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Fusion gene ID: 21726 |
FusionGeneSummary for MET_C8orf34 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MET_C8orf34 | Fusion gene ID: 21726 | Hgene | Tgene | Gene symbol | MET | C8orf34 | Gene ID | 8731 | 116328 |
| Gene name | RNA guanine-7 methyltransferase | chromosome 8 open reading frame 34 | |
| Synonyms | CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet | VEST-1|VEST1 | |
| Cytomap | 18p11.21 | 8q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase | uncharacterized protein C8orf34protein VEST-1vestibule-1 protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P08581 | Q49A92 | |
| Ensembl transtripts involved in fusion gene | ENST00000397752, ENST00000318493, ENST00000436117, ENST00000495962, ENST00000539704, | ENST00000539993, ENST00000518698, ENST00000349492, ENST00000523686, ENST00000348340, ENST00000337103, ENST00000325233, | |
| Fusion gene scores | * DoF score | 8 X 7 X 8=448 | 11 X 8 X 9=792 |
| # samples | 10 | 10 | |
| ** MAII score | log2(10/448*10)=-2.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/792*10)=-2.98550043030489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MET [Title/Abstract] AND C8orf34 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MET | GO:0006370 | 7-methylguanosine mRNA capping | 27422871 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-GL-7773-01A | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000397752 | ENST00000539993 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| In-frame | ENST00000397752 | ENST00000518698 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-3UTR | ENST00000397752 | ENST00000349492 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-3UTR | ENST00000397752 | ENST00000523686 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-3UTR | ENST00000397752 | ENST00000348340 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-3UTR | ENST00000397752 | ENST00000337103 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-intron | ENST00000397752 | ENST00000325233 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| In-frame | ENST00000318493 | ENST00000539993 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| In-frame | ENST00000318493 | ENST00000518698 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-3UTR | ENST00000318493 | ENST00000349492 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-3UTR | ENST00000318493 | ENST00000523686 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-3UTR | ENST00000318493 | ENST00000348340 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-3UTR | ENST00000318493 | ENST00000337103 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| 5CDS-intron | ENST00000318493 | ENST00000325233 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3CDS | ENST00000436117 | ENST00000539993 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3CDS | ENST00000436117 | ENST00000518698 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000436117 | ENST00000349492 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000436117 | ENST00000523686 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000436117 | ENST00000348340 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000436117 | ENST00000337103 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-intron | ENST00000436117 | ENST00000325233 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3CDS | ENST00000495962 | ENST00000539993 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3CDS | ENST00000495962 | ENST00000518698 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000495962 | ENST00000349492 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000495962 | ENST00000523686 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000495962 | ENST00000348340 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000495962 | ENST00000337103 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-intron | ENST00000495962 | ENST00000325233 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3CDS | ENST00000539704 | ENST00000539993 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3CDS | ENST00000539704 | ENST00000518698 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000539704 | ENST00000349492 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000539704 | ENST00000523686 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000539704 | ENST00000348340 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-3UTR | ENST00000539704 | ENST00000337103 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
| intron-intron | ENST00000539704 | ENST00000325233 | MET | chr7 | 116412043 | + | C8orf34 | chr8 | 69358564 | + |
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FusionProtFeatures for MET_C8orf34 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MET | C8orf34 |
| Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding tohepatocyte growth factor/HGF ligand. Regulates many physiologicalprocesses including proliferation, scattering, morphogenesis andsurvival. Ligand binding at the cell surface inducesautophosphorylation of MET on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with the PI3-kinasesubunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.Recruitment of these downstream effectors by MET leads to theactivation of several signaling cascades including the RAS-ERK,PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation isassociated with the morphogenetic effects while PI3K/AKTcoordinates prosurvival effects. During embryonic development, METsignaling plays a role in gastrulation, development and migrationof muscles and neuronal precursors, angiogenesis and kidneyformation. In adults, participates in wound healing as well asorgan regeneration and tissue remodeling. Promotes alsodifferentiation and proliferation of hematopoietic cells. Mayregulate cortical bone osteogenesis (By similarity).{ECO:0000250|UniProtKB:P16056}. Acts as a receptor for Listeria internalin inlB,mediating entry of the pathogen into cells. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 27_515 | 1027 | 1409 | Domain | Sema |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 563_655 | 1027 | 1409 | Domain | Note=IPT/TIG 1 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 657_739 | 1027 | 1409 | Domain | Note=IPT/TIG 2 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 742_836 | 1027 | 1409 | Domain | Note=IPT/TIG 3 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 27_515 | 1009 | 1391 | Domain | Sema |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 563_655 | 1009 | 1391 | Domain | Note=IPT/TIG 1 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 657_739 | 1009 | 1391 | Domain | Note=IPT/TIG 2 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 742_836 | 1009 | 1391 | Domain | Note=IPT/TIG 3 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 25_932 | 1027 | 1409 | Topological domain | Extracellular |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 25_932 | 1009 | 1391 | Topological domain | Extracellular |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 933_955 | 1027 | 1409 | Transmembrane | Helical |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 933_955 | 1009 | 1391 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 1078_1345 | 1027 | 1409 | Domain | Protein kinase |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 1078_1345 | 1009 | 1391 | Domain | Protein kinase |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 1078_1345 | 0 | 765 | Domain | Protein kinase |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 27_515 | 0 | 765 | Domain | Sema |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 563_655 | 0 | 765 | Domain | Note=IPT/TIG 1 |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 657_739 | 0 | 765 | Domain | Note=IPT/TIG 2 |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 742_836 | 0 | 765 | Domain | Note=IPT/TIG 3 |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 1084_1092 | 1027 | 1409 | Nucleotide binding | ATP |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 1084_1092 | 1009 | 1391 | Nucleotide binding | ATP |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 1084_1092 | 0 | 765 | Nucleotide binding | ATP |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 956_1390 | 1027 | 1409 | Topological domain | Cytoplasmic |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 956_1390 | 1009 | 1391 | Topological domain | Cytoplasmic |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 25_932 | 0 | 765 | Topological domain | Extracellular |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 956_1390 | 0 | 765 | Topological domain | Cytoplasmic |
| Hgene | >MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 933_955 | 0 | 765 | Transmembrane | Helical |
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FusionGeneSequence for MET_C8orf34 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MET_ENST00000397752_chr7_116412043_+_C8orf34_ENST00000539993_chr8_69358564_+_1390aa MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLN LQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVS PTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKPQSRDFDELNHI LQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPK NKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQGRPTYPAEPQAKVTLNIC SRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKNYMEEDESLKQLQVVHQPW >In-frame_MET_ENST00000397752_chr7_116412043_+_C8orf34_ENST00000518698_chr8_69358564_+_1390aa MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLN LQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVS PTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKPQSRDFDELNHI LQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPK NKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQGRPTYPAEPQAKVTLNIC SRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKNYMEEDESLKQLQVVHQPW >In-frame_MET_ENST00000318493_chr7_116412043_+_C8orf34_ENST00000539993_chr8_69358564_+_1408aa MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQH RSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPK WNWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQW ESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQ GRPTYPAEPQAKVTLNICSRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKN >In-frame_MET_ENST00000318493_chr7_116412043_+_C8orf34_ENST00000518698_chr8_69358564_+_1408aa MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQH RSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPK WNWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQW ESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQ GRPTYPAEPQAKVTLNICSRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MET_ENST00000397752_chr7_116412043_+_C8orf34_ENST00000539993_chr8_69358564_+_4170nt ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC GGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAACAGAGTTT ACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGGAGACCTC ACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAATTTTCTC CTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAAGAAGATC ACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTGTGGCTGG TGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGTTTTCCCA AATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTTAAAGAAA ACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCCTGCCATG AATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGTAATAACA AGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAGACACATT TCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAACTGAGTTT GCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCATCCAACC AAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCAT GAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAAT CTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTG TTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTT AAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTG CTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAAT TTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAA ATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGC CCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGC TATGATAAACCTTGGCAATTAAATGCAAAGAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGAC TCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATC CTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACA TTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTA CAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAG AACAAAGGATTAAAACAGCAGCAACAGCAACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCT ACCCCATCTGTAACAGAAGAAGATATTGATAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTA ACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGT TCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCA GATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGA GAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGG ATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTCTTTGCGTTCCATGCTCTTCT >In-frame_MET_ENST00000397752_chr7_116412043_+_C8orf34_ENST00000518698_chr8_69358564_+_4170nt ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC GGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAACAGAGTTT ACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGGAGACCTC ACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAATTTTCTC CTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAAGAAGATC ACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTGTGGCTGG TGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGTTTTCCCA AATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTTAAAGAAA ACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCCTGCCATG AATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGTAATAACA AGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAGACACATT TCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAACTGAGTTT GCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCATCCAACC AAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCAT GAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAAT CTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTG TTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTT AAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTG CTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAAT TTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAA ATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGC CCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGC TATGATAAACCTTGGCAATTAAATGCAAAGAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGAC TCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATC CTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACA TTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTA CAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAG AACAAAGGATTAAAACAGCAGCAACAGCAACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCT ACCCCATCTGTAACAGAAGAAGATATTGATAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTA ACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGT TCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCA GATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGA GAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGG ATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTCTTTGCGTTCCATGCTCTTCT >In-frame_MET_ENST00000318493_chr7_116412043_+_C8orf34_ENST00000539993_chr8_69358564_+_4224nt ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC GGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAACAGAGTTT ACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGGAGACCTC ACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAATTTTCTC CTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAAGAAGATC ACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTGTGGCTGG TGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGTTTTCCCA AATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTTAAAGAAA ACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCCTGCCATG AATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGTAATAACA AGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAGACACATT TCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAACTGAGTTT GCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCATCCAACC AAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTTGCTTTGCCAGTGGTGGGAGCACAATAACAGGT GTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACAT CGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATG TTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATG GGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGT GAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAG CAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCA ACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGAT GCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGAC TACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAAGAAGCCT AAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAG TGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAG AATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGA GAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGG GAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCAACATAAG AAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGATAATGAA GATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAA GGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAA GAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCA CTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAAC TACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAA >In-frame_MET_ENST00000318493_chr7_116412043_+_C8orf34_ENST00000518698_chr8_69358564_+_4224nt ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC GGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAACAGAGTTT ACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGGAGACCTC ACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAATTTTCTC CTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAAGAAGATC ACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTGTGGCTGG TGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGTTTTCCCA AATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTTAAAGAAA ACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCCTGCCATG AATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGTAATAACA AGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAGACACATT TCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAACTGAGTTT GCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCATCCAACC AAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTTGCTTTGCCAGTGGTGGGAGCACAATAACAGGT GTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACAT CGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATG TTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATG GGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGT GAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAG CAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCA ACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGAT GCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGAC TACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAAGAAGCCT AAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAG TGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAG AATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGA GAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGG GAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCAACATAAG AAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGATAATGAA GATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAA GGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAA GAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCA CTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAAC TACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MET_ENST00000397752_chr7_116412043_+_C8orf34_ENST00000539993_chr8_69358564_+_4679nt AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTG ATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCA CCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAA CCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGG TTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCAC CCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTG CAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATA ATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAAT GCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCT ATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACA GTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCC AAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTG TCTATGAAATTCATCCAACCAAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGA GAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTC CTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCA TTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATG ATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTAT GCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAA TAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGT GGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTG TAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAA CAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAAGAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATA TTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATT TTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAAC TCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATC CCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAA GCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCAACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTT TTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGATAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATG ATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCA AGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATT CTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCAT CTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGC AGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTC TTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTGAAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGC AGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAATCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAAC AAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACTAATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTG >In-frame_MET_ENST00000397752_chr7_116412043_+_C8orf34_ENST00000518698_chr8_69358564_+_4685nt AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTG ATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCA CCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAA CCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGG TTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCAC CCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTG CAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATA ATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAAT GCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCT ATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACA GTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCC AAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTG TCTATGAAATTCATCCAACCAAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGA GAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTC CTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCA TTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATG ATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTAT GCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAA TAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGT GGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTG TAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAA CAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAAGAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATA TTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATT TTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAAC TCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATC CCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAA GCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCAACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTT TTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGATAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATG ATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCA AGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATT CTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCAT CTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGC AGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTC TTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTGAAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGC AGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAATCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAAC AAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACTAATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTG CCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTTATTAAGATTAATATTTGATATATTAAATATTGCCTGATTCA >In-frame_MET_ENST00000318493_chr7_116412043_+_C8orf34_ENST00000539993_chr8_69358564_+_4720nt GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAAC AGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGG AGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAA TTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAA GAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTG TGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGT TTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTT AAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCC TGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGT AATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAG ACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAAC TGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCA TCCAACCAAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTTGCTTTGCCAGTGGTGGGAGCACAAT AACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATG TCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTT TTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGAT CTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAA GAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGA GTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTC AATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCG CTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATC TGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAA GAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCA TCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGC CCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGT GATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGA CCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCA ACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGA TAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATT TAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAA CCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGA AGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACT GAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGG AGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTCTTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTG AAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGCAGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAA TCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAACAAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACT AATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTGCCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTT >In-frame_MET_ENST00000318493_chr7_116412043_+_C8orf34_ENST00000518698_chr8_69358564_+_4726nt GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAAC AGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGG AGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAA TTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAA GAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTG TGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGT TTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTT AAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCC TGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGT AATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAG ACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAAC TGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCA TCCAACCAAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTTGCTTTGCCAGTGGTGGGAGCACAAT AACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATG TCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTT TTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGAT CTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAA GAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGA GTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTC AATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCG CTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATC TGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAA GAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCA TCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGC CCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGT GATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGA CCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCA ACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGA TAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATT TAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAA CCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGA AGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACT GAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGG AGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTCTTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTG AAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGCAGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAA TCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAACAAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACT AATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTGCCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTT |
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FusionGenePPI for MET_C8orf34 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MET | GLMN, CDH1, CTNNB1, HGF, RANBP9, GRB2, CBL, SH3KBP1, RANBP10, SRC, SHC1, SOS1, STAT3, GAB1, GAB2, LRIG1, INPPL1, DCN, SPSB1, SPSB2, SPSB3, SPSB4, CBLC, STUB1, HSPA4, HSP90AA1, GGA3, GNG12, FBXO6, HGS, CRK, CEACAM21, LGALS9, PCBP1, CASP3, SOCS1, HSP90AB1, EGFR, ERBB3, MET, CHEK1, PTEN, SCGB1D1 | C8orf34 | UBC, MCM7, MTUS2, C8orf34, ASB7, CNDP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 1320_1359 | 1027 | 1409 | MUC20 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 1320_1359 | 1009 | 1391 | MUC20 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 1320_1359 | 0 | 765 | MUC20 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000318493 | + | 14 | 21 | 1212_1390 | 1027 | 1409 | RANBP9 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000397752 | + | 14 | 21 | 1212_1390 | 1009 | 1391 | RANBP9 |
| Hgene | MET | chr7:116412043 | chr8:69358564 | ENST00000436117 | + | 1 | 9 | 1212_1390 | 0 | 765 | RANBP9 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MET_C8orf34 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MET | P08581 | DB08865 | Crizotinib | Hepatocyte growth factor receptor | small molecule | approved |
| Hgene | MET | P08581 | DB08875 | Cabozantinib | Hepatocyte growth factor receptor | small molecule | approved|investigational |
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RelatedDiseases for MET_C8orf34 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MET | C1336839 | Type 1 Papillary Renal Cell Carcinoma | 5 | UNIPROT |
| Hgene | MET | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CTD_human |
| Hgene | MET | C0001418 | Adenocarcinoma | 2 | CTD_human |
| Hgene | MET | C0004352 | Autistic Disorder | 2 | CTD_human |
| Hgene | MET | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Hgene | MET | C0038356 | Stomach Neoplasms | 2 | CTD_human |
| Hgene | MET | C0004114 | Astrocytoma | 1 | CTD_human |
| Hgene | MET | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | MET | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | MET | C0009241 | Cognition Disorders | 1 | CTD_human |
| Hgene | MET | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | MET | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | MET | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
| Hgene | MET | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | MET | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| Hgene | MET | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | MET | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | MET | C0027819 | Neuroblastoma | 1 | CTD_human |
| Hgene | MET | C0029463 | Osteosarcoma | 1 | CTD_human |
| Hgene | MET | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | MET | C0037199 | Sinusitis | 1 | CTD_human |
| Hgene | MET | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | MET | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Hgene | MET | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |
| Hgene | MET | C2239176 | Liver carcinoma | 1 | CTD_human;HPO;UNIPROT |
| Hgene | MET | C4084709 | DEAFNESS, AUTOSOMAL RECESSIVE 97 | 1 | UNIPROT |
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