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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21652

FusionGeneSummary for MERTK_SHISA5

check button Fusion gene summary
Fusion gene informationFusion gene name: MERTK_SHISA5
Fusion gene ID: 21652
HgeneTgene
Gene symbol

MERTK

SHISA5

Gene ID

10461

51246

Gene nameMER proto-oncogene, tyrosine kinaseshisa family member 5
SynonymsMER|RP38|Tyro12|c-Eyk|c-merSCOTIN
Cytomap

2q13

3p21.31

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase MerMER receptor tyrosine kinaseSTK kinasec-mer proto-oncogene tyrosine kinaseproto-oncogene c-Merreceptor tyrosine kinase MerTKprotein shisa-5putative NF-kappa-B-activating protein 120shisa homolog 5
Modification date2018052320180523
UniProtAcc

Q12866

Q8N114

Ensembl transtripts involved in fusion geneENST00000295408, ENST00000421804, 
ENST00000409780, 		ENST00000296444, 
ENST00000444115, ENST00000426002, 
ENST00000465449, ENST00000442747, 
ENST00000443308, 
Fusion gene scores* DoF score2 X 2 X 1=413 X 10 X 7=910
# samples 213
** MAII scorelog2(2/4*10)=2.32192809488736log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MERTK [Title/Abstract] AND SHISA5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMERTK

GO:0050766

positive regulation of phagocytosis

18395422


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE772596MERTKchr2

112687011

-SHISA5chr3

48510868

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000295408ENST00000296444MERTKchr2

112687011

-SHISA5chr3

48510868

+
Frame-shiftENST00000295408ENST00000444115MERTKchr2

112687011

-SHISA5chr3

48510868

+
Frame-shiftENST00000295408ENST00000426002MERTKchr2

112687011

-SHISA5chr3

48510868

+
5CDS-5UTRENST00000295408ENST00000465449MERTKchr2

112687011

-SHISA5chr3

48510868

+
5CDS-5UTRENST00000295408ENST00000442747MERTKchr2

112687011

-SHISA5chr3

48510868

+
5CDS-5UTRENST00000295408ENST00000443308MERTKchr2

112687011

-SHISA5chr3

48510868

+
Frame-shiftENST00000421804ENST00000296444MERTKchr2

112687011

-SHISA5chr3

48510868

+
Frame-shiftENST00000421804ENST00000444115MERTKchr2

112687011

-SHISA5chr3

48510868

+
Frame-shiftENST00000421804ENST00000426002MERTKchr2

112687011

-SHISA5chr3

48510868

+
5CDS-5UTRENST00000421804ENST00000465449MERTKchr2

112687011

-SHISA5chr3

48510868

+
5CDS-5UTRENST00000421804ENST00000442747MERTKchr2

112687011

-SHISA5chr3

48510868

+
5CDS-5UTRENST00000421804ENST00000443308MERTKchr2

112687011

-SHISA5chr3

48510868

+
intron-3CDSENST00000409780ENST00000296444MERTKchr2

112687011

-SHISA5chr3

48510868

+
intron-3CDSENST00000409780ENST00000444115MERTKchr2

112687011

-SHISA5chr3

48510868

+
intron-3CDSENST00000409780ENST00000426002MERTKchr2

112687011

-SHISA5chr3

48510868

+
intron-5UTRENST00000409780ENST00000465449MERTKchr2

112687011

-SHISA5chr3

48510868

+
intron-5UTRENST00000409780ENST00000442747MERTKchr2

112687011

-SHISA5chr3

48510868

+
intron-5UTRENST00000409780ENST00000443308MERTKchr2

112687011

-SHISA5chr3

48510868

+

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FusionProtFeatures for MERTK_SHISA5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MERTK

Q12866

SHISA5

Q8N114

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to severalligands including LGALS3, TUB, TULP1 or GAS6. Regulates manyphysiological processes including cell survival, migration,differentiation, and phagocytosis of apoptotic cells(efferocytosis). Ligand binding at the cell surface inducesautophosphorylation of MERTK on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with GRB2 or PLCG2 andinduces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTKsignaling plays a role in various processes such as macrophageclearance of apoptotic cells, platelet aggregation, cytoskeletonreorganization and engulfment. Functions in the retinal pigmentepithelium (RPE) as a regulator of rod outer segments fragmentsphagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response byactivating STAT1, which selectively induces production ofsuppressors of cytokine signaling SOCS1 and SOCS3.{ECO:0000269|PubMed:17005688}. Can induce apoptosis in a caspase-dependent manner andplays a role in p53/TP53-dependent apoptosis.{ECO:0000269|PubMed:12135983}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MERTK_SHISA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MERTK_SHISA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MERTK_SHISA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MERTK_SHISA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMERTKC0017661IGA Glomerulonephritis1CTD_human
HgeneMERTKC0034065Pulmonary Embolism1CTD_human
HgeneMERTKC0035334Retinitis Pigmentosa1CTD_human;HPO;ORPHANET
HgeneMERTKC0040038Thromboembolism1CTD_human
HgeneMERTKC0040053Thrombosis1CTD_human
HgeneMERTKC3151228RETINITIS PIGMENTOSA 38 (disorder)1UNIPROT