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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2199

FusionGeneSummary for APOA2_SND1

check button Fusion gene summary
Fusion gene informationFusion gene name: APOA2_SND1
Fusion gene ID: 2199
HgeneTgene
Gene symbol

APOA2

SND1

Gene ID

80350

27044

Gene namelipoprotein(a) like 2, pseudogenestaphylococcal nuclease and tudor domain containing 1
SynonymsAPOA2|APOAL|APOARGC|apo(a)rg-CTDRD11|Tudor-SN|p100
Cytomap

6q25.3

7q32.1

Type of genepseudoprotein-coding
Descriptionapolipoprotein (a) related gene Capolipoprotein A-IIlipoprotein, Lp(a)-like 2, pseudogenestaphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11
Modification date2018052320180523
UniProtAcc

P02652

Q7KZF4

Ensembl transtripts involved in fusion geneENST00000367990, ENST00000468465, 
ENST00000463812, ENST00000470459, 
ENST00000464492, ENST00000491350, 
ENST00000354725, ENST00000467238, 
Fusion gene scores* DoF score5 X 4 X 2=4020 X 15 X 10=3000
# samples 821
** MAII scorelog2(8/40*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(21/3000*10)=-3.83650126771712
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOA2 [Title/Abstract] AND SND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI207725APOA2chr1

161193414

+SND1chr7

127732510

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000367990ENST00000354725APOA2chr1

161193414

+SND1chr7

127732510

+
intron-intronENST00000367990ENST00000467238APOA2chr1

161193414

+SND1chr7

127732510

+
intron-3UTRENST00000468465ENST00000354725APOA2chr1

161193414

+SND1chr7

127732510

+
intron-intronENST00000468465ENST00000467238APOA2chr1

161193414

+SND1chr7

127732510

+
intron-3UTRENST00000463812ENST00000354725APOA2chr1

161193414

+SND1chr7

127732510

+
intron-intronENST00000463812ENST00000467238APOA2chr1

161193414

+SND1chr7

127732510

+
intron-3UTRENST00000470459ENST00000354725APOA2chr1

161193414

+SND1chr7

127732510

+
intron-intronENST00000470459ENST00000467238APOA2chr1

161193414

+SND1chr7

127732510

+
intron-3UTRENST00000464492ENST00000354725APOA2chr1

161193414

+SND1chr7

127732510

+
intron-intronENST00000464492ENST00000467238APOA2chr1

161193414

+SND1chr7

127732510

+
intron-3UTRENST00000491350ENST00000354725APOA2chr1

161193414

+SND1chr7

127732510

+
intron-intronENST00000491350ENST00000467238APOA2chr1

161193414

+SND1chr7

127732510

+

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FusionProtFeatures for APOA2_SND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APOA2

P02652

SND1

Q7KZF4

May stabilize HDL (high density lipoprotein) structureby its association with lipids, and affect the HDL metabolism. Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for APOA2_SND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for APOA2_SND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for APOA2_SND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneAPOA2P02652DB01593ZincApolipoprotein A-IIsmall moleculeapproved|investigational

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RelatedDiseases for APOA2_SND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPOA2C0020445Hypercholesterolemia, Familial1CTD_human
TgeneSND1C0004352Autistic Disorder1CTD_human
TgeneSND1C0024121Lung Neoplasms1CTD_human