FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 21762

FusionGeneSummary for MFSD10_ATAD3B

check button Fusion gene summary
Fusion gene informationFusion gene name: MFSD10_ATAD3B
Fusion gene ID: 21762
HgeneTgene
Gene symbol

MFSD10

ATAD3B

Gene ID

10227

83858

Gene namemajor facilitator superfamily domain containing 10ATPase family, AAA domain containing 3B
SynonymsTETRAN|TETTRANAAA-TOB3|TOB3
Cytomap

4p16.3

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionmajor facilitator superfamily domain-containing protein 10tetracycline transporter-like proteinATPase family AAA domain-containing protein 3BAAA-ATPase TOB3
Modification date2018052520180523
UniProtAcc

Q14728

Q5T9A4

Ensembl transtripts involved in fusion geneENST00000514800, ENST00000355443, 
ENST00000329687, ENST00000508221, 
ENST00000507555, 
ENST00000378741, 
ENST00000308647, ENST00000378736, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: MFSD10 [Title/Abstract] AND ATAD3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMFSD10

GO:0043252

sodium-independent organic anion transport

18638446


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AC-A2QJ-01AMFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000514800ENST00000378741MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000514800ENST00000308647MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000514800ENST00000378736MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000355443ENST00000378741MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000355443ENST00000308647MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000355443ENST00000378736MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000329687ENST00000378741MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000329687ENST00000308647MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000329687ENST00000378736MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000508221ENST00000378741MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000508221ENST00000308647MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000508221ENST00000378736MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000507555ENST00000378741MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000507555ENST00000308647MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+
5CDS-intronENST00000507555ENST00000378736MFSD10chr4

2933552

-ATAD3Bchr1

1425637

+

Top

FusionProtFeatures for MFSD10_ATAD3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFSD10

Q14728

ATAD3B

Q5T9A4

Confers cellular resistance to apoptosis induced by thenon-steroidal anti-inflammatory drugs indomethacin and diclofenac.May act as an efflux pump. {ECO:0000269|PubMed:17362938}. May play a role in a mitochondrial network organizationtypical for stem cells, characterized by reduced mitochondrialmetabolism, low mtDNA copies and fragmentated mitochondrialnetwork. may act by suppressing ATAD3A function, interfering withATAD3A interaction with matrix nucleoid complexes.{ECO:0000269|PubMed:22664726}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MFSD10_ATAD3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MFSD10_ATAD3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MFSD10SRPK2, CLK1, TCTN2, TCTN3, TMEM63AATAD3BC20orf24, PNKP, USP11, USP20, MLH1, PPP2R2D, PPP4C, ICT1, AGO3, FBXO25, CUL3, CUL5, SMAD2, SHC1, DYRK1B, CDK15, FBXO6, PARK2, LGR4, UBC, AURKA, EGFR, NTRK1, CYC1, EPRS, NOP56, PPP2R1A, EIF2S2, FTSJ3, PHB2, RPN1, SRP68, SSR1, VCP, ECSIT, NDUFAF1, NF2, PDHA1, SOAT1, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MFSD10_ATAD3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MFSD10_ATAD3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource