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Fusion gene ID: 2168 |
FusionGeneSummary for APLP1_DBH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APLP1_DBH | Fusion gene ID: 2168 | Hgene | Tgene | Gene symbol | APLP1 | DBH | Gene ID | 333 | 1621 |
| Gene name | amyloid beta precursor like protein 1 | dopamine beta-hydroxylase | |
| Synonyms | APLP | DBM | |
| Cytomap | 19q13.12 | 9q34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | amyloid-like protein 1amyloid beta (A4) precursor-like protein 1amyloid precursor-like protein 1 | dopamine beta-hydroxylasedopamine beta-hydroxylase (dopamine beta-monooxygenase) | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P51693 | P09172 | |
| Ensembl transtripts involved in fusion gene | ENST00000537454, ENST00000221891, ENST00000586861, ENST00000589298, | ENST00000393056, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: APLP1 [Title/Abstract] AND DBH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APLP1 | GO:0071874 | cellular response to norepinephrine stimulus | 16531006 |
| Hgene | APLP1 | GO:0106072 | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | 16531006 |
| Tgene | DBH | GO:0042420 | dopamine catabolic process | 3443096|7961964 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PCPG | TCGA-SR-A6MT-01A | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000537454 | ENST00000393056 | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
| In-frame | ENST00000221891 | ENST00000393056 | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
| In-frame | ENST00000586861 | ENST00000393056 | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
| 3UTR-3CDS | ENST00000589298 | ENST00000393056 | APLP1 | chr19 | 36365771 | + | DBH | chr9 | 136523438 | + |
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FusionProtFeatures for APLP1_DBH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APLP1 | DBH |
| May play a role in postsynaptic function. The C-terminalgamma-secretase processed fragment, ALID1, activates transcriptionactivation through APBB1 (Fe65) binding (By similarity). Couplesto JIP signal transduction through C-terminal binding. Mayinteract with cellular G-protein signaling pathways. Can regulateneurite outgrowth through binding to components of theextracellular matrix such as heparin and collagen I.{ECO:0000250}. The gamma-CTF peptide, C30, is a potent enhancer ofneuronal apoptosis. {ECO:0000250}. | Conversion of dopamine to noradrenaline.{ECO:0000269|PubMed:27148966, ECO:0000269|PubMed:3443096,ECO:0000269|PubMed:7961964, ECO:0000269|PubMed:8546710}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 241_247 | 448 | 652 | Compositional bias | Note=Poly-Glu |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 264_268 | 448 | 652 | Compositional bias | Note=Poly-Glu |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 158_178 | 448 | 652 | Region | Copper-binding |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 204_211 | 448 | 652 | Region | Note=Zinc-binding |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 285_305 | 448 | 652 | Region | Note=O-glycosylated at three sites |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 310_342 | 448 | 652 | Region | Heparin-binding |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 410_441 | 448 | 652 | Region | Heparin-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 604_615 | 448 | 652 | Motif | Basolateral sorting signal |
| Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 640_643 | 448 | 652 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 442_459 | 448 | 652 | Region | Collagen-binding |
| Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 39_580 | 448 | 652 | Topological domain | Extracellular |
| Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 604_650 | 448 | 652 | Topological domain | Cytoplasmic |
| Hgene | >APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 581_603 | 448 | 652 | Transmembrane | Helical |
| Tgene | DBH | chr19:36365771 | chr9:136523438 | ENST00000393056 | + | 10 | 12 | 57_173 | 574 | 618 | Domain | DOMON |
| Tgene | DBH | chr19:36365771 | chr9:136523438 | ENST00000393056 | + | 10 | 12 | 1_16 | 574 | 618 | Topological domain | Cytoplasmic |
| Tgene | DBH | chr19:36365771 | chr9:136523438 | ENST00000393056 | + | 10 | 12 | 38_617 | 574 | 618 | Topological domain | Intragranular |
| Tgene | DBH | chr19:36365771 | chr9:136523438 | ENST00000393056 | + | 10 | 12 | 17_37 | 574 | 618 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for APLP1_DBH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_APLP1_ENST00000537454_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_453aa MLASLEKDKTAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCA HPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPS GTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEG FLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAAL QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGEWNLQPLPKVISTLEEPTPQCPTSQGRSPAGPTVVSIGGG >In-frame_APLP1_ENST00000221891_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_492aa MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQR VLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETV PPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGE >In-frame_APLP1_ENST00000586861_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_486aa MEAVCGAWGRGLVLGVSVLGSKEPGDPHANAPRALTVLSTSIQAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCR QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGL ILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSH TLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVS GERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGEWNLQPL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_APLP1_ENST00000537454_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_1359nt ATGCTTGCATCCTTGGAAAAGGACAAAACTGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTG CGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTAC CCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCC CACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTG CACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCAC GGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCT GGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTC CCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCA GTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGG TTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCC AAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGA CAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTG CAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGC CACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTC ATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGC >In-frame_APLP1_ENST00000221891_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_1476nt ATGGGGCCCGCCAGCCCCGCTGCTCGCGGTCTAAGTCGCCGCCCGGGCCAGCCGCCGCTGCCGCTGCTGCTGCCACTATTGCTGCTGCTT CTGCGCGCGCAGCCCGCCATCGGGAGCCTGGCCGGTGGGAGCCCCGGCGCGGCCGAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGC GGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGC GTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGC GGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTG CTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCC TGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGT CCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCT GAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTC CCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATG CCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGT GAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACT CTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCT GCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAG CAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAA TGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGC >In-frame_APLP1_ENST00000586861_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_1458nt ATGGAGGCGGTGTGCGGTGCTTGGGGGAGGGGGCTGGTGCTGGGGGTCTCGGTCCTAGGGAGCAAAGAACCAGGGGACCCTCATGCCAAC GCCCCCCGAGCCCTCACTGTCCTTTCCACTTCCATCCAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCAC CGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGA CAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGC AGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGC CGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTC ATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCC GACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAG GAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCAT ACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAG CACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGAC AACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCT GGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTG GCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCAC ACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTG CCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_APLP1_ENST00000537454_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_2601nt AATCCTGAGGTGCTGCATCCACAGTGGGCATGGTGCTGGTGCCTGCTTGGATGATCCTTAAAGAAAGGTCCTGGGGGCTTTGGTTCATGG ATCCTTGAGCTAGGAGTTAAAGGTCCAGGCCCCTGGGACCCTTGGGAAGCAGAGCAAGAAGAGTGAACTCCTGGGTCTGAAGGAGAATGG GCTGGGGGCTTGGTCTCTGGTCCTGAGAGAGAAGGTGCCCAGACTTCTGGATCTGAAAGAGGAAGGGACTAGGTCTCAACTGCTGCCTTC TTGACTGGGGACATTTTGGAGGCCTGTATTCCTGAGCCCTCAACAGAGGAATGTACTAGGGGATGGGGGTCTCTGATGCTTGCATCCTTG GAAAAGGACAAAACTGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGG GAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATT GCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAG GTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATG GACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTC TTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGT GACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGAT GATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTC ACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAG ATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAA GCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAA ACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCT CAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTG GCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAA GAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGG ACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCT GCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTG AGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGC CTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGC CGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGC TGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGC TCCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGC GGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGG TGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCT >In-frame_APLP1_ENST00000221891_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_2565nt ACTCTGCGCGAAGCCGCCACGCTATTGTCCTGACCAGGAAGGCGGGGCCGGCGCGGGGCGGGGCTGGCGGCGCCGGCGCAGCCCGGGGGC GGCGGGAGGAGGAGGTGGCGGCGGTGGCGCTGGGAGCTCCTGTCACCGCTGGGGCCGGGCCGGGCGGGAGTGCAGGGGACGTGAGGGCGC AAGGGCCGGGACATGGGGCCCGCCAGCCCCGCTGCTCGCGGTCTAAGTCGCCGCCCGGGCCAGCCGCCGCTGCCGCTGCTGCTGCCACTA TTGCTGCTGCTTCTGCGCGCGCAGCCCGCCATCGGGAGCCTGGCCGGTGGGAGCCCCGGCGCGGCCGAGGCCCCGGGGTCGGCCCAGGTG GCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGG GACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATG GAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTG AGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAG GCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAG TATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGA GTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAA GAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATT TACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAAT GAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCC ATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGAC CAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTAC CTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGC TTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGA AGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGGACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGG GCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCTGCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTG CCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTGAGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACC GAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGCCTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCC CTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGCCGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCG CCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGCTGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTG CGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGCTCCATTCCTGAGTAAACAGATATTTTCGCCCACCTA AAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGCGGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAAT TATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGGTGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCA CTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCTCATCTGTAAAACCAGGCTGATGCCGTGCGGGCTAAT >In-frame_APLP1_ENST00000586861_chr19_36365771_+_DBH_ENST00000393056_chr9_136523438_+_2420nt ATAGCAACGGGAGCGCTGGGGCGCCCCCGCCCTACGGGAGCTGTTTCCCAGGGAACGGTGCCTCCATGGAGGCGGTGTGCGGTGCTTGGG GGAGGGGGCTGGTGCTGGGGGTCTCGGTCCTAGGGAGCAAAGAACCAGGGGACCCTCATGCCAACGCCCCCCGAGCCCTCACTGTCCTTT CCACTTCCATCCAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGG AACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTG CACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGG TTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGG ACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCT TACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTG ACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATG ATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCA CTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGA TGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAG CCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAA CCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTC AGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGG CCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAAG AGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGGA CCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCTG CACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTGA GAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGCC TGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGCC GGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGCT GAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGCT CCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGCG GGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGGT GGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCTC 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FusionGenePPI for APLP1_DBH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| APLP1 | DAB1, CRCT1, PHF10, TCF21, TOE1, UTP14A, CDKN2C, GSTM4, HLA-DQA1, MPHOSPH6, NACA, STX5, TSC22D1, EIF2S2, HSPE1, PCDHA4, SAT1, TK1, ZNF24, PNP, DAB2, APBB3, APBB1, RAP1B, CSNK2B, SNCA, CDKN1A, CDK4, SMN1, RCC1, PIN1, VIM, ANXA7, KAT5, ARRB1, EEF1A1, ING5, GDF9, SETDB1, LRIF1, HAP1, RBM48, GLP1R, APBB2 | DBH | CLN3, CLN5, PPT1, NTRK1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 632_649 | 448 | 652 | DAB1 |
| Hgene | APLP1 | chr19:36365771 | chr9:136523438 | ENST00000221891 | + | 10 | 17 | 636_650 | 448 | 652 | DAB2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for APLP1_DBH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | APLP1 | P51693 | DB01593 | Zinc | Amyloid-like protein 1 | small molecule | approved|investigational |
| Tgene | DBH | P09172 | DB00822 | Disulfiram | Dopamine beta-hydroxylase | small molecule | approved |
| Tgene | DBH | P09172 | DB00988 | Dopamine | Dopamine beta-hydroxylase | small molecule | approved |
| Tgene | DBH | P09172 | DB00126 | Vitamin C | Dopamine beta-hydroxylase | small molecule | approved|nutraceutical |
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RelatedDiseases for APLP1_DBH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DBH | C0001973 | Alcoholic Intoxication, Chronic | 5 | PSYGENET |
| Tgene | DBH | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Tgene | DBH | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | DBH | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | DBH | C0600427 | Cocaine Dependence | 5 | PSYGENET |
| Tgene | DBH | C0525045 | Mood Disorders | 4 | PSYGENET |
| Tgene | DBH | C0041696 | Unipolar Depression | 3 | PSYGENET |
| Tgene | DBH | C1269683 | Major Depressive Disorder | 3 | PSYGENET |
| Tgene | DBH | C1306067 | Drug-induced paranoid state | 3 | PSYGENET |
| Tgene | DBH | C1456784 | Paranoia | 3 | CTD_human |
| Tgene | DBH | C0027819 | Neuroblastoma | 1 | CTD_human |
| Tgene | DBH | C0031511 | Pheochromocytoma | 1 | CTD_human |
| Tgene | DBH | C0342687 | dopamine beta hydroxylase deficiency | 1 | CTD_human;ORPHANET;UNIPROT |
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