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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21945

FusionGeneSummary for MIEN1_HNRNPDL

check button Fusion gene summary
Fusion gene informationFusion gene name: MIEN1_HNRNPDL
Fusion gene ID: 21945
HgeneTgene
Gene symbol

MIEN1

HNRNPDL

Gene ID

84299

9987

Gene namemigration and invasion enhancer 1heterogeneous nuclear ribonucleoprotein D like
SynonymsC17orf37|C35|ORB3|RDX12|XTP4HNRNP|HNRPDL|JKTBP|JKTBP2|LGMD1G|laAUF1
Cytomap

17q12

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionmigration and invasion enhancer 1HBV X-transactivated gene 4 proteinHBV XAg-transactivated protein 4protein C17orf37heterogeneous nuclear ribonucleoprotein D-likeA+U-rich element RNA binding factorAU-rich element RNA-binding factorJKT41-binding proteinhnRNP D-likehnRNP DLprotein laAUF1
Modification date2018052320180523
UniProtAcc

Q9BRT3

O14979

Ensembl transtripts involved in fusion geneENST00000474210, ENST00000394231, 
ENST00000577810, 
ENST00000295470, 
ENST00000349655, ENST00000602300, 
ENST00000502762, ENST00000514511, 
Fusion gene scores* DoF score4 X 3 X 4=487 X 7 X 3=147
# samples 59
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIEN1 [Title/Abstract] AND HNRNPDL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMIEN1

GO:0030335

positive regulation of cell migration

21628459

HgeneMIEN1

GO:0043066

negative regulation of apoptotic process

21068479

HgeneMIEN1

GO:0051491

positive regulation of filopodium assembly

21628459


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA456091MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
ChiTaRS3.1AA456092MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000474210ENST00000295470MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000474210ENST00000349655MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000474210ENST00000602300MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000474210ENST00000502762MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000474210ENST00000514511MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000394231ENST00000295470MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000394231ENST00000349655MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000394231ENST00000602300MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000394231ENST00000502762MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000394231ENST00000514511MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000577810ENST00000295470MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000577810ENST00000349655MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000577810ENST00000602300MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000577810ENST00000502762MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+
intron-intronENST00000577810ENST00000514511MIEN1chr17

37885624

+HNRNPDLchr4

83346687

+

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FusionProtFeatures for MIEN1_HNRNPDL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIEN1

Q9BRT3

HNRNPDL

O14979

Increases cell migration by inducing filopodia formationat the leading edge of migrating cells. Plays a role in regulationof apoptosis, possibly through control of CASP3. May be involvedin a redox-related process. {ECO:0000269|PubMed:19503095,ECO:0000269|PubMed:21628459}. Acts as a transcriptional regulator. Promotestranscription repression. Promotes transcription activation indifferentiated myotubes (By similarity). Binds to double- andsingle-stranded DNA sequences. Binds to the transcriptionsuppressor CATR sequence of the COX5B promoter (By similarity).Binds with high affinity to RNA molecules that contain AU-richelements (AREs) found within the 3'-UTR of many proto-oncogenesand cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A)mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C)RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensussequence. {ECO:0000250, ECO:0000269|PubMed:9538234}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIEN1_HNRNPDL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIEN1_HNRNPDL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIEN1_HNRNPDL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIEN1_HNRNPDL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHNRNPDLC1836765LIMB-GIRDLE MUSCULAR DYSTROPHY, TYPE 1G (disorder)1ORPHANET;UNIPROT