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Fusion gene ID: 21962 |
FusionGeneSummary for MINK1_ALOX12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MINK1_ALOX12 | Fusion gene ID: 21962 | Hgene | Tgene | Gene symbol | MINK1 | ALOX12 | Gene ID | 50488 | 239 |
| Gene name | misshapen like kinase 1 | arachidonate 12-lipoxygenase, 12S type | |
| Synonyms | B55|MAP4K6|MINK|YSK2|ZC3 | 12-LOX|12S-LOX|LOG12 | |
| Cytomap | 17p13.2 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | misshapen-like kinase 1GCK family kinase MINKMAPK/ERK kinase kinase kinase 6MEK kinase kinase 6MEKKK 6misshapen/NIK-related kinasemitogen-activated protein kinase kinase kinase kinase 6 | arachidonate 12-lipoxygenase, 12S-type12S-lipoxygenaselipoxin synthase 12-LOplatelet 12-LOXplatelet-type 12-lipoxygenaseplatelet-type lipoxygenase 12 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8N4C8 | P18054 | |
| Ensembl transtripts involved in fusion gene | ENST00000355280, ENST00000347992, ENST00000453408, | ENST00000251535, | |
| Fusion gene scores | * DoF score | 8 X 4 X 5=160 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/160*10)=-0.830074998557688 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MINK1 [Title/Abstract] AND ALOX12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MINK1 | GO:0046777 | protein autophosphorylation | 15469942 |
| Tgene | ALOX12 | GO:0019369 | arachidonic acid metabolic process | 1851637|8319693 |
| Tgene | ALOX12 | GO:0019372 | lipoxygenase pathway | 8319693 |
| Tgene | ALOX12 | GO:0043651 | linoleic acid metabolic process | 8319693 |
| Tgene | ALOX12 | GO:0043651 | linoleic acid metabolic process | 1851637 |
| Tgene | ALOX12 | GO:1901751 | leukotriene A4 metabolic process | 8250832 |
| Tgene | ALOX12 | GO:1901751 | leukotriene A4 metabolic process | 1851637 |
| Tgene | ALOX12 | GO:2001303 | lipoxin A4 biosynthetic process | 8250832 |
| Tgene | ALOX12 | GO:2001306 | lipoxin B4 biosynthetic process | 8250832 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-D6-A6EN-01A | MINK1 | chr17 | 4736935 | + | ALOX12 | chr17 | 6903655 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000355280 | ENST00000251535 | MINK1 | chr17 | 4736935 | + | ALOX12 | chr17 | 6903655 | + |
| In-frame | ENST00000347992 | ENST00000251535 | MINK1 | chr17 | 4736935 | + | ALOX12 | chr17 | 6903655 | + |
| In-frame | ENST00000453408 | ENST00000251535 | MINK1 | chr17 | 4736935 | + | ALOX12 | chr17 | 6903655 | + |
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FusionProtFeatures for MINK1_ALOX12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MINK1 | ALOX12 |
| Serine/threonine kinase which acts as a negativeregulator of Ras-related Rap2-mediated signal transduction tocontrol neuronal structure and AMPA receptor trafficking. Requiredfor normal synaptic density, dendrite complexity, as well assurface AMPA receptor expression in hippocampal neurons. Canactivate the JNK and MAPK14/p38 pathways and mediates stimulationof the stress-activated protein kinase MAPK14/p38 MAPK downstreamof the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation byRAP2A, MBP and SMAD1. Has an essential function in negativeselection of thymocytes, perhaps by coupling NCK1 to activation ofJNK1. Isoform 4 can activate the JNK pathway. Involved in theregulation of actin cytoskeleton reorganization, cell-matrixadhesion, cell-cell adhesion and cell migration. | Non-heme iron-containing dioxygenase that catalyzes thestereo-specific peroxidation of free and esterifiedpolyunsaturated fatty acids generating a spectrum of bioactivelipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can alsometabolize linoleic acid. Has a dual activity since it alsoconverts leukotriene A4/LTA4 into both the bioactive lipoxinA4/LXA4 and lipoxin B4/LXB4. Through the production of specificbioactive lipids like (12S)-HPETE it regulates differentbiological processes including platelet activation. It alsoprobably positively regulates angiogenesis through regulation ofthe expression of the vascular endothelial growth factor. Plays arole in apoptotic process, promoting the survival of vascularsmooth muscle cells for instance. May also play a role in thecontrol of cell migration and proliferation.{ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:22237009,ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:8250832,ECO:0000269|PubMed:9751607}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000347992 | + | 1 | 32 | 359_495 | 19 | 1304 | Compositional bias | Note=Gln-rich |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000347992 | + | 1 | 32 | 542_729 | 19 | 1304 | Compositional bias | Note=Pro-rich |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000355280 | + | 1 | 32 | 359_495 | 19 | 1333 | Compositional bias | Note=Gln-rich |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000355280 | + | 1 | 32 | 542_729 | 19 | 1333 | Compositional bias | Note=Pro-rich |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000453408 | + | 1 | 32 | 359_495 | 19 | 1313 | Compositional bias | Note=Gln-rich |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000453408 | + | 1 | 32 | 542_729 | 19 | 1313 | Compositional bias | Note=Pro-rich |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000347992 | + | 1 | 32 | 1019_1306 | 19 | 1304 | Domain | CNH |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000347992 | + | 1 | 32 | 25_289 | 19 | 1304 | Domain | Protein kinase |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000355280 | + | 1 | 32 | 1019_1306 | 19 | 1333 | Domain | CNH |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000355280 | + | 1 | 32 | 25_289 | 19 | 1333 | Domain | Protein kinase |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000453408 | + | 1 | 32 | 1019_1306 | 19 | 1313 | Domain | CNH |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000453408 | + | 1 | 32 | 25_289 | 19 | 1313 | Domain | Protein kinase |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000347992 | + | 1 | 32 | 31_39 | 19 | 1304 | Nucleotide binding | ATP |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000355280 | + | 1 | 32 | 31_39 | 19 | 1333 | Nucleotide binding | ATP |
| Hgene | >MINK1 | chr17:4736935 | chr17:6903655 | ENST00000453408 | + | 1 | 32 | 31_39 | 19 | 1313 | Nucleotide binding | ATP |
| Tgene | ALOX12 | chr17:4736935 | chr17:6903655 | ENST00000251535 | + | 5 | 14 | 115_663 | 269 | 664 | Domain | Lipoxygenase |
| Tgene | ALOX12 | chr17:4736935 | chr17:6903655 | ENST00000251535 | + | 5 | 14 | 2_114 | 269 | 664 | Domain | PLAT |
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FusionGeneSequence for MINK1_ALOX12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MINK1_ENST00000355280_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_414aa MGDPAPARSLDDIDLSALRNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAW LLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLR RAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQ SQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHH >In-frame_MINK1_ENST00000347992_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_414aa MGDPAPARSLDDIDLSALRNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAW LLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLR RAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQ SQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHH >In-frame_MINK1_ENST00000453408_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_414aa MGDPAPARSLDDIDLSALRNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAW LLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLR RAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQ SQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MINK1_ENST00000355280_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_1242nt ATGGGCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGAATGGTTCCCTGTTTGAAGCTGACTTCATCCTT CTGGATGGAATTCCAGCCAACGTGATCCGAGGAGAGAAGCAATACCTGGCTGCCCCCCTCGTTATGCTGAAGATGGAGCCCAATGGGAAG CTGCAGCCCATGGTCATCCAGATTCAGCCTCCCAACCCCAGCTCTCCAACCCCAACACTGTTCCTGCCCTCAGACCCCCCACTTGCCTGG CTCCTGGCAAAGTCCTGGGTCCGAAATTCAGATTTCCAACTGCACGAGATCCAGTATCACTTGCTGAACACTCACCTGGTGGCTGAGGTC ATCGCTGTCGCCACCATGCGGTGCCTCCCAGGACTGCACCCCATCTTCAAGTTCCTGATCCCCCATATCCGCTACACCATGGAAATCAAC ACCCGGGCCCGGACCCAACTCATCTCAGATGGAGGAATTTTTGATAAGGCAGTGAGCACAGGTGGAGGGGGCCATGTACAGTTGCTCCGT CGGGCGGCAGCTCAGCTGACCTACTGCTCCCTCTGTCCTCCTGACGACCTGGCTGACCGGGGCCTGCTGGGACTCCCAGGTGCTCTCTAT GCCCATGATGCTTTACGGCTCTGGGAGATCATTGCCAGGTATGTGGAGGGGATCGTCCACCTCTTCTACCAAAGGGATGACATAGTGAAG GGGGACCCTGAGCTGCAGGCCTGGTGTCGGGAGATCACGGAGGTGGGGCTGTGCCAGGCCCAGGACCGAGGTTTCCCTGTCTCCTTCCAG TCCCAGAGTCAACTCTGCCATTTCCTCACCATGTGCGTCTTCACGTGCACTGCCCAGCATGCCGCCATCAACCAGGGCCAGCTGGACTGG TATGCCTGGGTCCCTAATGCTCCATGCACAATGCGGATGCCCCCACCCACCACCAAGGAAGATGTGACGATGGCCACAGTGATGGGGTCA CTACCTGATGTCCGGCAGGCCTGTCTTCAAATGGCCATCTCATGGCATCTGAGTCGCCGCCAGCCAGACATGGTGCCTCTGGGGCACCAC AAAGAAAAATATTTCTCAGGCCCCAAGCCCAAAGCTGTGCTAAACCAATTCCGAACAGATTTGGAAAAGCTGGAAAAGGAGATTACAGCC >In-frame_MINK1_ENST00000347992_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_1242nt ATGGGCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGAATGGTTCCCTGTTTGAAGCTGACTTCATCCTT CTGGATGGAATTCCAGCCAACGTGATCCGAGGAGAGAAGCAATACCTGGCTGCCCCCCTCGTTATGCTGAAGATGGAGCCCAATGGGAAG CTGCAGCCCATGGTCATCCAGATTCAGCCTCCCAACCCCAGCTCTCCAACCCCAACACTGTTCCTGCCCTCAGACCCCCCACTTGCCTGG CTCCTGGCAAAGTCCTGGGTCCGAAATTCAGATTTCCAACTGCACGAGATCCAGTATCACTTGCTGAACACTCACCTGGTGGCTGAGGTC ATCGCTGTCGCCACCATGCGGTGCCTCCCAGGACTGCACCCCATCTTCAAGTTCCTGATCCCCCATATCCGCTACACCATGGAAATCAAC ACCCGGGCCCGGACCCAACTCATCTCAGATGGAGGAATTTTTGATAAGGCAGTGAGCACAGGTGGAGGGGGCCATGTACAGTTGCTCCGT CGGGCGGCAGCTCAGCTGACCTACTGCTCCCTCTGTCCTCCTGACGACCTGGCTGACCGGGGCCTGCTGGGACTCCCAGGTGCTCTCTAT GCCCATGATGCTTTACGGCTCTGGGAGATCATTGCCAGGTATGTGGAGGGGATCGTCCACCTCTTCTACCAAAGGGATGACATAGTGAAG GGGGACCCTGAGCTGCAGGCCTGGTGTCGGGAGATCACGGAGGTGGGGCTGTGCCAGGCCCAGGACCGAGGTTTCCCTGTCTCCTTCCAG TCCCAGAGTCAACTCTGCCATTTCCTCACCATGTGCGTCTTCACGTGCACTGCCCAGCATGCCGCCATCAACCAGGGCCAGCTGGACTGG TATGCCTGGGTCCCTAATGCTCCATGCACAATGCGGATGCCCCCACCCACCACCAAGGAAGATGTGACGATGGCCACAGTGATGGGGTCA CTACCTGATGTCCGGCAGGCCTGTCTTCAAATGGCCATCTCATGGCATCTGAGTCGCCGCCAGCCAGACATGGTGCCTCTGGGGCACCAC AAAGAAAAATATTTCTCAGGCCCCAAGCCCAAAGCTGTGCTAAACCAATTCCGAACAGATTTGGAAAAGCTGGAAAAGGAGATTACAGCC >In-frame_MINK1_ENST00000453408_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_1242nt ATGGGCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGAATGGTTCCCTGTTTGAAGCTGACTTCATCCTT CTGGATGGAATTCCAGCCAACGTGATCCGAGGAGAGAAGCAATACCTGGCTGCCCCCCTCGTTATGCTGAAGATGGAGCCCAATGGGAAG CTGCAGCCCATGGTCATCCAGATTCAGCCTCCCAACCCCAGCTCTCCAACCCCAACACTGTTCCTGCCCTCAGACCCCCCACTTGCCTGG CTCCTGGCAAAGTCCTGGGTCCGAAATTCAGATTTCCAACTGCACGAGATCCAGTATCACTTGCTGAACACTCACCTGGTGGCTGAGGTC ATCGCTGTCGCCACCATGCGGTGCCTCCCAGGACTGCACCCCATCTTCAAGTTCCTGATCCCCCATATCCGCTACACCATGGAAATCAAC ACCCGGGCCCGGACCCAACTCATCTCAGATGGAGGAATTTTTGATAAGGCAGTGAGCACAGGTGGAGGGGGCCATGTACAGTTGCTCCGT CGGGCGGCAGCTCAGCTGACCTACTGCTCCCTCTGTCCTCCTGACGACCTGGCTGACCGGGGCCTGCTGGGACTCCCAGGTGCTCTCTAT GCCCATGATGCTTTACGGCTCTGGGAGATCATTGCCAGGTATGTGGAGGGGATCGTCCACCTCTTCTACCAAAGGGATGACATAGTGAAG GGGGACCCTGAGCTGCAGGCCTGGTGTCGGGAGATCACGGAGGTGGGGCTGTGCCAGGCCCAGGACCGAGGTTTCCCTGTCTCCTTCCAG TCCCAGAGTCAACTCTGCCATTTCCTCACCATGTGCGTCTTCACGTGCACTGCCCAGCATGCCGCCATCAACCAGGGCCAGCTGGACTGG TATGCCTGGGTCCCTAATGCTCCATGCACAATGCGGATGCCCCCACCCACCACCAAGGAAGATGTGACGATGGCCACAGTGATGGGGTCA CTACCTGATGTCCGGCAGGCCTGTCTTCAAATGGCCATCTCATGGCATCTGAGTCGCCGCCAGCCAGACATGGTGCCTCTGGGGCACCAC AAAGAAAAATATTTCTCAGGCCCCAAGCCCAAAGCTGTGCTAAACCAATTCCGAACAGATTTGGAAAAGCTGGAAAAGGAGATTACAGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MINK1_ENST00000355280_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_1751nt GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTG GAGTCCGCCCCCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCC GTTCCCCACGGAGGCCATGGGCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGAATGGTTCCCTGTTTGA AGCTGACTTCATCCTTCTGGATGGAATTCCAGCCAACGTGATCCGAGGAGAGAAGCAATACCTGGCTGCCCCCCTCGTTATGCTGAAGAT GGAGCCCAATGGGAAGCTGCAGCCCATGGTCATCCAGATTCAGCCTCCCAACCCCAGCTCTCCAACCCCAACACTGTTCCTGCCCTCAGA CCCCCCACTTGCCTGGCTCCTGGCAAAGTCCTGGGTCCGAAATTCAGATTTCCAACTGCACGAGATCCAGTATCACTTGCTGAACACTCA CCTGGTGGCTGAGGTCATCGCTGTCGCCACCATGCGGTGCCTCCCAGGACTGCACCCCATCTTCAAGTTCCTGATCCCCCATATCCGCTA CACCATGGAAATCAACACCCGGGCCCGGACCCAACTCATCTCAGATGGAGGAATTTTTGATAAGGCAGTGAGCACAGGTGGAGGGGGCCA TGTACAGTTGCTCCGTCGGGCGGCAGCTCAGCTGACCTACTGCTCCCTCTGTCCTCCTGACGACCTGGCTGACCGGGGCCTGCTGGGACT CCCAGGTGCTCTCTATGCCCATGATGCTTTACGGCTCTGGGAGATCATTGCCAGGTATGTGGAGGGGATCGTCCACCTCTTCTACCAAAG GGATGACATAGTGAAGGGGGACCCTGAGCTGCAGGCCTGGTGTCGGGAGATCACGGAGGTGGGGCTGTGCCAGGCCCAGGACCGAGGTTT CCCTGTCTCCTTCCAGTCCCAGAGTCAACTCTGCCATTTCCTCACCATGTGCGTCTTCACGTGCACTGCCCAGCATGCCGCCATCAACCA GGGCCAGCTGGACTGGTATGCCTGGGTCCCTAATGCTCCATGCACAATGCGGATGCCCCCACCCACCACCAAGGAAGATGTGACGATGGC CACAGTGATGGGGTCACTACCTGATGTCCGGCAGGCCTGTCTTCAAATGGCCATCTCATGGCATCTGAGTCGCCGCCAGCCAGACATGGT GCCTCTGGGGCACCACAAAGAAAAATATTTCTCAGGCCCCAAGCCCAAAGCTGTGCTAAACCAATTCCGAACAGATTTGGAAAAGCTGGA AAAGGAGATTACAGCCCGGAATGAGCAACTTGACTGGCCCTATGAATATCTGAAGCCCAGCTGCATAGAGAACAGTGTCACCATCTGAGC CCTAGAGTGACTCTACCTGCAAGATTTCACATCAGCTTTAGGACTGACATTTCTATCTTGAATTTCATGCTTTCCTAAAGTCTCTGCTGC TAAGGCTCTATTTCCTCCCCCAGTTAAACCCCCTACATTAGTATCCCACTAGCCCAGGGGAGCAGTAAACTTTCTCTGCAAAGACTAGAT CCTTTTTTACGCTTTGCAGACCGCATAGTCACTGTCTCAACTACTCAGCTCTCCTGCTGCAGCATGAAGGCAGCCACAGACAACATGGAA >In-frame_MINK1_ENST00000347992_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_1739nt GGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCCCC GGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGA GGCCATGGGCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGAATGGTTCCCTGTTTGAAGCTGACTTCAT CCTTCTGGATGGAATTCCAGCCAACGTGATCCGAGGAGAGAAGCAATACCTGGCTGCCCCCCTCGTTATGCTGAAGATGGAGCCCAATGG GAAGCTGCAGCCCATGGTCATCCAGATTCAGCCTCCCAACCCCAGCTCTCCAACCCCAACACTGTTCCTGCCCTCAGACCCCCCACTTGC CTGGCTCCTGGCAAAGTCCTGGGTCCGAAATTCAGATTTCCAACTGCACGAGATCCAGTATCACTTGCTGAACACTCACCTGGTGGCTGA GGTCATCGCTGTCGCCACCATGCGGTGCCTCCCAGGACTGCACCCCATCTTCAAGTTCCTGATCCCCCATATCCGCTACACCATGGAAAT CAACACCCGGGCCCGGACCCAACTCATCTCAGATGGAGGAATTTTTGATAAGGCAGTGAGCACAGGTGGAGGGGGCCATGTACAGTTGCT CCGTCGGGCGGCAGCTCAGCTGACCTACTGCTCCCTCTGTCCTCCTGACGACCTGGCTGACCGGGGCCTGCTGGGACTCCCAGGTGCTCT CTATGCCCATGATGCTTTACGGCTCTGGGAGATCATTGCCAGGTATGTGGAGGGGATCGTCCACCTCTTCTACCAAAGGGATGACATAGT GAAGGGGGACCCTGAGCTGCAGGCCTGGTGTCGGGAGATCACGGAGGTGGGGCTGTGCCAGGCCCAGGACCGAGGTTTCCCTGTCTCCTT CCAGTCCCAGAGTCAACTCTGCCATTTCCTCACCATGTGCGTCTTCACGTGCACTGCCCAGCATGCCGCCATCAACCAGGGCCAGCTGGA CTGGTATGCCTGGGTCCCTAATGCTCCATGCACAATGCGGATGCCCCCACCCACCACCAAGGAAGATGTGACGATGGCCACAGTGATGGG GTCACTACCTGATGTCCGGCAGGCCTGTCTTCAAATGGCCATCTCATGGCATCTGAGTCGCCGCCAGCCAGACATGGTGCCTCTGGGGCA CCACAAAGAAAAATATTTCTCAGGCCCCAAGCCCAAAGCTGTGCTAAACCAATTCCGAACAGATTTGGAAAAGCTGGAAAAGGAGATTAC AGCCCGGAATGAGCAACTTGACTGGCCCTATGAATATCTGAAGCCCAGCTGCATAGAGAACAGTGTCACCATCTGAGCCCTAGAGTGACT CTACCTGCAAGATTTCACATCAGCTTTAGGACTGACATTTCTATCTTGAATTTCATGCTTTCCTAAAGTCTCTGCTGCTAAGGCTCTATT TCCTCCCCCAGTTAAACCCCCTACATTAGTATCCCACTAGCCCAGGGGAGCAGTAAACTTTCTCTGCAAAGACTAGATCCTTTTTTACGC TTTGCAGACCGCATAGTCACTGTCTCAACTACTCAGCTCTCCTGCTGCAGCATGAAGGCAGCCACAGACAACATGGAAATGAGTGTGACT >In-frame_MINK1_ENST00000453408_chr17_4736935_+_ALOX12_ENST00000251535_chr17_6903655_+_1555nt ATGGGCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGAATGGTTCCCTGTTTGAAGCTGACTTCATCCTT CTGGATGGAATTCCAGCCAACGTGATCCGAGGAGAGAAGCAATACCTGGCTGCCCCCCTCGTTATGCTGAAGATGGAGCCCAATGGGAAG CTGCAGCCCATGGTCATCCAGATTCAGCCTCCCAACCCCAGCTCTCCAACCCCAACACTGTTCCTGCCCTCAGACCCCCCACTTGCCTGG CTCCTGGCAAAGTCCTGGGTCCGAAATTCAGATTTCCAACTGCACGAGATCCAGTATCACTTGCTGAACACTCACCTGGTGGCTGAGGTC ATCGCTGTCGCCACCATGCGGTGCCTCCCAGGACTGCACCCCATCTTCAAGTTCCTGATCCCCCATATCCGCTACACCATGGAAATCAAC ACCCGGGCCCGGACCCAACTCATCTCAGATGGAGGAATTTTTGATAAGGCAGTGAGCACAGGTGGAGGGGGCCATGTACAGTTGCTCCGT CGGGCGGCAGCTCAGCTGACCTACTGCTCCCTCTGTCCTCCTGACGACCTGGCTGACCGGGGCCTGCTGGGACTCCCAGGTGCTCTCTAT GCCCATGATGCTTTACGGCTCTGGGAGATCATTGCCAGGTATGTGGAGGGGATCGTCCACCTCTTCTACCAAAGGGATGACATAGTGAAG GGGGACCCTGAGCTGCAGGCCTGGTGTCGGGAGATCACGGAGGTGGGGCTGTGCCAGGCCCAGGACCGAGGTTTCCCTGTCTCCTTCCAG TCCCAGAGTCAACTCTGCCATTTCCTCACCATGTGCGTCTTCACGTGCACTGCCCAGCATGCCGCCATCAACCAGGGCCAGCTGGACTGG TATGCCTGGGTCCCTAATGCTCCATGCACAATGCGGATGCCCCCACCCACCACCAAGGAAGATGTGACGATGGCCACAGTGATGGGGTCA CTACCTGATGTCCGGCAGGCCTGTCTTCAAATGGCCATCTCATGGCATCTGAGTCGCCGCCAGCCAGACATGGTGCCTCTGGGGCACCAC AAAGAAAAATATTTCTCAGGCCCCAAGCCCAAAGCTGTGCTAAACCAATTCCGAACAGATTTGGAAAAGCTGGAAAAGGAGATTACAGCC CGGAATGAGCAACTTGACTGGCCCTATGAATATCTGAAGCCCAGCTGCATAGAGAACAGTGTCACCATCTGAGCCCTAGAGTGACTCTAC CTGCAAGATTTCACATCAGCTTTAGGACTGACATTTCTATCTTGAATTTCATGCTTTCCTAAAGTCTCTGCTGCTAAGGCTCTATTTCCT CCCCCAGTTAAACCCCCTACATTAGTATCCCACTAGCCCAGGGGAGCAGTAAACTTTCTCTGCAAAGACTAGATCCTTTTTTACGCTTTG CAGACCGCATAGTCACTGTCTCAACTACTCAGCTCTCCTGCTGCAGCATGAAGGCAGCCACAGACAACATGGAAATGAGTGTGACTATGT |
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FusionGenePPI for MINK1_ALOX12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MINK1 | NCK1, NEDD4L, HSP90AA1, MAP4K4, TEX264, NCK2, NOP2, ATM, CDH1, PTPRK, NANOS2, PPP1R15A, TSEN15, TRIM25 | ALOX12 | LMNA, ITGB4, TRIB1, KRT5, ALOX12, ACTA2, PLA2G4A, PLA2G2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MINK1_ALOX12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MINK1_ALOX12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ALOX12 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | ALOX12 | C0020429 | Hyperalgesia | 1 | CTD_human |
| Tgene | ALOX12 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| Tgene | ALOX12 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | ALOX12 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Tgene | ALOX12 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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