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Fusion gene ID: 21616 |
FusionGeneSummary for MEGF11_RPL4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MEGF11_RPL4 | Fusion gene ID: 21616 | Hgene | Tgene | Gene symbol | MEGF11 | RPL4 | Gene ID | 84465 | 6124 |
| Gene name | multiple EGF like domains 11 | ribosomal protein L4 | |
| Synonyms | - | L4 | |
| Cytomap | 15q22.31 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | multiple epidermal growth factor-like domains protein 11multiple EGF-like domains protein 11 | 60S ribosomal protein L460S ribosomal protein L1large ribosomal subunit protein uL4 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | A6BM72 | P36578 | |
| Ensembl transtripts involved in fusion gene | ENST00000409699, ENST00000360698, ENST00000422354, ENST00000395625, ENST00000288745, ENST00000478721, ENST00000395614, | ENST00000307961, ENST00000568588, ENST00000564517, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 9 X 8 X 4=288 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MEGF11 [Title/Abstract] AND RPL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-DU-7298-01A | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000409699 | ENST00000307961 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-5UTR | ENST00000409699 | ENST00000568588 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-intron | ENST00000409699 | ENST00000564517 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| Frame-shift | ENST00000360698 | ENST00000307961 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-5UTR | ENST00000360698 | ENST00000568588 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-intron | ENST00000360698 | ENST00000564517 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| In-frame | ENST00000422354 | ENST00000307961 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-5UTR | ENST00000422354 | ENST00000568588 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-intron | ENST00000422354 | ENST00000564517 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| In-frame | ENST00000395625 | ENST00000307961 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-5UTR | ENST00000395625 | ENST00000568588 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-intron | ENST00000395625 | ENST00000564517 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| Frame-shift | ENST00000288745 | ENST00000307961 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-5UTR | ENST00000288745 | ENST00000568588 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5CDS-intron | ENST00000288745 | ENST00000564517 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| intron-3CDS | ENST00000478721 | ENST00000307961 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| intron-5UTR | ENST00000478721 | ENST00000568588 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| intron-intron | ENST00000478721 | ENST00000564517 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5UTR-3CDS | ENST00000395614 | ENST00000307961 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5UTR-5UTR | ENST00000395614 | ENST00000568588 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
| 5UTR-intron | ENST00000395614 | ENST00000564517 | MEGF11 | chr15 | 66273116 | - | RPL4 | chr15 | 66795867 | - |
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FusionProtFeatures for MEGF11_RPL4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MEGF11 | RPL4 |
| May regulate the mosaic spacing of specific neuronsubtypes in the retina through homotypic retinal neuron repulsion.Mosaics provide a mechanism to distribute each cell type evenlyacross the retina, ensuring that all parts of the visual fieldhave access to a full set of processing elements (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MEGF11_RPL4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MEGF11_ENST00000422354_chr15_66273116_-_RPL4_ENST00000307961_chr15_66795867_-_681aa MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCP GYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGT HGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTACARPLISVYSEKGES SGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKT WRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMR NRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINT DLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAALQAKSDEKAAVAGKKPV >In-frame_MEGF11_ENST00000395625_chr15_66273116_-_RPL4_ENST00000307961_chr15_66795867_-_606aa MHTPSIRSITHDAQTSSTGSSAPGTALCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAA GFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTA CARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAF GNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIKK VYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAAS LKSNYNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAALQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MEGF11_ENST00000422354_chr15_66273116_-_RPL4_ENST00000307961_chr15_66795867_-_2043nt ATGGTGCTCTCCCTGACGGGGCTCATTGCCTTCTCCTTCCTGCAAGCCACCCTTGCCCTGAACCCCGAGGACCCCAACGTGTGCAGCCAC TGGGAGAGCTATGCTGTGACTGTCCAGGAATCGTATGCACACCCCTTCGATCAGATCTATTACACACGATGCACAGACATCCTCAACTGG TTCAAGTGCACCAGGCACCGGATCAGTTATAAGACGGCGTATCGGAGAGGCCTCCGGACCATGTACCGGCGGAGGTCCCAGTGCTGCCCT GGCTACTATGAGAGCGGAGACTTCTGCATACCCCTGTGTACGGAGGAGTGTGTGCACGGCCGCTGCGTTTCCCCGGACACCTGCCACTGC GAGCCTGGCTGGGGAGGGCCCGACTGCTCCAGCGGCTGCGACAGCGACCACTGGGGGCCCCACTGCAGCAACCGGTGCCAGTGCCAGAAC GGCGCCCTGTGTAACCCCATCACAGGCGCCTGCGTGTGCGCCGCCGGCTTCCGTGGATGGCGCTGCGAGGAGCTCTGCGCACCTGGCACC CACGGCAAGGGATGCCAGCTGCCGTGCCAGTGCCGACACGGTGCCAGCTGCGACCCCCGCGCCGGCGAGTGCCTCTGCGCACCTGGCTAC ACCGGCGTCTACTGCGAGGAGCTGTGCCCTCCTGGGAGCCATGGAGCTCACTGTGAGCTGCGCTGCCCCTGTCAGAATGGGGGCACCTGC CACCACATCACTGGCGAGTGTGCCTGCCCCCCAGGCTGGACGGCGTGTGCTCGCCCACTGATATCGGTGTACTCCGAAAAGGGGGAGTCA TCTGGCAAAAATGTCACTTTGCCTGCTGTATTCAAGGCTCCTATTCGACCAGATATTGTGAACTTTGTTCACACCAACTTGCGCAAAAAC AACAGACAGCCCTATGCTGTCAGTGAATTAGCAGGTCATCAGACTAGTGCTGAGTCTTGGGGTACTGGCAGAGCTGTGGCTCGAATTCCC AGAGTTCGAGGTGGTGGGACTCACCGCTCTGGCCAGGGTGCTTTTGGAAACATGTGTCGTGGAGGCCGAATGTTTGCACCAACCAAAACC TGGCGCCGTTGGCATCGTAGAGTGAACACAACCCAAAAACGATACGCCATCTGTTCTGCCCTGGCTGCCTCAGCCCTACCAGCACTGGTC ATGTCTAAAGGTCATCGTATTGAGGAAGTTCCTGAACTTCCTTTGGTAGTTGAAGATAAAGTTGAAGGCTACAAGAAGACCAAGGAAGCT GTTTTGCTCCTTAAGAAACTTAAAGCCTGGAATGATATCAAAAAGGTCTATGCCTCTCAGCGAATGAGAGCTGGCAAAGGCAAAATGAGA AACCGTCGCCGTATCCAGCGCAGGGGCCCGTGCATCATCTATAATGAGGATAATGGTATCATCAAGGCCTTCAGAAACATCCCTGGAATT ACTCTGCTTAATGTAAGCAAGCTGAACATTTTGAAGCTTGCTCCTGGTGGGCATGTGGGACGTTTCTGCATTTGGACTGAAAGTGCTTTC CGGAAGTTAGATGAATTGTACGGCACTTGGCGTAAAGCCGCTTCCCTCAAGAGTAACTACAATCTTCCCATGCACAAGATGATTAATACA GATCTTAGCAGAATCTTGAAAAGCCCAGAGATCCAAAGAGCCCTTCGAGCACCACGCAAGAAGATCCATCGCAGAGTCCTAAAGAAGAAC CCACTGAAAAACTTGAGAATCATGTTGAAGCTAAACCCATATGCAAAGACCATGCGCCGGAACACCATTCTTCGCCAGGCCAGGAATCAC AAGCTCCGGGTGGATAAGGCAGCTGCTGCAGCAGCGGCACTACAAGCCAAATCAGATGAGAAGGCGGCGGTTGCAGGCAAGAAGCCTGTG GTAGGTAAGAAAGGAAAGAAGGCTGCTGTTGGTGTTAAGAAGCAGAAGAAGCCTCTGGTGGGAAAAAAGGCAGCAGCTACCAAGAAACCA >In-frame_MEGF11_ENST00000395625_chr15_66273116_-_RPL4_ENST00000307961_chr15_66795867_-_1818nt ATGCACACCCCTTCGATCAGATCTATTACACACGATGCACAGACATCCTCAACTGGTTCAAGTGCACCAGGCACCGCCCTGTGTACGGAG GAGTGTGTGCACGGCCGCTGCGTTTCCCCGGACACCTGCCACTGCGAGCCTGGCTGGGGAGGGCCCGACTGCTCCAGCGGCTGCGACAGC GACCACTGGGGGCCCCACTGCAGCAACCGGTGCCAGTGCCAGAACGGCGCCCTGTGTAACCCCATCACAGGCGCCTGCGTGTGCGCCGCC GGCTTCCGTGGATGGCGCTGCGAGGAGCTCTGCGCACCTGGCACCCACGGCAAGGGATGCCAGCTGCCGTGCCAGTGCCGACACGGTGCC AGCTGCGACCCCCGCGCCGGCGAGTGCCTCTGCGCACCTGGCTACACCGGCGTCTACTGCGAGGAGCTGTGCCCTCCTGGGAGCCATGGA GCTCACTGTGAGCTGCGCTGCCCCTGTCAGAATGGGGGCACCTGCCACCACATCACTGGCGAGTGTGCCTGCCCCCCAGGCTGGACGGCG TGTGCTCGCCCACTGATATCGGTGTACTCCGAAAAGGGGGAGTCATCTGGCAAAAATGTCACTTTGCCTGCTGTATTCAAGGCTCCTATT CGACCAGATATTGTGAACTTTGTTCACACCAACTTGCGCAAAAACAACAGACAGCCCTATGCTGTCAGTGAATTAGCAGGTCATCAGACT AGTGCTGAGTCTTGGGGTACTGGCAGAGCTGTGGCTCGAATTCCCAGAGTTCGAGGTGGTGGGACTCACCGCTCTGGCCAGGGTGCTTTT GGAAACATGTGTCGTGGAGGCCGAATGTTTGCACCAACCAAAACCTGGCGCCGTTGGCATCGTAGAGTGAACACAACCCAAAAACGATAC GCCATCTGTTCTGCCCTGGCTGCCTCAGCCCTACCAGCACTGGTCATGTCTAAAGGTCATCGTATTGAGGAAGTTCCTGAACTTCCTTTG GTAGTTGAAGATAAAGTTGAAGGCTACAAGAAGACCAAGGAAGCTGTTTTGCTCCTTAAGAAACTTAAAGCCTGGAATGATATCAAAAAG GTCTATGCCTCTCAGCGAATGAGAGCTGGCAAAGGCAAAATGAGAAACCGTCGCCGTATCCAGCGCAGGGGCCCGTGCATCATCTATAAT GAGGATAATGGTATCATCAAGGCCTTCAGAAACATCCCTGGAATTACTCTGCTTAATGTAAGCAAGCTGAACATTTTGAAGCTTGCTCCT GGTGGGCATGTGGGACGTTTCTGCATTTGGACTGAAAGTGCTTTCCGGAAGTTAGATGAATTGTACGGCACTTGGCGTAAAGCCGCTTCC CTCAAGAGTAACTACAATCTTCCCATGCACAAGATGATTAATACAGATCTTAGCAGAATCTTGAAAAGCCCAGAGATCCAAAGAGCCCTT CGAGCACCACGCAAGAAGATCCATCGCAGAGTCCTAAAGAAGAACCCACTGAAAAACTTGAGAATCATGTTGAAGCTAAACCCATATGCA AAGACCATGCGCCGGAACACCATTCTTCGCCAGGCCAGGAATCACAAGCTCCGGGTGGATAAGGCAGCTGCTGCAGCAGCGGCACTACAA GCCAAATCAGATGAGAAGGCGGCGGTTGCAGGCAAGAAGCCTGTGGTAGGTAAGAAAGGAAAGAAGGCTGCTGTTGGTGTTAAGAAGCAG AAGAAGCCTCTGGTGGGAAAAAAGGCAGCAGCTACCAAGAAACCAGCCCCTGAAAAGAAGCCTGCAGAGAAGAAACCTACTACAGAGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MEGF11_ENST00000422354_chr15_66273116_-_RPL4_ENST00000307961_chr15_66795867_-_3574nt GCCCGCTGCCCGCCGCCCGGCTCCCGGCTGCTCGCGGCCCCCTGCTCCTGCCTGGCGCTCTGGCCAGGCTCGGGCTCCGGAGGACAGGAC CGCGCGACTGGCCGGCCGATCCCTGGGCCGGCCGCGGGAGCAGGGCCCGGGATGGTGCTCTCCCTGACGGGGCTCATTGCCTTCTCCTTC CTGCAAGCCACCCTTGCCCTGAACCCCGAGGACCCCAACGTGTGCAGCCACTGGGAGAGCTATGCTGTGACTGTCCAGGAATCGTATGCA CACCCCTTCGATCAGATCTATTACACACGATGCACAGACATCCTCAACTGGTTCAAGTGCACCAGGCACCGGATCAGTTATAAGACGGCG TATCGGAGAGGCCTCCGGACCATGTACCGGCGGAGGTCCCAGTGCTGCCCTGGCTACTATGAGAGCGGAGACTTCTGCATACCCCTGTGT ACGGAGGAGTGTGTGCACGGCCGCTGCGTTTCCCCGGACACCTGCCACTGCGAGCCTGGCTGGGGAGGGCCCGACTGCTCCAGCGGCTGC GACAGCGACCACTGGGGGCCCCACTGCAGCAACCGGTGCCAGTGCCAGAACGGCGCCCTGTGTAACCCCATCACAGGCGCCTGCGTGTGC GCCGCCGGCTTCCGTGGATGGCGCTGCGAGGAGCTCTGCGCACCTGGCACCCACGGCAAGGGATGCCAGCTGCCGTGCCAGTGCCGACAC GGTGCCAGCTGCGACCCCCGCGCCGGCGAGTGCCTCTGCGCACCTGGCTACACCGGCGTCTACTGCGAGGAGCTGTGCCCTCCTGGGAGC CATGGAGCTCACTGTGAGCTGCGCTGCCCCTGTCAGAATGGGGGCACCTGCCACCACATCACTGGCGAGTGTGCCTGCCCCCCAGGCTGG ACGGCGTGTGCTCGCCCACTGATATCGGTGTACTCCGAAAAGGGGGAGTCATCTGGCAAAAATGTCACTTTGCCTGCTGTATTCAAGGCT CCTATTCGACCAGATATTGTGAACTTTGTTCACACCAACTTGCGCAAAAACAACAGACAGCCCTATGCTGTCAGTGAATTAGCAGGTCAT CAGACTAGTGCTGAGTCTTGGGGTACTGGCAGAGCTGTGGCTCGAATTCCCAGAGTTCGAGGTGGTGGGACTCACCGCTCTGGCCAGGGT GCTTTTGGAAACATGTGTCGTGGAGGCCGAATGTTTGCACCAACCAAAACCTGGCGCCGTTGGCATCGTAGAGTGAACACAACCCAAAAA CGATACGCCATCTGTTCTGCCCTGGCTGCCTCAGCCCTACCAGCACTGGTCATGTCTAAAGGTCATCGTATTGAGGAAGTTCCTGAACTT CCTTTGGTAGTTGAAGATAAAGTTGAAGGCTACAAGAAGACCAAGGAAGCTGTTTTGCTCCTTAAGAAACTTAAAGCCTGGAATGATATC AAAAAGGTCTATGCCTCTCAGCGAATGAGAGCTGGCAAAGGCAAAATGAGAAACCGTCGCCGTATCCAGCGCAGGGGCCCGTGCATCATC TATAATGAGGATAATGGTATCATCAAGGCCTTCAGAAACATCCCTGGAATTACTCTGCTTAATGTAAGCAAGCTGAACATTTTGAAGCTT GCTCCTGGTGGGCATGTGGGACGTTTCTGCATTTGGACTGAAAGTGCTTTCCGGAAGTTAGATGAATTGTACGGCACTTGGCGTAAAGCC GCTTCCCTCAAGAGTAACTACAATCTTCCCATGCACAAGATGATTAATACAGATCTTAGCAGAATCTTGAAAAGCCCAGAGATCCAAAGA GCCCTTCGAGCACCACGCAAGAAGATCCATCGCAGAGTCCTAAAGAAGAACCCACTGAAAAACTTGAGAATCATGTTGAAGCTAAACCCA TATGCAAAGACCATGCGCCGGAACACCATTCTTCGCCAGGCCAGGAATCACAAGCTCCGGGTGGATAAGGCAGCTGCTGCAGCAGCGGCA CTACAAGCCAAATCAGATGAGAAGGCGGCGGTTGCAGGCAAGAAGCCTGTGGTAGGTAAGAAAGGAAAGAAGGCTGCTGTTGGTGTTAAG AAGCAGAAGAAGCCTCTGGTGGGAAAAAAGGCAGCAGCTACCAAGAAACCAGCCCCTGAAAAGAAGCCTGCAGAGAAGAAACCTACTACA GAGGAGAAGAAGCCTGCTGCATAAACTCTTAAATTTGATTATTCCATAAAGGTCAAATCATTTTGGACAGCTTCTTTTGAATAAAGACCT GATTATACAGGCAGTGAGAAACATGACTTGGTGTGCTCTGTAAAGCTTGGTTAGAATTTTTTTAAAGTGACATTTTGTTGGCCATAATTT AGACTGTTACATTTTATATAGTGTGGTATAAAATGGGGCATGGATTTATACTAAGTCCATGGAGTTCAGTGGAAGGGGAATGATTTAAAA AAAGTTGTGGTTTTCTAAATAATGTGGCTTGAAAAATAGGTGTAACAGGACTTGGTCAGAAACGCAGAGGCTGTTCAAGTTTAGCTCCCC ACCAGATGGAAAATAGGTTAAATTCTGTAAAGATTTAACTTTAACCACAAGAGGGCACAACTGGAGAGCACAATTTTTTTGGTACTGCAG TAAAATTGATTACCTCTTGAGAAGTGTTCTTTTTAACCAGCTATAACAATAGAGTTGAGTATTTTCACCCATGGTTTGAAAAAGTGCCAG AAGGCCACACTGGCCCACATCTGTAATCCCAACACTTTGGGACCCTAAGGTGGGCAGAGCACTTGAGCCAATGAGTTCAAGACCAGCCTG GTCAACATGATGAAATCTCGTCTCTACTGAAAATATAAAAAATAGCCAGTCATGGTGCATGCCTGTAACCCCAGCTACTTGGAGGCTGAG GCAAGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAATGAGCCAAGATTGTACCATTGCCCTCCAGCCTGGGCGTCAGAGCAAGACTC TCTGAAAAGTACCAGAAGCATTTTTCAGGACTGCCTGTGTGTCTTGGTGATTATGTTAACCAACTGTGTTCAAAAGAAGTACCCATGAAA TGCCTCCAGATATAAGGGTGTTTTTTTTTACCCATAAAGCTAAACTGCAAATATTACCCTAGAATTAACCTCTTGTCCTGTGTCAAAAGT CTTGTTTTGCATCTGGATTGTTAAACTGTCAGCTTCTCTCTGACAGTCTCGAACTGTCAAGACAGTCTCAGTTCACAGCCAAGGTGATCT GTTAACCCTCCCCATTTCCAGGGCCAAATCTCAGTTCTTAAGCACGTCGTTTCTTAGCACGGCTTTATTTTCATGCTCTTTATTTCTCTA TTTTGTGCAGCCTTACCCCTTTAAAGTCCACTGTGAGTCCTACCCTGCAGGGCCTCTTAACACAGTAGAGTTCATGTGCTACTGATTTGG TGCCTGCCTTCAAACACATGTGCAAGTTTTGTGGGGTTAAAGATAGCCACTTGGTGGCACACCACATTGGAAGTGCTGTTCACCCGGTCA >In-frame_MEGF11_ENST00000395625_chr15_66273116_-_RPL4_ENST00000307961_chr15_66795867_-_3473nt GCCCGCTGCCCGCCGCCCGGCTCCCGGCTGCTCGCGGCCCCCTGCTCCTGCCTGGCGCTCTGGCCAGGCTCGGGCTCCGGAGGACAGGAC CGCGCGACTGGCCGGCCGATCCCTGGGCCGGCCGCGGGAGCAGGGCCCGGGATGGTGCTCTCCCTGACGGGGCTCATTGCCTTCTCCTTC CTGCAAGCCACCCTTGCCCTGAACCCCGAGGACCCCAACGTGTGCAGCCACTGGGAGAGCTATGCTGTGACTGTCCAGGAATCGTATGCA CACCCCTTCGATCAGATCTATTACACACGATGCACAGACATCCTCAACTGGTTCAAGTGCACCAGGCACCGCCCTGTGTACGGAGGAGTG TGTGCACGGCCGCTGCGTTTCCCCGGACACCTGCCACTGCGAGCCTGGCTGGGGAGGGCCCGACTGCTCCAGCGGCTGCGACAGCGACCA CTGGGGGCCCCACTGCAGCAACCGGTGCCAGTGCCAGAACGGCGCCCTGTGTAACCCCATCACAGGCGCCTGCGTGTGCGCCGCCGGCTT CCGTGGATGGCGCTGCGAGGAGCTCTGCGCACCTGGCACCCACGGCAAGGGATGCCAGCTGCCGTGCCAGTGCCGACACGGTGCCAGCTG CGACCCCCGCGCCGGCGAGTGCCTCTGCGCACCTGGCTACACCGGCGTCTACTGCGAGGAGCTGTGCCCTCCTGGGAGCCATGGAGCTCA CTGTGAGCTGCGCTGCCCCTGTCAGAATGGGGGCACCTGCCACCACATCACTGGCGAGTGTGCCTGCCCCCCAGGCTGGACGGCGTGTGC TCGCCCACTGATATCGGTGTACTCCGAAAAGGGGGAGTCATCTGGCAAAAATGTCACTTTGCCTGCTGTATTCAAGGCTCCTATTCGACC AGATATTGTGAACTTTGTTCACACCAACTTGCGCAAAAACAACAGACAGCCCTATGCTGTCAGTGAATTAGCAGGTCATCAGACTAGTGC TGAGTCTTGGGGTACTGGCAGAGCTGTGGCTCGAATTCCCAGAGTTCGAGGTGGTGGGACTCACCGCTCTGGCCAGGGTGCTTTTGGAAA CATGTGTCGTGGAGGCCGAATGTTTGCACCAACCAAAACCTGGCGCCGTTGGCATCGTAGAGTGAACACAACCCAAAAACGATACGCCAT CTGTTCTGCCCTGGCTGCCTCAGCCCTACCAGCACTGGTCATGTCTAAAGGTCATCGTATTGAGGAAGTTCCTGAACTTCCTTTGGTAGT TGAAGATAAAGTTGAAGGCTACAAGAAGACCAAGGAAGCTGTTTTGCTCCTTAAGAAACTTAAAGCCTGGAATGATATCAAAAAGGTCTA TGCCTCTCAGCGAATGAGAGCTGGCAAAGGCAAAATGAGAAACCGTCGCCGTATCCAGCGCAGGGGCCCGTGCATCATCTATAATGAGGA TAATGGTATCATCAAGGCCTTCAGAAACATCCCTGGAATTACTCTGCTTAATGTAAGCAAGCTGAACATTTTGAAGCTTGCTCCTGGTGG GCATGTGGGACGTTTCTGCATTTGGACTGAAAGTGCTTTCCGGAAGTTAGATGAATTGTACGGCACTTGGCGTAAAGCCGCTTCCCTCAA GAGTAACTACAATCTTCCCATGCACAAGATGATTAATACAGATCTTAGCAGAATCTTGAAAAGCCCAGAGATCCAAAGAGCCCTTCGAGC ACCACGCAAGAAGATCCATCGCAGAGTCCTAAAGAAGAACCCACTGAAAAACTTGAGAATCATGTTGAAGCTAAACCCATATGCAAAGAC CATGCGCCGGAACACCATTCTTCGCCAGGCCAGGAATCACAAGCTCCGGGTGGATAAGGCAGCTGCTGCAGCAGCGGCACTACAAGCCAA ATCAGATGAGAAGGCGGCGGTTGCAGGCAAGAAGCCTGTGGTAGGTAAGAAAGGAAAGAAGGCTGCTGTTGGTGTTAAGAAGCAGAAGAA GCCTCTGGTGGGAAAAAAGGCAGCAGCTACCAAGAAACCAGCCCCTGAAAAGAAGCCTGCAGAGAAGAAACCTACTACAGAGGAGAAGAA GCCTGCTGCATAAACTCTTAAATTTGATTATTCCATAAAGGTCAAATCATTTTGGACAGCTTCTTTTGAATAAAGACCTGATTATACAGG CAGTGAGAAACATGACTTGGTGTGCTCTGTAAAGCTTGGTTAGAATTTTTTTAAAGTGACATTTTGTTGGCCATAATTTAGACTGTTACA TTTTATATAGTGTGGTATAAAATGGGGCATGGATTTATACTAAGTCCATGGAGTTCAGTGGAAGGGGAATGATTTAAAAAAAGTTGTGGT TTTCTAAATAATGTGGCTTGAAAAATAGGTGTAACAGGACTTGGTCAGAAACGCAGAGGCTGTTCAAGTTTAGCTCCCCACCAGATGGAA AATAGGTTAAATTCTGTAAAGATTTAACTTTAACCACAAGAGGGCACAACTGGAGAGCACAATTTTTTTGGTACTGCAGTAAAATTGATT ACCTCTTGAGAAGTGTTCTTTTTAACCAGCTATAACAATAGAGTTGAGTATTTTCACCCATGGTTTGAAAAAGTGCCAGAAGGCCACACT GGCCCACATCTGTAATCCCAACACTTTGGGACCCTAAGGTGGGCAGAGCACTTGAGCCAATGAGTTCAAGACCAGCCTGGTCAACATGAT GAAATCTCGTCTCTACTGAAAATATAAAAAATAGCCAGTCATGGTGCATGCCTGTAACCCCAGCTACTTGGAGGCTGAGGCAAGAGAATC ACTTGAACCTGGGAGGTGGAGGTTGCAATGAGCCAAGATTGTACCATTGCCCTCCAGCCTGGGCGTCAGAGCAAGACTCTCTGAAAAGTA CCAGAAGCATTTTTCAGGACTGCCTGTGTGTCTTGGTGATTATGTTAACCAACTGTGTTCAAAAGAAGTACCCATGAAATGCCTCCAGAT ATAAGGGTGTTTTTTTTTACCCATAAAGCTAAACTGCAAATATTACCCTAGAATTAACCTCTTGTCCTGTGTCAAAAGTCTTGTTTTGCA TCTGGATTGTTAAACTGTCAGCTTCTCTCTGACAGTCTCGAACTGTCAAGACAGTCTCAGTTCACAGCCAAGGTGATCTGTTAACCCTCC CCATTTCCAGGGCCAAATCTCAGTTCTTAAGCACGTCGTTTCTTAGCACGGCTTTATTTTCATGCTCTTTATTTCTCTATTTTGTGCAGC CTTACCCCTTTAAAGTCCACTGTGAGTCCTACCCTGCAGGGCCTCTTAACACAGTAGAGTTCATGTGCTACTGATTTGGTGCCTGCCTTC AAACACATGTGCAAGTTTTGTGGGGTTAAAGATAGCCACTTGGTGGCACACCACATTGGAAGTGCTGTTCACCCGGTCATTTGAAACGGT |
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FusionGenePPI for MEGF11_RPL4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MEGF11 | ATN1, EWSR1 | RPL4 | MAP3K1, RRP1B, MYB, HDAC5, NOP56, DYRK2, PCK1, NDRG1, ARRB2, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, GRK5, SMAD3, APOE, RPL21, RPL30, RPL6, RPL8, RPS11, RPS13, RPS3, RPL7, RPS3A, RPL10A, RPL7A, RPLP0, RPS9, RPL12, RPL13, RPL14, RPL15, RPL17, RPL18A, RPL18, RPL19, RPL24, RPL3, RPL5, RPL9, RPS14, RPS15A, RPS16, RPS20, RPS26, RPS2, RPS6, RPS8, RPSA, RPL23, RPS23, RPS5, RPS4X, RPLP1, RPL37A, RPL11, RPS24, RPS7, RPL23A, RPL10, RPL22, RPS17, RPS25, RPL31, RPS19, RPL27, RPS28, RPS12, RPL36, RPL32, RPL29, RPS27A, FBL, RPS21, NOP58, EEF1A1, EEF2, NCL, MYBBP1A, ILF3, ILF2, GNL3, RSL1D1, SLC25A5, EIF6, PABPC1, NHP2L1, NOLC1, RPS27L, NOP2, GNB2L1, RPLP0P6, RPL10L, NIFK, SND1, PTGES3, TUBA1C, ICT1, ATP5B, TARS, SERBP1, UQCRH, ESR1, MAGOH, EIF4A3, YWHAE, PA2G4, FN1, VCAM1, MAP1LC3A, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, SORBS1, HTT, FBXO6, TARDBP, PARK2, PRPF40A, APBB1, PIN1, STAU1, CEP250, TP53, HUWE1, IL32, FUS, PHF6, RNF2, EGFR, SUMO2, NPM1, NTRK1, FTSJ3, GTPBP4, NIP7, PES1, RNPS1, RPL26, RPL26L1, RPL27A, RPL35A, RPL3L, ABCE1, BRIX1, DDX24, EEF1A2, NOC3L, RPL13A, RPL34, RPL35, RPL38, RPS10, UBA52, WDR12, RPLP2, RPS15, RPS18, LOC101929876, RPS27, SFN, XPO1, HNRNPU, TFG, GAN, SKI, NF2, RC3H1, MDM2, ATOH1, ZNF746, CNBP, RRS1, RPL28, MAGEB10, MAK16, KIAA0020, GLTSCR2, PRDM5, GPATCH4, ZNF512, PRR11, H2AFY2, SART3, RRP8, CYLD, INO80B, TRIM25, BRCA1, MTF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MEGF11_RPL4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | RPL4 | P36578 | DB11638 | Artenimol | 60S ribosomal protein L4 | small molecule | approved|investigational |
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RelatedDiseases for MEGF11_RPL4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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