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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21665

FusionGeneSummary for METRNL_PPP1R1B

check button Fusion gene summary
Fusion gene informationFusion gene name: METRNL_PPP1R1B
Fusion gene ID: 21665
HgeneTgene
Gene symbol

METRNL

PPP1R1B

Gene ID

284207

84152

Gene namemeteorin like, glial cell differentiation regulatorprotein phosphatase 1 regulatory inhibitor subunit 1B
Synonyms-DARPP-32|DARPP32
Cytomap

17q25.3

17q12

Type of geneprotein-codingprotein-coding
Descriptionmeteorin-like proteinmeteorin, glial cell differentiation regulator-likesubfatinprotein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32
Modification date2018051920180527
UniProtAcc

Q641Q3

Q9UD71

Ensembl transtripts involved in fusion geneENST00000320095, ENST00000570778, 
ENST00000571814, ENST00000571940, 
ENST00000580825, ENST00000254079, 
ENST00000579000, ENST00000394265, 
ENST00000394267, 
Fusion gene scores* DoF score3 X 2 X 3=1810 X 5 X 11=550
# samples 319
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(19/550*10)=-1.53343220008107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: METRNL [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP1R1B

GO:0032515

negative regulation of phosphoprotein phosphatase activity

10807923


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0T1-01AMETRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000320095ENST00000580825METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
Frame-shitENST00000320095ENST00000254079METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
Frame-shitENST00000320095ENST00000579000METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
5CDS-5UTRENST00000320095ENST00000394265METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
5CDS-5UTRENST00000320095ENST00000394267METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
Frame-shitENST00000570778ENST00000580825METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
Frame-shitENST00000570778ENST00000254079METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
Frame-shitENST00000570778ENST00000579000METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
5CDS-5UTRENST00000570778ENST00000394265METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
5CDS-5UTRENST00000570778ENST00000394267METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
Frame-shitENST00000571814ENST00000580825METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
Frame-shitENST00000571814ENST00000254079METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
Frame-shitENST00000571814ENST00000579000METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
5CDS-5UTRENST00000571814ENST00000394265METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
5CDS-5UTRENST00000571814ENST00000394267METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
intron-3CDSENST00000571940ENST00000580825METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
intron-3CDSENST00000571940ENST00000254079METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
intron-3CDSENST00000571940ENST00000579000METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
intron-5UTRENST00000571940ENST00000394265METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+
intron-5UTRENST00000571940ENST00000394267METRNLchr17

81043199

+PPP1R1Bchr17

37785423

+

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FusionProtFeatures for METRNL_PPP1R1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METRNL

Q641Q3

PPP1R1B

Q9UD71

Hormone induced following exercise or cold exposure thatpromotes energy expenditure. Induced either in the skeletal muscleafter exercise or in adipose tissue following cold exposure and ispresent in the circulation. Able to stimulate energy expenditureassociated with the browning of the white fat depots and improvesglucose tolerance. Does not promote an increase in a thermogenicgene program via direct action on adipocytes, but acts bystimulating several immune cell subtypes to enter the adiposetissue and activate their prothermogenic actions. Stimulates aneosinophil-dependent increase in IL4 expression and promotesalternative activation of adipose tissue macrophages, which arerequired for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-inducedthermogenic responses, suggesting a role in metabolic adaptationsto cold temperatures (By similarity). {ECO:0000250}. Inhibitor of protein-phosphatase 1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for METRNL_PPP1R1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for METRNL_PPP1R1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
METRNLCHMP4B, DEFA5, A2MPPP1R1BDLGAP4, CSNK2A1, PPP1CC, PPP1CA, TFCP2, KLHL6, ACTBL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for METRNL_PPP1R1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for METRNL_PPP1R1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMETRNLC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePPP1R1BC0036341Schizophrenia5PSYGENET
TgenePPP1R1BC0005586Bipolar Disorder4PSYGENET
TgenePPP1R1BC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgenePPP1R1BC0007370Catalepsy1CTD_human
TgenePPP1R1BC0011570Mental Depression1PSYGENET
TgenePPP1R1BC0011581Depressive disorder1PSYGENET
TgenePPP1R1BC0013384Dyskinetic syndrome1CTD_human