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Fusion gene ID: 2199 |
FusionGeneSummary for APOA2_SND1 |
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Fusion gene information | Fusion gene name: APOA2_SND1 | Fusion gene ID: 2199 | Hgene | Tgene | Gene symbol | APOA2 | SND1 | Gene ID | 80350 | 27044 |
Gene name | lipoprotein(a) like 2, pseudogene | staphylococcal nuclease and tudor domain containing 1 | |
Synonyms | APOA2|APOAL|APOARGC|apo(a)rg-C | TDRD11|Tudor-SN|p100 | |
Cytomap | 6q25.3 | 7q32.1 | |
Type of gene | pseudo | protein-coding | |
Description | apolipoprotein (a) related gene Capolipoprotein A-IIlipoprotein, Lp(a)-like 2, pseudogene | staphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P02652 | Q7KZF4 | |
Ensembl transtripts involved in fusion gene | ENST00000367990, ENST00000468465, ENST00000463812, ENST00000470459, ENST00000464492, ENST00000491350, | ENST00000354725, ENST00000467238, | |
Fusion gene scores | * DoF score | 5 X 4 X 2=40 | 20 X 15 X 10=3000 |
# samples | 8 | 21 | |
** MAII score | log2(8/40*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(21/3000*10)=-3.83650126771712 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: APOA2 [Title/Abstract] AND SND1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI207725 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000367990 | ENST00000354725 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-intron | ENST00000367990 | ENST00000467238 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-3UTR | ENST00000468465 | ENST00000354725 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-intron | ENST00000468465 | ENST00000467238 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-3UTR | ENST00000463812 | ENST00000354725 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-intron | ENST00000463812 | ENST00000467238 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-3UTR | ENST00000470459 | ENST00000354725 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-intron | ENST00000470459 | ENST00000467238 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-3UTR | ENST00000464492 | ENST00000354725 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-intron | ENST00000464492 | ENST00000467238 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-3UTR | ENST00000491350 | ENST00000354725 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
intron-intron | ENST00000491350 | ENST00000467238 | APOA2 | chr1 | 161193414 | + | SND1 | chr7 | 127732510 | + |
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FusionProtFeatures for APOA2_SND1 |
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Hgene | Tgene |
APOA2 | SND1 |
May stabilize HDL (high density lipoprotein) structureby its association with lipids, and affect the HDL metabolism. | Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for APOA2_SND1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for APOA2_SND1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for APOA2_SND1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | APOA2 | P02652 | DB01593 | Zinc | Apolipoprotein A-II | small molecule | approved|investigational |
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RelatedDiseases for APOA2_SND1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | APOA2 | C0020445 | Hypercholesterolemia, Familial | 1 | CTD_human |
Tgene | SND1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | SND1 | C0024121 | Lung Neoplasms | 1 | CTD_human |