|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 21661 |
FusionGeneSummary for METAP1_EIF4E |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METAP1_EIF4E | Fusion gene ID: 21661 | Hgene | Tgene | Gene symbol | METAP1 | EIF4E | Gene ID | 23173 | 1977 |
| Gene name | methionyl aminopeptidase 1 | eukaryotic translation initiation factor 4E | |
| Synonyms | MAP1A|MetAP1A | AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E | |
| Cytomap | 4q23 | 4q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methionine aminopeptidase 1MAP 1metAP 1peptidase M 1 | eukaryotic translation initiation factor 4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P53582 | P06730 | |
| Ensembl transtripts involved in fusion gene | ENST00000296411, ENST00000506548, ENST00000544031, | ENST00000450253, ENST00000280892, ENST00000504432, ENST00000505992, ENST00000504472, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: METAP1 [Title/Abstract] AND EIF4E [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EIF4E | GO:0006417 | regulation of translation | 22578813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A1IL-01A | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000296411 | ENST00000450253 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| In-frame | ENST00000296411 | ENST00000280892 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| In-frame | ENST00000296411 | ENST00000504432 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| In-frame | ENST00000296411 | ENST00000505992 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| 5CDS-5UTR | ENST00000296411 | ENST00000504472 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000506548 | ENST00000450253 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000506548 | ENST00000280892 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000506548 | ENST00000504432 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000506548 | ENST00000505992 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-5UTR | ENST00000506548 | ENST00000504472 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000544031 | ENST00000450253 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000544031 | ENST00000280892 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000544031 | ENST00000504432 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-3CDS | ENST00000544031 | ENST00000505992 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
| intron-5UTR | ENST00000544031 | ENST00000504472 | METAP1 | chr4 | 99917018 | + | EIF4E | chr4 | 99823133 | - |
Top |
FusionProtFeatures for METAP1_EIF4E |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METAP1 | EIF4E |
| Cotranslationally removes the N-terminal methionine fromnascent proteins. The N-terminal methionine is often cleaved whenthe second residue in the primary sequence is small and uncharged(Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normalprogression through the cell cycle. {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:17114291}. | Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis and facilitates ribosome binding by inducing theunwinding of the mRNAs secondary structures. Component of theCYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediatestranslational repression. In the CYFIP1-EIF4E-FMR1 complex thissubunit mediates the binding to the mRNA cap.{ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000280892 | - | 0 | 7 | 102_103 | 26 | 238 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000280892 | - | 0 | 7 | 132_139 | 26 | 238 | Region | Note=EIF4EBP1/2/3 binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000280892 | - | 0 | 7 | 157_162 | 26 | 238 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000280892 | - | 0 | 7 | 37_40 | 26 | 238 | Region | Note=EIF4EBP1/2/3 binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000280892 | - | 0 | 7 | 56_57 | 26 | 238 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000280892 | - | 0 | 7 | 73_77 | 26 | 238 | Region | Note=EIF4EBP1/2/3 binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000450253 | - | 0 | 7 | 102_103 | 6 | 218 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000450253 | - | 0 | 7 | 132_139 | 6 | 218 | Region | Note=EIF4EBP1/2/3 binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000450253 | - | 0 | 7 | 157_162 | 6 | 218 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000450253 | - | 0 | 7 | 37_40 | 6 | 218 | Region | Note=EIF4EBP1/2/3 binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000450253 | - | 0 | 7 | 56_57 | 6 | 218 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000450253 | - | 0 | 7 | 73_77 | 6 | 218 | Region | Note=EIF4EBP1/2/3 binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000505992 | - | 0 | 8 | 102_103 | 6 | 249 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000505992 | - | 0 | 8 | 132_139 | 6 | 249 | Region | Note=EIF4EBP1/2/3 binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000505992 | - | 0 | 8 | 157_162 | 6 | 249 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000505992 | - | 0 | 8 | 37_40 | 6 | 249 | Region | Note=EIF4EBP1/2/3 binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000505992 | - | 0 | 8 | 56_57 | 6 | 249 | Region | Note=7-methylguanosine-containing mRNA cap binding |
| Tgene | >EIF4E | chr4:99917018 | chr4:99823133 | ENST00000505992 | - | 0 | 8 | 73_77 | 6 | 249 | Region | Note=EIF4EBP1/2/3 binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >METAP1 | chr4:99917018 | chr4:99823133 | ENST00000296411 | + | 1 | 11 | 9_52 | 38 | 387 | Region | Zinc finger-like%3B important for proper ribosome association |
Top |
FusionGeneSequence for METAP1_EIF4E |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for METAP1_EIF4E |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| METAP1 | SMAD9, HECW2, GH2, CBWD1, LPPR2, CBWD2, EXOC3, RBM42, ZMAT2, HNRNPU, NAA40, NPPA, TRIM25, G3BP1 | EIF4E | EIF4EBP1, EIF4A2, EIF4A1, EIF4ENIF1, PML, EIF4G1, EIF4EBP2, EIF3B, MKNK1, EIF4EBP3, EIF3F, STUB1, DCC, HSPB2, RPTOR, APP, EIF4H, GEMIN5, ITGA4, CD83, PRDM4, AHSA1, ASS1, CAPN1, HSPA9, NANS, EIF6, HSPD1, PEPD, PROSC, TYMP, KANK2, TDO2, TRIM27, UBXN11, RPS6KB1, MTOR, TRIM22, EIF4G3, ANGEL1, DDX19A, CSK, UBFD1, KIAA0368, PABPC1, PABPC3, PABPC4, PDXK, NTRK1, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for METAP1_EIF4E |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for METAP1_EIF4E |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | EIF4E | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|