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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21823

FusionGeneSummary for MGA_ZFAND6

check button Fusion gene summary
Fusion gene informationFusion gene name: MGA_ZFAND6
Fusion gene ID: 21823
HgeneTgene
Gene symbol

MGA

ZFAND6

Gene ID

23269

54469

Gene nameMGA, MAX dimerization proteinzinc finger AN1-type containing 6
SynonymsMAD5|MXD5AWP1|ZA20D3|ZFAND5B
Cytomap

15q15.1

15q25.1

Type of geneprotein-codingprotein-coding
DescriptionMAX gene-associated proteinMAX dimerization protein 5AN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6
Modification date2018051920180522
UniProtAcc

Q8IWI9

Q6FIF0

Ensembl transtripts involved in fusion geneENST00000568630, ENST00000545763, 
ENST00000389936, ENST00000219905, 
ENST00000566586, ENST00000570161, 
ENST00000261749, ENST00000561060, 
ENST00000559157, ENST00000558494, 
ENST00000559835, ENST00000559775, 
ENST00000558688, ENST00000558087, 
Fusion gene scores* DoF score14 X 10 X 9=12603 X 3 X 2=18
# samples 144
** MAII scorelog2(14/1260*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MGA [Title/Abstract] AND ZFAND6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-5506-01AMGAchr15

41913496

+ZFAND6chr15

80412670

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000568630ENST00000261749MGAchr15

41913496

+ZFAND6chr15

80412670

+
3UTR-5UTRENST00000568630ENST00000561060MGAchr15

41913496

+ZFAND6chr15

80412670

+
3UTR-5UTRENST00000568630ENST00000559157MGAchr15

41913496

+ZFAND6chr15

80412670

+
3UTR-5UTRENST00000568630ENST00000558494MGAchr15

41913496

+ZFAND6chr15

80412670

+
3UTR-5UTRENST00000568630ENST00000559835MGAchr15

41913496

+ZFAND6chr15

80412670

+
3UTR-5UTRENST00000568630ENST00000559775MGAchr15

41913496

+ZFAND6chr15

80412670

+
3UTR-5UTRENST00000568630ENST00000558688MGAchr15

41913496

+ZFAND6chr15

80412670

+
3UTR-5UTRENST00000568630ENST00000558087MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000545763ENST00000261749MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000545763ENST00000561060MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000545763ENST00000559157MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000545763ENST00000558494MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000545763ENST00000559835MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000545763ENST00000559775MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000545763ENST00000558688MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000545763ENST00000558087MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000389936ENST00000261749MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000389936ENST00000561060MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000389936ENST00000559157MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000389936ENST00000558494MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000389936ENST00000559835MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000389936ENST00000559775MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000389936ENST00000558688MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000389936ENST00000558087MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000219905ENST00000261749MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000219905ENST00000561060MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000219905ENST00000559157MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000219905ENST00000558494MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000219905ENST00000559835MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000219905ENST00000559775MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000219905ENST00000558688MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000219905ENST00000558087MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000566586ENST00000261749MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000566586ENST00000561060MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000566586ENST00000559157MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000566586ENST00000558494MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000566586ENST00000559835MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000566586ENST00000559775MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000566586ENST00000558688MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000566586ENST00000558087MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000570161ENST00000261749MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000570161ENST00000561060MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000570161ENST00000559157MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000570161ENST00000558494MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000570161ENST00000559835MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000570161ENST00000559775MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000570161ENST00000558688MGAchr15

41913496

+ZFAND6chr15

80412670

+
intron-5UTRENST00000570161ENST00000558087MGAchr15

41913496

+ZFAND6chr15

80412670

+

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FusionProtFeatures for MGA_ZFAND6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGA

Q8IWI9

ZFAND6

Q6FIF0

Functions as a dual-specificity transcription factor,regulating the expression of both MAX-network and T-box familytarget genes. Functions as a repressor or an activator. Binds to5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulateMYC-MAX target genes. Suppresses transcriptional activation by MYCand inhibits MYC-dependent cell transformation. Function activatedby heterodimerization with MAX. This heterodimerization serves thedual function of both generating an E-box-binding heterodimer andsimultaneously blocking interaction of a corepressor (Bysimilarity). {ECO:0000250}. Involved in regulation of TNF-alpha induced NF-kappa-Bactivation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreasesassociation of TRAF2 with RIPK1. Required for PTS1 targetsequence-dependent protein import into peroxisomes and PEX5stability; may cooperate with PEX6. In vitro involved in PEX5export from the cytosol to peroxisomes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19285159,ECO:0000269|PubMed:21810480}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MGA_ZFAND6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MGA_ZFAND6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MGAE2F1, E2F3, E2F4, CBX3, MAX, PCGF3, PCGF6, RNF2, CBX2, CBX4, RYBP, YAF2, CD2BP2, SMAD1, LSM8, HIST3H3, OBSL1, EED, PSME3, RFPL4B, E2F6, WBP2NL, WDR5, CARD8, LTBR, PSMC3, MIER2, UNK, NIN, HIST1H3E, HDAC1, ZMYND8, KDM5C, ALKBH3, RC3H1, ATOH1, L3MBTL2, ZNF692, KLHL40, MLX, CDC16, CDH19, ASB6, DYNC1I1, CYLDZFAND6TRAF2, UBC, CDC34, USP3, WIPI2, PPP2R1A, TRAF5, CDV3, CIRBP, GSS, HNRNPA3, NONO, TXLNG, BIRC2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MGA_ZFAND6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MGA_ZFAND6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMGAC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneMGAC0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneMGAC0079772T-Cell Lymphoma1CTD_human
TgeneZFAND6C0037274Dermatologic disorders1CTD_human
TgeneZFAND6C0311375Arsenic Poisoning1CTD_human
TgeneZFAND6C0520757Delayed Emergence from Anesthesia1CTD_human