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Fusion gene ID: 21717 |
FusionGeneSummary for METTL2B_CA10 |
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Fusion gene information | Fusion gene name: METTL2B_CA10 | Fusion gene ID: 21717 | Hgene | Tgene | Gene symbol | METTL2B | CA10 | Gene ID | 55798 | 56934 |
Gene name | methyltransferase like 2B | carbonic anhydrase 10 | |
Synonyms | METL|METTL2|METTL2A|PSENIP1 | CA-RPX|CARPX|HUCEP-15 | |
Cytomap | 7q32.1 | 17q21.33-q22 | |
Type of gene | protein-coding | protein-coding | |
Description | methyltransferase-like protein 2B | carbonic anhydrase-related protein 10CA-RP XCARP Xcarbonic anhydrase Xcarbonic anhydrase-related protein Xcerebral protein-15 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q6P1Q9 | Q9NS85 | |
Ensembl transtripts involved in fusion gene | ENST00000262432, ENST00000480046, ENST00000473488, | ENST00000570565, ENST00000442502, ENST00000340813, ENST00000451037, ENST00000285273, ENST00000571918, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 18 X 7 X 8=1008 |
# samples | 1 | 18 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(18/1008*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: METTL2B [Title/Abstract] AND CA10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A09I-01A | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000262432 | ENST00000570565 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000262432 | ENST00000442502 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000262432 | ENST00000340813 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000262432 | ENST00000451037 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000262432 | ENST00000285273 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000262432 | ENST00000571918 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000480046 | ENST00000570565 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000480046 | ENST00000442502 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000480046 | ENST00000340813 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000480046 | ENST00000451037 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000480046 | ENST00000285273 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
5CDS-intron | ENST00000480046 | ENST00000571918 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
3UTR-intron | ENST00000473488 | ENST00000570565 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
3UTR-intron | ENST00000473488 | ENST00000442502 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
3UTR-intron | ENST00000473488 | ENST00000340813 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
3UTR-intron | ENST00000473488 | ENST00000451037 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
3UTR-intron | ENST00000473488 | ENST00000285273 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
3UTR-intron | ENST00000473488 | ENST00000571918 | METTL2B | chr7 | 128120750 | + | CA10 | chr17 | 49739206 | - |
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FusionProtFeatures for METTL2B_CA10 |
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Hgene | Tgene |
METTL2B | CA10 |
Probable S-adenosyl-L-methionine-dependentmethyltransferase that mediates 3-methylcytidine modification ofsome tRNAs. {ECO:0000269|PubMed:21518805}. | Does not have a catalytic activity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for METTL2B_CA10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for METTL2B_CA10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
METTL2B | APP, MAPK3, CENPU, METTL2A, NAT16, TPM3 | CA10 | PARL, MTHFD1, WDHD1, TSC22D1, IMPACT, ASS1, CALCOCO1, TOR1AIP1, PHYHIP, COL6A2, ABT1, INO80, ACTR10, MTERF4, G6PD, LYRM7, NRBP1, NSUN4, PSMG1, KCTD15, PIAS4, PSMG2, PSMG3, PSMG4, DCTN3, PPRC1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for METTL2B_CA10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CA10 | Q9NS85 | DB00909 | Zonisamide | Carbonic anhydrase-related protein 10 | small molecule | approved|investigational |
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RelatedDiseases for METTL2B_CA10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |