothelial cell differentiation | 24792364 |
Hgene | MIR34A | GO:1901985 | positive regulation of protein acetylation | 20424141 |
Hgene | MIR34A | GO:1903671 | negative regulation of sprouting angiogenesis | 23426265 |
Hgene | MIR34A | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | 24792364|26493107 |
Hgene | MIR34A | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration | 26493107 |
Hgene | MIR34A | GO:1905563 | negative regulation of vascular endothelial cell proliferation | 28276476 |
Hgene | MIR34A | GO:2000774 | positive regulation of cellular senescence | 20424141 |
Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI013096 | MIR34A | chr1 | 9227880 | - | BOLA2 | chr16 | 30005986 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000385130 | ENST00000330978 | MIR34A | chr1 | 9227880 | - | BOLA2 | chr16 | 30005986 | - |
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FusionProtFeatures for MIR34A_BOLA2 |
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Hgene | Tgene |
MIR34A | BOLA2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MIR34A_BOLA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MIR34A_BOLA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MIR34A_BOLA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MIR34A_BOLA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MIR34A | C0015695 | Fatty Liver | 1 | CTD_human |
Hgene | MIR34A | C0018799 | Heart Diseases | 1 | CTD_human |
Hgene | MIR34A | C0021368 | Inflammation | 1 | CTD_human |
Hgene | MIR34A | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Hgene | MIR34A | C0028754 | Obesity | 1 | CTD_human |
Hgene | MIR34A | C0271650 | Impaired glucose tolerance | 1 | CTD_human |