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Fusion gene ID: 21734 |
FusionGeneSummary for MEX3A_MEX3A |
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Fusion gene information | Fusion gene name: MEX3A_MEX3A | Fusion gene ID: 21734 | Hgene | Tgene | Gene symbol | MEX3A | MEX3A | Gene ID | 92312 | 92312 |
Gene name | mex-3 RNA binding family member A | mex-3 RNA binding family member A | |
Synonyms | MEX-3A|RKHD4|RNF162 | MEX-3A|RKHD4|RNF162 | |
Cytomap | 1q22 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | RNA-binding protein MEX3ARING finger and KH domain-containing protein 4ring finger and KH domain containing 4ring finger and KH domain containing protein | RNA-binding protein MEX3ARING finger and KH domain-containing protein 4ring finger and KH domain containing 4ring finger and KH domain containing protein | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | A1L020 | A1L020 | |
Ensembl transtripts involved in fusion gene | ENST00000532414, ENST00000442784, | ENST00000532414, ENST00000442784, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MEX3A [Title/Abstract] AND MEX3A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM971922 | MEX3A | chr1 | 156044263 | + | MEX3A | chr1 | 156043410 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000532414 | ENST00000532414 | MEX3A | chr1 | 156044263 | + | MEX3A | chr1 | 156043410 | + |
intron-intron | ENST00000532414 | ENST00000442784 | MEX3A | chr1 | 156044263 | + | MEX3A | chr1 | 156043410 | + |
intron-3UTR | ENST00000442784 | ENST00000532414 | MEX3A | chr1 | 156044263 | + | MEX3A | chr1 | 156043410 | + |
intron-intron | ENST00000442784 | ENST00000442784 | MEX3A | chr1 | 156044263 | + | MEX3A | chr1 | 156043410 | + |
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FusionProtFeatures for MEX3A_MEX3A |
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Hgene | Tgene |
MEX3A | MEX3A |
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MEX3A_MEX3A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MEX3A_MEX3A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MEX3A_MEX3A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MEX3A_MEX3A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |