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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21751

FusionGeneSummary for MFGE8_UGP2

check button Fusion gene summary
Fusion gene informationFusion gene name: MFGE8_UGP2
Fusion gene ID: 21751
HgeneTgene
Gene symbol

MFGE8

UGP2

Gene ID

4240

7360

Gene namemilk fat globule-EGF factor 8 proteinUDP-glucose pyrophosphorylase 2
SynonymsBA46|EDIL1|HMFG|HsT19888|MFG-E8|MFGM|OAcGD3S|SED1|SPAG10|hP47UDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379
Cytomap

15q26.1

2p15

Type of geneprotein-codingprotein-coding
DescriptionlactadherinO-acetyl disialoganglioside synthasebreast epithelial antigen BA46medinsperm associated antigen 10sperm surface protein hP47UTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testi
Modification date2018052320180523
UniProtAcc

Q08431

Q16851

Ensembl transtripts involved in fusion geneENST00000539437, ENST00000268151, 
ENST00000268150, ENST00000566497, 
ENST00000542878, ENST00000559997, 
ENST00000394417, ENST00000467648, 
ENST00000487469, ENST00000337130, 
ENST00000445915, 
Fusion gene scores* DoF score5 X 4 X 3=602 X 2 X 1=4
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: MFGE8 [Title/Abstract] AND UGP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA314258MFGE8chr15

89442382

+UGP2chr2

64094006

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000539437ENST00000394417MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000539437ENST00000467648MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000539437ENST00000487469MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000539437ENST00000337130MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000539437ENST00000445915MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268151ENST00000394417MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268151ENST00000467648MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268151ENST00000487469MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268151ENST00000337130MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268151ENST00000445915MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268150ENST00000394417MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268150ENST00000467648MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268150ENST00000487469MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268150ENST00000337130MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000268150ENST00000445915MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000566497ENST00000394417MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000566497ENST00000467648MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000566497ENST00000487469MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000566497ENST00000337130MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000566497ENST00000445915MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000542878ENST00000394417MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000542878ENST00000467648MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000542878ENST00000487469MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000542878ENST00000337130MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000542878ENST00000445915MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000559997ENST00000394417MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000559997ENST00000467648MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000559997ENST00000487469MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000559997ENST00000337130MFGE8chr15

89442382

+UGP2chr2

64094006

-
intron-intronENST00000559997ENST00000445915MFGE8chr15

89442382

+UGP2chr2

64094006

-

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FusionProtFeatures for MFGE8_UGP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFGE8

Q08431

UGP2

Q16851

Plays an important role in the maintenance of intestinalepithelial homeostasis and the promotion of mucosal healing.Promotes VEGF-dependent neovascularization (By similarity).Contributes to phagocytic removal of apoptotic cells in manytissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5receptors. Also binds to phosphatidylserine-enriched cell surfacesin a receptor-independent manner. Zona pellucida-binding proteinwhich may play a role in gamete interaction. {ECO:0000250,ECO:0000269|PubMed:19204935}. Medin is the main constituent of aortic medial amyloid.{ECO:0000269|PubMed:19204935}. Plays a central role as a glucosyl donor in cellularmetabolic pathways.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MFGE8_UGP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MFGE8_UGP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MFGE8_UGP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MFGE8_UGP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMFGE8C0005586Bipolar Disorder1PSYGENET
HgeneMFGE8C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneMFGE8C0023904Liver Neoplasms, Experimental1CTD_human
HgeneMFGE8C1458155Mammary Neoplasms1CTD_human