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Fusion gene ID: 21762 |
FusionGeneSummary for MFSD10_ATAD3B |
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Fusion gene information | Fusion gene name: MFSD10_ATAD3B | Fusion gene ID: 21762 | Hgene | Tgene | Gene symbol | MFSD10 | ATAD3B | Gene ID | 10227 | 83858 |
Gene name | major facilitator superfamily domain containing 10 | ATPase family, AAA domain containing 3B | |
Synonyms | TETRAN|TETTRAN | AAA-TOB3|TOB3 | |
Cytomap | 4p16.3 | 1p36.33 | |
Type of gene | protein-coding | protein-coding | |
Description | major facilitator superfamily domain-containing protein 10tetracycline transporter-like protein | ATPase family AAA domain-containing protein 3BAAA-ATPase TOB3 | |
Modification date | 20180525 | 20180523 | |
UniProtAcc | Q14728 | Q5T9A4 | |
Ensembl transtripts involved in fusion gene | ENST00000514800, ENST00000355443, ENST00000329687, ENST00000508221, ENST00000507555, | ENST00000378741, ENST00000308647, ENST00000378736, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: MFSD10 [Title/Abstract] AND ATAD3B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MFSD10 | GO:0043252 | sodium-independent organic anion transport | 18638446 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AC-A2QJ-01A | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000514800 | ENST00000378741 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000514800 | ENST00000308647 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000514800 | ENST00000378736 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000355443 | ENST00000378741 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000355443 | ENST00000308647 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000355443 | ENST00000378736 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000329687 | ENST00000378741 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000329687 | ENST00000308647 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000329687 | ENST00000378736 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000508221 | ENST00000378741 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000508221 | ENST00000308647 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000508221 | ENST00000378736 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000507555 | ENST00000378741 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000507555 | ENST00000308647 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
5CDS-intron | ENST00000507555 | ENST00000378736 | MFSD10 | chr4 | 2933552 | - | ATAD3B | chr1 | 1425637 | + |
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FusionProtFeatures for MFSD10_ATAD3B |
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Hgene | Tgene |
MFSD10 | ATAD3B |
Confers cellular resistance to apoptosis induced by thenon-steroidal anti-inflammatory drugs indomethacin and diclofenac.May act as an efflux pump. {ECO:0000269|PubMed:17362938}. | May play a role in a mitochondrial network organizationtypical for stem cells, characterized by reduced mitochondrialmetabolism, low mtDNA copies and fragmentated mitochondrialnetwork. may act by suppressing ATAD3A function, interfering withATAD3A interaction with matrix nucleoid complexes.{ECO:0000269|PubMed:22664726}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MFSD10_ATAD3B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MFSD10_ATAD3B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MFSD10 | SRPK2, CLK1, TCTN2, TCTN3, TMEM63A | ATAD3B | C20orf24, PNKP, USP11, USP20, MLH1, PPP2R2D, PPP4C, ICT1, AGO3, FBXO25, CUL3, CUL5, SMAD2, SHC1, DYRK1B, CDK15, FBXO6, PARK2, LGR4, UBC, AURKA, EGFR, NTRK1, CYC1, EPRS, NOP56, PPP2R1A, EIF2S2, FTSJ3, PHB2, RPN1, SRP68, SSR1, VCP, ECSIT, NDUFAF1, NF2, PDHA1, SOAT1, MTF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MFSD10_ATAD3B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MFSD10_ATAD3B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |