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Fusion gene ID: 21945 |
FusionGeneSummary for MIEN1_HNRNPDL |
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Fusion gene information | Fusion gene name: MIEN1_HNRNPDL | Fusion gene ID: 21945 | Hgene | Tgene | Gene symbol | MIEN1 | HNRNPDL | Gene ID | 84299 | 9987 |
Gene name | migration and invasion enhancer 1 | heterogeneous nuclear ribonucleoprotein D like | |
Synonyms | C17orf37|C35|ORB3|RDX12|XTP4 | HNRNP|HNRPDL|JKTBP|JKTBP2|LGMD1G|laAUF1 | |
Cytomap | 17q12 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | migration and invasion enhancer 1HBV X-transactivated gene 4 proteinHBV XAg-transactivated protein 4protein C17orf37 | heterogeneous nuclear ribonucleoprotein D-likeA+U-rich element RNA binding factorAU-rich element RNA-binding factorJKT41-binding proteinhnRNP D-likehnRNP DLprotein laAUF1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BRT3 | O14979 | |
Ensembl transtripts involved in fusion gene | ENST00000474210, ENST00000394231, ENST00000577810, | ENST00000295470, ENST00000349655, ENST00000602300, ENST00000502762, ENST00000514511, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 7 X 7 X 3=147 |
# samples | 5 | 9 | |
** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/147*10)=-0.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MIEN1 [Title/Abstract] AND HNRNPDL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MIEN1 | GO:0030335 | positive regulation of cell migration | 21628459 |
Hgene | MIEN1 | GO:0043066 | negative regulation of apoptotic process | 21068479 |
Hgene | MIEN1 | GO:0051491 | positive regulation of filopodium assembly | 21628459 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA456091 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + | ||
ChiTaRS3.1 | AA456092 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000474210 | ENST00000295470 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000474210 | ENST00000349655 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000474210 | ENST00000602300 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000474210 | ENST00000502762 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000474210 | ENST00000514511 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000394231 | ENST00000295470 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000394231 | ENST00000349655 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000394231 | ENST00000602300 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000394231 | ENST00000502762 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000394231 | ENST00000514511 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000577810 | ENST00000295470 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000577810 | ENST00000349655 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000577810 | ENST00000602300 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000577810 | ENST00000502762 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
intron-intron | ENST00000577810 | ENST00000514511 | MIEN1 | chr17 | 37885624 | + | HNRNPDL | chr4 | 83346687 | + |
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FusionProtFeatures for MIEN1_HNRNPDL |
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Hgene | Tgene |
MIEN1 | HNRNPDL |
Increases cell migration by inducing filopodia formationat the leading edge of migrating cells. Plays a role in regulationof apoptosis, possibly through control of CASP3. May be involvedin a redox-related process. {ECO:0000269|PubMed:19503095,ECO:0000269|PubMed:21628459}. | Acts as a transcriptional regulator. Promotestranscription repression. Promotes transcription activation indifferentiated myotubes (By similarity). Binds to double- andsingle-stranded DNA sequences. Binds to the transcriptionsuppressor CATR sequence of the COX5B promoter (By similarity).Binds with high affinity to RNA molecules that contain AU-richelements (AREs) found within the 3'-UTR of many proto-oncogenesand cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A)mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C)RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensussequence. {ECO:0000250, ECO:0000269|PubMed:9538234}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MIEN1_HNRNPDL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MIEN1_HNRNPDL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MIEN1_HNRNPDL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MIEN1_HNRNPDL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HNRNPDL | C1836765 | LIMB-GIRDLE MUSCULAR DYSTROPHY, TYPE 1G (disorder) | 1 | ORPHANET;UNIPROT |