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Fusion gene ID: 21640 |
FusionGeneSummary for MEMO1_CORIN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MEMO1_CORIN | Fusion gene ID: 21640 | Hgene | Tgene | Gene symbol | MEMO1 | CORIN | Gene ID | 51072 | 10699 |
| Gene name | mediator of cell motility 1 | corin, serine peptidase | |
| Synonyms | C2orf4|CGI-27|MEMO|NS5ATP7 | ATC2|CRN|Lrp4|PEE5|TMPRSS10 | |
| Cytomap | 2p22.3 | 4p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein MEMO1C21orf19-like proteinHCV NS5A-transactivated protein 7hepatitis C virus NS5A-transactivated protein 7mediator of ErbB2-driven cell motility 1 | atrial natriuretic peptide-converting enzymeheart-specific serine proteinase ATC2pro-ANP-convertasepro-ANP-converting enzymetransmembrane protease serine 10 | |
| Modification date | 20180523 | 20180506 | |
| UniProtAcc | Q9Y316 | Q9Y5Q5 | |
| Ensembl transtripts involved in fusion gene | ENST00000295065, ENST00000379383, ENST00000404530, ENST00000490459, ENST00000426310, ENST00000407893, | ENST00000273857, ENST00000508498, ENST00000502252, ENST00000505909, ENST00000504584, ENST00000515827, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 5 X 6 X 5=150 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/150*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MEMO1 [Title/Abstract] AND CORIN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CORIN | GO:0016486 | peptide hormone processing | 10880574 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CN274312 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000295065 | ENST00000273857 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000295065 | ENST00000508498 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000295065 | ENST00000502252 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000295065 | ENST00000505909 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000295065 | ENST00000504584 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000295065 | ENST00000515827 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-3CDS | ENST00000379383 | ENST00000273857 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000379383 | ENST00000508498 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000379383 | ENST00000502252 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000379383 | ENST00000505909 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000379383 | ENST00000504584 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000379383 | ENST00000515827 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-3CDS | ENST00000404530 | ENST00000273857 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000404530 | ENST00000508498 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000404530 | ENST00000502252 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000404530 | ENST00000505909 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000404530 | ENST00000504584 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000404530 | ENST00000515827 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-3CDS | ENST00000490459 | ENST00000273857 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000490459 | ENST00000508498 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000490459 | ENST00000502252 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000490459 | ENST00000505909 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000490459 | ENST00000504584 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000490459 | ENST00000515827 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-3CDS | ENST00000426310 | ENST00000273857 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000426310 | ENST00000508498 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000426310 | ENST00000502252 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000426310 | ENST00000505909 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000426310 | ENST00000504584 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000426310 | ENST00000515827 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-3CDS | ENST00000407893 | ENST00000273857 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000407893 | ENST00000508498 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000407893 | ENST00000502252 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000407893 | ENST00000505909 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000407893 | ENST00000504584 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
| intron-intron | ENST00000407893 | ENST00000515827 | MEMO1 | chr2 | 32264346 | - | CORIN | chr4 | 47809066 | - |
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FusionProtFeatures for MEMO1_CORIN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MEMO1 | CORIN |
| May control cell migration by relaying extracellularchemotactic signals to the microtubule cytoskeleton. Mediator ofERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays animportant role in ERBB2-dependent stabilization of microtubules atthe cell cortex. It controls the localization of APC and CLASP2 tothe cell membrane, via the regulation of GSK3B activity. In turn,membrane-bound APC allows the localization of the MACF1 to thecell membrane, which is required for microtubule capture andstabilization. Is required for breast carcinoma cell migration.{ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}. | Serine-type endopeptidase involved in atrial natriureticpeptide hormone (NPPA) processing. Converts through proteolyticcleavage the non-functional propeptide NPPA into the activehormone, thereby regulating blood pressure in heart and promotingnatriuresis, diuresis and vasodilation. Proteolytic cleavage ofpro-NPPA also plays a role in female pregnancy by promotingtrophoblast invasion and spiral artery remodeling in uterus. Alsoacts as a regulator of sodium reabsorption in kidney. May alsoprocess pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared toisoform 1. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MEMO1_CORIN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MEMO1_CORIN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MEMO1_CORIN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MEMO1_CORIN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CORIN | C3281288 | PREECLAMPSIA/ECLAMPSIA 5 | 1 | UNIPROT |
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