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Fusion gene ID: 21583 |
FusionGeneSummary for MED4_TENM3 |
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Fusion gene information | Fusion gene name: MED4_TENM3 | Fusion gene ID: 21583 | Hgene | Tgene | Gene symbol | MED4 | TENM3 | Gene ID | 29079 | 55714 |
Gene name | mediator complex subunit 4 | teneurin transmembrane protein 3 | |
Synonyms | ARC36|DRIP36|HSPC126|TRAP36|VDRIP | MCOPCB9|ODZ3|TNM3|Ten-m3|ten-3 | |
Cytomap | 13q14.2 | 4q34.3-q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | mediator of RNA polymerase II transcription subunit 4TRAP/SMCC/PC2 subunit p36activator-recruited cofactor 36 kDa componentmediator, 34-kD subunit, homologvitamin D receptor-interacting protein, 36-kDvitamin D3 receptor-interacting protein complex 36 | teneurin-3ODZ3-like proteinodz, odd Oz/ten-m homolog 3protein Odd Oz/ten-m homolog 3tenascin-M3testicular tissue protein Li 195 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NPJ6 | Q9P273 | |
Ensembl transtripts involved in fusion gene | ENST00000495013, ENST00000258648, ENST00000378586, | ENST00000511685, ENST00000406950, ENST00000502950, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 4 X 2=32 |
# samples | 5 | 4 | |
** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MED4 [Title/Abstract] AND TENM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MED4 | GO:0006366 | transcription by RNA polymerase II | 10882111 |
Hgene | MED4 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 12218053 |
Hgene | MED4 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 11867769 |
Hgene | MED4 | GO:0030521 | androgen receptor signaling pathway | 12218053 |
Hgene | MED4 | GO:0045893 | positive regulation of transcription, DNA-templated | 10198638 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ774587 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000495013 | ENST00000511685 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
intron-intron | ENST00000495013 | ENST00000406950 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
intron-intron | ENST00000495013 | ENST00000502950 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
intron-3UTR | ENST00000258648 | ENST00000511685 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
intron-intron | ENST00000258648 | ENST00000406950 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
intron-intron | ENST00000258648 | ENST00000502950 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
intron-3UTR | ENST00000378586 | ENST00000511685 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
intron-intron | ENST00000378586 | ENST00000406950 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
intron-intron | ENST00000378586 | ENST00000502950 | MED4 | chr13 | 48650783 | + | TENM3 | chr4 | 183722647 | - |
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FusionProtFeatures for MED4_TENM3 |
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Hgene | Tgene |
MED4 | TENM3 |
Involved in neural development by regulating theestablishment of proper connectivity within the nervous system.Acts in both pre- and postsynaptic neurons in the hippocampus tocontrol the assembly of a precise topographic projection: requiredin both CA1 and subicular neurons for the precise targeting ofproximal CA1 axons to distal subiculum, probably by promotinghomophilic cell adhesion. Required for proper dendritemorphogenesis and axon targeting in the vertebrate visual system,thereby playing a key role in the development of the visualpathway. Regulates the formation in ipsilateral retinal mapping toboth the dorsal lateral geniculate nucleus (dLGN) and the superiorcolliculus (SC). May also be involved in the differentiation ofthe fibroblast-like cells in the superficial layer of mandibularcondylar cartilage into chondrocytes.{ECO:0000250|UniProtKB:Q9WTS6}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MED4_TENM3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MED4_TENM3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED4_TENM3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED4_TENM3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MED4 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | TENM3 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Tgene | TENM3 | C0264423 | Asthma, Occupational | 1 | CTD_human |