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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21657

FusionGeneSummary for MEST_MEST

check button Fusion gene summary
Fusion gene informationFusion gene name: MEST_MEST
Fusion gene ID: 21657
HgeneTgene
Gene symbol

MEST

MEST

Gene ID

4232

4232

Gene namemesoderm specific transcriptmesoderm specific transcript
SynonymsPEG1PEG1
Cytomap

7q32.2

7q32.2

Type of geneprotein-codingprotein-coding
Descriptionmesoderm-specific transcript homolog proteinpaternally-expressed gene 1 proteinmesoderm-specific transcript homolog proteinpaternally-expressed gene 1 protein
Modification date2018052320180523
UniProtAcc

Q5EB52

Q5EB52

Ensembl transtripts involved in fusion geneENST00000341441, ENST00000378576, 
ENST00000416162, ENST00000393187, 
ENST00000223215, ENST00000437945, 
ENST00000462132, 		ENST00000341441, 
ENST00000378576, ENST00000416162, 
ENST00000393187, ENST00000223215, 
ENST00000437945, ENST00000462132, 
Fusion gene scores* DoF score4 X 4 X 2=323 X 3 X 1=9
# samples 43
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MEST [Title/Abstract] AND MEST [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA568356MESTchr7

130144831

+MESTchr7

130135276

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000341441ENST00000341441MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000341441ENST00000378576MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000341441ENST00000416162MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000341441ENST00000393187MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000341441ENST00000223215MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000341441ENST00000437945MESTchr7

130144831

+MESTchr7

130135276

+
5CDS-intronENST00000341441ENST00000462132MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000378576ENST00000341441MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000378576ENST00000378576MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000378576ENST00000416162MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000378576ENST00000393187MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000378576ENST00000223215MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000378576ENST00000437945MESTchr7

130144831

+MESTchr7

130135276

+
5CDS-intronENST00000378576ENST00000462132MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000416162ENST00000341441MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000416162ENST00000378576MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000416162ENST00000416162MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000416162ENST00000393187MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000416162ENST00000223215MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000416162ENST00000437945MESTchr7

130144831

+MESTchr7

130135276

+
5CDS-intronENST00000416162ENST00000462132MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000393187ENST00000341441MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000393187ENST00000378576MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000393187ENST00000416162MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000393187ENST00000393187MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000393187ENST00000223215MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000393187ENST00000437945MESTchr7

130144831

+MESTchr7

130135276

+
5CDS-intronENST00000393187ENST00000462132MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000223215ENST00000341441MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000223215ENST00000378576MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000223215ENST00000416162MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000223215ENST00000393187MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000223215ENST00000223215MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000223215ENST00000437945MESTchr7

130144831

+MESTchr7

130135276

+
5CDS-intronENST00000223215ENST00000462132MESTchr7

130144831

+MESTchr7

130135276

+
In-frameENST00000437945ENST00000341441MESTchr7

130144831

+MESTchr7

130135276

+
Frame-shiftENST00000437945ENST00000378576MESTchr7

130144831

+MESTchr7

130135276

+
In-frameENST00000437945ENST00000416162MESTchr7

130144831

+MESTchr7

130135276

+
In-frameENST00000437945ENST00000393187MESTchr7

130144831

+MESTchr7

130135276

+
In-frameENST00000437945ENST00000223215MESTchr7

130144831

+MESTchr7

130135276

+
In-frameENST00000437945ENST00000437945MESTchr7

130144831

+MESTchr7

130135276

+
5CDS-intronENST00000437945ENST00000462132MESTchr7

130144831

+MESTchr7

130135276

+
intron-3CDSENST00000462132ENST00000341441MESTchr7

130144831

+MESTchr7

130135276

+
intron-3CDSENST00000462132ENST00000378576MESTchr7

130144831

+MESTchr7

130135276

+
intron-3CDSENST00000462132ENST00000416162MESTchr7

130144831

+MESTchr7

130135276

+
intron-3CDSENST00000462132ENST00000393187MESTchr7

130144831

+MESTchr7

130135276

+
intron-3CDSENST00000462132ENST00000223215MESTchr7

130144831

+MESTchr7

130135276

+
intron-3CDSENST00000462132ENST00000437945MESTchr7

130144831

+MESTchr7

130135276

+
intron-intronENST00000462132ENST00000462132MESTchr7

130144831

+MESTchr7

130135276

+

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FusionProtFeatures for MEST_MEST


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEST

Q5EB52

MEST

Q5EB52


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MEST_MEST


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MEST_MEST


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MEST_MEST


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MEST_MEST


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMESTC0043094Weight Gain1CTD_human
TgeneMESTC0043094Weight Gain1CTD_human