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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21763

FusionGeneSummary for MFSD10_PDXDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: MFSD10_PDXDC1
Fusion gene ID: 21763
HgeneTgene
Gene symbol

MFSD10

PDXDC1

Gene ID

10227

23042

Gene namemajor facilitator superfamily domain containing 10pyridoxal dependent decarboxylase domain containing 1
SynonymsTETRAN|TETTRANLP8165
Cytomap

4p16.3

16p13.11

Type of geneprotein-codingprotein-coding
Descriptionmajor facilitator superfamily domain-containing protein 10tetracycline transporter-like proteinpyridoxal-dependent decarboxylase domain-containing protein 1
Modification date2018052520180526
UniProtAcc

Q14728

Q6P996

Ensembl transtripts involved in fusion geneENST00000514800, ENST00000355443, 
ENST00000329687, ENST00000508221, 
ENST00000507555, 		ENST00000563679, 
ENST00000325823, ENST00000447912, 
ENST00000535621, ENST00000455313, 
ENST00000396410, ENST00000569715, 
ENST00000450288, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 8 X 2=96
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MFSD10 [Title/Abstract] AND PDXDC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMFSD10

GO:0043252

sodium-independent organic anion transport

18638446


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP417084MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000514800ENST00000563679MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000514800ENST00000325823MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000514800ENST00000447912MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000514800ENST00000535621MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000514800ENST00000455313MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000514800ENST00000396410MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000514800ENST00000569715MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000514800ENST00000450288MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000355443ENST00000563679MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000355443ENST00000325823MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000355443ENST00000447912MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000355443ENST00000535621MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000355443ENST00000455313MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000355443ENST00000396410MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000355443ENST00000569715MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000355443ENST00000450288MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000329687ENST00000563679MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000329687ENST00000325823MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000329687ENST00000447912MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000329687ENST00000535621MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000329687ENST00000455313MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000329687ENST00000396410MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000329687ENST00000569715MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000329687ENST00000450288MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000508221ENST00000563679MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000508221ENST00000325823MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000508221ENST00000447912MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000508221ENST00000535621MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000508221ENST00000455313MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000508221ENST00000396410MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000508221ENST00000569715MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000508221ENST00000450288MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000507555ENST00000563679MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000507555ENST00000325823MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-3CDSENST00000507555ENST00000447912MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000507555ENST00000535621MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000507555ENST00000455313MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000507555ENST00000396410MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000507555ENST00000569715MFSD10chr4

2935680

-PDXDC1chr16

15127153

+
intron-intronENST00000507555ENST00000450288MFSD10chr4

2935680

-PDXDC1chr16

15127153

+

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FusionProtFeatures for MFSD10_PDXDC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFSD10

Q14728

PDXDC1

Q6P996

Confers cellular resistance to apoptosis induced by thenon-steroidal anti-inflammatory drugs indomethacin and diclofenac.May act as an efflux pump. {ECO:0000269|PubMed:17362938}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MFSD10_PDXDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MFSD10_PDXDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MFSD10_PDXDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePDXDC1Q6P996DB00114Pyridoxal PhosphatePyridoxal-dependent decarboxylase domain-containing protein 1small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for MFSD10_PDXDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDXDC1C0007134Renal Cell Carcinoma1CTD_human