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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21743

FusionGeneSummary for MFAP3L_MFAP3L

check button Fusion gene summary
Fusion gene informationFusion gene name: MFAP3L_MFAP3L
Fusion gene ID: 21743
HgeneTgene
Gene symbol

MFAP3L

MFAP3L

Gene ID

9848

9848

Gene namemicrofibril associated protein 3 likemicrofibril associated protein 3 like
SynonymsNYD-sp9NYD-sp9
Cytomap

4q33

4q33

Type of geneprotein-codingprotein-coding
Descriptionmicrofibrillar-associated protein 3-likemicrofi brillar-associated protein 3-likemicrofibrillar associated protein 3 liketestis development protein NYD-SP9microfibrillar-associated protein 3-likemicrofi brillar-associated protein 3-likemicrofibrillar associated protein 3 liketestis development protein NYD-SP9
Modification date2018032920180329
UniProtAcc

O75121

O75121

Ensembl transtripts involved in fusion geneENST00000393704, ENST00000361618, 
ENST00000393702, ENST00000506110, 
ENST00000514683, 
ENST00000393704, 
ENST00000361618, ENST00000393702, 
ENST00000506110, ENST00000514683, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 32
** MAII scorelog2(3/4*10)=2.90689059560852log2(2/1*10)=4.32192809488736
Context

PubMed: MFAP3L [Title/Abstract] AND MFAP3L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE073870MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
ChiTaRS3.1BE073871MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000393704ENST00000393704MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000393704ENST00000361618MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000393704ENST00000393702MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000393704ENST00000506110MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000393704ENST00000514683MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000361618ENST00000393704MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000361618ENST00000361618MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000361618ENST00000393702MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000361618ENST00000506110MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000361618ENST00000514683MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000393702ENST00000393704MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000393702ENST00000361618MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000393702ENST00000393702MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000393702ENST00000506110MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000393702ENST00000514683MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000506110ENST00000393704MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000506110ENST00000361618MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000506110ENST00000393702MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000506110ENST00000506110MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000506110ENST00000514683MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000514683ENST00000393704MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-3UTRENST00000514683ENST00000361618MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000514683ENST00000393702MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000514683ENST00000506110MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-
intron-intronENST00000514683ENST00000514683MFAP3Lchr4

170908746

+MFAP3Lchr4

170908721

-

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FusionProtFeatures for MFAP3L_MFAP3L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFAP3L

O75121

MFAP3L

O75121

May participate in the nuclear signaling of EGFR andMAPK1/ERK2. May a have a role in metastasis.{ECO:0000269|PubMed:24735981}. May participate in the nuclear signaling of EGFR andMAPK1/ERK2. May a have a role in metastasis.{ECO:0000269|PubMed:24735981}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MFAP3L_MFAP3L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MFAP3L_MFAP3L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MFAP3L_MFAP3L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MFAP3L_MFAP3L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource