FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 21710

FusionGeneSummary for METTL25_CPM

check button Fusion gene summary
Fusion gene informationFusion gene name: METTL25_CPM
Fusion gene ID: 21710
HgeneTgene
Gene symbol

METTL25

CPM

Gene ID

84190

1368

Gene namemethyltransferase like 25carboxypeptidase M
SynonymsC12orf26-
Cytomap

12q21.31

12q15

Type of geneprotein-codingprotein-coding
Descriptionmethyltransferase-like protein 25carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B
Modification date2018051920180523
UniProtAcc

Q8N6Q8

P14384

Ensembl transtripts involved in fusion geneENST00000248306, ENST00000547357, 
ENST00000546373, ENST00000551568, 
ENST00000338356, ENST00000549691, 
Fusion gene scores* DoF score5 X 4 X 1=2038 X 10 X 8=3040
# samples 535
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(35/3040*10)=-3.11864449649862
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: METTL25 [Title/Abstract] AND CPM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A6BG-01AMETTL25chr12

82850599

+CPMchr12

69326620

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000248306ENST00000546373METTL25chr12

82850599

+CPMchr12

69326620

-
5CDS-5UTRENST00000248306ENST00000551568METTL25chr12

82850599

+CPMchr12

69326620

-
5CDS-5UTRENST00000248306ENST00000338356METTL25chr12

82850599

+CPMchr12

69326620

-
5CDS-intronENST00000248306ENST00000549691METTL25chr12

82850599

+CPMchr12

69326620

-
3UTR-5UTRENST00000547357ENST00000546373METTL25chr12

82850599

+CPMchr12

69326620

-
3UTR-5UTRENST00000547357ENST00000551568METTL25chr12

82850599

+CPMchr12

69326620

-
3UTR-5UTRENST00000547357ENST00000338356METTL25chr12

82850599

+CPMchr12

69326620

-
3UTR-intronENST00000547357ENST00000549691METTL25chr12

82850599

+CPMchr12

69326620

-

Top

FusionProtFeatures for METTL25_CPM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METTL25

Q8N6Q8

CPM

P14384

Putative methyltransferase. {ECO:0000250}. Specifically removes C-terminal basic residues (Arg orLys) from peptides and proteins. It is believed to play importantroles in the control of peptide hormone and growth factor activityat the cell surface, and in the membrane-localized degradation ofextracellular proteins. {ECO:0000269|PubMed:12457462}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for METTL25_CPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for METTL25_CPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
METTL25APP, HTR3C, NRD1, PCBP3, RPGRIP1CPMELAVL1, CAPZA2, DBN1, FLNA, GAK, MYH9, PPP1CC, RAB7A, PDLIM7, ATP6AP2, SYNPO, MAPRE1, GOLT1B, LIMA1, ANLN, MYO19, ZSCAN12, ULBP1, FTH1, TBC1D22B, GTPBP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for METTL25_CPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for METTL25_CPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCPMC0014175Endometriosis1CTD_human
TgeneCPMC0037116Silicosis1CTD_human