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Fusion gene ID: 21735 |
FusionGeneSummary for MEX3C_ATP9B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MEX3C_ATP9B | Fusion gene ID: 21735 | Hgene | Tgene | Gene symbol | MEX3C | ATP9B | Gene ID | 51320 | 374868 |
| Gene name | mex-3 RNA binding family member C | ATPase phospholipid transporting 9B (putative) | |
| Synonyms | BM-013|MEX-3C|RKHD2|RNF194 | ATPASEP|ATPIIB|HUSSY-20|NEO1L|hMMR1 | |
| Cytomap | 18q21.2 | 18q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding E3 ubiquitin-protein ligase MEX3CMEX3C variant 1MEX3C variant 2RING finger and KH domain-containing protein 2RING finger protein 194RING-type E3 ubiquitin transferase MEX3CRNA-binding protein MEX3Cring finger and KH domain containing 2 | probable phospholipid-transporting ATPase IIBATPase type IV, phospholipid transporting (P-type)ATPase, class II, type 9Bmacrophage MHC receptor 1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q5U5Q3 | O43861 | |
| Ensembl transtripts involved in fusion gene | ENST00000591040, ENST00000592416, | ENST00000426216, ENST00000307671, ENST00000586722, ENST00000591464, ENST00000458297, ENST00000543761, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MEX3C [Title/Abstract] AND ATP9B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-5413-01A | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000591040 | ENST00000426216 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-3CDS | ENST00000591040 | ENST00000307671 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-intron | ENST00000591040 | ENST00000586722 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-intron | ENST00000591040 | ENST00000591464 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-intron | ENST00000591040 | ENST00000458297 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-intron | ENST00000591040 | ENST00000543761 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-3CDS | ENST00000592416 | ENST00000426216 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-3CDS | ENST00000592416 | ENST00000307671 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-intron | ENST00000592416 | ENST00000586722 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-intron | ENST00000592416 | ENST00000591464 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-intron | ENST00000592416 | ENST00000458297 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
| intron-intron | ENST00000592416 | ENST00000543761 | MEX3C | chr18 | 48722937 | - | ATP9B | chr18 | 77037054 | + |
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FusionProtFeatures for MEX3C_ATP9B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MEX3C | ATP9B |
| E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNAdecay. RNA binding is sufficient to prevent translation, butubiquitin ligase activity is required for mRNA degradation.{ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MEX3C_ATP9B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MEX3C_ATP9B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MEX3C | ELAVL1, USP7, PABPC1, YWHAH, DDX58, XPO1, ADAR, AIFM1, AP2A1, AP2A2, AP2B1, ATAD3A, ATXN2L, BMS1, MTHFD1, CAD, CCAR2, CNOT1, CNOT3, DHX37, PRKDC, EEF1A1, EIF3A, GIGYF2, GLE1, GTPBP1, HNRNPUL2, HSPA5, ILF3, LENG8, LRPPRC, MARK3, MRPS30, MYCBP2, MYO1C, NOL6, NUFIP2, NXF1, POLRMT, PRPF6, PRPF8, RBM19, SAFB2, TRIM28, WDR6, ZC3HAV1, ZNF574, CNOT7, PAN2, PIP4K2A, LMO2 | ATP9B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MEX3C_ATP9B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MEX3C_ATP9B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MEX3C | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | ATP9B | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
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