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Fusion gene ID: 21835 |
FusionGeneSummary for MGP_ESR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MGP_ESR1 | Fusion gene ID: 21835 | Hgene | Tgene | Gene symbol | MGP | ESR1 | Gene ID | 4256 | 2099 |
| Gene name | matrix Gla protein | estrogen receptor 1 | |
| Synonyms | GIG36|MGLAP|NTI | ER|ESR|ESRA|ESTRR|Era|NR3A1 | |
| Cytomap | 12p12.3 | 6q25.1-q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | matrix Gla proteincell growth-inhibiting gene 36 protein | estrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alpha | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | P08493 | P03372 | |
| Ensembl transtripts involved in fusion gene | ENST00000539261, ENST00000228938, | ENST00000440973, ENST00000338799, ENST00000456483, ENST00000443427, ENST00000206249, ENST00000406599, ENST00000427531, ENST00000482101, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 5 X 5=175 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MGP [Title/Abstract] AND ESR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ESR1 | GO:0006366 | transcription by RNA polymerase II | 15831516 |
| Tgene | ESR1 | GO:0010629 | negative regulation of gene expression | 21695196 |
| Tgene | ESR1 | GO:0030520 | intracellular estrogen receptor signaling pathway | 9841876 |
| Tgene | ESR1 | GO:0032355 | response to estradiol | 15304487 |
| Tgene | ESR1 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 7651415|16043358 |
| Tgene | ESR1 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 10816575 |
| Tgene | ESR1 | GO:0043627 | response to estrogen | 11581164 |
| Tgene | ESR1 | GO:0045893 | positive regulation of transcription, DNA-templated | 9841876|20074560 |
| Tgene | ESR1 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | 9841876 |
| Tgene | ESR1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11544182|12047722|15345745|15831516|18563714 |
| Tgene | ESR1 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 9328340|10681512 |
| Tgene | ESR1 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A0U3-01A | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000539261 | ENST00000440973 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| In-frame | ENST00000539261 | ENST00000338799 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000539261 | ENST00000456483 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000539261 | ENST00000443427 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000539261 | ENST00000206249 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000539261 | ENST00000406599 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000539261 | ENST00000427531 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000539261 | ENST00000482101 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| In-frame | ENST00000228938 | ENST00000440973 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| In-frame | ENST00000228938 | ENST00000338799 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000228938 | ENST00000456483 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000228938 | ENST00000443427 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000228938 | ENST00000206249 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000228938 | ENST00000406599 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000228938 | ENST00000427531 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
| 5CDS-intron | ENST00000228938 | ENST00000482101 | MGP | chr12 | 15037147 | - | ESR1 | chr6 | 152265308 | + |
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FusionProtFeatures for MGP_ESR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MGP | ESR1 |
| Associates with the organic matrix of bone andcartilage. Thought to act as an inhibitor of bone formation. | Nuclear hormone receptor. The steroid hormones and theirreceptors are involved in the regulation of eukaryotic geneexpression and affect cellular proliferation and differentiationin target tissues. Ligand-dependent nuclear transactivationinvolves either direct homodimer binding to a palindromic estrogenresponse element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2,Sp1 and Sp3, to mediate ERE-independent signaling. Ligand bindinginduces a conformational change allowing subsequent orcombinatorial association with multiprotein coactivator complexesthrough LXXLL motifs of their respective components. Mutualtransrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcriptionfrom the IL6 promoter and displace RELA/p65 and associatedcoregulators from the promoter. Recruited to the NF-kappa-Bresponse element of the CCL2 and IL8 promoters and can displaceCREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50on ERE sequences. Can also act synergistically with NF-kappa-B toactivate transcription involving respective recruitment adjacentresponse elements; the function involves CREBBP. Can activate thetranscriptional activity of TFF1. Also mediates membrane-initiatedestrogen signaling involving various kinase cascades. Isoform 3 isinvolved in activation of NOS3 and endothelial nitric oxideproduction. Isoforms lacking one or several functional domains arethought to modulate transcriptional activity by competitive ligandor DNA binding and/or heterodimerization with the full-lengthreceptor. Essential for MTA1-mediated transcriptional regulationof BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform1. {ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575,ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626,ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875,ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358,ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779,ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106,ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539,ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611,ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956,ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 185_250 | -73 | 484 | DNA binding | Nuclear receptor |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 311_547 | 253 | 596 | Domain | NR LBD |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 311_547 | 253 | 596 | Domain | NR LBD |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 311_547 | 253 | 596 | Domain | NR LBD |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 311_547 | 253 | 596 | Domain | NR LBD |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 311_547 | -73 | 484 | Domain | NR LBD |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 251_310 | 253 | 596 | Region | Note=Hinge |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 264_595 | 253 | 596 | Region | Note=Self-association |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 311_595 | 253 | 596 | Region | Note=Transactivation AF-2 |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 251_310 | 253 | 596 | Region | Note=Hinge |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 264_595 | 253 | 596 | Region | Note=Self-association |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 311_595 | 253 | 596 | Region | Note=Transactivation AF-2 |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 251_310 | 253 | 596 | Region | Note=Hinge |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 264_595 | 253 | 596 | Region | Note=Self-association |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 311_595 | 253 | 596 | Region | Note=Transactivation AF-2 |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 251_310 | 253 | 596 | Region | Note=Hinge |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 264_595 | 253 | 596 | Region | Note=Self-association |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 311_595 | 253 | 596 | Region | Note=Transactivation AF-2 |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 251_310 | -73 | 484 | Region | Note=Hinge |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 264_595 | -73 | 484 | Region | Note=Self-association |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 311_595 | -73 | 484 | Region | Note=Transactivation AF-2 |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 185_205 | -73 | 484 | Zinc finger | NR C4-type |
| Tgene | >ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 221_245 | -73 | 484 | Zinc finger | NR C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MGP | chr12:15037147 | chr6:152265308 | ENST00000228938 | - | 3 | 5 | 51_97 | 56 | 129 | Domain | Gla |
| Hgene | >MGP | chr12:15037147 | chr6:152265308 | ENST00000539261 | - | 2 | 4 | 51_97 | 31 | 104 | Domain | Gla |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 185_250 | 253 | 596 | DNA binding | Nuclear receptor |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 185_250 | 253 | 596 | DNA binding | Nuclear receptor |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 185_250 | 253 | 596 | DNA binding | Nuclear receptor |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 185_250 | 253 | 596 | DNA binding | Nuclear receptor |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 185_205 | 253 | 596 | Zinc finger | NR C4-type |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 221_245 | 253 | 596 | Zinc finger | NR C4-type |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 185_205 | 253 | 596 | Zinc finger | NR C4-type |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 221_245 | 253 | 596 | Zinc finger | NR C4-type |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 185_205 | 253 | 596 | Zinc finger | NR C4-type |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 221_245 | 253 | 596 | Zinc finger | NR C4-type |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 185_205 | 253 | 596 | Zinc finger | NR C4-type |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 221_245 | 253 | 596 | Zinc finger | NR C4-type |
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FusionGeneSequence for MGP_ESR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MGP_ENST00000539261_chr12_15037147_-_ESR1_ENST00000440973_chr6_152265308_+_374aa MKSLILLAILAALAVVTLCYESHESMESYELRIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTA DQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKL LFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAK AGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKY >In-frame_MGP_ENST00000539261_chr12_15037147_-_ESR1_ENST00000338799_chr6_152265308_+_374aa MKSLILLAILAALAVVTLCYESHESMESYELRIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTA DQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKL LFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAK AGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKY >In-frame_MGP_ENST00000228938_chr12_15037147_-_ESR1_ENST00000440973_chr6_152265308_+_399aa MKSLILLAILAALAVVTLCYGEWQKEENFGFDIVSVLSLNWHRAQESHESMESYELRIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMR AANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVH LLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLK SLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGG >In-frame_MGP_ENST00000228938_chr12_15037147_-_ESR1_ENST00000338799_chr6_152265308_+_399aa MKSLILLAILAALAVVTLCYGEWQKEENFGFDIVSVLSLNWHRAQESHESMESYELRIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMR AANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVH LLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLK SLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MGP_ENST00000539261_chr12_15037147_-_ESR1_ENST00000440973_chr6_152265308_+_1122nt ATGAAGAGCCTGATCCTTCTTGCCATCCTGGCCGCCTTAGCGGTAGTAACTTTGTGTTATGAATCACATGAAAGCATGGAATCTTATGAA CTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCT GCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCC GACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATG ATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTC CATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTA CTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCA TCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTG TCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAG GCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATG GAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTATGACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCC ACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAAAGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTAT >In-frame_MGP_ENST00000539261_chr12_15037147_-_ESR1_ENST00000338799_chr6_152265308_+_1122nt ATGAAGAGCCTGATCCTTCTTGCCATCCTGGCCGCCTTAGCGGTAGTAACTTTGTGTTATGAATCACATGAAAGCATGGAATCTTATGAA CTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCT GCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCC GACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATG ATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTC CATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTA CTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCA TCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTG TCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAG GCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATG GAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTATGACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCC ACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAAAGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTAT >In-frame_MGP_ENST00000228938_chr12_15037147_-_ESR1_ENST00000440973_chr6_152265308_+_1197nt ATGAAGAGCCTGATCCTTCTTGCCATCCTGGCCGCCTTAGCGGTAGTAACTTTGTGTTATGGAGAGTGGCAGAAAGAAGAAAACTTCGGC TTTGATATCGTTTCAGTTCTCTCTCTGAACTGGCATCGTGCCCAGGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAA GACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGA GCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGT GCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACC AACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCAC CTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAAC TTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATG ATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAG TCTCTGGAAGAGAAGGACCATATCCACCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTG CAGCAGCAGCACCAGCGGCTGGCCCAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGC ATGAAGTGCAAGAACGTGGTGCCCCTCTATGACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGG GCATCCGTGGAGGAGACGGACCAAAGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAG >In-frame_MGP_ENST00000228938_chr12_15037147_-_ESR1_ENST00000338799_chr6_152265308_+_1197nt ATGAAGAGCCTGATCCTTCTTGCCATCCTGGCCGCCTTAGCGGTAGTAACTTTGTGTTATGGAGAGTGGCAGAAAGAAGAAAACTTCGGC TTTGATATCGTTTCAGTTCTCTCTCTGAACTGGCATCGTGCCCAGGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAA GACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGA GCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGT GCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACC AACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCAC CTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAAC TTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATG ATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAG TCTCTGGAAGAGAAGGACCATATCCACCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTG CAGCAGCAGCACCAGCGGCTGGCCCAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGC ATGAAGTGCAAGAACGTGGTGCCCCTCTATGACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGG GCATCCGTGGAGGAGACGGACCAAAGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MGP_ENST00000539261_chr12_15037147_-_ESR1_ENST00000440973_chr6_152265308_+_5565nt TCTCCCACTGGTTCCTCCCCTCTCAACTGCTCTGGTTCTTATAAAAACCTCACAGCCTTCCACTAACATCCCGTAGGAGCCTCTCTCCCT ACTGCTGCTACACAAGACCCTGAGACTGACCTGCAGGACGAAACCATGAAGAGCCTGATCCTTCTTGCCATCCTGGCCGCCTTAGCGGTA GTAACTTTGTGTTATGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACAC AAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATG ATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTC TATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATG ATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTG ATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGT GTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGC CTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCGA GTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTC CTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTAT GACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAAAGCCAC TTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTCTGAGAG CTCCCTGGCTCCCACACGGTTCAGATAATCCCTGCTGCATTTTACCCTCATCATGCACCACTTTAGCCAAATTCTGTCTCCTGCATACAC TCCGGCATGCATCCAACACCAATGGCTTTCTAGATGAGTGGCCATTCATTTGCTTGCTCAGTTCTTAGTGGCACATCTTCTGTCTTCTGT TGGGAACAGCCAAAGGGATTCCAAGGCTAAATCTTTGTAACAGCTCTCTTTCCCCCTTGCTATGTTACTAAGCGTGAGGATTCCCGTAGC TCTTCACAGCTGAACTCAGTCTATGGGTTGGGGCTCAGATAACTCTGTGCATTTAAGCTACTTGTAGAGACCCAGGCCTGGAGAGTAGAC ATTTTGCCTCTGATAAGCACTTTTTAAATGGCTCTAAGAATAAGCCACAGCAAAGAATTTAAAGTGGCTCCTTTAATTGGTGACTTGGAG AAAGCTAGGTCAAGGGTTTATTATAGCACCCTCTTGTATTCCTATGGCAATGCATCCTTTTATGAAAGTGGTACACCTTAAAGCTTTTAT ATGACTGTAGCAGAGTATCTGGTGATTGTCAATTCATTCCCCCTATAGGAATACAAGGGGCACACAGGGAAGGCAGATCCCCTAGTTGGC AAGACTATTTTAACTTGATACACTGCAGATTCAGATGTGCTGAAAGCTCTGCCTCTGGCTTTCCGGTCATGGGTTCCAGTTAATTCATGC CTCCCATGGACCTATGGAGAGCAGCAAGTTGATCTTAGTTAAGTCTCCCTATATGAGGGATAAGTTCCTGATTTTTGTTTTTATTTTTGT GTTACAAAAGAAAGCCCTCCCTCCCTGAACTTGCAGTAAGGTCAGCTTCAGGACCTGTTCCAGTGGGCACTGTACTTGGATCTTCCCGGC GTGTGTGTGCCTTACACAGGGGTGAACTGTTCACTGTGGTGATGCATGATGAGGGTAAATGGTAGTTGAAAGGAGCAGGGGCCCTGGTGT TGCATTTAGCCCTGGGGCATGGAGCTGAACAGTACTTGTGCAGGATTGTTGTGGCTACTAGAGAACAAGAGGGAAAGTAGGGCAGAAACT GGATACAGTTCTGAGGCACAGCCAGACTTGCTCAGGGTGGCCCTGCCACAGGCTGCAGCTACCTAGGAACATTCCTTGCAGACCCCGCAT TGCCCTTTGGGGGTGCCCTGGGATCCCTGGGGTAGTCCAGCTCTTCTTCATTTCCCAGCGTGGCCCTGGTTGGAAGAAGCAGCTGTCACA GCTGCTGTAGACAGCTGTGTTCCTACAATTGGCCCAGCACCCTGGGGCACGGGAGAAGGGTGGGGACCGTTGCTGTCACTACTCAGGCTG ACTGGGGCCTGGTCAGATTACGTATGCCCTTGGTGGTTTAGAGATAATCCAAAATCAGGGTTTGGTTTGGGGAAGAAAATCCTCCCCCTT CCTCCCCCGCCCCGTTCCCTACCGCCTCCACTCCTGCCAGCTCATTTCCTTCAATTTCCTTTGACCTATAGGCTAAAAAAGAAAGGCTCA TTCCAGCCACAGGGCAGCCTTCCCTGGGCCTTTGCTTCTCTAGCACAATTATGGGTTACTTCCTTTTTCTTAACAAAAAAGAATGTTTGA TTTCCTCTGGGTGACCTTATTGTCTGTAATTGAAACCCTATTGAGAGGTGATGTCTGTGTTAGCCAATGACCCAGGTGAGCTGCTCGGGC TTCTCTTGGTATGTCTTGTTTGGAAAAGTGGATTTCATTCATTTCTGATTGTCCAGTTAAGTGATCACCAAAGGACTGAGAATCTGGGAG GGCAAAAAAAAAAAAAAAGTTTTTATGTGCACTTAAATTTGGGGACAATTTTATGTATCTGTGTTAAGGATATGTTTAAGAACATAATTC TTTTGTTGCTGTTTGTTTAAGAAGCACCTTAGTTTGTTTAAGAAGCACCTTATATAGTATAATATATATTTTTTTGAAATTACATTGCTT GTTTATCAGACAATTGAATGTAGTAATTCTGTTCTGGATTTAATTTGACTGGGTTAACATGCAAAAACCAAGGAAAAATATTTAGTTTTT TTTTTTTTTTTTGTATACTTTTCAAGCTACCTTGTCATGTATACAGTCATTTATGCCTAAAGCCTGGTGATTATTCATTTAAATGAAGAT CACATTTCATATCAACTTTTGTATCCACAGTAGACAAAATAGCACTAATCCAGATGCCTATTGTTGGATACTGAATGACAGACAATCTTA TGTAGCAAAGATTATGCCTGAAAAGGAAAATTATTCAGGGCAGCTAATTTTGCTTTTACCAAAATATCAGTAGTAATATTTTTGGACAGT AGCTAATGGGTCAGTGGGTTCTTTTTAATGTTTATACTTAGATTTTCTTTTAAAAAAATTAAAATAAAACAAAAAAAAATTTCTAGGACT AGACGATGTAATACCAGCTAAAGCCAAACAATTATACAGTGGAAGGTTTTACATTATTCATCCAATGTGTTTCTATTCATGTTAAGATAC TACTACATTTGAAGTGGGCAGAGAACATCAGATGATTGAAATGTTCGCCCAGGGGTCTCCAGCAACTTTGGAAATCTCTTTGTATTTTTA CTTGAAGTGCCACTAATGGACAGCAGATATTTTCTGGCTGATGTTGGTATTGGGTGTAGGAACATGATTTAAAAAAAAACTCTTGCCTCT GCTTTCCCCCACTCTGAGGCAAGTTAAAATGTAAAAGATGTGATTTATCTGGGGGGCTCAGGTATGGTGGGGAAGTGGATTCAGGAATCT GGGGAATGGCAAATATATTAAGAAGAGTATTGAAAGTATTTGGAGGAAAATGGTTAATTCTGGGTGTGCACCAGGGTTCAGTAGAGTCCA CTTCTGCCCTGGAGACCACAAATCAACTAGCTCCATTTACAGCCATTTCTAAAATGGCAGCTTCAGTTCTAGAGAAGAAAGAACAACATC AGCAGTAAAGTCCATGGAATAGCTAGTGGTCTGTGTTTCTTTTCGCCATTGCCTAGCTTGCCGTAATGATTCTATAATGCCATCATGCAG CAATTATGAGAGGCTAGGTCATCCAAAGAGAAGACCCTATCAATGTAGGTTGCAAAATCTAACCCCTAAGGAAGTGCAGTCTTTGATTTG ATTTCCCTAGTAACCTTGCAGATATGTTTAACCAAGCCATAGCCCATGCCTTTTGAGGGCTGAACAAATAAGGGACTTACTGATAATTTA CTTTTGATCACATTAAGGTGTTCTCACCTTGAAATCTTATACACTGAAATGGCCATTGATTTAGGCCACTGGCTTAGAGTACTCCTTCCC CTGCATGACACTGATTACAAATACTTTCCTATTCATACTTTCCAATTATGAGATGGACTGTGGGTACTGGGAGTGATCACTAACACCATA GTAATGTCTAATATTCACAGGCAGATCTGCTTGGGGAAGCTAGTTATGTGAAAGGCAAATAGAGTCATACAGTAGCTCAAAAGGCAACCA TAATTCTCTTTGGTGCAGGTCTTGGGAGCGTGATCTAGATTACACTGCACCATTCCCAAGTTAATCCCCTGAAAACTTACTCTCAACTGG AGCAAATGAACTTTGGTCCCAAATATCCATCTTTTCAGTAGCGTTAATTATGCTCTGTTTCCAACTGCATTTCCTTTCCAATTGAATTAA AGTGTGGCCTCGTTTTTAGTCATTTAAAATTGTTTTCTAAGTAATTGCTGCCTCTATTATGGCACTTCAATTTTGCACTGTCTTTTGAGA TTCAAGAAAAATTTCTATTCTTTTTTTTGCATCCAATTGTGCCTGAACTTTTAAAATATGTAAATGCTGCCATGTTCCAAACCCATCGTC AGTGTGTGTGTTTAGAGCTGTGCACCCTAGAAACAACATATTGTCCCATGAGCAGGTGCCTGAGACACAGACCCCTTTGCATTCACAGAG AGGTCATTGGTTATAGAGACTTGAATTAATAAGTGACATTATGCCAGTTTCTGTTCTCTCACAGGTGATAAACAATGCTTTTTGTGCACT ACATACTCTTCAGTGTAGAGCTCTTGTTTTATGGGAAAAGGCTCAAATGCCAAATTGTGTTTGATGGATTAATATGCCCTTTTGCCGATG CATACTATTACTGATGTGACTCGGTTTTGTCGCAGCTTTGCTTTGTTTAATGAAACACACTTGTAAACCTCTTTTGCACTTTGAAAAAGA >In-frame_MGP_ENST00000539261_chr12_15037147_-_ESR1_ENST00000338799_chr6_152265308_+_1344nt TCTCCCACTGGTTCCTCCCCTCTCAACTGCTCTGGTTCTTATAAAAACCTCACAGCCTTCCACTAACATCCCGTAGGAGCCTCTCTCCCT ACTGCTGCTACACAAGACCCTGAGACTGACCTGCAGGACGAAACCATGAAGAGCCTGATCCTTCTTGCCATCCTGGCCGCCTTAGCGGTA GTAACTTTGTGTTATGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACAC AAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATG ATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTC TATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATG ATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTG ATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGT GTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGC CTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCGA GTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTC CTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTAT GACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAAAGCCAC TTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTCTGAGAG >In-frame_MGP_ENST00000228938_chr12_15037147_-_ESR1_ENST00000440973_chr6_152265308_+_5571nt CCCGTAGGAGCCTCTCTCCCTACTGCTGCTACACAAGACCCTGAGACTGACCTGCAGGACGAAACCATGAAGAGCCTGATCCTTCTTGCC ATCCTGGCCGCCTTAGCGGTAGTAACTTTGTGTTATGGAGAGTGGCAGAAAGAAGAAAACTTCGGCTTTGATATCGTTTCAGTTCTCTCT CTGAACTGGCATCGTGCCCAGGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTG AAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCG CTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCG ATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTT CACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAG ATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGA AAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTT GTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATC CACCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCC CAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCC CTCTATGACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAA AGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTC TGAGAGCTCCCTGGCTCCCACACGGTTCAGATAATCCCTGCTGCATTTTACCCTCATCATGCACCACTTTAGCCAAATTCTGTCTCCTGC ATACACTCCGGCATGCATCCAACACCAATGGCTTTCTAGATGAGTGGCCATTCATTTGCTTGCTCAGTTCTTAGTGGCACATCTTCTGTC TTCTGTTGGGAACAGCCAAAGGGATTCCAAGGCTAAATCTTTGTAACAGCTCTCTTTCCCCCTTGCTATGTTACTAAGCGTGAGGATTCC CGTAGCTCTTCACAGCTGAACTCAGTCTATGGGTTGGGGCTCAGATAACTCTGTGCATTTAAGCTACTTGTAGAGACCCAGGCCTGGAGA GTAGACATTTTGCCTCTGATAAGCACTTTTTAAATGGCTCTAAGAATAAGCCACAGCAAAGAATTTAAAGTGGCTCCTTTAATTGGTGAC TTGGAGAAAGCTAGGTCAAGGGTTTATTATAGCACCCTCTTGTATTCCTATGGCAATGCATCCTTTTATGAAAGTGGTACACCTTAAAGC TTTTATATGACTGTAGCAGAGTATCTGGTGATTGTCAATTCATTCCCCCTATAGGAATACAAGGGGCACACAGGGAAGGCAGATCCCCTA GTTGGCAAGACTATTTTAACTTGATACACTGCAGATTCAGATGTGCTGAAAGCTCTGCCTCTGGCTTTCCGGTCATGGGTTCCAGTTAAT TCATGCCTCCCATGGACCTATGGAGAGCAGCAAGTTGATCTTAGTTAAGTCTCCCTATATGAGGGATAAGTTCCTGATTTTTGTTTTTAT TTTTGTGTTACAAAAGAAAGCCCTCCCTCCCTGAACTTGCAGTAAGGTCAGCTTCAGGACCTGTTCCAGTGGGCACTGTACTTGGATCTT CCCGGCGTGTGTGTGCCTTACACAGGGGTGAACTGTTCACTGTGGTGATGCATGATGAGGGTAAATGGTAGTTGAAAGGAGCAGGGGCCC TGGTGTTGCATTTAGCCCTGGGGCATGGAGCTGAACAGTACTTGTGCAGGATTGTTGTGGCTACTAGAGAACAAGAGGGAAAGTAGGGCA GAAACTGGATACAGTTCTGAGGCACAGCCAGACTTGCTCAGGGTGGCCCTGCCACAGGCTGCAGCTACCTAGGAACATTCCTTGCAGACC CCGCATTGCCCTTTGGGGGTGCCCTGGGATCCCTGGGGTAGTCCAGCTCTTCTTCATTTCCCAGCGTGGCCCTGGTTGGAAGAAGCAGCT GTCACAGCTGCTGTAGACAGCTGTGTTCCTACAATTGGCCCAGCACCCTGGGGCACGGGAGAAGGGTGGGGACCGTTGCTGTCACTACTC AGGCTGACTGGGGCCTGGTCAGATTACGTATGCCCTTGGTGGTTTAGAGATAATCCAAAATCAGGGTTTGGTTTGGGGAAGAAAATCCTC CCCCTTCCTCCCCCGCCCCGTTCCCTACCGCCTCCACTCCTGCCAGCTCATTTCCTTCAATTTCCTTTGACCTATAGGCTAAAAAAGAAA GGCTCATTCCAGCCACAGGGCAGCCTTCCCTGGGCCTTTGCTTCTCTAGCACAATTATGGGTTACTTCCTTTTTCTTAACAAAAAAGAAT GTTTGATTTCCTCTGGGTGACCTTATTGTCTGTAATTGAAACCCTATTGAGAGGTGATGTCTGTGTTAGCCAATGACCCAGGTGAGCTGC TCGGGCTTCTCTTGGTATGTCTTGTTTGGAAAAGTGGATTTCATTCATTTCTGATTGTCCAGTTAAGTGATCACCAAAGGACTGAGAATC TGGGAGGGCAAAAAAAAAAAAAAAGTTTTTATGTGCACTTAAATTTGGGGACAATTTTATGTATCTGTGTTAAGGATATGTTTAAGAACA TAATTCTTTTGTTGCTGTTTGTTTAAGAAGCACCTTAGTTTGTTTAAGAAGCACCTTATATAGTATAATATATATTTTTTTGAAATTACA TTGCTTGTTTATCAGACAATTGAATGTAGTAATTCTGTTCTGGATTTAATTTGACTGGGTTAACATGCAAAAACCAAGGAAAAATATTTA GTTTTTTTTTTTTTTTTTGTATACTTTTCAAGCTACCTTGTCATGTATACAGTCATTTATGCCTAAAGCCTGGTGATTATTCATTTAAAT GAAGATCACATTTCATATCAACTTTTGTATCCACAGTAGACAAAATAGCACTAATCCAGATGCCTATTGTTGGATACTGAATGACAGACA ATCTTATGTAGCAAAGATTATGCCTGAAAAGGAAAATTATTCAGGGCAGCTAATTTTGCTTTTACCAAAATATCAGTAGTAATATTTTTG GACAGTAGCTAATGGGTCAGTGGGTTCTTTTTAATGTTTATACTTAGATTTTCTTTTAAAAAAATTAAAATAAAACAAAAAAAAATTTCT AGGACTAGACGATGTAATACCAGCTAAAGCCAAACAATTATACAGTGGAAGGTTTTACATTATTCATCCAATGTGTTTCTATTCATGTTA AGATACTACTACATTTGAAGTGGGCAGAGAACATCAGATGATTGAAATGTTCGCCCAGGGGTCTCCAGCAACTTTGGAAATCTCTTTGTA TTTTTACTTGAAGTGCCACTAATGGACAGCAGATATTTTCTGGCTGATGTTGGTATTGGGTGTAGGAACATGATTTAAAAAAAAACTCTT GCCTCTGCTTTCCCCCACTCTGAGGCAAGTTAAAATGTAAAAGATGTGATTTATCTGGGGGGCTCAGGTATGGTGGGGAAGTGGATTCAG GAATCTGGGGAATGGCAAATATATTAAGAAGAGTATTGAAAGTATTTGGAGGAAAATGGTTAATTCTGGGTGTGCACCAGGGTTCAGTAG AGTCCACTTCTGCCCTGGAGACCACAAATCAACTAGCTCCATTTACAGCCATTTCTAAAATGGCAGCTTCAGTTCTAGAGAAGAAAGAAC AACATCAGCAGTAAAGTCCATGGAATAGCTAGTGGTCTGTGTTTCTTTTCGCCATTGCCTAGCTTGCCGTAATGATTCTATAATGCCATC ATGCAGCAATTATGAGAGGCTAGGTCATCCAAAGAGAAGACCCTATCAATGTAGGTTGCAAAATCTAACCCCTAAGGAAGTGCAGTCTTT GATTTGATTTCCCTAGTAACCTTGCAGATATGTTTAACCAAGCCATAGCCCATGCCTTTTGAGGGCTGAACAAATAAGGGACTTACTGAT AATTTACTTTTGATCACATTAAGGTGTTCTCACCTTGAAATCTTATACACTGAAATGGCCATTGATTTAGGCCACTGGCTTAGAGTACTC CTTCCCCTGCATGACACTGATTACAAATACTTTCCTATTCATACTTTCCAATTATGAGATGGACTGTGGGTACTGGGAGTGATCACTAAC ACCATAGTAATGTCTAATATTCACAGGCAGATCTGCTTGGGGAAGCTAGTTATGTGAAAGGCAAATAGAGTCATACAGTAGCTCAAAAGG CAACCATAATTCTCTTTGGTGCAGGTCTTGGGAGCGTGATCTAGATTACACTGCACCATTCCCAAGTTAATCCCCTGAAAACTTACTCTC AACTGGAGCAAATGAACTTTGGTCCCAAATATCCATCTTTTCAGTAGCGTTAATTATGCTCTGTTTCCAACTGCATTTCCTTTCCAATTG AATTAAAGTGTGGCCTCGTTTTTAGTCATTTAAAATTGTTTTCTAAGTAATTGCTGCCTCTATTATGGCACTTCAATTTTGCACTGTCTT TTGAGATTCAAGAAAAATTTCTATTCTTTTTTTTGCATCCAATTGTGCCTGAACTTTTAAAATATGTAAATGCTGCCATGTTCCAAACCC ATCGTCAGTGTGTGTGTTTAGAGCTGTGCACCCTAGAAACAACATATTGTCCCATGAGCAGGTGCCTGAGACACAGACCCCTTTGCATTC ACAGAGAGGTCATTGGTTATAGAGACTTGAATTAATAAGTGACATTATGCCAGTTTCTGTTCTCTCACAGGTGATAAACAATGCTTTTTG TGCACTACATACTCTTCAGTGTAGAGCTCTTGTTTTATGGGAAAAGGCTCAAATGCCAAATTGTGTTTGATGGATTAATATGCCCTTTTG CCGATGCATACTATTACTGATGTGACTCGGTTTTGTCGCAGCTTTGCTTTGTTTAATGAAACACACTTGTAAACCTCTTTTGCACTTTGA >In-frame_MGP_ENST00000228938_chr12_15037147_-_ESR1_ENST00000338799_chr6_152265308_+_1350nt CCCGTAGGAGCCTCTCTCCCTACTGCTGCTACACAAGACCCTGAGACTGACCTGCAGGACGAAACCATGAAGAGCCTGATCCTTCTTGCC ATCCTGGCCGCCTTAGCGGTAGTAACTTTGTGTTATGGAGAGTGGCAGAAAGAAGAAAACTTCGGCTTTGATATCGTTTCAGTTCTCTCT CTGAACTGGCATCGTGCCCAGGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTG AAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCG CTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCG ATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTT CACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAG ATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGA AAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTT GTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATC CACCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCC CAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCC CTCTATGACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAA AGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTC TGAGAGCTCCCTGGCTCCCACACGGTTCAGATAATCCCTGCTGCATTTTACCCTCATCATGCACCACTTTAGCCAAATTCTGTCTCCTGC |
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FusionGenePPI for MGP_ESR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MGP | BMP2 | ESR1 | PPARGC1B, SMARCA4, DDX54, DNTTIP2, NCOA6, BRCA1, NCOA4, RBM39, SRC, NELFB, GADD45G, GADD45A, CTNNB1, PTEN, SAFB, ZBTB16, XBP1, PHB2, PTMA, SMARCD1, TDG, SAFB2, AHR, EP300, MTA1, MNAT1, CCNH, SMARCE1, SMARCA2, FKBP5, FKBP4, HSP90AA1, HSPA4, PPID, PTGES3, YWHAQ, CDC25B, MGMT, PELP1, TRIP4, NCOA1, CREBBP, PRDM2, KDM5A, PRMT1, ESR1, NR2C2, POU2F1, POU2F2, STAT5A, RBFOX2, DAP3, NR2F1, MAPK1, TP53, MDM2, CDK7, GTF2H1, NCOA2, MVP, ESR2, NRIP1, CEBPA, CEBPB, CCND1, STAT3, SVIL, NR0B2, IGF1R, PAK6, POU4F1, POU4F2, REXO4, NR2C1, AKAP13, TBP, PPARGC1A, NCOA3, SHC1, TADA3, CAV1, RNF4, PIAS2, TRIM24, NR2F6, ISL1, NCOA7, FOXO1, FOXO4, PIK3R1, BAG1, NCOR1, JUN, ZNF398, PRMT2, SMAD2, MED12, MED1, MED14, MED23, MED24, MED16, MED6, MED20, MED10, MED17, MED7, MED21, MED13, CCNC, CDK8, RLIM, PDLIM1, LDB1, TRAM1, TRIM25, KAT5, MUC1, UBE3A, STUB1, HSPA8, HDAC7, HDAC4, HDAC5, HDAC9, FLII, SP1, SIN3A, KLF5, SMYD3, MYOD1, TOP2B, PRKDC, PARP1, XRCC5, XRCC6, MEN1, SP3, MTA2, RELA, MYC, RBBP7, RBBP4, AHRR, ING1, HDAC1, LMO4, LCOR, TAF1A, TAF1B, SETD7, SP2, MSH2, PGC, CDKN1A, IRS1, IRS2, CITED1, GRIP1, ATAD2, RPS6KA1, GTF2B, NCOR2, LRIF1, HDAC3, PHB, KAT6A, FOS, HDAC2, KDM1A, GSN, ACTB, NPM1, ACTC1, RPL18, DDX5, RPLP0, RPL7A, MYL6, RPL7, RPS4X, MYO1C, DDX3X, RPS9, RPS8, ACTR3, ACTR2, POLR2A, MBD2, RBBP6, SMAD3, SMURF1, SGK3, BARD1, ACTN4, OTUB1, DUT, NPPA, MTCH2, PNRC2, KIF1A, KMT2D, RBBP5, ASH2L, WDR5, AKT1, TUBB1, TUBA1A, MED25, PSMC5, RPS6KA3, AKT2, DDX17, TRRAP, MPG, BCAR1, PIK3R2, ERBB2, SOS2, FHL2, UBE2I, PIAS1, CUEDC2, SKIL, SKI, KDM4B, ARHGDIA, SIRT1, PRKCZ, TFF1, CALM1, BLOC1S1, EHMT2, TAF2, PGR, XPO1, RAN, E2F1, RABGEF1, TAB2, UIMC1, CBLL1, PPP1CC, CDK11B, SPOP, CUL3, COPS5, ANIB1, ARID5A, TRAF6, RBCK1, TBL1XR1, SIN3B, RBM23, ANP32A, CHUK, BCL3, CRIPAK, TSC2, EGFR, MYLK2, ARG1, DSG1, HIF1A, CLTCL1, HPCAL1, APOD, SERPINH1, BUD13, AKAP8, ATAD3A, BCLAF1, ELMSAN1, CAPRIN1, CLTC, DDX18, DDX21, DDX27, DHX15, DHX9, DKC1, EWSR1, FLNA, FTSJ3, FUS, GNL3, GTPBP4, HNRNPA3, HNRNPF, HNRNPK, HNRNPM, HNRNPR, HNRNPA1, HNRNPA1L2, ILF2, JUP, MKI67, MYBBP1A, MYH9, MYO1B, NAT10, NCL, NOP56, NUMA1, PABPC1, PGAM5, PTPLAD1, RBM14, RBMX, RPL10, RPL13, RPL13A, RPL14, RPL17, RPL18A, RPL19, RPL22, RPL24, RPL27A, RPL3, RPL36AL, RPL36A, RPL37A, RPL4, RPL6, RPL8, RPN1, RPN2, RPS14, RPS16, RPS2, RPS23, RPS26, RPS3A, RPS6, RRP12, RSL1D1, SRSF1, SRSF2, SRSF7, SLC25A5, SRRM1, TF, TFRC, THRAP3, TOP1, TOP2A, TRIP12, UBTF, U2AF2, ACTN1, AHNAK, AIFM1, ALKBH7, AP2M1, ARFGAP2, ARSB, ATP5B, ATP9A, BRI3BP, CAPZB, CHD4, LUC7L3, YBX3, DBN1, DDX50, DECR1, DEK, DHX30, DNAH2, DNAJB11, EFTUD2, EIF4A1, EIF4G1, EIF4G3, EP400, EPB41L5, FLNB, FMR1, G3BP1, G3BP2, GNB1, GNB2, GNB4, GNL2, GOLGA2, HNRNPA0, HNRNPA2B1, HNRNPAB, LYAR, MRPS9, MTDH, MYH14, MYO6, NOP2, NOP58, GLYR1, NUP153, POP1, PPP1CA, PRPF4B, PSIP1, RBM28, RPL10A, RPL11, RPL23A, RPL36, RPL5, RPL9, RPS12, RPS13, RPS15A, RPS20, RPS24, RPS3, RPSA, RUVBL1, RUVBL2, SCYL2, SRSF6, SHOC2, SNRPD1, SPTAN1, SPTBN1, SRPK1, SRPK2, SRRM2, STAU1, SUPT16H, TBL2, TCOF1, UBAP2L, UNC45A, UPF1, UTP3, WDR36, YBX1, YTHDF2, ANXA2, DDX3Y, THEM6, EMD, EPPK1, EXOSC10, H2AFX, HSPA1L, SYNCRIP, GAPDH, TECR, KHDRBS1, LGALS7, MAPKAPK2, MYL6B, NCCRP1, POF1B, PLEC, RPL29, RRP1B, RPL12, RPL28, RPL21, RPS18, RDX, SRSF5, S100A7, SERPINB4, SFN, SEC61B, SF3B1, SRSF3, S100A8, U2SURP, WDR18, VPS13D, ZNF512B, SRA1, NR1H4, BTF3, FHL1, VAV3, PPP5C, HEXIM1, CCNT1, PAK1, RAC3, SLC25A20, EZH2, TSC1, PAGR1, MMS19, CHD9, BCAS2, PIK3CA, ESRRA, FKBPL, ZDHHC21, ZDHHC7, KRT1, CEP290, HSPB1, PRDX2, NME2, PPIA, PFN1, CBR1, GSTM3, RNF31, RANBP9, WIPI1, NSD1, ZNF131, PSMB9, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2L, POLR2J, POLR2K, TTC5, ASCC1, SKP2, SKP1, CUL1, RBX1, CDK2, SMYD2, SUV39H1, WHSC1, SUV420H1, ANP32B, SND1, SFPQ, PQBP1, ALYREF, GNB2L1, CCT2, TCERG1, NUDT21, TOPBP1, CIRBP, DARS, DDX1, EEF2, EIF5A, TUBB, EPRS, FARSA, SEPT8, SERBP1, PRPF19, PDIA3, HIST1H2BD, H3F3A, H3F3B, HDLBP, HNRNPC, HNRNPD, ILF3, KARS, KRT8, KRT10, KRT18, KRT19, MARS, MTHFD1, NAP1L4, SEPT2, NONO, NSF, P4HB, PA2G4, RTCB, LARS, PPIB, SARS2, PPP2R1A, PSPC1, PRKCSH, PSMD1, SNX6, SET, SHMT2, HSP90B1, VCP, SMC1A, HIST2H2AC, HIST1H2BG, HIST1H2BF, HIST1H2BE, HIST1H2BI, HIST1H2BC, GRWD1, SARNP, TUBA1C, FBXO18, YARS, FUBP1, EIF2S2, SMC3, MED27, EIF4A3, BCAS3, DYX1C1, GNAI1, GNAI2, GNAI3, SMARCD3, ARID1A, SUPT6H, RNF40, FOXK2, ANGPTL4, BAP1, CXCL1, EPSTI1, GLCE, KLK5, KLK9, PSMC3IP, SERPINB5, WHSC1L1, CFL1, CSRP1, HBP1, UBE4B, RAD51, TUBG1, HECTD1, PPP2R3A, SASH1, UBE3C, USP16, SUZ12, NDC80, ZNF182, TAB3, HSPD1, TXNRD1, PATZ1, PPP2CA, PPP2CB, TRAF3, TBK1, IKBKE, FBXO45, TTK, CHD6, MPRIP, SNRPN, TMOD3, AGFG1, EIF6, GCN1L1, CORO1C, RAD50, APITD1-CORT, PRPF8, CAT, AP2A2, STOM, MED9, PRR12, BCOR, YTHDF1, HOXD9, HOXC10, NFYA, E2F6, HNRNPH2, FIP1L1, TIA1, SMC2, NCAPG, NCAPH2, SMC4, NCAPD2, NCAPH, NCAPD3, NCAPG2, DNMT3L, ARNT, VPRBP, LATS1, DCAF13, PPP1R14C, GBP1, PGK2, SIGLEC10, PNMT, CNDP1, ERBB4, RPTOR, MTOR, WBP2, FOXA1, HSPA1A, HSPA2, HSPA5, HSPA6, HSPA9, HSP90AB1, HSPH1, HSPA4L, DNAJA2, DNAJA3, DNAJB1, DNAJB4, DNAJB6, DNAJC7, DNAJC9, DNAJC10, HSPB8, HSPE1, PBX1, CARM1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 262_595 | 253 | 596 | AKAP13 |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 262_595 | 253 | 596 | AKAP13 |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 262_595 | 253 | 596 | AKAP13 |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 262_595 | 253 | 596 | AKAP13 |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 262_595 | -73 | 484 | AKAP13 |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000456483 | + | 0 | 8 | 35_174 | -73 | 484 | DDX5%3B self-association |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000206249 | + | 2 | 8 | 35_174 | 253 | 596 | DDX5%3B self-association |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000338799 | + | 3 | 9 | 35_174 | 253 | 596 | DDX5%3B self-association |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000440973 | + | 4 | 10 | 35_174 | 253 | 596 | DDX5%3B self-association |
| Tgene | ESR1 | chr12:15037147 | chr6:152265308 | ENST00000443427 | + | 3 | 9 | 35_174 | 253 | 596 | DDX5%3B self-association |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MGP_ESR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MGP | P08493 | DB01373 | Calcium | Matrix Gla protein | small molecule | approved|nutraceutical |
| Tgene | ESR1 | P03372 | DB00286 | Conjugated estrogens | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB00304 | Desogestrel | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB00648 | Mitotane | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB00655 | Estrone | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB00675 | Tamoxifen | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB00841 | Dobutamine | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB00977 | Ethinyl Estradiol | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB01406 | Danazol | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB01431 | Allylestrenol | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB06710 | Methyltestosterone | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB09369 | Polyestradiol phosphate | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB09371 | Norethynodrel | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB11071 | Phenyl salicylate | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB11619 | Gestrinone | Estrogen receptor | small molecule | approved |
| Tgene | ESR1 | P03372 | DB01185 | Fluoxymesterone | Estrogen receptor | small molecule | approved|illicit |
| Tgene | ESR1 | P03372 | DB00255 | Diethylstilbestrol | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00294 | Etonogestrel | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00367 | Levonorgestrel | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00481 | Raloxifene | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00539 | Toremifene | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00603 | Medroxyprogesterone acetate | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00624 | Testosterone | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00882 | Clomifene | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00890 | Dienestrol | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00947 | Fulvestrant | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB00957 | Norgestimate | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB01196 | Estramustine | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB01593 | Zinc | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB04930 | Permethrin | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB04938 | Ospemifene | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB06202 | Lasofoxifene | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB06401 | Bazedoxifene | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB09070 | Tibolone | Estrogen receptor | small molecule | approved|investigational |
| Tgene | ESR1 | P03372 | DB01708 | Prasterone | Estrogen receptor | small molecule | approved|investigational|nutraceutical |
| Tgene | ESR1 | P03372 | DB00783 | Estradiol | Estrogen receptor | small molecule | approved|investigational|vet_approved |
| Tgene | ESR1 | P03372 | DB04573 | Estriol | Estrogen receptor | small molecule | approved|investigational|vet_approved |
| Tgene | ESR1 | P03372 | DB01108 | Trilostane | Estrogen receptor | small molecule | approved|investigational|vet_approved|withdrawn |
| Tgene | ESR1 | P03372 | DB01065 | Melatonin | Estrogen receptor | small molecule | approved|nutraceutical|vet_approved |
| Tgene | ESR1 | P03372 | DB00396 | Progesterone | Estrogen receptor | small molecule | approved|vet_approved |
| Tgene | ESR1 | P03372 | DB01183 | Naloxone | Estrogen receptor | small molecule | approved|vet_approved |
| Tgene | ESR1 | P03372 | DB00431 | Lindane | Estrogen receptor | small molecule | approved|withdrawn |
| Tgene | ESR1 | P03372 | DB00756 | Hexachlorophene | Estrogen receptor | small molecule | approved|withdrawn |
| Tgene | ESR1 | P03372 | DB04824 | Phenolphthalein | Estrogen receptor | small molecule | approved|withdrawn |
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RelatedDiseases for MGP_ESR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MGP | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Hgene | MGP | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
| Hgene | MGP | C0000786 | Spontaneous abortion | 1 | CTD_human;HPO |
| Hgene | MGP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | MGP | C0041948 | Uremia | 1 | CTD_human |
| Hgene | MGP | C0042345 | Varicosity | 1 | CTD_human |
| Hgene | MGP | C0342649 | Vascular calcification | 1 | CTD_human |
| Hgene | MGP | C1855607 | Keutel syndrome | 1 | CTD_human;ORPHANET |
| Tgene | ESR1 | C1458155 | Mammary Neoplasms | 11 | CTD_human |
| Tgene | ESR1 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Tgene | ESR1 | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | ESR1 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | ESR1 | C0036341 | Schizophrenia | 5 | PSYGENET |
| Tgene | ESR1 | C0525045 | Mood Disorders | 4 | PSYGENET |
| Tgene | ESR1 | C0001418 | Adenocarcinoma | 2 | CTD_human |
| Tgene | ESR1 | C0021364 | Male infertility | 2 | CTD_human |
| Tgene | ESR1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
| Tgene | ESR1 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | ESR1 | C0025500 | Mesothelioma | 2 | CTD_human |
| Tgene | ESR1 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | ESR1 | C1956346 | Coronary Artery Disease | 2 | CTD_human |
| Tgene | ESR1 | C3809250 | ESTROGEN RESISTANCE | 2 | ORPHANET;UNIPROT |
| Tgene | ESR1 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Tgene | ESR1 | C0004114 | Astrocytoma | 1 | CTD_human |
| Tgene | ESR1 | C0004153 | Atherosclerosis | 1 | CTD_human |
| Tgene | ESR1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | ESR1 | C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
| Tgene | ESR1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Tgene | ESR1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Tgene | ESR1 | C0015799 | Feminization | 1 | CTD_human |
| Tgene | ESR1 | C0017658 | Glomerulonephritis | 1 | CTD_human |
| Tgene | ESR1 | C0021361 | Female infertility | 1 | CTD_human |
| Tgene | ESR1 | C0023267 | Fibroid Tumor | 1 | CTD_human |
| Tgene | ESR1 | C0023418 | leukemia | 1 | CTD_human |
| Tgene | ESR1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | ESR1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | ESR1 | C0024809 | Marijuana Abuse | 1 | PSYGENET |
| Tgene | ESR1 | C0026858 | Musculoskeletal Pain | 1 | CTD_human |
| Tgene | ESR1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
| Tgene | ESR1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | ESR1 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| Tgene | ESR1 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | ESR1 | C0028960 | Oligospermia | 1 | CTD_human |
| Tgene | ESR1 | C0033941 | Psychoses, Substance-Induced | 1 | CTD_human |
| Tgene | ESR1 | C0036939 | Shared Paranoid Disorder | 1 | PSYGENET |
| Tgene | ESR1 | C0149931 | Migraine Disorders | 1 | CTD_human |
| Tgene | ESR1 | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
| Tgene | ESR1 | C1720887 | Female Urogenital Diseases | 1 | CTD_human |
| Tgene | ESR1 | C2239176 | Liver carcinoma | 1 | CTD_human |
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