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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22011

FusionGeneSummary for MIR34A_BOLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: MIR34A_BOLA2
Fusion gene ID: 22011
HgeneTgene
Gene symbol

MIR34A

BOLA2

Gene ID

407040

654483

Gene namemicroRNA 34abolA family member 2B
SynonymsMIRN34A|miRNA34A|mir-34|mir-34aBOLA2
Cytomap

1p36.22|1p36.22

16p11.2

Type of genencRNAprotein-coding
Descriptionhsa-mir-34abolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B
Modification date2018052720180519
UniProtAcc

Q9H3K6

Ensembl transtripts involved in fusion geneENST00000385130, ENST00000330978, 
Fusion gene scores* DoF score1 X 1 X 1=119 X 26 X 1=494
# samples 128
** MAII scorelog2(1/1*10)=3.32192809488736log2(28/494*10)=-0.819084214639711
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIR34A [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMIR34A

GO:0010666

positive regulation of cardiac muscle cell apoptotic process

23426265

HgeneMIR34A

GO:0016525

negative regulation of angiogenesis

20424141|24048733

HgeneMIR34A

GO:0035195

gene silencing by miRNA

20424141|22651868|23426265|24792364

HgeneMIR34A

GO:0051152

positive regulation of smooth muscle cell differentiation

25526086

HgeneMIR34A

GO:0061044

negative regulation of vascular wound healing

26493107

HgeneMIR34A

GO:0071672

negative regulation of smooth muscle cell chemotaxis

26493107

HgeneMIR34A

GO:0110058

positive regulation of blood vessel endothelial cell differentiation

24792364

HgeneMIR34A

GO:1901985

positive regulation of protein acetylation

20424141

HgeneMIR34A

GO:1903671

negative regulation of sprouting angiogenesis

23426265

HgeneMIR34A

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

24792364|26493107

HgeneMIR34A

GO:1904753

negative regulation of vascular associated smooth muscle cell migration

26493107

HgeneMIR34A

GO:1905563

negative regulation of vascular endothelial cell proliferation

28276476

HgeneMIR34A

GO:2000774

positive regulation of cellular senescence

20424141

TgeneBOLA2

GO:0044571

[2Fe-2S] cluster assembly

27519415

TgeneBOLA2

GO:0097428

protein maturation by iron-sulfur cluster transfer

27519415


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI013096MIR34Achr1

9227880

-BOLA2chr16

30005986

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000385130ENST00000330978MIR34Achr1

9227880

-BOLA2chr16

30005986

-

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FusionProtFeatures for MIR34A_BOLA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIR34A

BOLA2

Q9H3K6

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIR34A_BOLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIR34A_BOLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIR34A_BOLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIR34A_BOLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIR34AC0015695Fatty Liver1CTD_human
HgeneMIR34AC0018799Heart Diseases1CTD_human
HgeneMIR34AC0021368Inflammation1CTD_human
HgeneMIR34AC0023904Liver Neoplasms, Experimental1CTD_human
HgeneMIR34AC0028754Obesity1CTD_human
HgeneMIR34AC0271650Impaired glucose tolerance1CTD_human