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Fusion gene ID: 21659 |
FusionGeneSummary for METAP1D_HAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METAP1D_HAT1 | Fusion gene ID: 21659 | Hgene | Tgene | Gene symbol | METAP1D | HAT1 | Gene ID | 254042 | 8520 |
| Gene name | methionyl aminopeptidase type 1D, mitochondrial | histone acetyltransferase 1 | |
| Synonyms | MAP 1D|MAP1D|MetAP 1D|Metap1l | KAT1 | |
| Cytomap | 2q31.1 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methionine aminopeptidase 1D, mitochondrialCDS of metAP-3 within PCR fragmentmetAP 1Dpeptidase M 1D | histone acetyltransferase type B catalytic subunit | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6UB28 | O14929 | |
| Ensembl transtripts involved in fusion gene | ENST00000315796, ENST00000488581, | ENST00000392584, ENST00000460481, ENST00000264108, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: METAP1D [Title/Abstract] AND HAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HAT1 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Tgene | HAT1 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Tgene | HAT1 | GO:0043967 | histone H4 acetylation | 22615379 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1549-01A | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315796 | ENST00000392584 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| 5CDS-intron | ENST00000315796 | ENST00000460481 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| 5CDS-intron | ENST00000315796 | ENST00000264108 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| intron-3CDS | ENST00000488581 | ENST00000392584 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| intron-intron | ENST00000488581 | ENST00000460481 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
| intron-intron | ENST00000488581 | ENST00000264108 | METAP1D | chr2 | 172864916 | + | HAT1 | chr2 | 172841096 | + |
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FusionProtFeatures for METAP1D_HAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METAP1D | HAT1 |
| Removes the N-terminal methionine from nascent proteins.The N-terminal methionine is often cleaved when the second residuein the primary sequence is small and uncharged (Met-Ala-, Cys,Gly, Pro, Ser, Thr, or Val). Requires deformylation of theN(alpha)-formylated initiator methionine before it can behydrolyzed (By similarity). May play a role in colontumorigenesis. {ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16568094}. | Acetylates soluble but not nucleosomal histone H4 at'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent,acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsicsubstrate specificity that modifies lysine in recognition sequenceGXGKXG. May be involved in nucleosome assembly during DNAreplication and repair as part of the histone H3.1 and H3.3complexes. May play a role in DNA repair in response to freeradical damage. {ECO:0000269|PubMed:11585814,ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379,ECO:0000269|PubMed:9427644}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >HAT1 | chr2:172864916 | chr2:172841096 | ENST00000392584 | + | 6 | 10 | 241_243 | 189 | 335 | Region | Acetyl-CoA binding |
| Tgene | >HAT1 | chr2:172864916 | chr2:172841096 | ENST00000392584 | + | 6 | 10 | 248_254 | 189 | 335 | Region | Acetyl-CoA binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | HAT1 | chr2:172864916 | chr2:172841096 | ENST00000264108 | + | 7 | 11 | 241_243 | 274 | 420 | Region | Acetyl-CoA binding |
| Tgene | HAT1 | chr2:172864916 | chr2:172841096 | ENST00000264108 | + | 7 | 11 | 248_254 | 274 | 420 | Region | Acetyl-CoA binding |
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FusionGeneSequence for METAP1D_HAT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for METAP1D_HAT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| METAP1D | XAGE3, PAK7, CPEB1, LRRC56, SIRT3 | HAT1 | BAP1, G3BP1, ATG10, HIST1H4A, HIST3H3, RBBP7, ASF1B, IPO4, HIST1H3A, H3F3A, H2AFX, HIST1H3E, HIST4H4, BCL2A1, CUL3, COPS5, ACAA1, HIST2H4A, HIST2H2AC, TP53BP1, YWHAQ, ZGPAT, HSPA1A, MEOX2, RBBP4, REL, TCF4, TNFAIP1, RPS6KB2, UNK, C5orf51, AP2M1, DDI2, TTC4, VPS29, SNF8, TLN2, NTRK1, NASP, ASF1A, CRY2, FAM204A, VTN, PRKAA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | HAT1 | chr2:172864916 | chr2:172841096 | ENST00000392584 | + | 6 | 10 | 225_227 | 189 | 335 | histone H4 N-terminus |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | HAT1 | chr2:172864916 | chr2:172841096 | ENST00000264108 | + | 7 | 11 | 62_64 | 274 | 420 | histone H4 N-terminus |
| Tgene | HAT1 | chr2:172864916 | chr2:172841096 | ENST00000392584 | + | 6 | 10 | 62_64 | 189 | 335 | histone H4 N-terminus |
| Tgene | HAT1 | chr2:172864916 | chr2:172841096 | ENST00000264108 | + | 7 | 11 | 225_227 | 274 | 420 | histone H4 N-terminus |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for METAP1D_HAT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for METAP1D_HAT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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