![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 21821 |
FusionGeneSummary for MGA_TMED7-TICAM2 |
![]() |
Fusion gene information | Fusion gene name: MGA_TMED7-TICAM2 | Fusion gene ID: 21821 | Hgene | Tgene | Gene symbol | MGA | TMED7-TICAM2 | Gene ID | 23269 | 100302736 |
Gene name | MGA, MAX dimerization protein | TMED7-TICAM2 readthrough | |
Synonyms | MAD5|MXD5 | - | |
Cytomap | 15q15.1 | 5q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | MAX gene-associated proteinMAX dimerization protein 5 | TRAM adaptor with GOLD domainTMED7-TICAM2 read-through transcript | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8IWI9 | ||
Ensembl transtripts involved in fusion gene | ENST00000568630, ENST00000545763, ENST00000389936, ENST00000219905, ENST00000566586, ENST00000570161, | ENST00000282382, ENST00000333314, | |
Fusion gene scores | * DoF score | 14 X 10 X 9=1260 | 2 X 2 X 1=4 |
# samples | 14 | 2 | |
** MAII score | log2(14/1260*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: MGA [Title/Abstract] AND TMED7-TICAM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA249870 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000568630 | ENST00000282382 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
intron-3CDS | ENST00000568630 | ENST00000333314 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000545763 | ENST00000282382 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000545763 | ENST00000333314 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000389936 | ENST00000282382 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000389936 | ENST00000333314 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000219905 | ENST00000282382 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000219905 | ENST00000333314 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000566586 | ENST00000282382 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000566586 | ENST00000333314 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000570161 | ENST00000282382 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Frame-shift | ENST00000570161 | ENST00000333314 | MGA | chr15 | 41961235 | + | TMED7-TICAM2 | chr5 | 114961407 | - |
Top |
FusionProtFeatures for MGA_TMED7-TICAM2 |
![]() |
Hgene | Tgene |
MGA | TMED7-TICAM2 |
Functions as a dual-specificity transcription factor,regulating the expression of both MAX-network and T-box familytarget genes. Functions as a repressor or an activator. Binds to5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulateMYC-MAX target genes. Suppresses transcriptional activation by MYCand inhibits MYC-dependent cell transformation. Function activatedby heterodimerization with MAX. This heterodimerization serves thedual function of both generating an E-box-binding heterodimer andsimultaneously blocking interaction of a corepressor (Bysimilarity). {ECO:0000250}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MGA_TMED7-TICAM2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MGA_TMED7-TICAM2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MGA_TMED7-TICAM2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MGA_TMED7-TICAM2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MGA | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | MGA | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
Hgene | MGA | C0079772 | T-Cell Lymphoma | 1 | CTD_human |