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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21734

FusionGeneSummary for MEX3A_MEX3A

check button Fusion gene summary
Fusion gene informationFusion gene name: MEX3A_MEX3A
Fusion gene ID: 21734
HgeneTgene
Gene symbol

MEX3A

MEX3A

Gene ID

92312

92312

Gene namemex-3 RNA binding family member Amex-3 RNA binding family member A
SynonymsMEX-3A|RKHD4|RNF162MEX-3A|RKHD4|RNF162
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein MEX3ARING finger and KH domain-containing protein 4ring finger and KH domain containing 4ring finger and KH domain containing proteinRNA-binding protein MEX3ARING finger and KH domain-containing protein 4ring finger and KH domain containing 4ring finger and KH domain containing protein
Modification date2018052220180522
UniProtAcc

A1L020

A1L020

Ensembl transtripts involved in fusion geneENST00000532414, ENST00000442784, 
ENST00000532414, ENST00000442784, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MEX3A [Title/Abstract] AND MEX3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM971922MEX3Achr1

156044263

+MEX3Achr1

156043410

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000532414ENST00000532414MEX3Achr1

156044263

+MEX3Achr1

156043410

+
intron-intronENST00000532414ENST00000442784MEX3Achr1

156044263

+MEX3Achr1

156043410

+
intron-3UTRENST00000442784ENST00000532414MEX3Achr1

156044263

+MEX3Achr1

156043410

+
intron-intronENST00000442784ENST00000442784MEX3Achr1

156044263

+MEX3Achr1

156043410

+

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FusionProtFeatures for MEX3A_MEX3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEX3A

A1L020

MEX3A

A1L020

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MEX3A_MEX3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MEX3A_MEX3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MEX3A_MEX3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MEX3A_MEX3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource