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Fusion gene ID: 21922 |
FusionGeneSummary for MICU2_ATP8A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MICU2_ATP8A2 | Fusion gene ID: 21922 | Hgene | Tgene | Gene symbol | MICU2 | ATP8A2 | Gene ID | 221154 | 51761 |
| Gene name | mitochondrial calcium uptake 2 | ATPase phospholipid transporting 8A2 | |
| Synonyms | 1110008L20Rik|EFHA1 | ATP|ATPIB|CAMRQ4|IB|ML-1 | |
| Cytomap | 13q12.11 | 13q12.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium uptake protein 2, mitochondrialEF hand domain family A1EF hand domain family, member A1EF-hand domain-containing family member A1Smhs2 homolog | phospholipid-transporting ATPase IBATPase, aminophospholipid transporter, class I, type 8A, member 2ATPase, aminophospholipid transporter-like, class I, type 8A, member 2P4-ATPase flippase complex alpha subunit ATP8A2probable phospholipid-transporting | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IYU8 | Q9NTI2 | |
| Ensembl transtripts involved in fusion gene | ENST00000382374, ENST00000479790, | ENST00000381655, ENST00000255283, ENST00000491840, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 4 X 5=120 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MICU2 [Title/Abstract] AND ATP8A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MICU2 | GO:0006851 | mitochondrial calcium ion transmembrane transport | 24560927 |
| Hgene | MICU2 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration | 24560927 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A22D-01A | MICU2 | chr13 | 22178078 | - | ATP8A2 | chr13 | 26402256 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000382374 | ENST00000381655 | MICU2 | chr13 | 22178078 | - | ATP8A2 | chr13 | 26402256 | + |
| 5CDS-intron | ENST00000382374 | ENST00000255283 | MICU2 | chr13 | 22178078 | - | ATP8A2 | chr13 | 26402256 | + |
| 5CDS-3UTR | ENST00000382374 | ENST00000491840 | MICU2 | chr13 | 22178078 | - | ATP8A2 | chr13 | 26402256 | + |
| intron-3CDS | ENST00000479790 | ENST00000381655 | MICU2 | chr13 | 22178078 | - | ATP8A2 | chr13 | 26402256 | + |
| intron-intron | ENST00000479790 | ENST00000255283 | MICU2 | chr13 | 22178078 | - | ATP8A2 | chr13 | 26402256 | + |
| intron-3UTR | ENST00000479790 | ENST00000491840 | MICU2 | chr13 | 22178078 | - | ATP8A2 | chr13 | 26402256 | + |
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FusionProtFeatures for MICU2_ATP8A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MICU2 | ATP8A2 |
| Key regulator of mitochondrial calcium uniporter (MCU)required to limit calcium uptake by MCU when cytoplasmic calciumis low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1and MICU2 form a disulfide-linked heterodimer that stimulate andinhibit MCU activity, depending on the concentration of calcium(PubMed:24560927). MICU2 acts as a gatekeeper of MCU that sensescalcium level via its EF-hand domains: prevents channel opening atresting calcium, avoiding energy dissipation and cell-deathtriggering (PubMed:24560927). {ECO:0000269|PubMed:24503055,ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26387864,ECO:0000269|PubMed:26903221}. | Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippasecomplex predomiminantly transports phosphatidylserine (PS) and toa lesser extent phosphatidylethanolamine (PE). Proposed tofunction in the generation and maintenance of phospholipidasymmetry in photoreceptor disk membranes and neuronal axonmembranes. May be involved in vesicle trafficking in neuronalcells. Involved in regulation of neurite outgrowth; acting insynergy with TMEM30A. Required for normal visual and auditoryfunction; involved in photoreceptor and inner ear spiral ganglioncell survival. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MICU2 | chr13:22178078 | chr13:26402256 | ENST00000382374 | - | 1 | 12 | 2_50 | 70 | 435 | Compositional bias | Note=Ala-rich |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 1007_1024 | 893 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 1050_1148 | 893 | 1189 | Topological domain | Cytoplasmic |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 891_920 | 893 | 1189 | Topological domain | Cytoplasmic |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 943_956 | 893 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 980_985 | 893 | 1189 | Topological domain | Cytoplasmic |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 1025_1049 | 893 | 1189 | Transmembrane | Helical |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 921_942 | 893 | 1189 | Transmembrane | Helical |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 957_979 | 893 | 1189 | Transmembrane | Helical |
| Tgene | >ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 986_1006 | 893 | 1189 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MICU2 | chr13:22178078 | chr13:26402256 | ENST00000382374 | - | 1 | 12 | 172_207 | 70 | 435 | Domain | EF-hand 1 |
| Hgene | >MICU2 | chr13:22178078 | chr13:26402256 | ENST00000382374 | - | 1 | 12 | 227_262 | 70 | 435 | Domain | EF-hand 2 |
| Hgene | >MICU2 | chr13:22178078 | chr13:26402256 | ENST00000382374 | - | 1 | 12 | 293_328 | 70 | 435 | Domain | EF-hand 3 |
| Hgene | >MICU2 | chr13:22178078 | chr13:26402256 | ENST00000382374 | - | 1 | 12 | 362_397 | 70 | 435 | Domain | EF-hand 4 |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 1_44 | 893 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 299_323 | 893 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 346_837 | 893 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 67_71 | 893 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 859_870 | 893 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 95_276 | 893 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 277_298 | 893 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 324_345 | 893 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 45_66 | 893 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 72_94 | 893 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 838_858 | 893 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:22178078 | chr13:26402256 | ENST00000381655 | + | 26 | 37 | 871_890 | 893 | 1189 | Transmembrane | Helical |
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FusionGeneSequence for MICU2_ATP8A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MICU2_ENST00000382374_chr13_22178078_-_ATP8A2_ENST00000381655_chr13_26402256_+_366aa MAAAAGSCARVAAWGGKLRRGLAVSRQAVRSPGPLAAAVAGAALAGAGAAWHHSRVSVAARDGSFTVSAQLWFAFVNGFSGQILFERWCI GLYNVIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNI VYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAK HTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVSQEEVIRAYDTTKK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MICU2_ENST00000382374_chr13_22178078_-_ATP8A2_ENST00000381655_chr13_26402256_+_1098nt ATGGCGGCGGCTGCGGGTAGCTGCGCGCGGGTGGCGGCCTGGGGCGGAAAACTGCGACGGGGGCTCGCTGTCAGCCGACAGGCTGTGCGG AGTCCCGGCCCCTTGGCAGCGGCAGTGGCCGGCGCGGCCCTGGCAGGAGCAGGAGCGGCCTGGCACCACAGCCGCGTCAGTGTTGCGGCG CGGGATGGCAGTTTTACAGTCTCCGCACAGCTTTGGTTCGCCTTTGTTAATGGATTTTCTGGGCAGATTTTATTTGAACGTTGGTGCATC GGCCTGTACAATGTGATTTTCACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTT CCCCAGCTCTACAAAATCACCCAGAATGGCGAAGGCTTCAACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTC ATCCTCTTCTGGTTTCCCATGAAAGCTCTGGAGCATGATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATT GTTTACACATATGTTGTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGA AGCATGCTGACCTGGCTGGTGTTTTTTGGCATCTACTCGACCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACT ATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAG CACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAAT GGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAG GGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MICU2_ENST00000382374_chr13_22178078_-_ATP8A2_ENST00000381655_chr13_26402256_+_7030nt GAGAGTTCCCAAGCGGTAGGCGGCGGCGCCGGGAGAGAAGCGCCGCCTAGCTGCGCTTCCGCAAAGATGGCGGCGGCTGCGGGTAGCTGC GCGCGGGTGGCGGCCTGGGGCGGAAAACTGCGACGGGGGCTCGCTGTCAGCCGACAGGCTGTGCGGAGTCCCGGCCCCTTGGCAGCGGCA GTGGCCGGCGCGGCCCTGGCAGGAGCAGGAGCGGCCTGGCACCACAGCCGCGTCAGTGTTGCGGCGCGGGATGGCAGTTTTACAGTCTCC GCACAGCTTTGGTTCGCCTTTGTTAATGGATTTTCTGGGCAGATTTTATTTGAACGTTGGTGCATCGGCCTGTACAATGTGATTTTCACC GCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAAATCACCCAG AATGGCGAAGGCTTCAACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTTCCCATGAAA GCTCTGGAGCATGATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATTGTTTACACATATGTTGTTGTTACT GTTTGTCTGAAAGCTGGTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGGCTGGTGTTT TTTGGCATCTACTCGACCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCCGCACACTTC TGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTG GAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGAC CGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTT TCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATG AATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCA AAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGA AGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTG TGAAATTAAAAACATTATGTTTCACCAATATTTAAACATCAGTACTAGTTGTCCTGGGAGAAAGGGAAAGGAGTTTTATGTTGCGTGAGA GGCCCATCCTGTGTAATTGGAGCAGGGCACACTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCAC TGTAGGCAGGTTGCTCTCCTGCTTTGATTCCTGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCT ATCGGGGTGGTCAACCTGAGAACATTTATTTGAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCC GCACCCTCTCCAGGTGCACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACT CAGTGCATGGCGGCCGATGGGCAGCCAACCCAAACCCGCGCCTTTCCTTGTTCCACTGCAGACTCAGATACAGATGCGAAAAATTCCTTC TTCCACCGCCCTTCTCGTTCTGTAAAGAAAGAAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATG GGGCCACCCCACAGGTCAGAGTGGTGGTAGAACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGA CTGCTGGGCCTTTGGCATCCACTTACATTAGAACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTT ATAACATGCCTGCACAGCGAAGGAACACACCTGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACA TTGAGTGGGGAGAACAAGACGACCACAGAAGTCCTCAGAAGGAGAAGGAAGGACACGGAGACACTGAGAGGAGGACACAGAGGAATCGCC ACCAGATCTTTGCAGTAGAAACTCTGAAATAGGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAG ACCTTCACACACAGTTCTAATTGAAAAGAATTCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGT ATCCCATCAGTGTTAGACACAGGTACCTATCAGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACT TTCCCAACTGCAGAGTCCCACACTTAAATCTCAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAA CCTGCCTGGAGCCCTGTTCTCTGCTCTGGTTGCCAAACCAGATTTTTGGATGGCCTAAATACTTGTGGGCAACTGTTACTGGTGAAAAAT GGGAGTGGAGAGCATGTTTTGGATTTTCACTGTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTC TTAGCTCTAGAGTCGGAGGATGAGTCAACCCTGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACC CTTTTTTGTCAGAAATCTACAACCTACTGGGCATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGA GGTGACCAGGATGCAGAGAGGGCCTGAGGGGCAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAA GGTGCATAGAACATTTTTAAATATCAGAGTACCCAGCAAGACGGAAGGACTGTCATGCAGGAACTCTAACACAAAATGTGCCTATGACTA ACACGACAAACCAAGGTGTATGGTTTCTTTGCACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGT GCATTAGGCATCTTAACTATTCATATTTTGTCTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAA ACAGTTAGCTCTGTCTTGAACTTGAAGCCTTCCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTT ACATTAGAGTTCATATTTTCTGGGATTTAAGGATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATG ACAGACGCACACAGAAGAAAACATTAGAAGAGATGCCTTTCTATCCTCTCATGTGGTTGAGCATTCTTACAGCCAAATGACTAAATTGGC TGTAAATTGGTTTCTAGGAGGAGCAGCTGTCACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCT ATCTTTAAATTGAGGTCAGAGTGTCACACACAACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCA GCAAAAATGCCACATGGGGCTTGTCACTCCGCCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTG ACTCTGGATTGAGCTAAACTGGCAGAATCCACTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTC TCTTCTCCTGGATGACCCTGCAAAAGGAAGAGACCAGTTGTACTGTGGGCTTAGTTCTGGGTTTCCACTGCACACTGACACGTGCCAGCA AGGGTAGCTGTGGAAAACACGTATCAGGAGAGCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGG AGTGGAGCTGATGTGTCTGTCCTGCCTCAGTGCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACAT GCACACATGAAAACAAAAACATGGTAACTCTTTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAAC ACTTGTAGAGGAATATCCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGC TTCAGGTTCGTCTCACTATAGGGAGCTGGCTGTGAAAATCAGTAATAACTTGTCAAGAAGCAGTGAAAAATGCGGGGGGGTGGAAAGAGC CTAGGTAACTAATGTCTTATAATGCATATGTATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAAT TTCCATTTGTTATAATAATGACCTTTAATCTTGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTC TTAGACCATAGCTGAATTGAATGTTTGCAAAACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTT TCAGCCAGGGTTTGAGTTACTGCCCAGGGTCATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCAT CTCCTGGGATCCATAAAAAAATGTGAACAGGGAAATGGTGGCTAAGCAGAGCCTGAAATAATAACTTGGCAAAGAAATGAGTTTATCAGG TCGAGTCAAAACATGGCATCCCCTGTTACACTCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCACAATGGGAAC AGTTAAAACCCCCTCCCTTCAAAAAAAGAAAATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTC AGTATAGCCTTCGGGGAGATTTAACCTCATTCTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTT TCGGAGGTGAGGGCCCAAGACCCCCATAATGACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCC TTCATTTATTTTTTTTTCTCAGCATCCCAAGTTGTCCATCAGTACATTCCCCTTCACCTTACCTGATCTTCATTTAATGCCCAGTCTGTA ACTAATGTTCTGTTTAAAGCTCTCTTAATTTGTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCAT TGAGCCAGCATAAATCTGAATGGGCAGAAGCCACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATA ATCCAGTGTTAACCTCTGAGGAACACCTCGGCTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTT TCAAGTGACAATCTCGGGCTCTAGTTGCCTTTGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAG ATTAGCCCATAGGCAGTTCTTGTGACCTGGCTGAAGAAAGAAAGGAGACCTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTCAGGTGGCTT TGATTTATGACAGAAAGAGGAAGAAGAAAGTTGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTT ATCAAGAGCCTTTTATAGGTAAGCTCTTCCGTGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCAC TTCCAATGGGATTGGAGTCTGTTGTATTCTTAAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAA AAAAAAAAAAAAAAAAGGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGG TTTTCATGGATAAAATCAATGTCAGTACTGAAACTCCTACTCTCCCCTCCCGCCCCACTCTCCCCCGTTGCCCGAGATGGCCAAGTTCAG GCCTGTGCAATGCCGCTTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGT CACTGAATTGTCGTTCAAATGCATCATCTTTGTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTG CCTGGATTGCTTAAATATTGTTTGTGATGGGGAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCT CCCAGCAGCGTGGGGGGTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTC CTCTGGTTGTTAAATTACAGCAGCACATTACAGTGCACTGGGTTCCCTCCTGGAGTGAATACAAACGGAGGGCATCTACTTGTATTTTTA GAAGTTTTGGGAGAATTTAGTGATTTGTGGCTTTGATCAATCCTGTTGACTGGTGTATGTCTGCGCAAACCTGTTTCAAATAAATCTTTT |
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FusionGenePPI for MICU2_ATP8A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MICU2 | COPS5, SPACA1, ASH2L, MICU1, ACOX3, CSNK1E, CSNK1D, GAPVD1, SMAP1, KIAA1217, TBC1D22A, KLHL22, CPLX4, CDH5, TRIM44, PON1, RANBP6, DCAF11, ARMC6, ATG7, BPNT1, SLC1A1, SLC39A12, TUBB | ATP8A2 | UIMC1, ZBTB8OS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MICU2_ATP8A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MICU2_ATP8A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ATP8A2 | C3808977 | CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME 4 | 1 | UNIPROT |
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