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Fusion gene ID: 2168 |
FusionGeneSummary for APLP1_DBH |
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Fusion gene information | Fusion gene name: APLP1_DBH | Fusion gene ID: 2168 | Hgene | Tgene | Gene symbol | APLP1 | DBH | Gene ID | 333 | 1621 |
Gene name | amyloid beta precursor like protein 1 | dopamine beta-hydroxylase | |
Synonyms | APLP | DBM | |
Cytomap | 19q13.12 | 9q34.2 | |
Type of gene | protein-coding | protein-coding | |
Description | amyloid-like protein 1amyloid beta (A4) precursor-like protein 1amyloid precursor-like protein 1 | dopamine beta-hydroxylasedopamine beta-hydroxylase (dopamine beta-monooxygenase) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P51693 | P09172 | |
Ensembl transtripts involved in fusion gene | ENST00000537454, ENST00000221891, ENST00000586861, ENST00000589298, | ENST00000393056, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: APLP1 [Title/Abstract] AND DBH [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | APLP1 | GO:0071874 | cellular response to norepinephrine stimulus | 16531006 |
Hgene | APLP1 | GO:0106072 | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | 16531006 |
Tgene | DBH | GO:0042420 | dopamine catabolic process | 3443096|7961964 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PCPG | TCGA-SR-A6MT-01A | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000537454 | ENST00000393056 | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
In-frame | ENST00000221891 | ENST00000393056 | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
In-frame | ENST00000586861 | ENST00000393056 | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
3UTR-3CDS | ENST00000589298 | ENST00000393056 | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
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FusionProtFeatures for APLP1_DBH |
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Hgene | Tgene |
APLP1 | DBH |
May play a role in postsynaptic function. The C-terminalgamma-secretase processed fragment, ALID1, activates transcriptionactivation through APBB1 (Fe65) binding (By similarity). Couplesto JIP signal transduction through C-terminal binding. Mayinteract with cellular G-protein signaling pathways. Can regulateneurite outgrowth through binding to components of theextracellular matrix such as heparin and collagen I.{ECO:0000250}. The gamma-CTF peptide, C30, is a potent enhancer ofneuronal apoptosis. {ECO:0000250}. | Conversion of dopamine to noradrenaline.{ECO:0000269|PubMed:27148966, ECO:0000269|PubMed:3443096,ECO:0000269|PubMed:7961964, ECO:0000269|PubMed:8546710}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 241_247 | 448 | 652 | Compositional bias | Note=Poly-Glu |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 264_268 | 448 | 652 | Compositional bias | Note=Poly-Glu |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 158_178 | 448 | 652 | Region | Copper-binding |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 204_211 | 448 | 652 | Region | Note=Zinc-binding |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 285_305 | 448 | 652 | Region | Note=O-glycosylated at three sites |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 310_342 | 448 | 652 | Region | Heparin-binding |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 410_441 | 448 | 652 | Region | Heparin-binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 604_615 | 448 | 652 | Motif | Basolateral sorting signal |
Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 640_643 | 448 | 652 | Motif | Note=NPXY motif%3B contains endocytosis signal |
Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 442_459 | 448 | 652 | Region | Collagen-binding |
Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 39_580 | 448 | 652 | Topological domain | Extracellular |
Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 604_650 | 448 | 652 | Topological domain | Cytoplasmic |
Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 581_603 | 448 | 652 | Transmembrane | Helical |
Tgene | DBH | chr19:36365771 | chr9:136523438 | ENST00000393056 | + | 10 | 12 | 57_173 | 574 | 618 | Domain | DOMON |
Tgene | DBH | chr19:36365771 | chr9:136523438 | ENST00000393056 | + | 10 | 12 | 1_16 | 574 | 618 | Topological domain | Cytoplasmic |
Tgene | DBH | chr19:36365771 | chr9:136523438 | ENST00000393056 | + | 10 | 12 | 38_617 | 574 | 618 | Topological domain | Intragranular |
Tgene | DBH | chr19:36365771 | chr9:136523438 | ENST00000393056 | + | 10 | 12 | 17_37 | 574 | 618 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for APLP1_DBH |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_APLP1_ENST00000537454_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_453aa MLASLEKDKTAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCA HPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPS GTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEG FLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAAL QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGEWNLQPLPKVISTLEEPTPQCPTSQGRSPAGPTVVSIGGG >In-frame_APLP1_ENST00000221891_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_492aa MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQR VLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETV PPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGE >In-frame_APLP1_ENST00000586861_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_486aa MEAVCGAWGRGLVLGVSVLGSKEPGDPHANAPRALTVLSTSIQAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCR QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGL ILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSH TLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVS GERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGEWNLQPL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_APLP1_ENST00000537454_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_1359nt ATGCTTGCATCCTTGGAAAAGGACAAAACTGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTG CGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTAC CCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCC CACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTG CACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCAC GGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCT GGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTC CCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCA GTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGG TTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCC AAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGA CAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTG CAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGC CACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTC ATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGC >In-frame_APLP1_ENST00000221891_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_1476nt ATGGGGCCCGCCAGCCCCGCTGCTCGCGGTCTAAGTCGCCGCCCGGGCCAGCCGCCGCTGCCGCTGCTGCTGCCACTATTGCTGCTGCTT CTGCGCGCGCAGCCCGCCATCGGGAGCCTGGCCGGTGGGAGCCCCGGCGCGGCCGAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGC GGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGC GTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGC GGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTG CTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCC TGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGT CCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCT GAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTC CCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATG CCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGT GAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACT CTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCT GCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAG CAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAA TGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGC >In-frame_APLP1_ENST00000586861_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_1458nt ATGGAGGCGGTGTGCGGTGCTTGGGGGAGGGGGCTGGTGCTGGGGGTCTCGGTCCTAGGGAGCAAAGAACCAGGGGACCCTCATGCCAAC GCCCCCCGAGCCCTCACTGTCCTTTCCACTTCCATCCAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCAC CGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGA CAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGC AGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGC CGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTC ATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCC GACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAG GAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCAT ACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAG CACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGAC AACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCT GGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTG GCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCAC ACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTG CCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_APLP1_ENST00000537454_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_2601nt AATCCTGAGGTGCTGCATCCACAGTGGGCATGGTGCTGGTGCCTGCTTGGATGATCCTTAAAGAAAGGTCCTGGGGGCTTTGGTTCATGG ATCCTTGAGCTAGGAGTTAAAGGTCCAGGCCCCTGGGACCCTTGGGAAGCAGAGCAAGAAGAGTGAACTCCTGGGTCTGAAGGAGAATGG GCTGGGGGCTTGGTCTCTGGTCCTGAGAGAGAAGGTGCCCAGACTTCTGGATCTGAAAGAGGAAGGGACTAGGTCTCAACTGCTGCCTTC TTGACTGGGGACATTTTGGAGGCCTGTATTCCTGAGCCCTCAACAGAGGAATGTACTAGGGGATGGGGGTCTCTGATGCTTGCATCCTTG GAAAAGGACAAAACTGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGG GAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATT GCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAG GTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATG GACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTC TTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGT GACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGAT GATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTC ACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAG ATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAA GCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAA ACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCT CAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTG GCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAA GAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGG ACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCT GCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTG AGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGC CTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGC CGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGC TGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGC TCCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGC GGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGG TGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCT >In-frame_APLP1_ENST00000221891_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_2565nt ACTCTGCGCGAAGCCGCCACGCTATTGTCCTGACCAGGAAGGCGGGGCCGGCGCGGGGCGGGGCTGGCGGCGCCGGCGCAGCCCGGGGGC GGCGGGAGGAGGAGGTGGCGGCGGTGGCGCTGGGAGCTCCTGTCACCGCTGGGGCCGGGCCGGGCGGGAGTGCAGGGGACGTGAGGGCGC AAGGGCCGGGACATGGGGCCCGCCAGCCCCGCTGCTCGCGGTCTAAGTCGCCGCCCGGGCCAGCCGCCGCTGCCGCTGCTGCTGCCACTA TTGCTGCTGCTTCTGCGCGCGCAGCCCGCCATCGGGAGCCTGGCCGGTGGGAGCCCCGGCGCGGCCGAGGCCCCGGGGTCGGCCCAGGTG GCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGG GACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATG GAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTG AGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAG GCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAG TATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGA GTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAA GAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATT TACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAAT GAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCC ATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGAC CAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTAC CTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGC TTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGA AGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGGACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGG GCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCTGCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTG CCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTGAGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACC GAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGCCTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCC CTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGCCGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCG CCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGCTGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTG CGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGCTCCATTCCTGAGTAAACAGATATTTTCGCCCACCTA AAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGCGGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAAT TATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGGTGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCA CTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCTCATCTGTAAAACCAGGCTGATGCCGTGCGGGCTAAT >In-frame_APLP1_ENST00000586861_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_2420nt ATAGCAACGGGAGCGCTGGGGCGCCCCCGCCCTACGGGAGCTGTTTCCCAGGGAACGGTGCCTCCATGGAGGCGGTGTGCGGTGCTTGGG GGAGGGGGCTGGTGCTGGGGGTCTCGGTCCTAGGGAGCAAAGAACCAGGGGACCCTCATGCCAACGCCCCCCGAGCCCTCACTGTCCTTT CCACTTCCATCCAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGG AACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTG CACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGG TTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGG ACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCT TACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTG ACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATG ATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCA CTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGA TGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAG CCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAA CCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTC AGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGG CCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAAG AGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGGA CCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCTG CACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTGA GAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGCC TGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGCC GGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGCT GAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGCT CCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGCG GGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGGT GGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCTC 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FusionGenePPI for APLP1_DBH |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
APLP1 | DAB1, CRCT1, PHF10, TCF21, TOE1, UTP14A, CDKN2C, GSTM4, HLA-DQA1, MPHOSPH6, NACA, STX5, TSC22D1, EIF2S2, HSPE1, PCDHA4, SAT1, TK1, ZNF24, PNP, DAB2, APBB3, APBB1, RAP1B, CSNK2B, SNCA, CDKN1A, CDK4, SMN1, RCC1, PIN1, VIM, ANXA7, KAT5, ARRB1, EEF1A1, ING5, GDF9, SETDB1, LRIF1, HAP1, RBM48, GLP1R, APBB2 | DBH | CLN3, CLN5, PPT1, NTRK1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 632_649 | 448 | 652 | DAB1 |
Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 636_650 | 448 | 652 | DAB2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for APLP1_DBH |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | APLP1 | P51693 | DB01593 | Zinc | Amyloid-like protein 1 | small molecule | approved|investigational |
Tgene | DBH | P09172 | DB00822 | Disulfiram | Dopamine beta-hydroxylase | small molecule | approved |
Tgene | DBH | P09172 | DB00988 | Dopamine | Dopamine beta-hydroxylase | small molecule | approved |
Tgene | DBH | P09172 | DB00126 | Vitamin C | Dopamine beta-hydroxylase | small molecule | approved|nutraceutical |
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RelatedDiseases for APLP1_DBH |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DBH | C0001973 | Alcoholic Intoxication, Chronic | 5 | PSYGENET |
Tgene | DBH | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Tgene | DBH | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | DBH | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | DBH | C0600427 | Cocaine Dependence | 5 | PSYGENET |
Tgene | DBH | C0525045 | Mood Disorders | 4 | PSYGENET |
Tgene | DBH | C0041696 | Unipolar Depression | 3 | PSYGENET |
Tgene | DBH | C1269683 | Major Depressive Disorder | 3 | PSYGENET |
Tgene | DBH | C1306067 | Drug-induced paranoid state | 3 | PSYGENET |
Tgene | DBH | C1456784 | Paranoia | 3 | CTD_human |
Tgene | DBH | C0027819 | Neuroblastoma | 1 | CTD_human |
Tgene | DBH | C0031511 | Pheochromocytoma | 1 | CTD_human |
Tgene | DBH | C0342687 | dopamine beta hydroxylase deficiency | 1 | CTD_human;ORPHANET;UNIPROT |