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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21865

FusionGeneSummary for MIB1_GREB1L

check button Fusion gene summary
Fusion gene informationFusion gene name: MIB1_GREB1L
Fusion gene ID: 21865
HgeneTgene
Gene symbol

MIB1

GREB1L

Gene ID

57534

80000

Gene namemindbomb E3 ubiquitin protein ligase 1GREB1 like retinoic acid receptor coactivator
SynonymsDIP-1|DIP1|LVNC7|MIB|ZZANK2|ZZZ6C18orf6|KIAA1772|RHDA3
Cytomap

18q11.2

18q11.1-q11.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MIB1DAPK-interacting protein 1RING-type E3 ubiquitin transferase MIB1ubiquitin ligase mind bombzinc finger ZZ type with ankyrin repeat domain protein 2GREB1-like proteingrowth regulation by estrogen in breast cancer 1 likegrowth regulation by estrogen in breast cancer 1-like proteingrowth regulation by estrogen in breast cancer-like
Modification date2018052320180519
UniProtAcc

Q86YT6

Q9C091

Ensembl transtripts involved in fusion geneENST00000578646, ENST00000261537, 
ENST00000431264, ENST00000424526, 
ENST00000400483, ENST00000269218, 
ENST00000580732, ENST00000578368, 
Fusion gene scores* DoF score8 X 8 X 7=4483 X 4 X 4=48
# samples 104
** MAII scorelog2(10/448*10)=-2.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIB1 [Title/Abstract] AND GREB1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGREB1L

GO:0001822

kidney development

29100091


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-IB-A5SQ-01AMIB1chr18

19321773

+GREB1Lchr18

19085373

+
TCGARVSTADTCGA-BR-8373-01AMIB1chr18

19359646

+GREB1Lchr18

19088079

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000578646ENST00000431264MIB1chr18

19321773

+GREB1Lchr18

19085373

+
intron-intronENST00000578646ENST00000424526MIB1chr18

19321773

+GREB1Lchr18

19085373

+
intron-3UTRENST00000578646ENST00000400483MIB1chr18

19321773

+GREB1Lchr18

19085373

+
intron-3UTRENST00000578646ENST00000269218MIB1chr18

19321773

+GREB1Lchr18

19085373

+
intron-3UTRENST00000578646ENST00000580732MIB1chr18

19321773

+GREB1Lchr18

19085373

+
intron-intronENST00000578646ENST00000578368MIB1chr18

19321773

+GREB1Lchr18

19085373

+
5CDS-intronENST00000261537ENST00000431264MIB1chr18

19321773

+GREB1Lchr18

19085373

+
5CDS-intronENST00000261537ENST00000424526MIB1chr18

19321773

+GREB1Lchr18

19085373

+
5CDS-3UTRENST00000261537ENST00000400483MIB1chr18

19321773

+GREB1Lchr18

19085373

+
5CDS-3UTRENST00000261537ENST00000269218MIB1chr18

19321773

+GREB1Lchr18

19085373

+
5CDS-3UTRENST00000261537ENST00000580732MIB1chr18

19321773

+GREB1Lchr18

19085373

+
5CDS-intronENST00000261537ENST00000578368MIB1chr18

19321773

+GREB1Lchr18

19085373

+
3UTR-intronENST00000578646ENST00000431264MIB1chr18

19359646

+GREB1Lchr18

19088079

+
3UTR-intronENST00000578646ENST00000424526MIB1chr18

19359646

+GREB1Lchr18

19088079

+
3UTR-3UTRENST00000578646ENST00000400483MIB1chr18

19359646

+GREB1Lchr18

19088079

+
3UTR-3UTRENST00000578646ENST00000269218MIB1chr18

19359646

+GREB1Lchr18

19088079

+
3UTR-3UTRENST00000578646ENST00000580732MIB1chr18

19359646

+GREB1Lchr18

19088079

+
3UTR-intronENST00000578646ENST00000578368MIB1chr18

19359646

+GREB1Lchr18

19088079

+
5CDS-intronENST00000261537ENST00000431264MIB1chr18

19359646

+GREB1Lchr18

19088079

+
5CDS-intronENST00000261537ENST00000424526MIB1chr18

19359646

+GREB1Lchr18

19088079

+
5CDS-3UTRENST00000261537ENST00000400483MIB1chr18

19359646

+GREB1Lchr18

19088079

+
5CDS-3UTRENST00000261537ENST00000269218MIB1chr18

19359646

+GREB1Lchr18

19088079

+
5CDS-3UTRENST00000261537ENST00000580732MIB1chr18

19359646

+GREB1Lchr18

19088079

+
5CDS-intronENST00000261537ENST00000578368MIB1chr18

19359646

+GREB1Lchr18

19088079

+

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FusionProtFeatures for MIB1_GREB1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIB1

Q86YT6

GREB1L

Q9C091

Plays a major role in early metanephros and genitaldevelopment. {ECO:0000269|PubMed:29100091}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIB1_GREB1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIB1_GREB1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MIB1UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2N, UBE2U, UBE2W, UBC, JAG1, RYK, DLL1, AZI2, TBK1, PCM1, SNX5, DAPK1, CMIP, SMN1, CEP131, BLM, MIB1, USP9X, ZFC3H1, RANGAP1, ZBTB10, GEMIN4, MCM3, TOP3A, DDB1, TOP3B, RBBP4, MCM7, CDC27, CEP250, FSD1, PLK4, NTRK1, CENPJ, MED4, CEP290, CEP162, SSX2IP, CEP128, CNTRL, POC5, PCNT, PRKAR2B, OFD1, DYNLL1, PER3, CEP135, FGFR1OP, MAPRE1, CCDC14, PTPN22, TPTE2, LRRCC1, CHRNA3, FAM171B, ANKRD55, LPXN, EPN3, EPB41L4A, EPB41L5GREB1LMOV10, NXF1, TSEN2, LYPD4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIB1_GREB1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIB1_GREB1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIB1C0036572Seizures1CTD_human
HgeneMIB1C3554496LEFT VENTRICULAR NONCOMPACTION 71UNIPROT