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Fusion gene ID: 21780 |
FusionGeneSummary for MFSD6_CXorf66 |
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Fusion gene information | Fusion gene name: MFSD6_CXorf66 | Fusion gene ID: 21780 | Hgene | Tgene | Gene symbol | MFSD6 | CXorf66 | Gene ID | 54842 | 347487 |
Gene name | major facilitator superfamily domain containing 6 | chromosome X open reading frame 66 | |
Synonyms | MMR2|hMMR2 | SGPX | |
Cytomap | 2q32.2 | Xq27.1 | |
Type of gene | protein-coding | protein-coding | |
Description | major facilitator superfamily domain-containing protein 6macrophage MHC class I receptor 2 homologmacrophage MHC receptor 2 | uncharacterized protein CXorf66RP11-35F15.2secreted glycoprotein, X-linked | |
Modification date | 20180329 | 20180329 | |
UniProtAcc | Q6ZSS7 | Q5JRM2 | |
Ensembl transtripts involved in fusion gene | ENST00000392328, ENST00000281416, ENST00000535751, ENST00000489793, | ENST00000370540, | |
Fusion gene scores | * DoF score | 6 X 2 X 4=48 | 3 X 1 X 2=6 |
# samples | 6 | 3 | |
** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/6*10)=2.32192809488736 | |
Context | PubMed: MFSD6 [Title/Abstract] AND CXorf66 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-A8-A06U-01A | MFSD6 | chr2 | 191302287 | + | CXorf66 | chrX | 139040376 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000392328 | ENST00000370540 | MFSD6 | chr2 | 191302287 | + | CXorf66 | chrX | 139040376 | - |
Frame-shift | ENST00000281416 | ENST00000370540 | MFSD6 | chr2 | 191302287 | + | CXorf66 | chrX | 139040376 | - |
intron-3CDS | ENST00000535751 | ENST00000370540 | MFSD6 | chr2 | 191302287 | + | CXorf66 | chrX | 139040376 | - |
intron-3CDS | ENST00000489793 | ENST00000370540 | MFSD6 | chr2 | 191302287 | + | CXorf66 | chrX | 139040376 | - |
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FusionProtFeatures for MFSD6_CXorf66 |
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Hgene | Tgene |
MFSD6 | CXorf66 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MFSD6_CXorf66 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MFSD6_CXorf66 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MFSD6 | CXorf66 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MFSD6_CXorf66 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MFSD6_CXorf66 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |