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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21895

FusionGeneSummary for MICALL1_PRLR

check button Fusion gene summary
Fusion gene informationFusion gene name: MICALL1_PRLR
Fusion gene ID: 21895
HgeneTgene
Gene symbol

MICALL1

PRLR

Gene ID

85377

5618

Gene nameMICAL like 1prolactin receptor
SynonymsMICAL-L1|MIRAB13HPRL|MFAB|RI-PRLR|hPRLrI
Cytomap

22q13.1

5p13.2

Type of geneprotein-codingprotein-coding
DescriptionMICAL-like protein 1molecule interacting with Rab13prolactin receptorhPRL receptorsecreted prolactin binding protein
Modification date2018052220180523
UniProtAcc

Q8N3F8

P16471

Ensembl transtripts involved in fusion geneENST00000215957, ENST00000402631, 
ENST00000342362, ENST00000382002, 
ENST00000231423, ENST00000513753, 
ENST00000397391, ENST00000348262, 
ENST00000542609, ENST00000310101, 
ENST00000511486, ENST00000509934, 
Fusion gene scores* DoF score5 X 6 X 6=1806 X 5 X 4=120
# samples 76
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MICALL1 [Title/Abstract] AND PRLR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICALL1

GO:0097320

plasma membrane tubulation

23596323

TgenePRLR

GO:0007171

activation of transmembrane receptor protein tyrosine kinase activity

10585417


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-FS-A4F4-06AMICALL1chr22

38329119

+PRLRchr5

35153075

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000215957ENST00000342362MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000382002MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000231423MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000513753MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000397391MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000348262MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000542609MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000310101MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000511486MICALL1chr22

38329119

+PRLRchr5

35153075

-
5CDS-intronENST00000215957ENST00000509934MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000342362MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000382002MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000231423MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000513753MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000397391MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000348262MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000542609MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000310101MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000511486MICALL1chr22

38329119

+PRLRchr5

35153075

-
3UTR-intronENST00000402631ENST00000509934MICALL1chr22

38329119

+PRLRchr5

35153075

-

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FusionProtFeatures for MICALL1_PRLR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICALL1

Q8N3F8

PRLR

P16471


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MICALL1_PRLR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MICALL1_PRLR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MICALL1PACSIN1, PACSIN2, PACSIN3, YWHAB, YWHAG, SH3KBP1, ZP3, ANKFY1, HECW2, EHD1, KLF8, EPHA2, RBM4, YEATS4, MRPL50, MRPL9, ACTR5, CDH1, RAB8B, ZNF785, KCTD3, KIF13B, CGN, ZBTB21, KSR1, CBY1, TRIM25PRLRPPIA, SOCS3, TEC, VAV1, SOCS2, JAK2, PTPN11, GTF3A, FBXW11, CREBBP, PRLR, STAT5B, BTRC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MICALL1_PRLR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePRLRP16471DB01185FluoxymesteroneProlactin receptorsmall moleculeapproved|illicit
TgenePRLRP16471DB00052SomatotropinProlactin receptorbiotechapproved|investigational

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RelatedDiseases for MICALL1_PRLR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRLRC0024667Animal Mammary Neoplasms2CTD_human
TgenePRLRC0000786Spontaneous abortion1CTD_human
TgenePRLRC0004352Autistic Disorder1CTD_human
TgenePRLRC0014175Endometriosis1CTD_human
TgenePRLRC0020514Hyperprolactinemia1HPO;ORPHANET;UNIPROT
TgenePRLRC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePRLRC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePRLRC3809918MULTIPLE FIBROADENOMAS OF THE BREAST1ORPHANET;UNIPROT