FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 21739

FusionGeneSummary for MEX3D_TCF3

check button Fusion gene summary
Fusion gene informationFusion gene name: MEX3D_TCF3
Fusion gene ID: 21739
HgeneTgene
Gene symbol

MEX3D

TCF3

Gene ID

399664

83439

Gene namemex-3 RNA binding family member Dtranscription factor 7 like 1
SynonymsMEX-3D|MEX3|OK/SW-cl.4|RKHD1|RNF193|TINOTCF-3|TCF3
Cytomap

19p13.3

2p11.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein MEX3DRING finger and KH domain-containing protein 1RING finger protein 193bcl-2 ARE RNA binding proteinring finger (C3HC4 type) and KH domain containing 1ring finger and KH domain containing 1transcription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)
Modification date2018052220180523
UniProtAcc

Q86XN8

P15923

Ensembl transtripts involved in fusion geneENST00000402693, ENST00000388824, 
ENST00000344749, ENST00000262965, 
ENST00000453954, ENST00000395423, 
ENST00000588136, 
Fusion gene scores* DoF score4 X 1 X 3=127 X 9 X 3=189
# samples 310
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/189*10)=-0.918386234446348
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MEX3D [Title/Abstract] AND TCF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-Q9-A6FU-01AMEX3Dchr19

1567463

-TCF3chr19

1646426

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000402693ENST00000344749MEX3Dchr19

1567463

-TCF3chr19

1646426

-
In-frameENST00000402693ENST00000262965MEX3Dchr19

1567463

-TCF3chr19

1646426

-
5CDS-intronENST00000402693ENST00000453954MEX3Dchr19

1567463

-TCF3chr19

1646426

-
5CDS-intronENST00000402693ENST00000395423MEX3Dchr19

1567463

-TCF3chr19

1646426

-
5CDS-intronENST00000402693ENST00000588136MEX3Dchr19

1567463

-TCF3chr19

1646426

-
In-frameENST00000388824ENST00000344749MEX3Dchr19

1567463

-TCF3chr19

1646426

-
In-frameENST00000388824ENST00000262965MEX3Dchr19

1567463

-TCF3chr19

1646426

-
5CDS-intronENST00000388824ENST00000453954MEX3Dchr19

1567463

-TCF3chr19

1646426

-
5CDS-intronENST00000388824ENST00000395423MEX3Dchr19

1567463

-TCF3chr19

1646426

-
5CDS-intronENST00000388824ENST00000588136MEX3Dchr19

1567463

-TCF3chr19

1646426

-

Top

FusionProtFeatures for MEX3D_TCF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEX3D

Q86XN8

TCF3

P15923

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major rolesin determining tissue-specific cell fate during embryogenesis,like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappaimmunoglobulin gene enhancer. Binds to IEB1 and IEB2, which areshort DNA sequences in the insulin gene transcription controlregion. {ECO:0000250|UniProtKB:P15806}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTCF3chr19:1567463chr19:1646426ENST00000262965-119549_60224655DomainbHLH
TgeneTCF3chr19:1567463chr19:1646426ENST00000344749-119549_60224652DomainbHLH
TgeneTCF3chr19:1567463chr19:1646426ENST00000588136-019549_60224527DomainbHLH
TgeneTCF3chr19:1567463chr19:1646426ENST00000262965-119170_17624655MotifNuclear localization signal
TgeneTCF3chr19:1567463chr19:1646426ENST00000344749-119170_17624652MotifNuclear localization signal
TgeneTCF3chr19:1567463chr19:1646426ENST00000588136-019170_17624527MotifNuclear localization signal
TgeneTCF3chr19:1567463chr19:1646426ENST00000262965-119389_42524655RegionNote=Leucine-zipper
TgeneTCF3chr19:1567463chr19:1646426ENST00000344749-119389_42524652RegionNote=Leucine-zipper
TgeneTCF3chr19:1567463chr19:1646426ENST00000588136-019389_42524527RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEX3Dchr19:1567463chr19:1646426ENST00000388824-13179_240198667DomainKH 1
HgeneMEX3Dchr19:1567463chr19:1646426ENST00000388824-13273_334198667DomainKH 2
HgeneMEX3Dchr19:1567463chr19:1646426ENST00000402693-12179_240198652DomainKH 1
HgeneMEX3Dchr19:1567463chr19:1646426ENST00000402693-12273_334198652DomainKH 2
HgeneMEX3Dchr19:1567463chr19:1646426ENST00000388824-13600_640198667Zinc fingerRING-type
HgeneMEX3Dchr19:1567463chr19:1646426ENST00000402693-12600_640198652Zinc fingerRING-type
TgeneTCF3chr19:1567463chr19:1646426ENST00000262965-11919_2724655MotifNote=9aaTAD
TgeneTCF3chr19:1567463chr19:1646426ENST00000344749-11919_2724652MotifNote=9aaTAD
TgeneTCF3chr19:1567463chr19:1646426ENST00000588136-01919_2724527MotifNote=9aaTAD


Top

FusionGeneSequence for MEX3D_TCF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MEX3D_TCF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MEX3DELAVL1, BCL2, AGO2, AGO1, YWHAH, NXF1, XPO1, LMO2, PLOD1, PSMC3TCF3HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, VDR, HDAC2, DNMT1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, HAND1, NEUROD1, MESP2, BHLHE40, PARP1, PSMD4, NEDD9, XPO1, BCOR, KIF18A, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MEX3D_TCF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MEX3D_TCF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTCF3C0006413Burkitt Lymphoma2CTD_human
TgeneTCF3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneTCF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human