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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21655

FusionGeneSummary for MEST_ATP6V0A1

check button Fusion gene summary
Fusion gene informationFusion gene name: MEST_ATP6V0A1
Fusion gene ID: 21655
HgeneTgene
Gene symbol

MEST

ATP6V0A1

Gene ID

4232

535

Gene namemesoderm specific transcriptATPase H+ transporting V0 subunit a1
SynonymsPEG1ATP6N1|ATP6N1A|Stv1|VPP1|Vph1|a1
Cytomap

7q32.2

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionmesoderm-specific transcript homolog proteinpaternally-expressed gene 1 proteinV-type proton ATPase 116 kDa subunit a isoform 1V-type proton ATPase 116 kDa subunit aATPase, H+ transporting, lysosomal V0 subunit a1ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)H(+)-transporting two-sector ATPase,
Modification date2018052320180523
UniProtAcc

Q5EB52

Q93050

Ensembl transtripts involved in fusion geneENST00000341441, ENST00000378576, 
ENST00000416162, ENST00000393187, 
ENST00000223215, ENST00000437945, 
ENST00000462132, 		ENST00000393829, 
ENST00000546249, ENST00000537728, 
ENST00000264649, ENST00000585525, 
ENST00000343619, ENST00000544137, 
ENST00000587797, 
Fusion gene scores* DoF score4 X 4 X 2=325 X 6 X 2=60
# samples 45
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MEST [Title/Abstract] AND ATP6V0A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA696958MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000341441ENST00000393829MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000341441ENST00000546249MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000341441ENST00000537728MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000341441ENST00000264649MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000341441ENST00000585525MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000341441ENST00000343619MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000341441ENST00000544137MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
5CDS-3UTRENST00000341441ENST00000587797MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000378576ENST00000393829MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000378576ENST00000546249MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000378576ENST00000537728MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000378576ENST00000264649MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000378576ENST00000585525MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000378576ENST00000343619MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000378576ENST00000544137MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
5CDS-3UTRENST00000378576ENST00000587797MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000416162ENST00000393829MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000416162ENST00000546249MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000416162ENST00000537728MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000416162ENST00000264649MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000416162ENST00000585525MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000416162ENST00000343619MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000416162ENST00000544137MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
5CDS-3UTRENST00000416162ENST00000587797MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000393187ENST00000393829MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000393187ENST00000546249MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000393187ENST00000537728MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000393187ENST00000264649MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000393187ENST00000585525MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000393187ENST00000343619MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000393187ENST00000544137MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
5CDS-3UTRENST00000393187ENST00000587797MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000223215ENST00000393829MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000223215ENST00000546249MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000223215ENST00000537728MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000223215ENST00000264649MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000223215ENST00000585525MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000223215ENST00000343619MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000223215ENST00000544137MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
5CDS-3UTRENST00000223215ENST00000587797MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000437945ENST00000393829MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000437945ENST00000546249MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000437945ENST00000537728MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
In-frameENST00000437945ENST00000264649MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000437945ENST00000585525MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000437945ENST00000343619MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
Frame-shiftENST00000437945ENST00000544137MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
5CDS-3UTRENST00000437945ENST00000587797MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
intron-3CDSENST00000462132ENST00000393829MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
intron-3CDSENST00000462132ENST00000546249MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
intron-3CDSENST00000462132ENST00000537728MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
intron-3CDSENST00000462132ENST00000264649MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
intron-3CDSENST00000462132ENST00000585525MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
intron-3CDSENST00000462132ENST00000343619MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
intron-3CDSENST00000462132ENST00000544137MESTchr7

130138000

+ATP6V0A1chr17

40673059

+
intron-3UTRENST00000462132ENST00000587797MESTchr7

130138000

+ATP6V0A1chr17

40673059

+

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FusionProtFeatures for MEST_ATP6V0A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEST

Q5EB52

ATP6V0A1

Q93050

Required for assembly and activity of the vacuolarATPase. Potential role in differential targeting and regulation ofthe enzyme for a specific organelle (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MEST_ATP6V0A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MEST_ENST00000341441_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000341441_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000378576_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000378576_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000416162_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000416162_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000393187_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000393187_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000223215_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000223215_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000437945_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0aa

>In-frame_MEST_ENST00000437945_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MEST_ENST00000341441_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000341441_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000378576_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000378576_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000416162_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000416162_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000393187_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000393187_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000223215_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000223215_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000437945_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000437945_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_MEST_ENST00000341441_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000341441_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000378576_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000378576_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000416162_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000416162_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000393187_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000393187_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000223215_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000223215_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000437945_chr7_130138000_+_ATP6V0A1_ENST00000537728_chr17_40673059_+_0nt

>In-frame_MEST_ENST00000437945_chr7_130138000_+_ATP6V0A1_ENST00000264649_chr17_40673059_+_0nt


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FusionGenePPI for MEST_ATP6V0A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MEST_ATP6V0A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MEST_ATP6V0A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMESTC0043094Weight Gain1CTD_human