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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21636

FusionGeneSummary for MELK_DCTN3

check button Fusion gene summary
Fusion gene informationFusion gene name: MELK_DCTN3
Fusion gene ID: 21636
HgeneTgene
Gene symbol

MELK

DCTN3

Gene ID

9833

11258

Gene namematernal embryonic leucine zipper kinasedynactin subunit 3
SynonymsHPK38DCTN-22|DCTN22
Cytomap

9p13.2

9p13.3

Type of geneprotein-codingprotein-coding
Descriptionmaternal embryonic leucine zipper kinasepEg3 kinaseprotein kinase Eg3protein kinase PK38tyrosine-protein kinase MELKdynactin subunit 3dynactin 3 (p22)dynactin complex subunit 22 kDa subunitdynactin light chain
Modification date2018052720180522
UniProtAcc

Q14680

O75935

Ensembl transtripts involved in fusion geneENST00000298048, ENST00000538311, 
ENST00000536987, ENST00000536860, 
ENST00000545008, ENST00000536329, 
ENST00000541717, ENST00000543751, 
ENST00000487398, 		ENST00000479399, 
ENST00000341694, ENST00000259632, 
ENST00000378916, ENST00000447983, 
ENST00000477738, ENST00000378913, 
Fusion gene scores* DoF score5 X 4 X 4=802 X 1 X 1=2
# samples 51
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: MELK [Title/Abstract] AND DCTN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMELK

GO:0006915

apoptotic process

17280616

HgeneMELK

GO:0008283

cell proliferation

17280616

HgeneMELK

GO:0046777

protein autophosphorylation

16216881

TgeneDCTN3

GO:0061640

cytoskeleton-dependent cytokinesis

9722614


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-XF-A9T4-01AMELKchr9

36573004

+DCTN3chr9

34618757

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000298048ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000298048ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000298048ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000298048ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000298048ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000298048ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000298048ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000538311ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000538311ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000538311ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000538311ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000538311ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000538311ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000538311ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536987ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536987ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536987ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536987ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536987ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536987ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536987ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536860ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536860ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536860ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536860ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536860ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536860ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536860ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000545008ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000545008ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000545008ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000545008ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000545008ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000545008ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000545008ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536329ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536329ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536329ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536329ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536329ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536329ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000536329ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000541717ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000541717ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000541717ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000541717ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000541717ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000541717ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000541717ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000543751ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000543751ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000543751ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000543751ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000543751ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000543751ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
5UTR-intronENST00000543751ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-
3UTR-intronENST00000487398ENST00000479399MELKchr9

36573004

+DCTN3chr9

34618757

-
3UTR-intronENST00000487398ENST00000341694MELKchr9

36573004

+DCTN3chr9

34618757

-
3UTR-intronENST00000487398ENST00000259632MELKchr9

36573004

+DCTN3chr9

34618757

-
3UTR-intronENST00000487398ENST00000378916MELKchr9

36573004

+DCTN3chr9

34618757

-
3UTR-intronENST00000487398ENST00000447983MELKchr9

36573004

+DCTN3chr9

34618757

-
3UTR-intronENST00000487398ENST00000477738MELKchr9

36573004

+DCTN3chr9

34618757

-
3UTR-intronENST00000487398ENST00000378913MELKchr9

36573004

+DCTN3chr9

34618757

-

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FusionProtFeatures for MELK_DCTN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MELK

Q14680

DCTN3

O75935

Together with dynein may be involved in spindle assemblyand cytokinesis. {ECO:0000269|PubMed:9722614}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MELK_DCTN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MELK_DCTN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MELKCDC25B, ZNF622, BABAM1, LMNB1, MBP, MELK, SPACA1, MLST8, PLAUR, CBWD1, PRG2, CDC5L, RHPN1, PCDHGA5, IL13RA2, PROZ, HAVCR2, CD79B, P4HA2, SNX21, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, RTKN, MAST3, PPM1H, SRSF12, SYDE1, DENND4C, CGN, AGAP1, CDK16, FAM110B, USP21, MAPKAP1, FAM53C, ANKRD34A, HDAC4, FAM110A, CBY1, RAB3IPDCTN3GSK3B, ATXN1, DCTN2, ACTR1B, DYNLT3, ACTR10, ACTR1A, FHL2, NUP85, FLNB, CCAR2, LEO1, LMNB1, TNKS1BP1, PHF19, THAP1, CSPP1, C4BPB, CAPZA2, NMI, GPS2, CA10, MED4, SCLT1, DCTN1, MAD2L2, L1TD1, LRIF1, DUSP13, DUSP28, DCTN6, RIC8A, DEFB127, KLHL2, MIS18A, PDGFD, UQCRH, RPS19BP1, ACTBL2, C1orf106


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MELK_DCTN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MELK_DCTN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource