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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21863

FusionGeneSummary for MIB1_ANKRD29

check button Fusion gene summary
Fusion gene informationFusion gene name: MIB1_ANKRD29
Fusion gene ID: 21863
HgeneTgene
Gene symbol

MIB1

ANKRD29

Gene ID

57534

147463

Gene namemindbomb E3 ubiquitin protein ligase 1ankyrin repeat domain 29
SynonymsDIP-1|DIP1|LVNC7|MIB|ZZANK2|ZZZ6-
Cytomap

18q11.2

18q11.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MIB1DAPK-interacting protein 1RING-type E3 ubiquitin transferase MIB1ubiquitin ligase mind bombzinc finger ZZ type with ankyrin repeat domain protein 2ankyrin repeat domain-containing protein 29
Modification date2018052320180519
UniProtAcc

Q86YT6

Q8N6D5

Ensembl transtripts involved in fusion geneENST00000578646, ENST00000261537, 
ENST00000592179, ENST00000322980, 
ENST00000585908, ENST00000284207, 
ENST00000586511, 
Fusion gene scores* DoF score8 X 8 X 7=4486 X 4 X 6=144
# samples 108
** MAII scorelog2(10/448*10)=-2.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIB1 [Title/Abstract] AND ANKRD29 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-CD-8526-01AMIB1chr18

19285084

+ANKRD29chr18

21181273

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578646ENST00000592179MIB1chr18

19285084

+ANKRD29chr18

21181273

-
3UTR-3CDSENST00000578646ENST00000322980MIB1chr18

19285084

+ANKRD29chr18

21181273

-
3UTR-intronENST00000578646ENST00000585908MIB1chr18

19285084

+ANKRD29chr18

21181273

-
3UTR-intronENST00000578646ENST00000284207MIB1chr18

19285084

+ANKRD29chr18

21181273

-
3UTR-intronENST00000578646ENST00000586511MIB1chr18

19285084

+ANKRD29chr18

21181273

-
intron-3CDSENST00000261537ENST00000592179MIB1chr18

19285084

+ANKRD29chr18

21181273

-
intron-3CDSENST00000261537ENST00000322980MIB1chr18

19285084

+ANKRD29chr18

21181273

-
intron-intronENST00000261537ENST00000585908MIB1chr18

19285084

+ANKRD29chr18

21181273

-
intron-intronENST00000261537ENST00000284207MIB1chr18

19285084

+ANKRD29chr18

21181273

-
intron-intronENST00000261537ENST00000586511MIB1chr18

19285084

+ANKRD29chr18

21181273

-

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FusionProtFeatures for MIB1_ANKRD29


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIB1

Q86YT6

ANKRD29

Q8N6D5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIB1_ANKRD29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIB1_ANKRD29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MIB1UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2N, UBE2U, UBE2W, UBC, JAG1, RYK, DLL1, AZI2, TBK1, PCM1, SNX5, DAPK1, CMIP, SMN1, CEP131, BLM, MIB1, USP9X, ZFC3H1, RANGAP1, ZBTB10, GEMIN4, MCM3, TOP3A, DDB1, TOP3B, RBBP4, MCM7, CDC27, CEP250, FSD1, PLK4, NTRK1, CENPJ, MED4, CEP290, CEP162, SSX2IP, CEP128, CNTRL, POC5, PCNT, PRKAR2B, OFD1, DYNLL1, PER3, CEP135, FGFR1OP, MAPRE1, CCDC14, PTPN22, TPTE2, LRRCC1, CHRNA3, FAM171B, ANKRD55, LPXN, EPN3, EPB41L4A, EPB41L5ANKRD29YTHDF1, ADD2, ADD1, FAM122B, UBP1, TFCP2, ADD3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIB1_ANKRD29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIB1_ANKRD29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIB1C0036572Seizures1CTD_human
HgeneMIB1C3554496LEFT VENTRICULAR NONCOMPACTION 71UNIPROT