![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 21820 |
FusionGeneSummary for MGA_STRC |
![]() |
Fusion gene information | Fusion gene name: MGA_STRC | Fusion gene ID: 21820 | Hgene | Tgene | Gene symbol | MGA | STRC | Gene ID | 23269 | 161497 |
Gene name | MGA, MAX dimerization protein | stereocilin | |
Synonyms | MAD5|MXD5 | DFNB16 | |
Cytomap | 15q15.1 | 15q15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | MAX gene-associated proteinMAX dimerization protein 5 | stereocilin | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8IWI9 | Q7RTU9 | |
Ensembl transtripts involved in fusion gene | ENST00000568630, ENST00000545763, ENST00000389936, ENST00000219905, ENST00000566586, ENST00000570161, | ENST00000450892, ENST00000541030, | |
Fusion gene scores | * DoF score | 14 X 10 X 9=1260 | 2 X 1 X 2=4 |
# samples | 14 | 2 | |
** MAII score | log2(14/1260*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: MGA [Title/Abstract] AND STRC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-MB-A8JL-01A | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000568630 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
3UTR-3CDS | ENST00000568630 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000545763 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000545763 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000389936 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000389936 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000219905 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000219905 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000566586 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000566586 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000570161 | ENST00000450892 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
intron-3CDS | ENST00000570161 | ENST00000541030 | MGA | chr15 | 41913496 | + | STRC | chr15 | 43897597 | - |
Top |
FusionProtFeatures for MGA_STRC |
![]() |
Hgene | Tgene |
MGA | STRC |
Functions as a dual-specificity transcription factor,regulating the expression of both MAX-network and T-box familytarget genes. Functions as a repressor or an activator. Binds to5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulateMYC-MAX target genes. Suppresses transcriptional activation by MYCand inhibits MYC-dependent cell transformation. Function activatedby heterodimerization with MAX. This heterodimerization serves thedual function of both generating an E-box-binding heterodimer andsimultaneously blocking interaction of a corepressor (Bysimilarity). {ECO:0000250}. | Essential to the formation of horizontal top connectorsbetween outer hair cell stereocilia. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MGA_STRC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MGA_STRC |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MGA | E2F1, E2F3, E2F4, CBX3, MAX, PCGF3, PCGF6, RNF2, CBX2, CBX4, RYBP, YAF2, CD2BP2, SMAD1, LSM8, HIST3H3, OBSL1, EED, PSME3, RFPL4B, E2F6, WBP2NL, WDR5, CARD8, LTBR, PSMC3, MIER2, UNK, NIN, HIST1H3E, HDAC1, ZMYND8, KDM5C, ALKBH3, RC3H1, ATOH1, L3MBTL2, ZNF692, KLHL40, MLX, CDC16, CDH19, ASB6, DYNC1I1, CYLD | STRC |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MGA_STRC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MGA_STRC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MGA | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | MGA | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
Hgene | MGA | C0079772 | T-Cell Lymphoma | 1 | CTD_human |