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Fusion gene ID: 21721 |
FusionGeneSummary for METTL5_MERTK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METTL5_MERTK | Fusion gene ID: 21721 | Hgene | Tgene | Gene symbol | METTL5 | MERTK | Gene ID | 29081 | 10461 |
| Gene name | methyltransferase like 5 | MER proto-oncogene, tyrosine kinase | |
| Synonyms | HSPC133 | MER|RP38|Tyro12|c-Eyk|c-mer | |
| Cytomap | 2q31.1 | 2q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyltransferase-like protein 5 | tyrosine-protein kinase MerMER receptor tyrosine kinaseSTK kinasec-mer proto-oncogene tyrosine kinaseproto-oncogene c-Merreceptor tyrosine kinase MerTK | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NRN9 | Q12866 | |
| Ensembl transtripts involved in fusion gene | ENST00000409837, ENST00000409340, ENST00000260953, ENST00000409965, ENST00000392640, ENST00000308099, ENST00000410097, | ENST00000295408, ENST00000421804, ENST00000409780, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 7 X 10=350 |
| # samples | 2 | 13 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(13/350*10)=-1.42884329880387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: METTL5 [Title/Abstract] AND MERTK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MERTK | GO:0050766 | positive regulation of phagocytosis | 18395422 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A3EV-06A | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000409837 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409837 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000409837 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409340 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000409340 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409340 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000260953 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000260953 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000260953 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409965 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000409965 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409965 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000392640 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000392640 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000392640 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| intron-3CDS | ENST00000308099 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| intron-3CDS | ENST00000308099 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| intron-3CDS | ENST00000308099 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000410097 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000410097 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000410097 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
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FusionProtFeatures for METTL5_MERTK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METTL5 | MERTK |
| Probable methyltransferase. {ECO:0000250}. | Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to severalligands including LGALS3, TUB, TULP1 or GAS6. Regulates manyphysiological processes including cell survival, migration,differentiation, and phagocytosis of apoptotic cells(efferocytosis). Ligand binding at the cell surface inducesautophosphorylation of MERTK on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with GRB2 or PLCG2 andinduces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTKsignaling plays a role in various processes such as macrophageclearance of apoptotic cells, platelet aggregation, cytoskeletonreorganization and engulfment. Functions in the retinal pigmentepithelium (RPE) as a regulator of rod outer segments fragmentsphagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response byactivating STAT1, which selectively induces production ofsuppressors of cytokine signaling SOCS1 and SOCS3.{ECO:0000269|PubMed:17005688}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for METTL5_MERTK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_METTL5_ENST00000409837_chr2_170676071_-_MERTK_ENST00000409780_chr2_112785928_+_334aa MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIF NRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSSTREVXNNVLLLENRSLRPPH LFSIEAAARKTLRKFAXRSEPSRRYLRQYTVAGELXGPGPGLHPCSTGLEHRPXLYNCLLHSPRCHQCGHSRSSXQQTSXRTVHPEWGQX >In-frame_METTL5_ENST00000409340_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_235aa MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAGTDMAFLKTALEMARTAVYSLHKSSTREVXNNVLLLENRSLRPPHLFSIEAAAR KTLRKFAXRSEPSRRYLRQYTVAGELXGPGPGLHPCSTGLEHRPXLYNCLLHSPRCHQCGHSRSSXQQTSXRTVHPEWGQXGMGRSDFCP >In-frame_METTL5_ENST00000260953_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_334aa MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIF NRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSSTREVXNNVLLLENRSLRPPH LFSIEAAARKTLRKFAXRSEPSRRYLRQYTVAGELXGPGPGLHPCSTGLEHRPXLYNCLLHSPRCHQCGHSRSSXQQTSXRTVHPEWGQX >In-frame_METTL5_ENST00000409965_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_334aa MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIF NRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSSTREVXNNVLLLENRSLRPPH LFSIEAAARKTLRKFAXRSEPSRRYLRQYTVAGELXGPGPGLHPCSTGLEHRPXLYNCLLHSPRCHQCGHSRSSXQQTSXRTVHPEWGQX >In-frame_METTL5_ENST00000392640_chr2_170676071_-_MERTK_ENST00000409780_chr2_112785928_+_334aa MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIF NRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSSTREVXNNVLLLENRSLRPPH LFSIEAAARKTLRKFAXRSEPSRRYLRQYTVAGELXGPGPGLHPCSTGLEHRPXLYNCLLHSPRCHQCGHSRSSXQQTSXRTVHPEWGQX >In-frame_METTL5_ENST00000410097_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_334aa MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIF NRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSSTREVXNNVLLLENRSLRPPH LFSIEAAARKTLRKFAXRSEPSRRYLRQYTVAGELXGPGPGLHPCSTGLEHRPXLYNCLLHSPRCHQCGHSRSSXQQTSXRTVHPEWGQX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_METTL5_ENST00000409837_chr2_170676071_-_MERTK_ENST00000409780_chr2_112785928_+_1003nt ATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCT ACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGT GGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTT AATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTC GATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGA ACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCAC CTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACA GTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTG CACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGA GGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGG GGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGA >In-frame_METTL5_ENST00000409340_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_706nt ATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCT ACCAGGCCGCACATTGCAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCC TCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGA AAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGC CCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGT CACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCC CTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCT >In-frame_METTL5_ENST00000260953_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_1003nt ATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCT ACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGT GGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTT AATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTC GATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGA ACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCAC CTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACA GTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTG CACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGA GGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGG GGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGA >In-frame_METTL5_ENST00000409965_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_1003nt ATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCT ACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGT GGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTT AATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTC GATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGA ACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCAC CTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACA GTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTG CACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGA GGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGG GGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGA >In-frame_METTL5_ENST00000392640_chr2_170676071_-_MERTK_ENST00000409780_chr2_112785928_+_1003nt ATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCT ACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGT GGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTT AATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTC GATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGA ACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCAC CTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACA GTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTG CACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGA GGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGG GGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGA >In-frame_METTL5_ENST00000410097_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_1003nt ATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCT ACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGT GGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTT AATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTC GATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGA ACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCAC CTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACA GTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTG CACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGA GGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGG GGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_METTL5_ENST00000409837_chr2_170676071_-_MERTK_ENST00000409780_chr2_112785928_+_1587nt GCTTCCGGCACCGGCCGAGGTGCGGGTCGCCTCCAGAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTAAAACAAAATGAAGAAA GTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCTACCAGGCCG CACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGTGGTTGTGGA GTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTTAATAGGAAT GCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTCGATACAGTA ATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTA TATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGT ATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGA GAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCG CGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGA AGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTG GTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGAT GTGAGGAGAGGTGCGGGGAGACATTCCAAAAATCAAGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTGATGTTTTTGGTATTTG TCTTCCTTACCAAGTGAACTCCATGGCCCCAAAGCACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATACATAATATATATTTAT TTAAAGAGAAAAAATATGTGTATATCATGGAAAAAGACAAGGATATTTTAATAAAACATTACTTATTTCATTTCACTTATCTTGCATATC TTAAAATTAAGCTTCAGCTGCTCCTTGATATTAACATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTCTTTTTCATGACTATTA AATGTAAAAATATTTGTAAAATGAAATGCCATATTTGACTTGGCTTCTGGTCTTGATGTATTTGATAAGAATGATTCATTCAATGTTTAA >In-frame_METTL5_ENST00000409340_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_1254nt CCGTCTCCTGGGGCGGCTTGGGTTAGCCGGGAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTAAAACAAAATGAAGAAAGTAAG GCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCTACCAGGCCGCACAT TGCAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGT ATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAA GTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCC TTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTC ATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCA CAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCT CATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAA TCAAGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTGATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAA AGCACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATACATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAA AAAGACAAGGATATTTTAATAAAACATTACTTATTTCATTTCACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATT AACATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTCTTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCAT >In-frame_METTL5_ENST00000260953_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_1792nt CGGCCTGGCGCTTCCGGCACCGGCCGAGGTGCGGGTCGCCTCCAGAGGTGCGTGGTCGTGGCGCGAGGGATCCTGAGGCTGCTCCAGCAG TGCGCCGCCGCCGTCTCCTGGGGCGGCTTGGGTTAGCCGGGAGGTGGGTCAGAGGCTCGCCCCGTGCCCTGCGTCCGGGCGTCTCCTTAG GGCGCGTCTTCGGGTCCGGCCAGCGGTGCTGAAAAAGGGAGAAGGTTGGGGGTAGGGAGGAAACAAGATCCCAGTTCAATAGATTTCTCC GCAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTAAAACAAAATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAAC AAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCTACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATA ACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGTGGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAG GGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTTAATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGG TTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTCGATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATA AAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTAT GAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGT TTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTT GCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCAT GACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACA GCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCA TTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAATC AAGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTGATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAAAG CACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATACATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAAAA AGACAAGGATATTTTAATAAAACATTACTTATTTCATTTCACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATTAA CATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTCTTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCATAT >In-frame_METTL5_ENST00000409965_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_1662nt GTGCGCGCGTGCGGCCTGGCGCTTCCGGCACCGGCCGAGGTGCGGGTCGCCTCCAGAGGTGCGTGGTCGTGGCGCGAGGGATCCTGAGGC TGCTCCAGCAGTGCGCCGCCGCCGTCTCCTGGGGCGGCTTGGGTTAGCCGGGAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTA AAACAAAATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACA GTATCCTACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCT AGGATGTGGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGA AATATTTAATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAA GTCATTCGATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAAT GGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACC GCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCA ATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTG CCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGG GCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTA GGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAG GCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAATCAAGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTG ATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAAAGCACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATA CATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAAAAAGACAAGGATATTTTAATAAAACATTACTTATTTCATTTC ACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATTAACATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTC TTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCATATTTGACTTGGCTTCTGGTCTTGATGTATTTGATAAGAATGA >In-frame_METTL5_ENST00000392640_chr2_170676071_-_MERTK_ENST00000409780_chr2_112785928_+_1613nt GAACGCGTGCGCGCGTGCGGCCTGGCGCTTCCGGCACCGGCCGAGGTGCGGGTCGCCTCCAGAGATCCTGTGCCTTCAAACCCTACGAGT CCATACTTTAAAACAAAATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTAC TTCTGGAACAGTATCCTACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCG TTGCAGATCTAGGATGTGGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAG ACGCATTGGAAATATTTAATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACA GAATGTCCAAGTCATTCGATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTG CTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGAT CCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTT ATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGAC TCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATC CTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAG AGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGAC TCCTCAGAAGGCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAATCAAGCCAATTCTTCTGCTGTAGGAGAATCCA ATTGTACCTGATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAAAGCACCAGATGAATGTTGTTAAGTAAGCTGTC ATTAAAAATACATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAAAAAGACAAGGATATTTTAATAAAACATTACTT ATTTCATTTCACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATTAACATTTGTACAGAGTTGAAGTTGTTTTTTCA AGTTCTTTTCTTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCATATTTGACTTGGCTTCTGGTCTTGATGTATTTG >In-frame_METTL5_ENST00000410097_chr2_170676071_-_MERTK_ENST00000421804_chr2_112785928_+_1611nt TCCAGAGGTGCGTGGTCGTGGCGCGAGGGATCCTGAGGCTGCTCCAGCAGTGCGCCGCCGCCGTCTCCTGGGGCGGCTTGGGTTAGCCGG GAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTAAAACAAAATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACA AGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCTACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAA CACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGTGGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGG GTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTTAATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGT TCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTCGATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAA AGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATG AAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTT TGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTG CTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATG ACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAG CTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCAT TGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAATCA AGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTGATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAAAGC ACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATACATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAAAAA GACAAGGATATTTTAATAAAACATTACTTATTTCATTTCACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATTAAC ATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTCTTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCATATT |
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FusionGenePPI for METTL5_MERTK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| METTL5 | THUMPD3 | MERTK | GAS6, IKBKG, NEDD4L, ITGB5, MERTK, TNK2, HSP90AA1, SKI |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for METTL5_MERTK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for METTL5_MERTK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MERTK | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| Tgene | MERTK | C0034065 | Pulmonary Embolism | 1 | CTD_human |
| Tgene | MERTK | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;HPO;ORPHANET |
| Tgene | MERTK | C0040038 | Thromboembolism | 1 | CTD_human |
| Tgene | MERTK | C0040053 | Thrombosis | 1 | CTD_human |
| Tgene | MERTK | C3151228 | RETINITIS PIGMENTOSA 38 (disorder) | 1 | UNIPROT |
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