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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21627

FusionGeneSummary for MEIS1_ARHGAP25

check button Fusion gene summary
Fusion gene informationFusion gene name: MEIS1_ARHGAP25
Fusion gene ID: 21627
HgeneTgene
Gene symbol

MEIS1

ARHGAP25

Gene ID

4211

9938

Gene nameMeis homeobox 1Rho GTPase activating protein 25
Synonyms-HEL-S-308|KAIA0053
Cytomap

2p14

2p13.3

Type of geneprotein-codingprotein-coding
Descriptionhomeobox protein Meis1Meis1, myeloid ecotropic viral integration site 1 homologWUGSC:H_NH0444B04.1leukemogenic homolog proteinrho GTPase-activating protein 25epididymis secretory protein Li 308rho-type GTPase-activating protein 25
Modification date2018052320180519
UniProtAcc

O00470

P42331

Ensembl transtripts involved in fusion geneENST00000560281, ENST00000407092, 
ENST00000272369, ENST00000488550, 
ENST00000398506, ENST00000444274, 
ENST00000495021, ENST00000409517, 
ENST00000544262, ENST00000295381, 
ENST00000409202, ENST00000456116, 
ENST00000467265, ENST00000409030, 
ENST00000409220, ENST00000497079, 
ENST00000479844, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MEIS1 [Title/Abstract] AND ARHGAP25 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A1ZY-06AMEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000560281ENST00000544262MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000560281ENST00000295381MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000560281ENST00000409202MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000560281ENST00000456116MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000560281ENST00000467265MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000560281ENST00000409030MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000560281ENST00000409220MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000560281ENST00000497079MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000560281ENST00000479844MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000407092ENST00000544262MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000407092ENST00000295381MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000407092ENST00000409202MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000407092ENST00000456116MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000407092ENST00000467265MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000407092ENST00000409030MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000407092ENST00000409220MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000407092ENST00000497079MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000407092ENST00000479844MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000272369ENST00000544262MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000272369ENST00000295381MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000272369ENST00000409202MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000272369ENST00000456116MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000272369ENST00000467265MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000272369ENST00000409030MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000272369ENST00000409220MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000272369ENST00000497079MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000272369ENST00000479844MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000488550ENST00000544262MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000488550ENST00000295381MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000488550ENST00000409202MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000488550ENST00000456116MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000488550ENST00000467265MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000488550ENST00000409030MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000488550ENST00000409220MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000488550ENST00000497079MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000488550ENST00000479844MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000398506ENST00000544262MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000398506ENST00000295381MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000398506ENST00000409202MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000398506ENST00000456116MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000398506ENST00000467265MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000398506ENST00000409030MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000398506ENST00000409220MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000398506ENST00000497079MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000398506ENST00000479844MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-3UTRENST00000444274ENST00000544262MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-3UTRENST00000444274ENST00000295381MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-3UTRENST00000444274ENST00000409202MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000444274ENST00000456116MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000444274ENST00000467265MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000444274ENST00000409030MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000444274ENST00000409220MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000444274ENST00000497079MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000444274ENST00000479844MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000495021ENST00000544262MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000495021ENST00000295381MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-3UTRENST00000495021ENST00000409202MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000495021ENST00000456116MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000495021ENST00000467265MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000495021ENST00000409030MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000495021ENST00000409220MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000495021ENST00000497079MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
5CDS-intronENST00000495021ENST00000479844MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-3UTRENST00000409517ENST00000544262MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-3UTRENST00000409517ENST00000295381MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-3UTRENST00000409517ENST00000409202MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000409517ENST00000456116MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000409517ENST00000467265MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000409517ENST00000409030MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000409517ENST00000409220MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000409517ENST00000497079MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+
intron-intronENST00000409517ENST00000479844MEIS1chr2

66739426

+ARHGAP25chr2

69043421

+

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FusionProtFeatures for MEIS1_ARHGAP25


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEIS1

O00470

ARHGAP25

P42331

Acts as a transcriptional regulator of PAX6. Acts as atranscriptional activator of PF4 in complex with PBX1 or PBX2.Required for hematopoiesis, megakaryocyte lineage development andvascular patterning. May function as a cofactor for HOXA7 andHOXA9 in the induction of myeloid leukemias.{ECO:0000269|PubMed:12609849}. GTPase activator for the Rho-type GTPases by convertingthem to an inactive GDP-bound state. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MEIS1_ARHGAP25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MEIS1_ARHGAP25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MEIS1HOXA9, PBX1, HOXD9, EMX2, TLX2, HOXC11, CREB1, CRTC1, CREBBP, ETS1, TRMT10B, SHMT2, LMX1B, MAB21L1, MEIS2, MAB21L2, FOXC1, FAM222A, C16orf71, CCDC120, C5orf24, COL20A1ARHGAP25DMWD, DYNC2H1, DSTYK, GTF2H2, POLD1, SEC23IP, DPYSL4, ACACA, TBL3, CAMK2D, CAMK2G, UBA6, DDX11L8, MSTO1, ATG7, DPP9, PER1, HERC3, ANGEL1, VWA9, RECQL4, THUMPD3, C2orf44, KDM5C, NPRL3, TRIM27, AP5B1, TRIM65, WRAP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MEIS1_ARHGAP25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MEIS1_ARHGAP25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMEIS1C0035258Restless Legs Syndrome1CTD_human
HgeneMEIS1C1458155Mammary Neoplasms1CTD_human