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Fusion gene ID: 21864 |
FusionGeneSummary for MIB1_CABYR |
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Fusion gene information | Fusion gene name: MIB1_CABYR | Fusion gene ID: 21864 | Hgene | Tgene | Gene symbol | MIB1 | CABYR | Gene ID | 57534 | 26256 |
Gene name | mindbomb E3 ubiquitin protein ligase 1 | calcium binding tyrosine phosphorylation regulated | |
Synonyms | DIP-1|DIP1|LVNC7|MIB|ZZANK2|ZZZ6 | CABYRa|CABYRc|CABYRc/d|CABYRe|CBP86|CT88|FSP-2|FSP2 | |
Cytomap | 18q11.2 | 18q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase MIB1DAPK-interacting protein 1RING-type E3 ubiquitin transferase MIB1ubiquitin ligase mind bombzinc finger ZZ type with ankyrin repeat domain protein 2 | calcium-binding tyrosine phosphorylation-regulated proteincalcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)calcium-binding protein 86cancer/testis antigen 88fibrousheathin IIfibrousheathin-2testis tissue sperm-binding protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q86YT6 | O75952 | |
Ensembl transtripts involved in fusion gene | ENST00000578646, ENST00000261537, | ENST00000399496, ENST00000399481, ENST00000415309, ENST00000327201, ENST00000581397, ENST00000399499, | |
Fusion gene scores | * DoF score | 8 X 8 X 7=448 | 3 X 2 X 3=18 |
# samples | 10 | 3 | |
** MAII score | log2(10/448*10)=-2.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MIB1 [Title/Abstract] AND CABYR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-FJ-A3ZE-01A | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000578646 | ENST00000399496 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
3UTR-5UTR | ENST00000578646 | ENST00000399481 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
3UTR-5UTR | ENST00000578646 | ENST00000415309 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
3UTR-5UTR | ENST00000578646 | ENST00000327201 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
3UTR-5UTR | ENST00000578646 | ENST00000581397 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
3UTR-5UTR | ENST00000578646 | ENST00000399499 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
Frame-shift | ENST00000261537 | ENST00000399496 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
5CDS-5UTR | ENST00000261537 | ENST00000399481 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
5CDS-5UTR | ENST00000261537 | ENST00000415309 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
5CDS-5UTR | ENST00000261537 | ENST00000327201 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
5CDS-5UTR | ENST00000261537 | ENST00000581397 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
5CDS-5UTR | ENST00000261537 | ENST00000399499 | MIB1 | chr18 | 19383975 | + | CABYR | chr18 | 21735665 | + |
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FusionProtFeatures for MIB1_CABYR |
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Hgene | Tgene |
MIB1 | CABYR |
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosomereaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform6 probably bind calcium. Isoform 3 and isoform 5 do not bindcalcium in vitro. Isoform 4 probably does not bind calcium. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MIB1_CABYR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MIB1_CABYR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MIB1 | UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2N, UBE2U, UBE2W, UBC, JAG1, RYK, DLL1, AZI2, TBK1, PCM1, SNX5, DAPK1, CMIP, SMN1, CEP131, BLM, MIB1, USP9X, ZFC3H1, RANGAP1, ZBTB10, GEMIN4, MCM3, TOP3A, DDB1, TOP3B, RBBP4, MCM7, CDC27, CEP250, FSD1, PLK4, NTRK1, CENPJ, MED4, CEP290, CEP162, SSX2IP, CEP128, CNTRL, POC5, PCNT, PRKAR2B, OFD1, DYNLL1, PER3, CEP135, FGFR1OP, MAPRE1, CCDC14, PTPN22, TPTE2, LRRCC1, CHRNA3, FAM171B, ANKRD55, LPXN, EPN3, EPB41L4A, EPB41L5 | CABYR | BRCA1, PAXIP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MIB1_CABYR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MIB1_CABYR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MIB1 | C0036572 | Seizures | 1 | CTD_human |
Hgene | MIB1 | C3554496 | LEFT VENTRICULAR NONCOMPACTION 7 | 1 | UNIPROT |
Tgene | CABYR | C0009404 | Colorectal Neoplasms | 1 | CTD_human |