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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21854

FusionGeneSummary for MGST3_UCK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MGST3_UCK2
Fusion gene ID: 21854
HgeneTgene
Gene symbol

MGST3

UCK2

Gene ID

4259

7371

Gene namemicrosomal glutathione S-transferase 3uridine-cytidine kinase 2
SynonymsGST-IIITSA903|UK|UMPK
Cytomap

1q24.1

1q24.1

Type of geneprotein-codingprotein-coding
Descriptionmicrosomal glutathione S-transferase 3microsomal GST-3microsomal GST-IIImicrosomal glutathione S-transferase IIIuridine-cytidine kinase 2cytidine monophosphokinase 2testis-specific protein TSA903uridine kinaseuridine monophosphate kinaseuridine monophosphokinase 2
Modification date2018052320180525
UniProtAcc

O14880

Q9BZX2

Ensembl transtripts involved in fusion geneENST00000367889, ENST00000367888, 
ENST00000367885, ENST00000367884, 
ENST00000367883, ENST00000367886, 
ENST00000461759, 		ENST00000367879, 
ENST00000372212, ENST00000462329, 
ENST00000469256, ENST00000470820, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 3 X 5=75
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MGST3 [Title/Abstract] AND UCK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMGST3

GO:0006629

lipid metabolic process

9278457

HgeneMGST3

GO:0019370

leukotriene biosynthetic process

9278457


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-BL-A13J-01AMGST3chr1

165600530

+UCK2chr1

165859441

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000367889ENST00000367879MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-3CDSENST00000367889ENST00000372212MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367889ENST00000462329MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367889ENST00000469256MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367889ENST00000470820MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-3CDSENST00000367888ENST00000367879MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-3CDSENST00000367888ENST00000372212MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367888ENST00000462329MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367888ENST00000469256MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367888ENST00000470820MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-3CDSENST00000367885ENST00000367879MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-3CDSENST00000367885ENST00000372212MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367885ENST00000462329MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367885ENST00000469256MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367885ENST00000470820MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-3CDSENST00000367884ENST00000367879MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-3CDSENST00000367884ENST00000372212MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367884ENST00000462329MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367884ENST00000469256MGST3chr1

165600530

+UCK2chr1

165859441

+
5UTR-intronENST00000367884ENST00000470820MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-3CDSENST00000367883ENST00000367879MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-3CDSENST00000367883ENST00000372212MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000367883ENST00000462329MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000367883ENST00000469256MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000367883ENST00000470820MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-3CDSENST00000367886ENST00000367879MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-3CDSENST00000367886ENST00000372212MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000367886ENST00000462329MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000367886ENST00000469256MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000367886ENST00000470820MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-3CDSENST00000461759ENST00000367879MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-3CDSENST00000461759ENST00000372212MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000461759ENST00000462329MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000461759ENST00000469256MGST3chr1

165600530

+UCK2chr1

165859441

+
intron-intronENST00000461759ENST00000470820MGST3chr1

165600530

+UCK2chr1

165859441

+

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FusionProtFeatures for MGST3_UCK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGST3

O14880

UCK2

Q9BZX2

Also functions as a glutathione peroxidase. Phosphorylates uridine and cytidine to uridinemonophosphate and cytidine monophosphate. Does not phosphorylatedeoxyribonucleosides or purine ribonucleosides. Can use ATP or GTPas a phosphate donor. Can also phosphorylate cytidine and uridinenucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MGST3_UCK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MGST3_UCK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MGST3ELAVL1, ZMPSTE24, MRPL49, MRPS26, ATP6V1C1, FAM3C, NDUFS4, CCNC, UNK, CNTRL, FBF1, VAPA, GOLT1B, MCM2, HRAS, S100A13, NMT1, GLMN, NMT2, GAPDHS, HSPA12A, BIRC6, RAP1A, SVIP, ATP6V0A1, LMNAUCK2UBC, UPP1, FBXO6, EGFR, CCDC8, UPRT, UCK1, UCKL1, IAH1, VARS2, RMND5B, DLD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MGST3_UCK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMGST3O14880DB00143GlutathioneMicrosomal glutathione S-transferase 3small moleculeapproved|investigational|nutraceutical
TgeneUCK2Q9BZX2DB04272Citric AcidUridine-cytidine kinase 2small moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for MGST3_UCK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUCK2C0033578Prostatic Neoplasms1CTD_human