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Fusion gene ID: 21813 |
FusionGeneSummary for MGA_MGA |
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Fusion gene information | Fusion gene name: MGA_MGA | Fusion gene ID: 21813 | Hgene | Tgene | Gene symbol | MGA | MGA | Gene ID | 23269 | 23269 |
Gene name | MGA, MAX dimerization protein | MGA, MAX dimerization protein | |
Synonyms | MAD5|MXD5 | MAD5|MXD5 | |
Cytomap | 15q15.1 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | MAX gene-associated proteinMAX dimerization protein 5 | MAX gene-associated proteinMAX dimerization protein 5 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8IWI9 | Q8IWI9 | |
Ensembl transtripts involved in fusion gene | ENST00000568630, ENST00000545763, ENST00000389936, ENST00000219905, ENST00000566586, ENST00000570161, | ENST00000568630, ENST00000545763, ENST00000389936, ENST00000219905, ENST00000566586, ENST00000570161, | |
Fusion gene scores | * DoF score | 14 X 10 X 9=1260 | 3 X 3 X 3=27 |
# samples | 14 | 4 | |
** MAII score | log2(14/1260*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MGA [Title/Abstract] AND MGA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AV747640 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + | ||
ChiTaRS3.1 | AV751072 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000568630 | ENST00000568630 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
intron-intron | ENST00000568630 | ENST00000545763 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
intron-intron | ENST00000568630 | ENST00000389936 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
intron-intron | ENST00000568630 | ENST00000219905 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
intron-intron | ENST00000568630 | ENST00000566586 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
intron-intron | ENST00000568630 | ENST00000570161 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000545763 | ENST00000568630 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000545763 | ENST00000545763 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000545763 | ENST00000389936 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000545763 | ENST00000219905 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000545763 | ENST00000566586 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000545763 | ENST00000570161 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000389936 | ENST00000568630 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000389936 | ENST00000545763 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000389936 | ENST00000389936 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000389936 | ENST00000219905 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000389936 | ENST00000566586 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000389936 | ENST00000570161 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000219905 | ENST00000568630 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000219905 | ENST00000545763 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000219905 | ENST00000389936 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000219905 | ENST00000219905 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000219905 | ENST00000566586 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000219905 | ENST00000570161 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000566586 | ENST00000568630 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000566586 | ENST00000545763 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000566586 | ENST00000389936 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000566586 | ENST00000219905 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000566586 | ENST00000566586 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000566586 | ENST00000570161 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000570161 | ENST00000568630 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000570161 | ENST00000545763 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000570161 | ENST00000389936 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000570161 | ENST00000219905 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000570161 | ENST00000566586 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
3UTR-intron | ENST00000570161 | ENST00000570161 | MGA | chr15 | 42060165 | + | MGA | chr15 | 42040931 | + |
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FusionProtFeatures for MGA_MGA |
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Hgene | Tgene |
MGA | MGA |
Functions as a dual-specificity transcription factor,regulating the expression of both MAX-network and T-box familytarget genes. Functions as a repressor or an activator. Binds to5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulateMYC-MAX target genes. Suppresses transcriptional activation by MYCand inhibits MYC-dependent cell transformation. Function activatedby heterodimerization with MAX. This heterodimerization serves thedual function of both generating an E-box-binding heterodimer andsimultaneously blocking interaction of a corepressor (Bysimilarity). {ECO:0000250}. | Functions as a dual-specificity transcription factor,regulating the expression of both MAX-network and T-box familytarget genes. Functions as a repressor or an activator. Binds to5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulateMYC-MAX target genes. Suppresses transcriptional activation by MYCand inhibits MYC-dependent cell transformation. Function activatedby heterodimerization with MAX. This heterodimerization serves thedual function of both generating an E-box-binding heterodimer andsimultaneously blocking interaction of a corepressor (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MGA_MGA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MGA_MGA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MGA_MGA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MGA_MGA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MGA | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | MGA | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
Hgene | MGA | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
Tgene | MGA | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | MGA | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
Tgene | MGA | C0079772 | T-Cell Lymphoma | 1 | CTD_human |