FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 21774

FusionGeneSummary for MFSD2A_LAPTM5

check button Fusion gene summary
Fusion gene informationFusion gene name: MFSD2A_LAPTM5
Fusion gene ID: 21774
HgeneTgene
Gene symbol

MFSD2A

LAPTM5

Gene ID

84879

7805

Gene namemajor facilitator superfamily domain containing 2Alysosomal protein transmembrane 5
SynonymsMCPH15|MFSD2|NLS1CLAST6
Cytomap

1p34.2

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionsodium-dependent lysophosphatidylcholine symporter 1major facilitator superfamily domain-containing protein 2Asodium-dependent LPC symporter 1lysosomal-associated transmembrane protein 5CD40-ligand-activated specific transcriptshuman retinoic acid-inducible E3 proteinlysosomal associated multispanning membrane protein 5lysosomal multispanning membrane protein 5lysosomal-associated multitra
Modification date2018032920180523
UniProtAcc

Q8NA29

Q13571

Ensembl transtripts involved in fusion geneENST00000372811, ENST00000420632, 
ENST00000372809, ENST00000480630, 
ENST00000294507, ENST00000476492, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 1 X 4=12
# samples 54
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MFSD2A [Title/Abstract] AND LAPTM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMFSD2A

GO:0051977

lysophospholipid transport

24828044


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-CS-6188-01AMFSD2Achr1

40421057

+LAPTM5chr1

31215396

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000372811ENST00000294507MFSD2Achr1

40421057

+LAPTM5chr1

31215396

-
5CDS-5UTRENST00000372811ENST00000476492MFSD2Achr1

40421057

+LAPTM5chr1

31215396

-
5UTR-3CDSENST00000420632ENST00000294507MFSD2Achr1

40421057

+LAPTM5chr1

31215396

-
5UTR-5UTRENST00000420632ENST00000476492MFSD2Achr1

40421057

+LAPTM5chr1

31215396

-
In-frameENST00000372809ENST00000294507MFSD2Achr1

40421057

+LAPTM5chr1

31215396

-
5CDS-5UTRENST00000372809ENST00000476492MFSD2Achr1

40421057

+LAPTM5chr1

31215396

-
intron-3CDSENST00000480630ENST00000294507MFSD2Achr1

40421057

+LAPTM5chr1

31215396

-
intron-5UTRENST00000480630ENST00000476492MFSD2Achr1

40421057

+LAPTM5chr1

31215396

-

Top

FusionProtFeatures for MFSD2A_LAPTM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFSD2A

Q8NA29

LAPTM5

Q13571

Sodium-dependent lysophosphatidylcholine (LPC)symporter, which plays an essential role for blood-brain barrierformation and function (By similarity). Specifically expressed inendothelium of the blood-brain barrier of micro-vessels andtransports LPC into the brain (By similarity). Transport of LPC isessential because it constitutes the major mechanism by whichdocosahexaenoic acid (DHA), an omega-3 fatty acid that isessential for normal brain growth and cognitive function, entersthe brain (PubMed:26005868). Transports LPC carrying long-chainfatty acids such LPC oleate and LPC palmitate with a minimum acylchain length of 14 carbons (By similarity). Does not transportdocosahexaenoic acid in unesterified fatty acid (By similarity).Specifically required for blood-brain barrier formation andfunction, probably by mediating lipid transport (By similarity).Not required for central nervous system vascular morphogenesis (Bysimilarity). Acts as a transporter for tunicamycin, an inhibitorof asparagine-linked glycosylation (PubMed:21677192). In placenta,acts as a receptor for ERVFRD-1/syncytin-2 and is required fortrophoblast fusion (PubMed:18988732, PubMed:23177091).{ECO:0000250|UniProtKB:Q9DA75, ECO:0000269|PubMed:18988732,ECO:0000269|PubMed:21677192, ECO:0000269|PubMed:23177091,ECO:0000269|PubMed:26005868}. May have a special functional role during embryogenesisand in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAPTM5chr1:40421057chr1:31215396ENST00000294507-08246_25829263Compositional biasNote=Pro-rich
TgeneLAPTM5chr1:40421057chr1:31215396ENST00000294507-08134_15429263TransmembraneHelical
TgeneLAPTM5chr1:40421057chr1:31215396ENST00000294507-08184_20429263TransmembraneHelical
TgeneLAPTM5chr1:40421057chr1:31215396ENST00000294507-0864_8429263TransmembraneHelical
TgeneLAPTM5chr1:40421057chr1:31215396ENST00000294507-0892_11229263TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+11435_3831544Compositional biasNote=Poly-Lys
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+11435_3831531Compositional biasNote=Poly-Lys
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114102_12831544Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114150_16031544Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114182_25631544Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+1141_4631544Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114278_31031544Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114332_34431544Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114366_37031544Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114392_39331544Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114415_43731544Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114459_48031544Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114502_54331544Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+11468_8031544Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114102_12831531Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114150_16031531Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114182_25631531Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+1141_4631531Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114278_31031531Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114332_34431531Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114366_37031531Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114392_39331531Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114415_43731531Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114459_48031531Topological domainExtracellular
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114502_54331531Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+11468_8031531Topological domainCytoplasmic
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114129_14931544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114161_18131544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114257_27731544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114311_33131544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114345_36531544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114371_39131544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114394_41431544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114438_45831544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+11447_6731544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+114481_50131544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372809+11481_10131544TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114129_14931531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114161_18131531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114257_27731531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114311_33131531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114345_36531531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114371_39131531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114394_41431531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114438_45831531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+11447_6731531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+114481_50131531TransmembraneHelical
HgeneMFSD2Achr1:40421057chr1:31215396ENST00000372811+11481_10131531TransmembraneHelical
TgeneLAPTM5chr1:40421057chr1:31215396ENST00000294507-0819_3929263TransmembraneHelical


Top

FusionGeneSequence for MFSD2A_LAPTM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MFSD2A_ENST00000372811_chr1_40421057_+_LAPTM5_ENST00000294507_chr1_31215396_-_265aa
MAKGEGAESGSAAGLLPTSILQSTERPAQVKIMSVLLFIEHSVEVAHGKASCKLSQMGYLRIADLISSFLLITMLFIISLSLLIGVVKNR
EKYLLPFLSLQIMDYLLCLLTLLGSYIELPAYLKLASRSRASSSKFPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQED

>In-frame_MFSD2A_ENST00000372809_chr1_40421057_+_LAPTM5_ENST00000294507_chr1_31215396_-_265aa
MAKGEGAESGSAAGLLPTSILQSTERPAQVKIMSVLLFIEHSVEVAHGKASCKLSQMGYLRIADLISSFLLITMLFIISLSLLIGVVKNR
EKYLLPFLSLQIMDYLLCLLTLLGSYIELPAYLKLASRSRASSSKFPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQED


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MFSD2A_ENST00000372811_chr1_40421057_+_LAPTM5_ENST00000294507_chr1_31215396_-_795nt
ATGGCCAAAGGAGAAGGCGCCGAGAGCGGCTCCGCGGCGGGGCTGCTACCCACCAGCATCCTCCAAAGCACTGAACGCCCGGCCCAGGTG
AAGATCATGAGCGTCTTGTTGTTCATCGAGCACTCAGTAGAGGTGGCCCATGGCAAGGCGTCCTGCAAGCTCTCCCAGATGGGCTACCTC
AGGATCGCTGACCTGATCTCCAGCTTCCTGCTCATCACCATGCTCTTCATCATCAGCCTGAGCCTACTGATCGGCGTAGTCAAGAACCGG
GAGAAGTACCTGCTGCCCTTCCTGTCCCTGCAAATCATGGACTATCTCCTGTGCCTGCTCACCCTGCTGGGCTCCTACATTGAGCTGCCC
GCCTACCTCAAGTTGGCCTCCCGGAGCCGTGCTAGCTCCTCCAAGTTCCCCCTGATGACGCTGCAGCTGCTGGACTTCTGCCTGAGCATC
CTGACCCTCTGCAGCTCCTACATGGAAGTGCCCACCTATCTCAACTTCAAGTCCATGAACCACATGAATTACCTCCCCAGCCAGGAGGAT
ATGCCTCATAACCAGTTCATCAAGATGATGATCATCTTTTCCATCGCCTTCATCACTGTCCTTATCTTCAAGGTCTACATGTTCAAGTGC
GTGTGGCGGTGCTACAGATTGATCAAGTGCATGAACTCGGTGGAGGAGAAGAGAAACTCCAAGATGCTCCAGAAGGTGGTCCTGCCGTCC

>In-frame_MFSD2A_ENST00000372809_chr1_40421057_+_LAPTM5_ENST00000294507_chr1_31215396_-_795nt
ATGGCCAAAGGAGAAGGCGCCGAGAGCGGCTCCGCGGCGGGGCTGCTACCCACCAGCATCCTCCAAAGCACTGAACGCCCGGCCCAGGTG
AAGATCATGAGCGTCTTGTTGTTCATCGAGCACTCAGTAGAGGTGGCCCATGGCAAGGCGTCCTGCAAGCTCTCCCAGATGGGCTACCTC
AGGATCGCTGACCTGATCTCCAGCTTCCTGCTCATCACCATGCTCTTCATCATCAGCCTGAGCCTACTGATCGGCGTAGTCAAGAACCGG
GAGAAGTACCTGCTGCCCTTCCTGTCCCTGCAAATCATGGACTATCTCCTGTGCCTGCTCACCCTGCTGGGCTCCTACATTGAGCTGCCC
GCCTACCTCAAGTTGGCCTCCCGGAGCCGTGCTAGCTCCTCCAAGTTCCCCCTGATGACGCTGCAGCTGCTGGACTTCTGCCTGAGCATC
CTGACCCTCTGCAGCTCCTACATGGAAGTGCCCACCTATCTCAACTTCAAGTCCATGAACCACATGAATTACCTCCCCAGCCAGGAGGAT
ATGCCTCATAACCAGTTCATCAAGATGATGATCATCTTTTCCATCGCCTTCATCACTGTCCTTATCTTCAAGGTCTACATGTTCAAGTGC
GTGTGGCGGTGCTACAGATTGATCAAGTGCATGAACTCGGTGGAGGAGAAGAGAAACTCCAAGATGCTCCAGAAGGTGGTCCTGCCGTCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MFSD2A_ENST00000372811_chr1_40421057_+_LAPTM5_ENST00000294507_chr1_31215396_-_2317nt
GAGGGGGCGTGCAGCAGAGTGCGTTCCTCGTCTGCCAGCCGGCTTGGCTAGCGCGCGGCGGCCGTGGCTAAGGCTGCTACGAAGCGAGCT
TGGGAGGAGCAGCGGCCTGCGGGGCAGAGGAGCATCCCGTCTACCAGGTCCCAAGCGGCGTGGCCCGCGGGTCATGGCCAAAGGAGAAGG
CGCCGAGAGCGGCTCCGCGGCGGGGCTGCTACCCACCAGCATCCTCCAAAGCACTGAACGCCCGGCCCAGGTGAAGATCATGAGCGTCTT
GTTGTTCATCGAGCACTCAGTAGAGGTGGCCCATGGCAAGGCGTCCTGCAAGCTCTCCCAGATGGGCTACCTCAGGATCGCTGACCTGAT
CTCCAGCTTCCTGCTCATCACCATGCTCTTCATCATCAGCCTGAGCCTACTGATCGGCGTAGTCAAGAACCGGGAGAAGTACCTGCTGCC
CTTCCTGTCCCTGCAAATCATGGACTATCTCCTGTGCCTGCTCACCCTGCTGGGCTCCTACATTGAGCTGCCCGCCTACCTCAAGTTGGC
CTCCCGGAGCCGTGCTAGCTCCTCCAAGTTCCCCCTGATGACGCTGCAGCTGCTGGACTTCTGCCTGAGCATCCTGACCCTCTGCAGCTC
CTACATGGAAGTGCCCACCTATCTCAACTTCAAGTCCATGAACCACATGAATTACCTCCCCAGCCAGGAGGATATGCCTCATAACCAGTT
CATCAAGATGATGATCATCTTTTCCATCGCCTTCATCACTGTCCTTATCTTCAAGGTCTACATGTTCAAGTGCGTGTGGCGGTGCTACAG
ATTGATCAAGTGCATGAACTCGGTGGAGGAGAAGAGAAACTCCAAGATGCTCCAGAAGGTGGTCCTGCCGTCCTACGAGGAAGCCCTGTC
TTTGCCATCGAAGACCCCAGAGGGGGGCCCAGCACCACCCCCATACTCAGAGGTGTGACCCTCGCCAGGCCCCAGCCCCAGTGCTGGGAG
GGGTGGAGCTGCCTCATAATCTGCTTTTTTGCTTTGGTGGCCCCTGTGGCCTGGGTGGGCCCTCCCGCCCCTCCCTGGCAGGACAATCTG
CTTGTGTCTCCCTCGCTGGCCTGCTCCTCCTGCAGGGCCTGTGAGCTGCTCACAACTGGGTCAACGCTTTAGGCTGAGTCACTCCTCGGG
TCTCTCCATAATTCAGCCCAACAATGCTTGGTTTATTTCAATCAGCTCTGACACTTGTTTAGACGATTGGCCATTCTAAAGTTGGTGAGT
TTGTCAAGCAACTATCGACTTGATCAGTTCAGCCAAGCAACTGACAAATCAAAAACCCACTTGTCAGTTCAGTAAAATAATTTGGTCAAA
CAACAGTCTATTGCATTGATTTATAAATAGTTGTCAGTTCACATAGCAATTTAATCAAGTAATCATTAATTAGTTACCCCCTATATATAA
ATATATGTAATCAATTTCTTCAAATAGCTTGCTTACATGATAATCAATTAGCCAACCATGAGTCATTTAGAATAGTGATAAATAGAATAC
ACAGAATAGTGATGAAATTCAATTTAAAAAATCACGTTAGCCTCCAAACCATTTAATTCAAATGAACCCATCAACTGGATGCCAACTCTG
GCGAATGTAGGACCTCTGAGTGGCTGTATAATTGTTAATTCAAATGAAATTCATTTAAACAGTTGACAAACTGTCATTCAACAATTAGCT
CCAGGAAATAACAGTTATTTCATCATAAAACAGTCCCTTCAAACACACAATTGTTCTGCTGAAGAGTTGTCATCAACAATCCAATGCTCA
CCTATTCAGTTGCTCTGTGGTCAGTGTGGCTGCATAACAGTGGATTCCATGAAAGGAGTCATTTTAGTGATGAGCTGCCAGTCCATTCCC
AGGCCAGGCTGTCGCTGGCCATCCATTCAGTCGATTCAGTCATAGGCGAATCTGTTCTGCCCGAGGCTTGTGGTCAAGCAAAAATTCAGC
CCTGAAATCAGGCACATCTGTTCGTTGGACTAAACCCACAGGTTAGTTCAGTCAAAGCAGGCAACCCCCTTGTGGGCACTGACCCTGCCA
CTGGGGTCATGGCGGTTGTGGCAGCTGGGGAGGTTTGGCCCCAACAGCCCTCCTGTGCCTGCTTCCCTGTGTGTCGGGGTCCTCCAGGGA
GCTGACCCAGAGGTGGAGGCCACGGAGGCAGGGTCTCTGGGGACTGTCGGGGGGTACAGAGGGAGAAGGCTCTGCAAGAGCTCCCTGGCA

>In-frame_MFSD2A_ENST00000372809_chr1_40421057_+_LAPTM5_ENST00000294507_chr1_31215396_-_2297nt
GCGTTCCTCGTCTGCCAGCCGGCTTGGCTAGCGCGCGGCGGCCGTGGCTAAGGCTGCTACGAAGCGAGCTTGGGAGGAGCAGCGGCCTGC
GGGGCAGAGGAGCATCCCGTCTACCAGGTCCCAAGCGGCGTGGCCCGCGGGTCATGGCCAAAGGAGAAGGCGCCGAGAGCGGCTCCGCGG
CGGGGCTGCTACCCACCAGCATCCTCCAAAGCACTGAACGCCCGGCCCAGGTGAAGATCATGAGCGTCTTGTTGTTCATCGAGCACTCAG
TAGAGGTGGCCCATGGCAAGGCGTCCTGCAAGCTCTCCCAGATGGGCTACCTCAGGATCGCTGACCTGATCTCCAGCTTCCTGCTCATCA
CCATGCTCTTCATCATCAGCCTGAGCCTACTGATCGGCGTAGTCAAGAACCGGGAGAAGTACCTGCTGCCCTTCCTGTCCCTGCAAATCA
TGGACTATCTCCTGTGCCTGCTCACCCTGCTGGGCTCCTACATTGAGCTGCCCGCCTACCTCAAGTTGGCCTCCCGGAGCCGTGCTAGCT
CCTCCAAGTTCCCCCTGATGACGCTGCAGCTGCTGGACTTCTGCCTGAGCATCCTGACCCTCTGCAGCTCCTACATGGAAGTGCCCACCT
ATCTCAACTTCAAGTCCATGAACCACATGAATTACCTCCCCAGCCAGGAGGATATGCCTCATAACCAGTTCATCAAGATGATGATCATCT
TTTCCATCGCCTTCATCACTGTCCTTATCTTCAAGGTCTACATGTTCAAGTGCGTGTGGCGGTGCTACAGATTGATCAAGTGCATGAACT
CGGTGGAGGAGAAGAGAAACTCCAAGATGCTCCAGAAGGTGGTCCTGCCGTCCTACGAGGAAGCCCTGTCTTTGCCATCGAAGACCCCAG
AGGGGGGCCCAGCACCACCCCCATACTCAGAGGTGTGACCCTCGCCAGGCCCCAGCCCCAGTGCTGGGAGGGGTGGAGCTGCCTCATAAT
CTGCTTTTTTGCTTTGGTGGCCCCTGTGGCCTGGGTGGGCCCTCCCGCCCCTCCCTGGCAGGACAATCTGCTTGTGTCTCCCTCGCTGGC
CTGCTCCTCCTGCAGGGCCTGTGAGCTGCTCACAACTGGGTCAACGCTTTAGGCTGAGTCACTCCTCGGGTCTCTCCATAATTCAGCCCA
ACAATGCTTGGTTTATTTCAATCAGCTCTGACACTTGTTTAGACGATTGGCCATTCTAAAGTTGGTGAGTTTGTCAAGCAACTATCGACT
TGATCAGTTCAGCCAAGCAACTGACAAATCAAAAACCCACTTGTCAGTTCAGTAAAATAATTTGGTCAAACAACAGTCTATTGCATTGAT
TTATAAATAGTTGTCAGTTCACATAGCAATTTAATCAAGTAATCATTAATTAGTTACCCCCTATATATAAATATATGTAATCAATTTCTT
CAAATAGCTTGCTTACATGATAATCAATTAGCCAACCATGAGTCATTTAGAATAGTGATAAATAGAATACACAGAATAGTGATGAAATTC
AATTTAAAAAATCACGTTAGCCTCCAAACCATTTAATTCAAATGAACCCATCAACTGGATGCCAACTCTGGCGAATGTAGGACCTCTGAG
TGGCTGTATAATTGTTAATTCAAATGAAATTCATTTAAACAGTTGACAAACTGTCATTCAACAATTAGCTCCAGGAAATAACAGTTATTT
CATCATAAAACAGTCCCTTCAAACACACAATTGTTCTGCTGAAGAGTTGTCATCAACAATCCAATGCTCACCTATTCAGTTGCTCTGTGG
TCAGTGTGGCTGCATAACAGTGGATTCCATGAAAGGAGTCATTTTAGTGATGAGCTGCCAGTCCATTCCCAGGCCAGGCTGTCGCTGGCC
ATCCATTCAGTCGATTCAGTCATAGGCGAATCTGTTCTGCCCGAGGCTTGTGGTCAAGCAAAAATTCAGCCCTGAAATCAGGCACATCTG
TTCGTTGGACTAAACCCACAGGTTAGTTCAGTCAAAGCAGGCAACCCCCTTGTGGGCACTGACCCTGCCACTGGGGTCATGGCGGTTGTG
GCAGCTGGGGAGGTTTGGCCCCAACAGCCCTCCTGTGCCTGCTTCCCTGTGTGTCGGGGTCCTCCAGGGAGCTGACCCAGAGGTGGAGGC
CACGGAGGCAGGGTCTCTGGGGACTGTCGGGGGGTACAGAGGGAGAAGGCTCTGCAAGAGCTCCCTGGCAATACCCCCTTGTGTAATTGC


Top

FusionGenePPI for MFSD2A_LAPTM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MFSD2ALAPTM5NEDD4, UBC, GGA3, ITCH, LAMP1, TNFAIP3, EPS15, UBA52, RNF168, ANKRD13A, TOM1L2, USP13, DCUN1D1, NEDD4L, WWP1, EPN3, SMURF2, HEYL, HEY1, EPN1, BAG3, DISP1, LDLRAD1, TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MFSD2A_LAPTM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MFSD2A_LAPTM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMFSD2AC0025958Microcephaly2CTD_human
HgeneMFSD2AC4225310MICROCEPHALY 15, PRIMARY, AUTOSOMAL RECESSIVE2UNIPROT
HgeneMFSD2AC0037822Speech Disorders1CTD_human
HgeneMFSD2AC3714756Intellectual Disability1CTD_human
TgeneLAPTM5C0017661IGA Glomerulonephritis1CTD_human
TgeneLAPTM5C0023893Liver Cirrhosis, Experimental1CTD_human