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Fusion gene ID: 21739 |
FusionGeneSummary for MEX3D_TCF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MEX3D_TCF3 | Fusion gene ID: 21739 | Hgene | Tgene | Gene symbol | MEX3D | TCF3 | Gene ID | 399664 | 83439 |
| Gene name | mex-3 RNA binding family member D | transcription factor 7 like 1 | |
| Synonyms | MEX-3D|MEX3|OK/SW-cl.4|RKHD1|RNF193|TINO | TCF-3|TCF3 | |
| Cytomap | 19p13.3 | 2p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein MEX3DRING finger and KH domain-containing protein 1RING finger protein 193bcl-2 ARE RNA binding proteinring finger (C3HC4 type) and KH domain containing 1ring finger and KH domain containing 1 | transcription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box) | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q86XN8 | P15923 | |
| Ensembl transtripts involved in fusion gene | ENST00000402693, ENST00000388824, | ENST00000344749, ENST00000262965, ENST00000453954, ENST00000395423, ENST00000588136, | |
| Fusion gene scores | * DoF score | 4 X 1 X 3=12 | 7 X 9 X 3=189 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/189*10)=-0.918386234446348 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MEX3D [Title/Abstract] AND TCF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-Q9-A6FU-01A | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000402693 | ENST00000344749 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| In-frame | ENST00000402693 | ENST00000262965 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| 5CDS-intron | ENST00000402693 | ENST00000453954 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| 5CDS-intron | ENST00000402693 | ENST00000395423 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| 5CDS-intron | ENST00000402693 | ENST00000588136 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| In-frame | ENST00000388824 | ENST00000344749 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| In-frame | ENST00000388824 | ENST00000262965 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| 5CDS-intron | ENST00000388824 | ENST00000453954 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| 5CDS-intron | ENST00000388824 | ENST00000395423 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
| 5CDS-intron | ENST00000388824 | ENST00000588136 | MEX3D | chr19 | 1567463 | - | TCF3 | chr19 | 1646426 | - |
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FusionProtFeatures for MEX3D_TCF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MEX3D | TCF3 |
| RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. | Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major rolesin determining tissue-specific cell fate during embryogenesis,like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappaimmunoglobulin gene enhancer. Binds to IEB1 and IEB2, which areshort DNA sequences in the insulin gene transcription controlregion. {ECO:0000250|UniProtKB:P15806}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000262965 | - | 1 | 19 | 549_602 | 24 | 655 | Domain | bHLH |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000344749 | - | 1 | 19 | 549_602 | 24 | 652 | Domain | bHLH |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000588136 | - | 0 | 19 | 549_602 | 24 | 527 | Domain | bHLH |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000262965 | - | 1 | 19 | 170_176 | 24 | 655 | Motif | Nuclear localization signal |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000344749 | - | 1 | 19 | 170_176 | 24 | 652 | Motif | Nuclear localization signal |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000588136 | - | 0 | 19 | 170_176 | 24 | 527 | Motif | Nuclear localization signal |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000262965 | - | 1 | 19 | 389_425 | 24 | 655 | Region | Note=Leucine-zipper |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000344749 | - | 1 | 19 | 389_425 | 24 | 652 | Region | Note=Leucine-zipper |
| Tgene | >TCF3 | chr19:1567463 | chr19:1646426 | ENST00000588136 | - | 0 | 19 | 389_425 | 24 | 527 | Region | Note=Leucine-zipper |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MEX3D | chr19:1567463 | chr19:1646426 | ENST00000388824 | - | 1 | 3 | 179_240 | 198 | 667 | Domain | KH 1 |
| Hgene | >MEX3D | chr19:1567463 | chr19:1646426 | ENST00000388824 | - | 1 | 3 | 273_334 | 198 | 667 | Domain | KH 2 |
| Hgene | >MEX3D | chr19:1567463 | chr19:1646426 | ENST00000402693 | - | 1 | 2 | 179_240 | 198 | 652 | Domain | KH 1 |
| Hgene | >MEX3D | chr19:1567463 | chr19:1646426 | ENST00000402693 | - | 1 | 2 | 273_334 | 198 | 652 | Domain | KH 2 |
| Hgene | >MEX3D | chr19:1567463 | chr19:1646426 | ENST00000388824 | - | 1 | 3 | 600_640 | 198 | 667 | Zinc finger | RING-type |
| Hgene | >MEX3D | chr19:1567463 | chr19:1646426 | ENST00000402693 | - | 1 | 2 | 600_640 | 198 | 652 | Zinc finger | RING-type |
| Tgene | TCF3 | chr19:1567463 | chr19:1646426 | ENST00000262965 | - | 1 | 19 | 19_27 | 24 | 655 | Motif | Note=9aaTAD |
| Tgene | TCF3 | chr19:1567463 | chr19:1646426 | ENST00000344749 | - | 1 | 19 | 19_27 | 24 | 652 | Motif | Note=9aaTAD |
| Tgene | TCF3 | chr19:1567463 | chr19:1646426 | ENST00000588136 | - | 0 | 19 | 19_27 | 24 | 527 | Motif | Note=9aaTAD |
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FusionGeneSequence for MEX3D_TCF3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MEX3D_TCF3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MEX3D | ELAVL1, BCL2, AGO2, AGO1, YWHAH, NXF1, XPO1, LMO2, PLOD1, PSMC3 | TCF3 | HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, VDR, HDAC2, DNMT1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, HAND1, NEUROD1, MESP2, BHLHE40, PARP1, PSMD4, NEDD9, XPO1, BCOR, KIF18A, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MEX3D_TCF3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MEX3D_TCF3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TCF3 | C0006413 | Burkitt Lymphoma | 2 | CTD_human |
| Tgene | TCF3 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
| Tgene | TCF3 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
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