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Fusion gene ID: 21923 |
FusionGeneSummary for MICU3_TGFBR3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MICU3_TGFBR3 | Fusion gene ID: 21923 | Hgene | Tgene | Gene symbol | MICU3 | TGFBR3 | Gene ID | 286097 | 7049 |
| Gene name | mitochondrial calcium uptake family member 3 | transforming growth factor beta receptor 3 | |
| Synonyms | EFHA2 | BGCAN|betaglycan | |
| Cytomap | 8p22 | 1p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium uptake protein 3, mitochondrialEF hand domain family A2EF-hand domain family, member A2EF-hand domain-containing family member A2mitochondrial uptake family, member 3 | transforming growth factor beta receptor type 3TGF-beta receptor type 3TGF-beta receptor type IIITGFR-3betaglycan proteoglycantransforming growth factor beta receptor III | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q86XE3 | Q03167 | |
| Ensembl transtripts involved in fusion gene | ENST00000318063, ENST00000519866, | ENST00000212355, ENST00000370399, ENST00000525962, ENST00000468996, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 6=216 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MICU3 [Title/Abstract] AND TGFBR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TGFBR3 | GO:0001837 | epithelial to mesenchymal transition | 18184661 |
| Tgene | TGFBR3 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 12958365 |
| Tgene | TGFBR3 | GO:0030509 | BMP signaling pathway | 18184661 |
| Tgene | TGFBR3 | GO:0032354 | response to follicle-stimulating hormone | 14557487 |
| Tgene | TGFBR3 | GO:0034695 | response to prostaglandin E | 14557487 |
| Tgene | TGFBR3 | GO:0034699 | response to luteinizing hormone | 14557487 |
| Tgene | TGFBR3 | GO:0051271 | negative regulation of cellular component movement | 17999987 |
| Tgene | TGFBR3 | GO:0060317 | cardiac epithelial to mesenchymal transition | 18184661 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EE-A29L-06A | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000318063 | ENST00000212355 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
| In-frame | ENST00000318063 | ENST00000370399 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
| In-frame | ENST00000318063 | ENST00000525962 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
| 5CDS-5UTR | ENST00000318063 | ENST00000468996 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
| intron-3CDS | ENST00000519866 | ENST00000212355 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
| intron-3CDS | ENST00000519866 | ENST00000370399 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
| intron-3CDS | ENST00000519866 | ENST00000525962 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
| intron-5UTR | ENST00000519866 | ENST00000468996 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
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FusionProtFeatures for MICU3_TGFBR3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MICU3 | TGFBR3 |
| May play a role in mitochondrial calcium uptake.{ECO:0000250}. | Binds to TGF-beta. Could be involved in capturing andretaining TGF-beta for presentation to the signaling receptors. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 59_63 | 127 | 1175 | Compositional bias | Note=Poly-Arg |
| Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 70_73 | 127 | 1175 | Compositional bias | Note=Poly-Ala |
| Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 67_83 | 127 | 1175 | Transmembrane | Helical |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | - | 3 | 17 | 455_730 | 128 | 852 | Domain | ZP |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | - | 4 | 18 | 455_730 | 128 | 851 | Domain | ZP |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | - | 2 | 16 | 455_730 | 128 | 852 | Domain | ZP |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | - | 3 | 17 | 810_851 | 128 | 852 | Topological domain | Cytoplasmic |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | - | 4 | 18 | 810_851 | 128 | 851 | Topological domain | Cytoplasmic |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | - | 2 | 16 | 810_851 | 128 | 852 | Topological domain | Cytoplasmic |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | - | 3 | 17 | 788_809 | 128 | 852 | Transmembrane | Helical |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | - | 4 | 18 | 788_809 | 128 | 851 | Transmembrane | Helical |
| Tgene | >TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | - | 2 | 16 | 788_809 | 128 | 852 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 245_256 | 127 | 1175 | Calcium binding | 1 |
| Hgene | >MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 483_494 | 127 | 1175 | Calcium binding | 2 |
| Hgene | >MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 232_267 | 127 | 1175 | Domain | EF-hand 1 |
| Hgene | >MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 401_436 | 127 | 1175 | Domain | EF-hand 2 |
| Hgene | >MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 470_505 | 127 | 1175 | Domain | EF-hand 3 |
| Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | - | 3 | 17 | 21_787 | 128 | 852 | Topological domain | Extracellular |
| Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | - | 4 | 18 | 21_787 | 128 | 851 | Topological domain | Extracellular |
| Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | - | 2 | 16 | 21_787 | 128 | 852 | Topological domain | Extracellular |
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FusionGeneSequence for MICU3_TGFBR3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000212355_chr1_92200516_-_851aa MAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCYQLYGDPR AGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIAR NIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLIL ILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEE MGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIA LSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYE DLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQE LGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLP KCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSH >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000370399_chr1_92200516_-_850aa MAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCYQLYGDPR AGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIAR NIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLIL ILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNEEM GDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIAL SVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYED LESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQEL GFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPK CVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHT >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000525962_chr1_92200516_-_851aa MAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCYQLYGDPR AGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIAR NIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLIL ILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEE MGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIA LSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYE DLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQE LGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLP KCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000212355_chr1_92200516_-_2553nt ATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCTCCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGG CCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGAGAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGG CGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGGCTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGG GCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAGCCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCA GTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTTTCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGG AACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAGTATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGA AACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGCAACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAG TACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCCCAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAAC TCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGACCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTG ATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGATGTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGC TTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGAGATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCT TTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTGGCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAGGAG ATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTGCTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATC CGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGATATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTC CCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGTCTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCC CTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAAGATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACC CTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTTTTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGG TCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTTCCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAA GATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGAGATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAAT TGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCCCACGGAAACATCACCTTCAACATGGAGCTATACAACACTGAC CTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGACACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAA CTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCTGATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCT AAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCTATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTC TTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTGACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCT AAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATAATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCC CTTGCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGCATGAAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGT CTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATCGGAGCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCAC ACAGGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCCTCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAG >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000370399_chr1_92200516_-_2550nt ATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCTCCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGG CCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGAGAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGG CGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGGCTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGG GCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAGCCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCA GTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTTTCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGG AACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAGTATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGA AACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGCAACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAG TACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCCCAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAAC TCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGACCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTG ATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGATGTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGC TTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGAGATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCT TTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTGGCTAATAGATTTCATCTTCGGCTTGAAAATAATGAGGAGATG GGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTGCTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGG GGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGATATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTCCCT CGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGTCTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTG TCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAAGATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACCCTG TTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTTTTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCA GCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTTCCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAAGAT CTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGAGATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGC AGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCCCACGGAAACATCACCTTCAACATGGAGCTATACAACACTGACCTC TTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGACACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTG GGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCTGATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCTAAA GATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCTATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTC AAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTGACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCTAAG TGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATAATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTT GCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGCATGAAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGTCTG GACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATCGGAGCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCACACA GGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCCTCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAGAGC >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000525962_chr1_92200516_-_2553nt ATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCTCCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGG CCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGAGAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGG CGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGGCTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGG GCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAGCCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCA GTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTTTCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGG AACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAGTATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGA AACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGCAACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAG TACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCCCAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAAC TCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGACCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTG ATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGATGTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGC TTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGAGATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCT TTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTGGCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAGGAG ATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTGCTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATC CGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGATATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTC CCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGTCTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCC CTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAAGATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACC CTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTTTTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGG TCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTTCCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAA GATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGAGATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAAT TGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCCCACGGAAACATCACCTTCAACATGGAGCTATACAACACTGAC CTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGACACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAA CTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCTGATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCT AAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCTATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTC TTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTGACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCT AAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATAATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCC CTTGCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGCATGAAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGT CTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATCGGAGCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCAC ACAGGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCCTCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000212355_chr1_92200516_-_5989nt GTTCTCTGCCCCCTCCCAGCTCTGGTGTGGGCGGCCTCCGCTATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCT CCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGGCCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGA GAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGGCGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGG CTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGGGCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAG CCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCAGTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTT TCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAG TATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGAAACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGC AACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCC CAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAACTCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGA CCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGAT GTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGA GATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTG GCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAGGAGATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTG CTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGAT ATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTCCCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGT CTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAA GATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACCCTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTT TTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTT CCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAAGATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGA GATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCC CACGGAAACATCACCTTCAACATGGAGCTATACAACACTGACCTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGA CACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCT GATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCTAAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCT ATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTG ACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCTAAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATA ATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGC ATGAAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGTCTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATC GGAGCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCACACAGGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCC TCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAGAGCACGCCTTGCTCCAGCAGCAGCACGGCCTAGCCCAACCCAGCCCAA CCCGGCCCAACCCAGCCCAGCCCAGCTCAGCTCAGCTACTGCCAAGGGCAGGACCAATGGCTGAGCCTCGTGTCCAGACTCAGAGGGCTG GATTTTGGTTCCCTTGTAAAGACAGAGTGAATTTCAGTATAAAGATCACCCGTTGTATTCACCCCACACCCAGGGCTAGTATAAACATGA CCCTGGGCTTCTGTACCACACTAGAATTCATGTGAGAAAGCTAAAATGGTGGTCTTCTCCACCAGCCCCTCACAGGCTTGGGGGTTTTCA ATGTGAAACACATGCCAGTTTTTAAAATGCTGCTTTGTCCAGGTGAGAACATCCATAATTTGGGGCCCTGAGTTTTACCCAGACTCAAGG AGTTGGTAAAGGGTTAATAGCCAGATAGTAGAACCAGTGAGGAGATGCGGCCAAAGATTCTTTATATCTGAACCAAGATGTAAAACAAGA AATGCTTTGAGGCTTTCTAAGCGATCCTCCTGTCTAATTTGCACCTTTGTCTGGATGCACACTTCTGACCTTGCTGCCACAACCTGTGGG GTCTGATGTGTCCCTTGATGGGTGCTGCCCTCAGGGACTGCACCCTGACAAGTGTTAAGGCAACATTCCTTTCTTGTGCCCTGGGCCAAA ACCAATGCTGATGACCTTATCAGCTTCCTGTTTCTTCCCATACTTGCATACACCACTGCAAAATGTCTTAATGCAAATTTTGTATTTCTT ACAGGCCTACAGAAATTGAAAATGACCAAAATCAGGAACCACAGATTTGTGCCCATTCCTAATATTTTGTTCTGCAAATTAATGTATAAT TTGAGGTGAAATTCAGTTATAAAGTCAAGGACGAATTTGCACAGTGATATATTTCTATGTGTATGCAAGTACAAGTATATAATATGTCAC CTGGCACATTCATTTTCTCAGTTGAAGAAGAGAAAATTTGAAAATGTCCTTATGCTTTTAGAGTTGCAACTTAAGTATATTTGGTAGGGT GAGTGTTTCCACTCAAAATATGTCAACTTAAAAAAAAATAGGCCCTTTCATAAAAACCAAACTGTAGCAAGATGCAAATGCATGGCAAAT CCTGTCGGTCTCCAGTTGGTTATCTGAATAGTGTCACCAATTCCACCAAGACAGTGCTGAGATTGGAAAAGGGCACTCATTTGGATTGCC TTACTTCTCTTGCCTTAAATATATCCCATATATTTAATATGTCAAAAAGGGCTTGAGGTGAATTTCATTAAATGGAATAATATGATGCCA CTTTGCAGCTAAAATAAGCTCAGTGATACCTCCTTGTTAAAAAAAAAAAAAAAAAAAAAGAATGCCAGGGGGGAATTATCATGCTAAATT ATTTTACTGCTGAAGATAGCTTCATTGCAAATTATTCTTTTTCCAGAATTTCCCCCAAACAACTTAGAATTCCATAAGTAGAACAAGATA GATTCTACCCCCAAAATATTCATAAGCAAATCCCACTGCCCTTAAAATAAGGAAGTTATGCCTGGTTGTCTGTGAATGGAACCTCAGTAG GTAATCCTGATGAAGCTTAAAACCTTAGGGCAGTGTCTACATGGGAAACAAGTATGTGGAAATTGACAATCATTTTTACCAAATCGTTGA GTAATAATATGACTTACCTGATAGATATACACATTCAATAAGGAACATTTTTTTTTTTCAATAAGGAACATTTTAACTAAAACATTACTT TAGGGCTGAGATTTCCAGGCTATCTACATTGATCTACTGAAAAATTTCTAGATTTCCATATACAAACGAAGAAGACATGAGTTTAGAGAA TTTTTTTCCTTTAATTTTTTTTTAACAGAAGGGTATCAGAGTGGAGGACCTAGATTACGCTACCTGTGTTTGAAAATATTGCGCTTTGCC TAACCTTCGGTGGAATGTATTGTTTCAGCATATTCTATGTATAAAAAAGTTTAAAGATGTCTTCAAAGAAGACTAGAGTCTTTAAGTCAC TTATAGCTATATTTTACTACAAAATTTGTGTATAAAGATATATTTAAGTGTTTTAGATAAATTTAAGTTACTCCATATGAAATGTTTAAT TTCAGCTACTGTGAATTCTTTCGATCAGTCCTTTGCTTTTTTAAAAAATCTTTTCCATCGTGTTAAAAAGAAAATTAGCTATTAGGAGAT ATTAAAAGATTGATGTCTTAGAAGGACAGGGTTAAAACCTTCTGTAATATATTTAAATATATATTTTTAAGAGAGATGCTACATTGCCAA TGATTTTATAAATAATTTAAAATTAATTTACAAATTTATAGATGCAAACCAAAAGATCTTTTTAAAAGAGAGAGAGAGGAAAAAAATCAC CTTTTATTTGTTTGGGTCTCATTGTCAGAATTATTATTCAGATCAAGAAATCTGTGTCGATAAAACCTAATCTCATATTGGAGAGTGAAT GTCGTTAAGTATTTCTGAAATGTTTCTAAAAAATGAACATGAAAAAAATAAGGTATTTTCTCCCTAGCTTCTCATTACAGTATTTCTAAT TGCTTCACACTTTACAGTTTTAATACAAAGTACAAGCTCTACTTTTATAACGTGTACTACAAGTTTCTTTAAAAGTATTGTTGTATTTCA GCTGAACTCTTGTATCTGCAGTCTTTTGTTATTTCTGCAGGCTACACCCTTAATTTGCAGAGGCCATTTTGTTGTTTGTTTGATGCTGAA GCTGTTGTTAAAATGCCCCAAACTCCAAGGCAGATTGTCTGTATAATACGCTATAGCTTTTCACCATGTGGTGTTTACCAGCTGTTACTC TGTATTTTAAAAAGCCAGAGATTTCTTCTGTCTAAACTGTTTCTATAGCATTTTCTAAACAAAAAAAATGGTTTTTTTCTTTGCCTTGTA ATAAGATTGTAAATCCATTTCCTGCTTGTGTTCTTAGTGGGCATGATTGTGAGTGTGTGTGGGGTGCTCACACGCGTGCCAGTCTTTTTG TACTGTAACTACCTCATGGTTTGAATGATGATTGTACTGCTGGTTGTGTTAACAGAGCACATTTTGTTGGGTGAGTCCTATGTGATTTTT TTCATGTTTGTTTTATCTGGGGGTTGTTCATGAAACTGACAGATGTTTTTCTAAAAAGGACTATTATCAGTTTCCAAATACAATACTTCT CTCTTCTGGTTTTTCCTGAATGAGCCTGATTTTGTTGCTGGTTTTCATCATCTATGAGGGTAAAACGAGTACCCTTAAAATCCCTGTGGC CAGTTTGAACACCCCTGTTGTATTCTTTTCTCTGTTCAGTGTGTCAGCTATTTTGTGAAGATGCTTAGATGTATAGTTTTGATAACCACA >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000370399_chr1_92200516_-_3905nt GTTCTCTGCCCCCTCCCAGCTCTGGTGTGGGCGGCCTCCGCTATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCT CCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGGCCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGA GAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGGCGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGG CTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGGGCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAG CCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCAGTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTT TCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAG TATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGAAACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGC AACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCC CAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAACTCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGA CCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGAT GTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGA GATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTG GCTAATAGATTTCATCTTCGGCTTGAAAATAATGAGGAGATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTGCTG GACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGATATT TCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTCCCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGTCTC AGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAAGAT TCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACCCTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTTTTG GAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTTCCA GCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAAGATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGAGAT GCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCCCAC GGAAACATCACCTTCAACATGGAGCTATACAACACTGACCTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGACAC GTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCTGAT AGGATGTCTCATTACACCATTATTGAGAATATTTGTCCTAAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCTATC CCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTGACG CTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCTAAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATAATC TGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGCATG AAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGTCTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATCGGA GCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCACACAGGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCCTCG GAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAGAGCACGCCTTGCTCCAGCAGCAGCACGGCCTAGCCCAACCCAGCCCAACCC GGCCCAACCCAGCCCAGCCCAGCTCAGCTCAGCTACTGCCAAGGGCAGGACCAATGGCTGAGCCTCGTGTCCAGACTCAGAGGGCTGGAT TTTGGTTCCCTTGTAAAGACAGAGTGAATTTCAGTATAAAGATCACCCGTTGTATTCACCCCACACCCAGGGCTAGTATAAACATGACCC TGGGCTTCTGTACCACACTAGAATTCATGTGAGAAAGCTAAAATGGTGGTCTTCTCCACCAGCCCCTCACAGGCTTGGGGGTTTTCAATG TGAAACACATGCCAGTTTTTAAAATGCTGCTTTGTCCAGGTGAGAACATCCATAATTTGGGGCCCTGAGTTTTACCCAGACTCAAGGAGT TGGTAAAGGGTTAATAGCCAGATAGTAGAACCAGTGAGGAGATGCGGCCAAAGATTCTTTATATCTGAACCAAGATGTAAAACAAGAAAT GCTTTGAGGCTTTCTAAGCGATCCTCCTGTCTAATTTGCACCTTTGTCTGGATGCACACTTCTGACCTTGCTGCCACAACCTGTGGGGTC TGATGTGTCCCTTGATGGGTGCTGCCCTCAGGGACTGCACCCTGACAAGTGTTAAGGCAACATTCCTTTCTTGTGCCCTGGGCCAAAACC AATGCTGATGACCTTATCAGCTTCCTGTTTCTTCCCATACTTGCATACACCACTGCAAAATGTCTTAATGCAAATTTTGTATTTCTTACA GGCCTACAGAAATTGAAAATGACCAAAATCAGGAACCACAGATTTGTGCCCATTCCTAATATTTTGTTCTGCAAATTAATGTATAATTTG AGGTGAAATTCAGTTATAAAGTCAAGGACGAATTTGCACAGTGATATATTTCTATGTGTATGCAAGTACAAGTATATAATATGTCACCTG GCACATTCATTTTCTCAGTTGAAGAAGAGAAAATTTGAAAATGTCCTTATGCTTTTAGAGTTGCAACTTAAGTATATTTGGTAGGGTGAG TGTTTCCACTCAAAATATGTCAACTTAAAAAAAAATAGGCCCTTTCATAAAAACCAAACTGTAGCAAGATGCAAATGCATGGCAAATCCT GTCGGTCTCCAGTTGGTTATCTGAATAGTGTCACCAATTCCACCAAGACAGTGCTGAGATTGGAAAAGGGCACTCATTTGGATTGCCTTA CTTCTCTTGCCTTAAATATATCCCATATATTTAATATGTCAAAAAGGGCTTGAGGTGAATTTCATTAAATGGAATAATATGATGCCACTT >In-frame_MICU3_ENST00000318063_chr8_16885169_+_TGFBR3_ENST00000525962_chr1_92200516_-_3904nt GTTCTCTGCCCCCTCCCAGCTCTGGTGTGGGCGGCCTCCGCTATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCT CCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGGCCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGA GAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGGCGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGG CTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGGGCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAG CCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCAGTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTT TCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAG TATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGAAACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGC AACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCC CAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAACTCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGA CCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGAT GTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGA GATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTG GCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAGGAGATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTG CTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGAT ATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTCCCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGT CTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAA GATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACCCTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTT TTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTT CCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAAGATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGA GATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCC CACGGAAACATCACCTTCAACATGGAGCTATACAACACTGACCTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGA CACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCT GATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCTAAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCT ATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTG ACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCTAAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATA ATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGC ATGAAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGTCTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATC GGAGCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCACACAGGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCC TCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAGAGCACGCCTTGCTCCAGCAGCAGCACGGCCTAGCCCAACCCAGCCCAA CCCGGCCCAACCCAGCCCAGCCCAGCTCAGCTCAGCTACTGCCAAGGGCAGGACCAATGGCTGAGCCTCGTGTCCAGACTCAGAGGGCTG GATTTTGGTTCCCTTGTAAAGACAGAGTGAATTTCAGTATAAAGATCACCCGTTGTATTCACCCCACACCCAGGGCTAGTATAAACATGA CCCTGGGCTTCTGTACCACACTAGAATTCATGTGAGAAAGCTAAAATGGTGGTCTTCTCCACCAGCCCCTCACAGGCTTGGGGGTTTTCA ATGTGAAACACATGCCAGTTTTTAAAATGCTGCTTTGTCCAGGTGAGAACATCCATAATTTGGGGCCCTGAGTTTTACCCAGACTCAAGG AGTTGGTAAAGGGTTAATAGCCAGATAGTAGAACCAGTGAGGAGATGCGGCCAAAGATTCTTTATATCTGAACCAAGATGTAAAACAAGA AATGCTTTGAGGCTTTCTAAGCGATCCTCCTGTCTAATTTGCACCTTTGTCTGGATGCACACTTCTGACCTTGCTGCCACAACCTGTGGG GTCTGATGTGTCCCTTGATGGGTGCTGCCCTCAGGGACTGCACCCTGACAAGTGTTAAGGCAACATTCCTTTCTTGTGCCCTGGGCCAAA ACCAATGCTGATGACCTTATCAGCTTCCTGTTTCTTCCCATACTTGCATACACCACTGCAAAATGTCTTAATGCAAATTTTGTATTTCTT ACAGGCCTACAGAAATTGAAAATGACCAAAATCAGGAACCACAGATTTGTGCCCATTCCTAATATTTTGTTCTGCAAATTAATGTATAAT TTGAGGTGAAATTCAGTTATAAAGTCAAGGACGAATTTGCACAGTGATATATTTCTATGTGTATGCAAGTACAAGTATATAATATGTCAC CTGGCACATTCATTTTCTCAGTTGAAGAAGAGAAAATTTGAAAATGTCCTTATGCTTTTAGAGTTGCAACTTAAGTATATTTGGTAGGGT GAGTGTTTCCACTCAAAATATGTCAACTTAAAAAAAAATAGGCCCTTTCATAAAAACCAAACTGTAGCAAGATGCAAATGCATGGCAAAT CCTGTCGGTCTCCAGTTGGTTATCTGAATAGTGTCACCAATTCCACCAAGACAGTGCTGAGATTGGAAAAGGGCACTCATTTGGATTGCC TTACTTCTCTTGCCTTAAATATATCCCATATATTTAATATGTCAAAAAGGGCTTGAGGTGAATTTCATTAAATGGAATAATATGATGCCA |
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FusionGenePPI for MICU3_TGFBR3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MICU3 | CLK1, THUMPD3, MICU1, CYLD | TGFBR3 | TGFBR2, TGFB1, ELAVL1, NRP1, KLK11, ITM2B, ATP1B3, FGF1, GPR183, ATP1B4, PTCH1, SIAE, PIP5K1A, CAMKV, DEFA5, ST8SIA4, FAM19A4, DKKL1, CANT1, DEFA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | - | 3 | 17 | 737_751 | 128 | 852 | TGF-beta ligand |
| Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | - | 4 | 18 | 737_751 | 128 | 851 | TGF-beta ligand |
| Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | - | 2 | 16 | 737_751 | 128 | 852 | TGF-beta ligand |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MICU3_TGFBR3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MICU3_TGFBR3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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