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Fusion gene ID: 21947 |
FusionGeneSummary for MIEN1_WIPF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MIEN1_WIPF2 | Fusion gene ID: 21947 | Hgene | Tgene | Gene symbol | MIEN1 | WIPF2 | Gene ID | 84299 | 147179 |
| Gene name | migration and invasion enhancer 1 | WAS/WASL interacting protein family member 2 | |
| Synonyms | C17orf37|C35|ORB3|RDX12|XTP4 | WICH|WIRE | |
| Cytomap | 17q12 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | migration and invasion enhancer 1HBV X-transactivated gene 4 proteinHBV XAg-transactivated protein 4protein C17orf37 | WAS/WASL-interacting protein family member 2WASP-binding proteinWASP-interacting protein-related proteinWIP- and CR16-homologous proteinWIP-related protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BRT3 | Q8TF74 | |
| Ensembl transtripts involved in fusion gene | ENST00000474210, ENST00000394231, ENST00000577810, | ENST00000494757, ENST00000323571, ENST00000585043, ENST00000394103, ENST00000536600, ENST00000583130, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 11 X 5 X 5=275 |
| # samples | 5 | 11 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/275*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MIEN1 [Title/Abstract] AND WIPF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MIEN1 | GO:0030335 | positive regulation of cell migration | 21628459 |
| Hgene | MIEN1 | GO:0043066 | negative regulation of apoptotic process | 21068479 |
| Hgene | MIEN1 | GO:0051491 | positive regulation of filopodium assembly | 21628459 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-30-1853-01A | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000474210 | ENST00000494757 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| intron-5UTR | ENST00000474210 | ENST00000323571 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| intron-5UTR | ENST00000474210 | ENST00000585043 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| intron-5UTR | ENST00000474210 | ENST00000394103 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| intron-5UTR | ENST00000474210 | ENST00000536600 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| intron-5UTR | ENST00000474210 | ENST00000583130 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-intron | ENST00000394231 | ENST00000494757 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000394231 | ENST00000323571 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000394231 | ENST00000585043 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000394231 | ENST00000394103 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000394231 | ENST00000536600 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000394231 | ENST00000583130 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-intron | ENST00000577810 | ENST00000494757 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000577810 | ENST00000323571 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000577810 | ENST00000585043 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000577810 | ENST00000394103 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000577810 | ENST00000536600 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
| 5CDS-5UTR | ENST00000577810 | ENST00000583130 | MIEN1 | chr17 | 37886447 | - | WIPF2 | chr17 | 38412643 | + |
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FusionProtFeatures for MIEN1_WIPF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MIEN1 | WIPF2 |
| Increases cell migration by inducing filopodia formationat the leading edge of migrating cells. Plays a role in regulationof apoptosis, possibly through control of CASP3. May be involvedin a redox-related process. {ECO:0000269|PubMed:19503095,ECO:0000269|PubMed:21628459}. | Plays an active role in the formation of cell surfaceprotrusions downstream of activated PDGFB receptors. Plays animportant role in actin-microspike formation through cooperationwith WASL. May cooperate with WASP and WASL to induce mobilizationand reorganization of the actin filament system.{ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MIEN1_WIPF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MIEN1_WIPF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MIEN1 | REL, MOV10, NXF1, SCCPDH, NLGN3 | WIPF2 | DNMBP, WAS, NCK2, GRB2, ITSN2, SH3KBP1, WASL, EIF4A3, TXLNG, SLC4A1AP, HNRNPDL, ZFAND5, ZNF830, TCERG1, APBB1, WWOX, PACSIN2, NCK1, CDH1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MIEN1_WIPF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MIEN1_WIPF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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