FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 21993

FusionGeneSummary for MIPOL1_NPAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: MIPOL1_NPAS3
Fusion gene ID: 21993
HgeneTgene
Gene symbol

MIPOL1

NPAS3

Gene ID

145282

64067

Gene namemirror-image polydactyly 1neuronal PAS domain protein 3
SynonymsCCDC193MOP6|PASD6|bHLHe12
Cytomap

14q13.3-q21.1

14q13.1

Type of geneprotein-codingprotein-coding
Descriptionmirror-image polydactyly gene 1 proteinneuronal PAS domain-containing protein 3PAS domain-containing protein 6basic-helix-loop-helix-PAS protein MOP6class E basic helix-loop-helix protein 12member of PAS protein 6neuronal PAS3
Modification date2018051920180523
UniProtAcc

Q8TD10

Q8IXF0

Ensembl transtripts involved in fusion geneENST00000536774, ENST00000327441, 
ENST00000539062, ENST00000556451, 
ENST00000396294, ENST00000545536, 
ENST00000537471, ENST00000539174, 
ENST00000551492, ENST00000346562, 
ENST00000341321, ENST00000548645, 
ENST00000356141, ENST00000357798, 
ENST00000547068, ENST00000551008, 
ENST00000550662, 
Fusion gene scores* DoF score10 X 7 X 7=4909 X 7 X 6=378
# samples 1110
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIPOL1 [Title/Abstract] AND NPAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-86-8358-01AMIPOL1chr14

37777724

+NPAS3chr14

34081611

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000536774ENST00000551492MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000536774ENST00000346562MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000536774ENST00000341321MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000536774ENST00000548645MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000536774ENST00000356141MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000536774ENST00000357798MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000536774ENST00000547068MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000536774ENST00000551008MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-3UTRENST00000536774ENST00000550662MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000327441ENST00000551492MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000327441ENST00000346562MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000327441ENST00000341321MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000327441ENST00000548645MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000327441ENST00000356141MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000327441ENST00000357798MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000327441ENST00000547068MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000327441ENST00000551008MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-3UTRENST00000327441ENST00000550662MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000539062ENST00000551492MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000539062ENST00000346562MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000539062ENST00000341321MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000539062ENST00000548645MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000539062ENST00000356141MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000539062ENST00000357798MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000539062ENST00000547068MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000539062ENST00000551008MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-3UTRENST00000539062ENST00000550662MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000556451ENST00000551492MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000556451ENST00000346562MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000556451ENST00000341321MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000556451ENST00000548645MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000556451ENST00000356141MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000556451ENST00000357798MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000556451ENST00000547068MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000556451ENST00000551008MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-3UTRENST00000556451ENST00000550662MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000396294ENST00000551492MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000396294ENST00000346562MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000396294ENST00000341321MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000396294ENST00000548645MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000396294ENST00000356141MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000396294ENST00000357798MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000396294ENST00000547068MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000396294ENST00000551008MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-3UTRENST00000396294ENST00000550662MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000545536ENST00000551492MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000545536ENST00000346562MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000545536ENST00000341321MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000545536ENST00000548645MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000545536ENST00000356141MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000545536ENST00000357798MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000545536ENST00000547068MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000545536ENST00000551008MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-3UTRENST00000545536ENST00000550662MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000537471ENST00000551492MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000537471ENST00000346562MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000537471ENST00000341321MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000537471ENST00000548645MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000537471ENST00000356141MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000537471ENST00000357798MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000537471ENST00000547068MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-intronENST00000537471ENST00000551008MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
5CDS-3UTRENST00000537471ENST00000550662MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-intronENST00000539174ENST00000551492MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-intronENST00000539174ENST00000346562MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-intronENST00000539174ENST00000341321MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-intronENST00000539174ENST00000548645MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-intronENST00000539174ENST00000356141MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-intronENST00000539174ENST00000357798MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-intronENST00000539174ENST00000547068MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-intronENST00000539174ENST00000551008MIPOL1chr14

37777724

+NPAS3chr14

34081611

+
intron-3UTRENST00000539174ENST00000550662MIPOL1chr14

37777724

+NPAS3chr14

34081611

+

Top

FusionProtFeatures for MIPOL1_NPAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIPOL1

Q8TD10

NPAS3

Q8IXF0

May play a broad role in neurogenesis. May controlregulatory pathways relevant to schizophrenia and to psychoticillness (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MIPOL1_NPAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MIPOL1_NPAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MIPOL1LATS2, ARNT2, DGCR6, ATP5O, BYSL, CKS1B, UBE2K, MAGEA6, MCM7, MFAP1, CDK18, SMARCE1, CCT3, EIF4E2, USH1C, SSX3, NEBL, PPP1R13B, PRPF31, DIEXF, MYLIP, TTC12, RBM41, RCOR3, SCNM1, CCDC33, ENKD1, FAM161A, TCHP, ZGPAT, BEX2, FBF1, EAF1, HAUS1, MIPOL1, RTP5, LRRC39, SRPK2, DUSP13, RGS2, ZNF408, CCDC172, SH3BP5L, TSPYL4NPAS3ARNT2, TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MIPOL1_NPAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MIPOL1_NPAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIPOL1C0152427Polydactyly1CTD_human
TgeneNPAS3C0036341Schizophrenia4PSYGENET
TgeneNPAS3C0005586Bipolar Disorder3PSYGENET
TgeneNPAS3C0033975Psychotic Disorders1PSYGENET
TgeneNPAS3C0041696Unipolar Depression1PSYGENET
TgeneNPAS3C0349204Nonorganic psychosis1PSYGENET
TgeneNPAS3C1269683Major Depressive Disorder1PSYGENET